Full Text Journal Articles by
Author Nathalie Dejucq Rainsford

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Exposure of human fetal kidneys to mild analgesics interferes with early nephrogenesis.

Sabrina Leverrier-Penna, Alain Michel, Laetitia L Lecante, Nathalie Costet, Antonio Suglia, Christèle Desdoits-Lethimonier, Hugoline Boulay, Roselyne Viel, Jonathan M Chemouny, Emmanuelle Becker, Vincent Lavoué, Antoine D Rolland, Nathalie Dejucq-Rainsford, Cécile Vigneau, Séverine Mazaud-Guittot,

Acetaminophen, aspirin, and ibuprofen are mild analgesics commonly used by pregnant women, the sole current recommendation being to avoid ibuprofen from the fifth month of gestation. The nephrotoxicity of these three analgesics is well documented in adults, as is their interference with prostaglandins biosynthesis. Here we investigated the effect of ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(7):e21718]

Cited: 0 times

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Long-term Zika virus infection of non-sperm cells in semen.

Dominique Mahé, Salomé Bourgeau, Julie Frouard, Guillaume Joguet, Christophe Pasquier, Louis Bujan, Nathalie Dejucq-Rainsford,

Lancet Infect Dis (The Lancet. Infectious diseases)
[2020, 20(12):1371]

Cited: 2 times

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Human USP18 is regulated by miRNAsviathe 3’UTR, a sequence duplicated in lincRNA genes residing in chr22q11.21

Erminia Rubino, Melania Cruciani, Nicolas Tchitchek, Anna Le Tortorec, Antoine Rolland, Önay Veli, Leslie Vallet, Giulia Gaggi, Frédérique Michel, Nathalie Dejucq-Rainsford, Sandra Pellegrini,

<h4>ABSTRACT</h4> Ubiquitin-specific peptidase 18 (USP18) acts as gatekeeper of type I interferon (IFN) responses by binding to the IFN receptor subunit IFNAR2 and preventing activation of the downstream JAK/STAT pathway. In any given cell type, the level of USP18 is a key determinant of the output of interferon-stimulated transcripts. How ... Read more >>

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Potential for virus endogenization in humans through testicular germ cell infection: the case of HIV

Dominique Mahé, Giulia Matusali, Claire Deleage, Raquel Alvarenga, Anne-Pascale Satie, Amélie Pagliuzza, Romain Mathieu, Sylvain Lavoué, Bernard Jégou, Luiz de França, Nicolas Chomont, Laurent Houzet, Antoine Rolland, Nathalie Dejucq-Rainsford,

Viruses have colonized the germ line of our ancestors at several occasions during evolution, leading to the integration in the human genome of viral sequences from over 30 retroviral groups and a few non-retroviruses. Among the recently emerged viruses infecting humans, several target the testis (eg HIV, Zika and Ebola ... Read more >>

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SARS-CoV-2 and human reproduction: An open question.

Frida Entezami, Marise Samama, Nathalie Dejucq-Rainsford, Louis Bujan,

EClinicalMedicine (EClinicalMedicine)
[2020, 25:100473]

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New insights into the genetic basis of premature ovarian insufficiency: Novel causative variants and candidate genes revealed by genomic sequencing.

Sylvie Jaillard, Katrina Bell, Linda Akloul, Kelly Walton, Kenneth McElreavy, William A Stocker, Marion Beaumont, Craig Harrisson, Tiina Jääskeläinen, Jorma J Palvimo, Gorjana Robevska, Erika Launay, Anne-Pascale Satié, Nurin Listyasari, Claude Bendavid, Rajini Sreenivasan, Solène Duros, Jocelyn van den Bergen, Catherine Henry, Mathilde Domin-Bernhard, Laurence Cornevin, Nathalie Dejucq-Rainsford, Marc-Antoine Belaud-Rotureau, Sylvie Odent, Katie L Ayers, Célia Ravel, Elena J Tucker, Andrew H Sinclair,

Ovarian deficiency, including premature ovarian insufficiency (POI) and diminished ovarian reserve (DOR), represents one of the main causes of female infertility. POI is a genetically heterogeneous condition but current understanding of its genetic basis is far from complete, with the cause remaining unknown in the majority of patients. The genes ... Read more >>

Maturitas (Maturitas)
[2020, 141:9-19]

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Minimal change nephrotic syndrome in patients infected with human immunodeficiency virus: a retrospective study of 8 cases.

Romain Arrestier, Anne-Pascale Satie, Shao-Yu Zhang, Emmanuelle Plaisier, Corinne Isnard-Bagnis, Philippe Gatault, Quentin Raimbourg, David Buob, Flavia Vocila, Anne-Elisabeth Heng, Helene Francois, Anissa Moktefi, Guillaume Canaud, Marie Matignon, Nathalie Dejucq-Rainsford, Isabelle Brocheriou, Dil Sahali, Vincent Audard,

<h4>Background</h4>Human immunodeficiency virus (HIV) is associated with diverse glomerular diseases. Characteristics of minimal change nephrotic syndrome (MCNS) in this setting have been little studied, and the specific features of this uncommon association remain to be determined.<h4>Methods</h4>We conduct a retrospective study. Clinical, biological and pathological characteristics of patients with MCNS and ... Read more >>

BMC Nephrol (BMC nephrology)
[2018, 19(1):331]

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Human Ubiquitin-Specific Peptidase 18 Is Regulated by microRNAs via the 3'Untranslated Region, A Sequence Duplicated in Long Intergenic Non-coding RNA Genes Residing in chr22q11.21.

Erminia Rubino, Melania Cruciani, Nicolas Tchitchek, Anna Le Tortorec, Antoine D Rolland, Önay Veli, Leslie Vallet, Giulia Gaggi, Frédérique Michel, Nathalie Dejucq-Rainsford, Sandra Pellegrini,

Ubiquitin-specific peptidase 18 (USP18) acts as gatekeeper of type I interferon (IFN) responses by binding to the IFN receptor subunit IFNAR2 and preventing activation of the downstream JAK/STAT pathway. In any given cell type, the level of USP18 is a key determinant of the output of IFN-stimulated transcripts. How the ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:627007]

Cited: 1 time

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[In vitro models for deciphering the mechanisms underlying the sexual transmission of viruses at the mucosal level].

Julie Frouard, Anna Le Tortorec, Nathalie Dejucq-Rainsford,

Sexually transmitted viruses infect the genital and colorectal mucosa of the partner exposed to contaminated genital secretions through a wide range of mechanisms, dictated in part by the organization of the mucosa. Because understanding the modes of entry into the organism of viruses transmitted through sexual intercourse is a necessary ... Read more >>

Virologie (Montrouge) (Virologie (Montrouge, France))
[2018, 22(1):9-26]

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In vitro models for deciphering the mechanisms underlying the sexual transmission of viruses at the mucosal level.

Julie Frouard, Anna Le Tortorec, Nathalie Dejucq-Rainsford,

Sexually transmitted viruses infect the genital and colorectal mucosa of the partner exposed to contaminated genital secretions through a wide range of mechanisms, dictated in part by the organization of the mucosa. Because understanding the modes of entry into the organism of viruses transmitted through sexual intercourse is a necessary ... Read more >>

Virology (Virology)
[2018, 515:1-10]

Cited: 1 time

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Endocrine Disruption in Human Fetal Testis Explants by Individual and Combined Exposures to Selected Pharmaceuticals, Pesticides, and Environmental Pollutants.

Pierre Gaudriault, Séverine Mazaud-Guittot, Vincent Lavoué, Isabelle Coiffec, Laurianne Lesné, Nathalie Dejucq-Rainsford, Martin Scholze, Andreas Kortenkamp, Bernard Jégou,

<h4>Background</h4>Numerous chemicals are capable of disrupting androgen production, but the possibility that they might act together to produce effects greater than those of the most effective component in the mixture has not been studied directly in human tissues. Suppression of androgen synthesis in fetal life has been associated with testis ... Read more >>

Environ Health Perspect (Environmental health perspectives)
[2017, 125(8):087004]

Cited: 9 times

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Effect of acute Zika virus infection on sperm and virus clearance in body fluids: a prospective observational study.

Guillaume Joguet, Jean-Michel Mansuy, Giulia Matusali, Safouane Hamdi, Marie Walschaerts, Lynda Pavili, Stefanie Guyomard, Nadia Prisant, Pierre Lamarre, Nathalie Dejucq-Rainsford, Christophe Pasquier, Louis Bujan,

<h4>Background</h4>Evidence of human sexual transmission during Zika virus emergence is a matter of concern, particularly in procreation, but to date, kinetics of seminal shedding and the effects of infection on human reproductive function have not been described. To investigate the effects of Zika virus infection on semen and clearance of ... Read more >>

Lancet Infect Dis (The Lancet. Infectious diseases)
[2017, 17(11):1200-1208]

Cited: 72 times

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Array-CGH diagnosis in ovarian failure: identification of new molecular actors for ovarian physiology.

Sylvie Jaillard, Linda Akloul, Marion Beaumont, Houda Hamdi-Roze, Christele Dubourg, Sylvie Odent, Solène Duros, Nathalie Dejucq-Rainsford, Marc-Antoine Belaud-Rotureau, Célia Ravel,

<h4>Background</h4>Ovarian failure (OF) is considered premature if it occurs before the age of 40. This study investigates the genetic aetiology underlying OF in women under the age of 40 years.<h4>Methods</h4>We conducted an experimental prospective study performing all genome microarrays in 60 patients younger than 40 years presenting an OF revealed by a ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2016, 9(1):63]

Cited: 8 times

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Adipose Tissue Is a Neglected Viral Reservoir and an Inflammatory Site during Chronic HIV and SIV Infection.

Abderaouf Damouche, Thierry Lazure, Véronique Avettand-Fènoël, Nicolas Huot, Nathalie Dejucq-Rainsford, Anne-Pascale Satie, Adeline Mélard, Ludivine David, Céline Gommet, Jade Ghosn, Nicolas Noel, Guillaume Pourcher, Valérie Martinez, Stéphane Benoist, Véronique Béréziat, Antonio Cosma, Benoit Favier, Bruno Vaslin, Christine Rouzioux, Jacqueline Capeau, Michaela Müller-Trutwin, Nathalie Dereuddre-Bosquet, Roger Le Grand, Olivier Lambotte, Christine Bourgeois,

Two of the crucial aspects of human immunodeficiency virus (HIV) infection are (i) viral persistence in reservoirs (precluding viral eradication) and (ii) chronic inflammation (directly associated with all-cause morbidities in antiretroviral therapy (ART)-controlled HIV-infected patients). The objective of the present study was to assess the potential involvement of adipose tissue ... Read more >>

PLoS Pathog (PLoS pathogens)
[2015, 11(9):e1005153]

Cited: 95 times

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An investigation of the endocrine-disruptive effects of bisphenol a in human and rat fetal testes.

Millissia Ben Maamar, Laurianne Lesné, Christèle Desdoits-Lethimonier, Isabelle Coiffec, Julie Lassurguère, Vincent Lavoué, Yoann Deceuninck, Jean-Philippe Antignac, Bruno Le Bizec, Elisabeth Perdu, Daniel Zalko, Charles Pineau, Cécile Chevrier, Nathalie Dejucq-Rainsford, Séverine Mazaud-Guittot, Bernard Jégou,

Few studies have been undertaken to assess the possible effects of bisphenol A (BPA) on the reproductive hormone balance in animals or humans with often contradictory results. We investigated possible direct endocrine disruption by BPA of the fetal testes of 2 rat strains (14.5-17.5 days post-coitum) and humans (8-12 gestational ... Read more >>

PLoS One (PloS one)
[2015, 10(2):e0117226]

Cited: 20 times

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Paracetamol, aspirin, and indomethacin induce endocrine disturbances in the human fetal testis capable of interfering with testicular descent.

Séverine Mazaud-Guittot, Christophe Nicolas Nicolaz, Christèle Desdoits-Lethimonier, Isabelle Coiffec, Millissia Ben Maamar, Patrick Balaguer, David M Kristensen, Cécile Chevrier, Vincent Lavoué, Patrice Poulain, Nathalie Dejucq-Rainsford, Bernard Jégou,

<h4>Context</h4>Masculinization depends on the fetal testis. Exposure of the human fetus during pregnancy to paracetamol and/or to other mild analgesics is associated with an increased risk of cryptorchidism.<h4>Objective</h4>We aimed to determine whether mild analgesics disrupted the morphology and endocrine function of the human testis.<h4>Design</h4>We used an in vitro system based ... Read more >>

J Clin Endocrinol Metab (The Journal of clinical endocrinology and metabolism)
[2013, 98(11):E1757-67]

Cited: 59 times

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HIV-1 interacts with human testicular germ cells in vitro

Dominique Mahé, Claire Deleage, Giulia Matusali, Anne-Pascale Satie, Karim Bensalah, Laurence Guézenec, Bernard Jégou, Nathalie Dejucq-Rainsford,

Retrovirology (Retrovirology)
[2013, 10(Suppl 1):P26-P26]

Cited: 0 times

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Mono-(2-ethylhexyl) phthalate directly alters the expression of Leydig cell genes and CYP17 lyase activity in cultured rat fetal testis.

François Chauvigné, Simon Plummer, Laurianne Lesné, Jean-Pierre Cravedi, Nathalie Dejucq-Rainsford, Alexis Fostier, Bernard Jégou,

Exposure to phthalates in utero alters fetal rat testis gene expression and testosterone production, but much remains to be done to understand the mechanisms underlying the direct action of phthalate within the fetal testis. We aimed to investigate the direct mechanisms of action of mono-(2-ethylhexyl) phthalate (MEHP) on the rat ... Read more >>

PLoS One (PloS one)
[2011, 6(11):e27172]

Cited: 25 times

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Excess type I interferon signaling in the mouse seminiferous tubules leads to germ cell loss and sterility.

Anne-Pascale Satie, Severine Mazaud-Guittot, Isabelle Seif, Dominique Mahé, Zhiguo He, Guilhem Jouve, Bernard Jégou, Nathalie Dejucq-Rainsford,

Type I (α and β) interferons (IFNs) elicit antiproliferative and antiviral activities via the surface receptor IFNAR. Serendipitous observations in transgenic mice in 1988 strongly suggested that IFNα/β overexpression in the testis disrupts spermatogenesis. Here, we compare a new mouse strain transgenic for IFNβ (Tg10) and a sister strain lacking ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2011, 286(26):23280-23295]

Cited: 11 times

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Infection of macaques after vaginal exposure to cell-associated simian immunodeficiency virus.

Bettina Sallé, Patricia Brochard, Olivier Bourry, Abdelkrim Mannioui, Thibault Andrieu, Sophie Prevot, Nathalie Dejucq-Rainsford, Nathalie Dereuddre-Bosquet, Roger Le Grand,

<h4>Background</h4>The contribution of infected semen cells to sexual transmission of human immunodeficiency virus (HIV) is still debated. We addressed this issue in the model of experimental infection of macaques with simian immunodeficiency virus (SIV).<h4>Methods</h4>Frozen stocks of cells obtained from the spleen of macaques at the peak of SIVmac251 viremia were ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2010, 202(3):337-344]

Cited: 66 times

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Impact of short term HAART initiated during the acute or chronic stage on SIV infection of the male genital tract

Marina Moreau, Anna Le Tortorec, Hélène Denis, Claire Deleage, Anne-Pascale Satie, Olivier Bourry, Pierre Roques, Bernard Jégou, Roger Le Grand, Nathalie Dejucq-Rainsford,

Retrovirology (Retrovirology)
[2010, 7(Suppl 1):P11-P11]

Cited: 0 times

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Production of the antiviral proteins 2'5'oligoadenylate synthetase, PKR and Mx in interstitial cells and spermatogonia.

Nathalie Melaine, Marie-Odile Liénard, Elisabeth Guillaume, Annick Ruffault, Nathalie Dejucq-Rainsford, Bernard Jégou,

We report an in vitro analysis of the spatial pattern of production of three antiviral proteins (2'5'oligoadenylate synthetase, 2'5'AS; double-stranded RNA-activated protein kinase, PKR; and Mx protein, Mx) in the rat testis, in basal conditions and following stimulation with interferon (IFN) or Sendai virus. The two major constituents of interstitial ... Read more >>

J Reprod Immunol (Journal of reproductive immunology)
[2003, 59(1):53-60]

Cited: 8 times

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