Full Text Journal Articles by
Author Nathalie Rioux Leclercq

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Cancer associated fibroblasts in Renal Cell Carcinoma: implication in prognosis and resistance to antiangiogenic therapy.

Damien Ambrosetti, Michael Coutts, Charlotte Paoli, Matthieu Durand, Delphine Borchiellini, Christopher Montemagno, Olivia Rastoin, Arnaud Borderie, Renaud Grepin, Nathalie Rioux-Leclercq, Jean-Christophe Bernhard, Gilles Pagès, Maeva Dufies,

<h4>Objectives</h4>To investigate the role of cancer-associated fibroblasts (CAFs) in clear cell renal cell carcinoma (ccRCC) with respect to tumor aggressiveness, metastasis development and resistance to antiangiogenic therapy (VEGFR-tyrosine kinase inhibitors, VEGFR-TKI).<h4>Methods</h4>Our study involved tissue samples from three distinct and independent cohorts of patients with ccRCC. The presence of CAFs and ... Read more >>

BJU Int (BJU international)
[2021, :]

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Non-clear cell renal carcinomas: Review of new molecular insights and recent clinical data.

Philippe Barthélémy, Nathalie Rioux-Leclercq, Constance Thibault, Carolina Saldana, Delphine Borchiellini, Christine Chevreau, Isabelle Desmoulins, Aurélien Gobert, Werner Hilgers, Ahmed Khalil, Nathalie Lemoine, Friederike Schlürmann-Constans, Sylvie Négrier,

Non-clear cell renal cell carcinomas (nccRCC) represent a highly heterogeneous group of kidney tumors, consisting of the following subtypes: papillary carcinomas, chromophobe renal cell carcinoma, so-called unclassified carcinomas or aggressive uncommon carcinomas such as Bellini carcinoma, renal cell carcinoma (RCC) with ALK rearrangement or fumarate hydratase-deficient RCC. Although non-clear cell ... Read more >>

Cancer Treat Rev (Cancer treatment reviews)
[2021, 97:102191]

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Kidney Biopsy in Type 2 Diabetes: A Multicenter Cross-Sectional Study.

Jonathan M Chemouny, Mickaël Bobot, Aurélie Sannier, Valentin Maisons, Noémie Jourde-Chiche, Elsa Ferriere, Dominique Joly, Cécile Vigneau, Nathalie Rioux-Leclercq, Christophe Barba, Laurent Daniel, Jean-Michel Halimi, Francois Vrtovsnik,

<h4>Introduction</h4>Kidney biopsies (KBs) are performed in patients with type 2 diabetes (T2D) to diagnose non-diabetic or hypertensive kidney disease (NDHKD) potentially requiring specific management compared to diabetic and or hypertensive nephropathy (absence of NDHKD). Indications for KB are based on the presence of atypical features compared to the typical course ... Read more >>

Am J Nephrol (American journal of nephrology)
[2021, 52(2):131-140]

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Multiple metastatic clones assessed by an integrative multiomics strategy in clear cell renal carcinoma: a case study.

Julien Dagher, Angelique Brunot, Bertrand Evrard, Solene-Florence Kammerer-Jacquet, Marion Beaumont, Laurence Cornevin, Fanny Derquin, Gregory Verhoest, Karim Bensalah, Alexandra Lespagnol, Frederic Dugay, Marc-Antoine Belaud-Rotureau, Frédéric Chalmel, Nathalie Rioux-Leclercq,

The dynamics of metastatic evolution in clear cell renal cell carcinoma (ccRCC) are complex. We report a case study where tumour heterogeneity resulting from clonal evolution is a frequent feature and could play a role in metastatic dissemination.We used an integrative multiomics strategy combining genomic and transcriptomic data to classify ... Read more >>

J Clin Pathol (Journal of clinical pathology)
[2021, :]

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Complete Transurethral Resection before Radical Cystectomy May Improve Oncological Outcomes.

Vivien Graffeille, Grégory Verhoest, Alexandre Gryn, Solène-Florence Kammerer-Jacquet, Quentin Alimi, Jean-Baptiste Beauval, Luc Beuzit, Benjamin Pradère, Matthieu Thoulouzan, Zine Eddine Khene, François Guille, Nathalie Rioux-Leclercq, Romain Mathieu, Xavier Gamé, Karim Bensalah, Michel Soulié, Mathieu Roumiguié, Benoit Peyronnet,

<h4>Objectives</h4>The objective of this study was to assess the impact of complete transurethral resection of bladder tumors (TURBTs) before radical cystectomy on pathological and oncological outcomes of patients with muscle-invasive bladder cancer (MIBC) and high-risk non-MIBC.<h4>Materials and methods</h4>The charts of all patients who underwent radical cystectomy for bladder cancer in ... Read more >>

Urol Int (Urologia internationalis)
[2021, :1-8]

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Plk1, upregulated by HIF-2, mediates metastasis and drug resistance of clear cell renal cell carcinoma.

Maeva Dufies, Annelies Verbiest, Lindsay S Cooley, Papa Diogop Ndiaye, Xingkang He, Nicolas Nottet, Wilfried Souleyreau, Anais Hagege, Stephanie Torrino, Julien Parola, Sandy Giuliano, Delphine Borchiellini, Renaud Schiappa, Baharia Mograbi, Jessica Zucman-Rossi, Karim Bensalah, Alain Ravaud, Patrick Auberger, Andréas Bikfalvi, Emmanuel Chamorey, Nathalie Rioux-Leclercq, Nathalie M Mazure, Benoit Beuselinck, Yihai Cao, Jean Christophe Bernhard, Damien Ambrosetti, Gilles Pagès,

Polo-like kinase 1 (Plk1) expression is inversely correlated with survival advantages in many cancers. However, molecular mechanisms that underlie Plk1 expression are poorly understood. Here, we uncover a hypoxia-regulated mechanism of Plk1-mediated cancer metastasis and drug resistance. We demonstrated that a HIF-2-dependent regulatory pathway drives Plk1 expression in clear cell ... Read more >>

Commun Biol (Communications biology)
[2021, 4(1):166]

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Adherent perinephric fat affects perioperative outcomes after partial nephrectomy: a systematic review and meta-analysis.

Zine-Eddine Khene, Gilles Dosin, Benoit Peyronnet, Anis Gasmi, Nicolas Doumerc, Idir Ouzaid, Benjamin Pradere, Marie Brassier, Mathieu Roumiguié, Romain Mathieu, Nathalie Rioux-Leclercq, Jay D Raman, Shahrokh Shariat, Karim Bensalah,

To investigate the association of adherent perinephric fat (APF) with perioperative outcomes, we conducted a systematic review and meta-analysis of the literature to clarify the impact of APF in patients undergoing partial nephrectomy. A systematic literature search using the Medline, Scopus, and Cochrane databases was performed in April 2019 and ... Read more >>

Int J Clin Oncol (International journal of clinical oncology)
[2021, 26(4):636-646]

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Towards a reduced in silico model predicting biochemical recurrence after radiotherapy in prostate cancer.

Carlos Sosa-Marrero, Renaud de Crevoisier, Alfredo Hernandez, Pierre Fontaine, Nathalie Rioux-Leclercq, Romain Mathieu, Alain Fautrel, Francois Paris, Oscar Acosta,

<h4>Objective</h4>Purposes of this work were i) to develop an in silico model of tumor response to radiotherapy, ii) to perform an exhaustive sensitivity analysis in order to iii) propose a simplified version and iv) to predict biochemical recurrence with both the comprehensive and the reduced model.<h4>Methods</h4>A multiscale computational model of ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
[2021, PP:]

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Soluble forms of PD-L1 and PD-1 as prognostic and predictive markers of sunitinib efficacy in patients with metastatic clear cell renal cell carcinoma.

Christopher Montemagno, Anais Hagege, Delphine Borchiellini, Brice Thamphya, Olivia Rastoin, Damien Ambrosetti, Juan Iovanna, Nathalie Rioux-Leclercq, Camillio Porta, Sylvie Negrier, Jean-Marc Ferrero, Emmanuel Chamorey, Gilles Pagès, Maeva Dufies,

Metastatic clear cell renal cell carcinoma (mccRCC) benefits from several treatment options in the first-line setting with VEGFR inhibitors and/or immunotherapy including anti-PD-L1 or anti-PD1 agents. Identification of predictive biomarkers is highly needed to optimize patient care. Circulating markers could reflect the biology of metastatic disease. Therefore, we evaluated soluble ... Read more >>

Oncoimmunology (Oncoimmunology)
[2020, 9(1):1846901]

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Prognostic Impact of pT3 Subclassification in a Multicentre Cohort of Patients with Urothelial Carcinoma of the Renal Pelvicalyceal System Undergoing Radical Nephroureterectomy: A Propensity Score-weighted Analysis After Central Pathology Review.

Thomas Seisen, Andrea Mari, Riccardo Campi, Benoit Peyronnet, Karim Bensalah, Nathalie Rioux-Leclercq, Christian Pfister, Françoise Gobet, Alexandre De La Taille, Yves Allory, Evanguelos Xylinas, Yann Neuzillet, Camelia Radulescu, Jean-Luc Descotes, Géraldine Saada-Sebag, Jacques Irani, Céline Delpech-Debiais, Pierre Bigot, Caroline Eymerit, Sebastien Crouzet, Florence Mege-Lechevallier, Alain Ruffion, Myriam Decaussin-Petrucci, Stéphane Droupy, Pascal Roger, Xavier Durand, Philippe Camparo, Olivier Cussenot, Eva Compérat, Morgan Rouprêt,

<h4>Background</h4>The current pathological tumour-node-metastasis (pTNM) classification for upper tract urothelial carcinoma (UTUC) does not include any risk stratification of pT3 renal pelvicalyceal tumours.<h4>Objective</h4>To assess the prognostic impact of pT3 subclassification in a multicentre cohort of patients with UTUC of the renal pelvicalyceal system undergoing radical nephroureterectomy (RNU).<h4>Design, setting, and participants</h4>Data ... Read more >>

Eur Urol Focus (European urology focus)
[2020, :]

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Renal cell carcinoma with leiomyomatous stroma in tuberous sclerosis complex: a distinct entity.

Marjorie Gournay, Frédéric Dugay, Marc-Antoine Belaud-Rotureau, Benoit Peyronnet, Romain Mathieu, Gregory Verhoest, Karim Bensalah, Sylvie Odent, Philippe Denizeau, Cécile Vigneau, Aurélien Morini, Nathalie Rioux-Leclercq, Solène-Florence Kammerer-Jacquet,

Renal cell carcinoma with leiomyomatous stroma (RCCLS) is an emerging entity frequently associated with tuberous sclerosis complex (TSC). We described herein a series of RCCLS in TSC patients at pathological and cytogenetic levels. Three male patients with TSC and RCCLS were identified between 2000 and 2019 at the University Hospital ... Read more >>

Virchows Arch (Virchows Archiv : an international journal of pathology)
[2021, 478(4):793-799]

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Specificities of small cell neuroendocrine prostate cancer: Adverse prognostic value of TTF1 expression.

Mathilde Cancel, Claire Castellier, Celine Debiais-Delpech, Thomas Charles, François Rozet, Nathalie Rioux-Leclercq, Romain Mathieu, Françoise Beltjens, Luc Cormier, Franck Bruyère, Gaëlle Fromont,

<h4>Objectives</h4>To determine whether small cell neuroendocrine prostate cancers (NEPCa) emerging after anti-androgen treatments are different from the rarest cases diagnosed de novo, and to identify effective predictive markers.<h4>Material and methods</h4>The expression of neuroendocrine markers, androgen receptor (AR) and androgen-regulated genes, as well as markers of aggressiveness, were analyzed by immunohistochemistry ... Read more >>

Urol Oncol (Urologic oncology)
[2021, 39(1):74.e17-74.e23]

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Radiomics can predict tumour response in patients treated with Nivolumab for a metastatic renal cell carcinoma: an artificial intelligence concept.

Zine-Eddine Khene, Romain Mathieu, Benoit Peyronnet, Romain Kokorian, Anis Gasmi, Fares Khene, Nathalie Rioux-Leclercq, Solène-Florence Kammerer-Jacquet, Shahrokh Shariat, Brigitte Laguerre, Karim Bensalah,

World J Urol (World journal of urology)
[2020, :]

Cited: 1 time

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Exploring Biological Predictive Factors of Progression After Surgery in High-Risk Renal Cell Carcinoma: Results From the French Cohort of the Randomized S-TRAC Trial Patients.

Idir Ouzaid, Solène Florence Kammerer-Jacquet, Zineddine Khene, Alain Ravaud, Jean-Jacques Patard, Karim Bensalah, Nathalie Rioux-Leclercq,

<b>Objective:</b> We aimed to explore biological predictive factors of progression after surgery in nonmetastatic renal cell carcinoma (RCC) using the collected tumors in the French cohort of the randomized S-TRAC trial patients. <b>Patients and Methods:</b> We analyzed the tumors of the French cohort of STRAC that included 44 cases of ... Read more >>

Front Surg (Frontiers in surgery)
[2020, 7:26]

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[Lysozyme-induced nephropathy: A rare cause of renal failure in chronic myelomonocytic leukemia].

Gwladys Robinet-Zimmermann, Nathalie Rioux-Leclercq, Thierry Frouget, Cécile Le Naoures,

INTRODUCTION:Lysozyme-induced nephropathy is a rare and unknown complication of chronic myelomonocytic leukemia with overproduction of lysozyme by tumoral cells leading to proximal tubular cells injuries. The present case reports a lysozyme nephropathy secondary to chronic myelomonocytic leukemia. OBSERVATION:We reported a case of a 82-years-old woman who presented an acute renal ... Read more >>

Ann Pathol (Annales de pathologie)
[2020, 40(6):478-482]

Cited: 1 time

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Bone metastasis is associated with poor prognosis in metastatic papillary renal cell carcinoma patients treated with first agent angiogenesis inhibitors.

Lorenz Haaker, Loesia Tryssesoone, Inne Renders, Annelies Verbiest, Evelyne Lerut, Marcella Baldewijns, Claire Bourgain, Eduard Roussel, Heidi Van den Bulck, Wim Wynendaele, Brigitte Laguerre, Nathalie Rioux-Leclercq, Stéphane Oudard, Annouschka Laenen, Philip R Debruyne, Maarten Albersen, Benoit Beuselinck,

<h4>Objective</h4>Papillary renal cell carcinoma (papRCC) is a rare (10%-15%) subtype of renal cancer. Few prognostic biomarkers have been described in metastatic papRCC (m-papRCC) patients treated with vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKIs). We aimed to study the prognostic impact of bone metastases (BM) on response rate, progression-free ... Read more >>

Urol Oncol (Urologic oncology)
[2020, 38(8):686.e1-686.e9]

Cited: 1 time

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[An unconventional renal tumor…].

Samah El Naderi, Claude Sader Ghorra, Rosy Abou-Jaoudé, Francisco Llamas-Gutierrez, Nathalie Rioux-Leclercq,

Ann Pathol (Annales de pathologie)
[2020, 40(6):483-486]

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Immunotherapy in Renal Cell Carcinoma: The Future Is Now.

Antoine Deleuze, Judikaël Saout, Frédéric Dugay, Benoit Peyronnet, Romain Mathieu, Gregory Verhoest, Karim Bensalah, Laurence Crouzet, Brigitte Laguerre, Marc-Antoine Belaud-Rotureau, Nathalie Rioux-Leclercq, Solène-Florence Kammerer-Jacquet,

Renal cell carcinoma is the third type of urologic cancer and has a poor prognosis with 30% of metastatic patients at diagnosis. The antiangiogenics and targeted immunotherapies led to treatment remodeling emphasizing the role of the tumour microenvironment. However, long-term responses are rare with a high rate of resistance. New ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(7):]

Cited: 6 times

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New clinical forms of hereditary apoA-I amyloidosis entail both glomerular and retinal amyloidosis.

Magali Colombat, Jean-Claude Aldigier, Pierre-Raphael Rothschild, Vincent Javaugue, Estelle Desport, Thierry Frouget, Jean-Michel Goujon, Nathalie Rioux-Leclercq, Nathalie Quellard, Jean Philippe Rerolle, François Paraf, Caroline Beugnet, Aurélien Tiple, Antoine Durrbach, Didier Samuel, Antoine Brézin, Frank Bridoux, Sophie Valleix,

Apolipoprotein A1 amyloidosis (ApoAI) results from specific mutations in the APOA1 gene causing abnormal accumulation of amyloid fibrils in diverse tissues. The kidney is a prominent target tissue in ApoAI amyloidosis with a remarkable selectivity for the renal medulla. Here, we investigated six French families with ApoAI Glu34Lys, p.His179Profs∗47, and ... Read more >>

Kidney Int (Kidney international)
[2020, 98(1):195-208]

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Axitinib in first-line for patients with metastatic papillary renal cell carcinoma: Results of the multicentre, open-label, single-arm, phase II AXIPAP trial.

Sylvie Negrier, Nathalie Rioux-Leclercq, Céline Ferlay, Marine Gross-Goupil, Gwenaëlle Gravis, Lionel Geoffrois, Christine Chevreau, Helen Boyle, Frederic Rolland, Ellen Blanc, Alain Ravaud, Slimane Dermeche, Aude Flechon, Laurence Albiges, David Pérol, Bernard Escudier, ,

INTRODUCTION:Papillary renal cell carcinoma (PRCC) represents 10%-15% of renal carcinomas. No standard treatments exist for metastatic PRCC (mPRCC) patients. Axitinib is indicated as second-line treatment in metastatic clear cell renal carcinoma, and we aim to assess the efficacy of this vascular endothelial growth factor receptor inhibitor in front line for ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2020, 129:107-116]

Cited: 2 times

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[MiT family translocation renal cell carcinomas: Natural history, molecular features and multidisciplinary management].

Hugo Herrscher, Alice Boilève, Véronique Lindner, Philippe Barthélémy, Émilie Hutt, Laure Pierard, Jean-Emmanuel Kurtz, Nathalie Rioux-Leclercq, Hervé Lang, Gabriel G Malouf,

MiT family translocation renal cell carcinomas (tRCC) represent a rare subtype of renal cell carcinomas. These tumors have been introduced for the first time in the World Health Classification (WHO) classification of kidney cancers in 2004. tRCC are characterized by reccurent translocations involving members of the MiT family transcription factors, ... Read more >>

Bull Cancer (Bulletin du cancer)
[2020, 107(2):272-280]

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Identification of a new aggressive axis driven by ciliogenesis and absence of VDAC1-ΔC in clear cell Renal Cell Carcinoma patients.

Lucilla Fabbri, Maeva Dufies, Sandra Lacas-Gervais, Betty Gardie, Sophie Gad-Lapiteau, Julien Parola, Nicolas Nottet, Monique Meyenberg Cunha de Padua, Julie Contenti, Delphine Borchiellini, Jean-Marc Ferrero, Nathalie Rioux Leclercq, Damien Ambrosetti, Baharia Mograbi, Stéphane Richard, Julien Viotti, Emmanuel Chamorey, Nirvana Sadaghianloo, Matthieu Rouleau, William J Craigen, Bernard Mari, Stéphan Clavel, Gilles Pagès, Jacques Pouysségur, Frédéric Bost, Nathalie M Mazure,

<b>Rationale</b>: Renal cell carcinoma (RCC) accounts for about 2% of all adult cancers, and clear cell RCC (ccRCC) is the most common RCC histologic subtype. A hallmark of ccRCC is the loss of the primary cilium, a cellular antenna that senses a wide variety of signals. Loss of this key ... Read more >>

Theranostics (Theranostics)
[2020, 10(6):2696-2713]

Cited: 2 times

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Exercise training improves radiotherapy efficiency in a murine model of prostate cancer.

Suzanne Dufresne, Jordan Guéritat, Sophie Chiavassa, Caroline Noblet, Mohamad Assi, Nathalie Rioux-Leclercq, Françoise Rannou-Bekono, Luz Lefeuvre-Orfila, François Paris, Amélie Rébillard,

Engaging in exercise while undergoing radiotherapy (RT) has been reported to be safe and achievable. The impact of exercise training (ET) on RT efficiency is however largely unknown. Our study aims to investigate the interactions between ET and RT on prostate cancer growth. Athymic mice received a subcutaneous injection of ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2020, 34(4):4984-4996]

Cited: 2 times

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A novel mechanism of HIF2-dependent PLK1-mediated metastasis and drug resistance of clear cell Renal Cell Carcinoma

Maeva Dufies, Annelies Verbiest, Lindsay Cooley, Papa Diogop Ndiaye, Julien Viotti, Xingkang He, Nicolas Nottet, Wilfried Souleyreau, Anais Hagege, Stephanie Torrino, Julien Parola, Sandy Giuliano, Delphine Borchiellini, Renaud Schiappa, Baharia Mograbi, Jessica Zucman-Rossi, Karim Bensalah, Alain Ravaud, Patrick Auberger, Andréas Bikfalvi, Emmanuel Chamorey, Nathalie Rioux-Leclercq, Nathalie Mazure, Benoit Beuselinck, Yihai Cao, Jean Christophe Bernhard, Damien Ambrosetti, Gilles Pagès,

Polo-Like Kinase 1 (Plk1) expression is inversely correlated with survival advantages in many cancers. However, molecular mechanisms that underlie Plk1 expression are poorly understood. Here, we uncover a novel hypoxia-regulated mechanism of Plk1-mediated cancer metastasis and drug resistance. We demonstrated that a new HIF-2-dependent regulatory pathway drives Plk1 expression in ... Read more >>

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PTRF independently predicts progression and survival in multiracial upper tract urothelial carcinoma following radical nephroureterectomy.

Hsin-Chih Yeh, Vitaly Margulis, Nirmish Singla, Elizabeth Hernandez, Vandana Panwar, Solomon L Woldu, Jose A Karam, Christopher G Wood, Alon Z Weizer, Jay D Raman, Mesut Remzi, Nathalie Rioux-Leclercq, Andrea Haitel, Marco Roscigno, Christian Bolenz, Karim Bensalah, Ching-Chia Li, Hung-Lung Ke, Wei-Ming Li, Hsiang-Ying Lee, Leonid M Rapoport, Yair Lotan, Payal Kapur, Shahrokh F Shariat, Jer-Tsong Hsieh, Wen-Jeng Wu,

<h4>Objectives</h4>Polymerase I and transcript release factor (PTRF) has been implicated in cancer biology but its role in upper tract urothelial carcinoma (UTUC) is unknown. From a pilot transcriptome, we identified PTRF was significantly upregulated in high stage UTUC. Bladder cancer transcriptome from The Cancer Genome Atlas (TCGA) supported our finding ... Read more >>

Urol Oncol (Urologic oncology)
[2020, 38(5):496-505]

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