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Author Nathalie K Zgheib

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A Signature of Four Circulating microRNAs as Potential Biomarkers for Diagnosing Early-Stage Breast Cancer.

Maha M Itani, Farah J Nassar, Arafat H Tfayli, Rabih S Talhouk, Ghada K Chamandi, Abdul Rahman S Itani, Joelle Makoukji, Rose-Mary N Boustany, Lifang Hou, Nathalie K Zgheib, Rihab R Nasr,

Breast cancer (BC) is the most predominant type of cancer among women. The aim of this study is to find new biomarkers that can help in early detection of BC, especially for those who are too young to be screened using mammography as per guidelines. Using microRNA microarray, we previously ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(11):]

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Knowledge, beliefs, and practices related to cancer screening and prevention in Lebanon: community and social media users' perspectives.

Talar Telvizian, Yasmina Al Ghadban, Jude Alawa, Deborah Mukherji, Nathalie K Zgheib, Bisher Sawaf, Rihab Nasr, Marco Bardus,

<h4>Objective</h4>Common to many countries in the Middle East, Lebanon has an increasing cancer burden; however, national screening programs are limited to breast cancer. The literature on cancer screening practices and beliefs is scarce. This cross-sectional study investigates the knowledge, beliefs, and practices related to the prevention and screening for breast, ... Read more >>

Eur J Cancer Prev (European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP))
[2021, 30(4):341-349]

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Primary care and pulmonary physicians' knowledge and practice concerning screening for lung cancer in Lebanon, a middle-income country.

Imad Bou Akl, Nathalie K Zgheib, Maroun Matar, Deborah Mukherji, Marco Bardus, Rihab Nasr,

<h4>Background</h4>Screening for lung cancer with low-dose computed tomography (LDCT) was shown to reduce lung cancer incidence and overall mortality, and it has been recently included in international guidelines. Despite the rising burden of lung cancer in low and middle-income countries (LMICs) such as Lebanon, little is known about what primary ... Read more >>

Cancer Med (Cancer medicine)
[2021, 10(8):2877-2884]

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LINE-1 methylation mediates the inverse association between body mass index and breast cancer risk: A pilot study in the Lebanese population.

Zainab Awada, Liacine Bouaoun, Rihab Nasr, Arafat Tfayli, Cyrille Cuenin, Reem Akika, Rose-Mary Boustany, Joelle Makoukji, Hani Tamim, Nathalie K Zgheib, Akram Ghantous,

<h4>Introduction</h4>Lebanon is among the top countries worldwide in combined incidence and mortality of breast cancer, which raises concern about risk factors peculiar to this country. The underlying molecular mechanisms of breast cancer require elucidation, particularly epigenetics, which is recognized as a molecular sensor to environmental exposures.<h4>Purpose</h4>We aim to explore whether ... Read more >>

Environ Res (Environmental research)
[2021, 197:111094]

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Pharmacogenetics in developing countries and low resource environments.

Said El Shamieh, Nathalie K Zgheib,

While significant advances have been made in pharmacogenetics (PGx), especially in countries with developed economies, this field remains at its infancy in developing countries and low resource environments. Herein, we provide insights into the gap and challenges of PGx at the research and clinical fronts, and some perspectives to bridge ... Read more >>

Hum Genet (Human genetics)
[2021, :]

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Editorial: Pharmacogenetics Research and Clinical Applications: An International Landscape of the Accomplishments, Challenges, and Opportunities.

Nathalie K Zgheib, George P Patrinos,

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:1217]

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Implementation of Pharmacogenetics to Individualize Treatment Regimens for Children with Acute Lymphoblastic Leukemia.

Dimitri Maamari, Habib El-Khoury, Omran Saifi, Samar A Muwakkit, Nathalie K Zgheib,

Despite major advances in the management and high cure rates of childhood acute lymphoblastic leukemia (ALL), patients still suffer from many drug-induced toxicities, sometimes necessitating dose reduction, or halting of cytotoxic drugs with a secondary risk of disease relapse. In addition, investigators have noted significant inter-individual variability in drug toxicities ... Read more >>

Pharmgenomics Pers Med (Pharmacogenomics and personalized medicine)
[2020, 13:295-317]

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Obesity Alters Endoxifen Plasma Levels in Young Breast Cancer Patients: A Pharmacometric Simulation Approach.

Anna Mueller-Schoell, Lena Klopp-Schulze, Werner Schroth, Thomas Mürdter, Robin Michelet, Hiltrud Brauch, Wilhelm Huisinga, Markus Joerger, Patrick Neven, Stijn L W Koolen, Ron H J Mathijssen, Ellen Copson, Diana Eccles, Sylvia Chen, Balram Chowbay, Arafat Tfayli, Nathalie K Zgheib, Matthias Schwab, Charlotte Kloft,

Endoxifen is one of the most important metabolites of the prodrug tamoxifen. High interindividual variability in endoxifen steady-state concentrations (C<sub>SS,min ENDX</sub> ) is observed under tamoxifen standard dosing and patients with breast cancer who do not reach endoxifen concentrations above a proposed therapeutic threshold of 5.97 ng/mL may be at a ... Read more >>

Clin Pharmacol Ther (Clinical pharmacology and therapeutics)
[2020, 108(3):661-670]

Cited: 7 times

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Effect of bisphenols on telomerase expression and activity in breast cancer cell lines.

Zainab Awada, Rihab Nasr, Reem Akika, Akram Ghantous, Lifang Hou, Nathalie K Zgheib,

Bisphenol A (BPA), a monomer of polycarbonates and resins, was shown to induce the expression of telomerase enzyme which has been associated with breast cancer development and progression. However, the effects of BPA analogues, bisphenol F (BPF) and bisphenol S (BPS) on telomere-linked pathway have not been evaluated. Herein, MCF-7 ... Read more >>

Mol Biol Rep (Molecular biology reports)
[2020, 47(5):3541-3549]

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Effect of Targeted Curricular Reform on the Learning Environment, Student Empathy, and Hidden Curriculum in a Medical School: A 7-Year Longitudinal Study.

Nathalie K Zgheib, Zakia Dimassi, Thalia Arawi, Kamal F Badr, Ramzi Sabra,

<h4>Objective</h4>The American University of Beirut Faculty of Medicine follows the American model of medical education. In 2013-2014, a carefully designed new curriculum replaced the previous, largely traditional curriculum, and aimed to improve student wellbeing, upgrade the learning environment, enhance student empathy, and counter the negative influences of the hidden curriculum. ... Read more >>

J Med Educ Curric Dev (Journal of medical education and curricular development)
[2020, 7:2382120520953106]

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Precision Medicine in Low- and Middle-Income Countries.

Nathalie K Zgheib, George P Patrinos, Reem Akika, Rami Mahfouz,

Clin Pharmacol Ther (Clinical pharmacology and therapeutics)
[2020, 107(1):29-32]

Cited: 2 times

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ITPA, TPMT, and NUDT15 Genetic Polymorphisms Predict 6-Mercaptopurine Toxicity in Middle Eastern Children With Acute Lymphoblastic Leukemia.

Borhan Moradveisi, Samar Muwakkit, Fatemeh Zamani, Ebrahim Ghaderi, Ebrahim Mohammadi, Nathalie K Zgheib,

Background: Acute lymphoblastic leukemia (ALL) is the most common cancer seen in children worldwide and in the Middle East. Although there have been major advances in treatment approaches for childhood ALL, serious toxicities do occur but with significant inter-individual variability. The aim of this study is to measure the frequency ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2019, 10:916]

Cited: 5 times

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μ-opioid receptor genetic polymorphisms and duration of epidural fentanyl analgesia during early labor.

Nathalie K Zgheib, Marie T Aouad, Samar K Taha, Anwar H Nassar, Riwa F Masri, Mira Y Khoury, Maha H Makki, Sahar M Siddik-Sayyid,

BACKGROUND:Epidural fentanyl is commonly used for initiation of early labor analgesia. The aim of this prospective study is to test the hypothesis that duration of epidural fentanyl analgesia differs in nulliparous women requesting epidural analgesia in early labor who are variant allele carriers of the OPRM1 SNVs 118A>G rs1799971, IVS2+31G>A ... Read more >>

Minerva Anestesiol (Minerva anestesiologica)
[2018, 84(8):946-954]

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Genetic polymorphisms in candidate genes are not associated with increased vincristine-related peripheral neuropathy in Arab children treated for acute childhood leukemia: a single institution study.

Nathalie K Zgheib, Khaled M Ghanem, Hani Tamim, Carole Aridi, Randa Shahine, Nidale Tarek, Raya Saab, Miguel R Abboud, Hassan El-Solh, Samar A Muwakkit,

OBJECTIVE:The aim of this study was to evaluate the potential association between candidate genetic polymorphisms and vincristine-related peripheral neuropathy in Arab children with acute lymphoblastic leukemia (ALL). PATIENTS AND METHODS:This is a retrospective evaluation of 133 Arab children treated for ALL at the Children's Cancer Center of Lebanon. Incidence and ... Read more >>

Pharmacogenet Genomics (Pharmacogenetics and genomics)
[2018, 28(8):189-195]

Cited: 6 times

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Short Telomere Length is Associated with Aging, Central Obesity, Poor Sleep and Hypertension in Lebanese Individuals.

Nathalie K Zgheib, Fatima Sleiman, Lara Nasreddine, Mona Nasrallah, Nancy Nakhoul, Hussain Isma'eel, Hani Tamim,

In Lebanon, data stemming from national cross-sectional surveys indicated significant increasing trends in the prevalence of cardiovascular diseases and associated behavioral and age-related risk factors. To our knowledge, no data are available on relative telomere length (RTL) as a potential biomarker for age-related diseases in a Lebanese population. The aim ... Read more >>

Aging Dis (Aging and disease)
[2018, 9(1):77-89]

Cited: 17 times

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The Pharmacogenetics Laboratory of the Department of Pharmacology and Toxicology at the American University of Beirut Faculty of Medicine.

Nathalie K Zgheib,

The pharmacogenetics (PGx) laboratory at the Department of Pharmacology and Toxicology at the American University of Beirut Faculty of Medicine was established in October 2007. Several projects on the genetic polymorphisms of drug metabolizing enzymes and transporters with treatment of noncommunicable diseases such as cardiac diseases and cancers are ongoing. ... Read more >>

Pharmacogenomics (Pharmacogenomics)
[2017, 18(14):1311-1316]

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microRNA Expression in Ethnic Specific Early Stage Breast Cancer: an Integration and Comparative Analysis.

Farah J Nassar, Rabih Talhouk, Nathalie K Zgheib, Arafat Tfayli, Maya El Sabban, Nagi S El Saghir, Fouad Boulos, Mark N Jabbour, Claude Chalala, Rose-Mary Boustany, Humam Kadara, Zhou Zhang, Yinan Zheng, Brian Joyce, Lifang Hou, Ali Bazarbachi, George Calin, George Calin, Rihab Nasr,

Breast cancer (BC) has a higher incidence in young Lebanese woman as compared to the West. We assessed the microRNA (miRNA) microarray profile of tissues derived from Lebanese patients with early BC and performed mRNA-miRNA integration analysis. 173 miRNAs were significantly dysregulated in 45 BC versus 17 normal adjacent breast ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):16829]

Cited: 7 times

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Distribution and Role of N-acetyltransferase 2 Genetic Polymorphisms in Bladder Cancer Risk in a Lebanese Population

Rami Nasr, Sally Temraz, Deborah Mukherji, Ali Shamseddine, Reem Akika, Sehrish Abbasi, Raja Khauli, Muhammad Bulbul, Hani Tamim, Nathalie K Zgheib,

Background: In Lebanon, bladder cancer (BC) has an unusually high prevalence. Individuals who are exposed to aromatic amines from smoking or certain occupations and carrying the slow N-acetyl transferase 2 (NAT2) acetylator’ phenotype may be at a higher risk. Methods: Data and DNA from 115 Lebanese BC cases and 306 controls were examined. ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2017, 18(9):2561-2568]

Cited: 0 times

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Region of interest methylation analysis: a comparison of MSP with MS-HRM and direct BSP.

Reem Akika, Zainab Awada, Nahed Mogharbil, Nathalie K Zgheib,

The aim of this study was to compare and contrast three DNA methylation methods of a specific region of interest (ROI): methylation-specific PCR (MSP), methylation-sensitive high resolution melting (MS-HRM) and direct bisulfite sequencing (BSP). The methylation of a CpG area in the promoter region of Estrogen receptor alpha (ESR1) was ... Read more >>

Mol Biol Rep (Molecular biology reports)
[2017, 44(3):295-305]

Cited: 3 times

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Precision Genetic and Genomic Medicine in the Middle East and North Africa Region: Are We There Yet?

Nadeem Bilani, Michael Dagher, Nathalie K Zgheib,

<h4>Purpose</h4>As precision medicine continues its expansion into clinical practice and research settings, it is time to investigate genetic and genomic research in the Middle East and North Africa (MENA) region to identify the strengths and deficits and to provide suggestions for future development.<h4>Methods</h4>We performed a literature review of any genetic ... Read more >>

Public Health Genomics (Public health genomics)
[2017, 20(3):149-157]

Cited: 2 times

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Improved Prediction of Endoxifen Metabolism by CYP2D6 Genotype in Breast Cancer Patients Treated with Tamoxifen.

Werner Schroth, Stefan Winter, Thomas Mürdter, Elke Schaeffeler, Diana Eccles, Bryony Eccles, Balram Chowbay, Chiea C Khor, Arafat Tfayli, Nathalie K Zgheib, Michel Eichelbaum, Matthias Schwab, Hiltrud Brauch,

<b>Purpose:</b> Prediction of impaired tamoxifen (TAM) to endoxifen metabolism may be relevant to improve breast cancer treatment, e.g., via TAM dose increase. The polymorphic cytochrome P450 2D6 (CYP2D6) strongly determines an individual's capacity for endoxifen formation, however, CYP2D6 phenotype assignments inferred from genotype widely differ between studies. Thus, we modeled ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2017, 8:582]

Cited: 14 times

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Drug metabolism and liver disease: a drug-gene-environment interaction.

Nathalie K Zgheib, Robert A Branch,

Despite the central role of the liver in drug metabolism, surprisingly there is lack of certainty in anticipating the extent of modification of the clearance of a given drug in a given patient. The intent of this review is to provide a conceptual framework in considering the impact of liver ... Read more >>

Drug Metab Rev (Drug metabolism reviews)
[2017, 49(1):35-55]

Cited: 1 time

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Interactive and collaborative learning in the classroom at the medical school Automated response systems and team-based learning.

Rihab Nasr, Jumana Antoun, Ramzi Sabra, Nathalie K Zgheib,

There has been a pedagogic shift in higher education from the traditional teacher centered to the student centered approach in teaching, necessitating a change in the role of the teacher from a supplier of information to passive receptive students into a more facilitative role. Active learning activities are based on ... Read more >>

J Med Liban (Le Journal medical libanais. The Lebanese medical journal)
[2016, 64(4):217-222]

Cited: 0 times

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NUDT15 and TPMT genetic polymorphisms are related to 6-mercaptopurine intolerance in children treated for acute lymphoblastic leukemia at the Children's Cancer Center of Lebanon.

Nathalie K Zgheib, Reem Akika, Rami Mahfouz, Carol Al Aridi, Khaled M Ghanem, Raya Saab, Miguel R Abboud, Nidale Tarek, Hassan El Solh, Samar A Muwakkit,

<h4>Background</h4>Interindividual variability in thiopurine-related toxicity could not be completely explained by thiopurine S-methyltransferase (TPMT) polymorphisms, as a number of patients who are homozygous wild type or normal for TPMT still develop toxicity that necessitates 6-mercaptopurine (MP) dose reduction or protocol interruption. Recently, few studies reported on an inherited nucleoside diphosphate-linked ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2017, 64(1):146-150]

Cited: 18 times

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The long-term impact of team-based learning on medical students' team performance scores and on their peer evaluation scores.

Nathalie K Zgheib, Zakia Dimassi, Imad Bou Akl, Kamal F Badr, Ramzi Sabra,

<h4>Background</h4>The Faculty of Medicine at the American University of Beirut implemented a new medical curriculum, which included 90 team-based learning (TBL) sessions in years 1 and 2 of medical school.<h4>Methods</h4>A validated team performance scale (TPS) and peer evaluation of communication skills, professionalism and personal development were collected at different time ... Read more >>

Med Teach (Medical teacher)
[2016, 38(10):1017-1024]

Cited: 8 times

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