Full Text Journal Articles by
Author Nathan R Haines

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Metabolomics Analysis of Human Vitreous in Diabetic Retinopathy and Rhegmatogenous Retinal Detachment.

Nathan R Haines, Niranjan Manoharan, Jeffrey L Olson, Angelo D'Alessandro, Julie A Reisz,

The vitreous humor is a highly aqueous eye fluid interfacing with the retina and lens and providing shape. Its molecular composition provides a readout for the eye's physiological status. Changes in cellular metabolism underlie vitreoretinal pathologies, but despite routine surgical collection of vitreous, only limited reports of metabolism in the ... Read more >>

J. Proteome Res. (Journal of proteome research)
[2018, 17(7):2421-2427]

Cited: 3 times

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Homocysteinemia due to MTHFR deficiency in a young adult presenting with bilateral lens subluxations.

Natario L Couser, Julie McClure, Michael W Evans, Nathan R Haines, Susan K Burden, Joseph Muenzer,

The most common cause of isolated inherited homocysteinemia is a deficiency of the enzyme cystathionine β-synthase (CBS). Clinical manifestations of CBS deficiency can include ectopia lentis, thromboembolism, marfanoid habits, and intellectual disability. CBS deficiency, which affects the transsulfuration pathway, is marked biochemically by elevated serum homocysteine and plasma methionine. We ... Read more >>

Ophthalmic Genet. (Ophthalmic genetics)
[2017, 38(1):91-94]

Cited: 2 times

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A sulfone-based strategy for the preparation of 2,4-disubstituted furan derivatives.

Nathan R Haines, Aaron N VanZanten, Anthony A Cuneo, John R Miller, William J Andrews, David A Carlson, Ryan M Harrington, Adam M Kiefer, Jeremy D Mason, Julie A Pigza, S Shaun Murphree,

2,4-Disubstituted furans are prepared by treating 2,3-dibromo-1-phenylsulfonyl-1-propene (DBP, 2) with 1,3-diketones under basic conditions. The furan-forming step involves a deacetylation, and the selectivity of this process depends upon the steric demand of the R group. The substituent in position 4 is elaborated by reaction of sulfonyl carbanions with alkyl halides, ... Read more >>

J. Org. Chem. (The Journal of organic chemistry)
[2011, 76(19):8131-8137]

Cited: 3 times

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