Full Text Journal Articles by
Author Natalie Suff

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FIGO good practice recommendations on progestogens for prevention of preterm delivery.

Andrew Shennan, Natalie Suff, Joe Leigh Simpson, Bo Jacobsson, Ben W Mol, William A Grobman, ,

Women at high risk of preterm birth (either a previous spontaneous preterm birth and/or sonographic short cervix) with a singleton gestation should be offered daily vaginal progesterone or weekly 17-OHPC treatment to prevent preterm birth. Benefit is most significant in those with prior history of preterm birth and a short ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 155(1):16-18]

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In Vitro and In Vivo Evaluation of Human Adenovirus Type 49 as a Vector for Therapeutic Applications

Emily Bates, John Counsell, Sophie Alizert, Alexander Baker, Natalie Suff, Ashley Boyle, Angela Bradshaw, Simon Waddington, Stuart Nicklin, Andrew Baker, Alan Parker,

The human adenovirus phylogenetic tree is split across seven species (A-G). Species D adenoviruses offer potential advantages for gene therapy applications, with low rates of preexisting immunity detected across screened populations. However, many aspects of the basic virology of species D, such as their cellular tropism, receptor usage and in ... Read more >>

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Gene therapy restores dopamine transporter expression and ameliorates pathology in iPSC and mouse models of infantile parkinsonism.

Joanne Ng, Serena Barral, Carmen De La Fuente Barrigon, Gabriele Lignani, Fatma A Erdem, Rebecca Wallings, Riccardo Privolizzi, Giada Rossignoli, Haya Alrashidi, Sonja Heasman, Esther Meyer, Adeline Ngoh, Simon Pope, Rajvinder Karda, Dany Perocheau, Julien Baruteau, Natalie Suff, Juan Antinao Diaz, Stephanie Schorge, Jane Vowles, Lucy R Marshall, Sally A Cowley, Sonja Sucic, Michael Freissmuth, John R Counsell, Richard Wade-Martins, Simon J R Heales, Ahad A Rahim, Maximilien Bencze, Simon N Waddington, Manju A Kurian,

Most inherited neurodegenerative disorders are incurable, and often only palliative treatment is available. Precision medicine has great potential to address this unmet clinical need. We explored this paradigm in dopamine transporter deficiency syndrome (DTDS), caused by biallelic loss-of-function mutations in <i>SLC6A3</i>, encoding the dopamine transporter (DAT). Patients present with early ... Read more >>

Sci Transl Med (Science translational medicine)
[2021, 13(594):]

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Optimal timing of cervical cerclage removal following preterm premature rupture of membranes; a retrospective analysis.

Natalie Suff, Maria Kunitsyna, Andrew Shennan, Manju Chandiramani,

<h4>Objective</h4>Preterm prelabour rupture of membranes occurs in over one third of pregnant women with a cervical cerclage in situ. In the setting of preterm prelabour rupture of membranes, clinicians are faced with the difficult decision of the optimal timing for removing the cerclage. We compared the maternal and neonatal outcomes ... Read more >>

Eur J Obstet Gynecol Reprod Biol (European journal of obstetrics, gynecology, and reproductive biology)
[2021, 259:75-80]

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Development of a video to teach clinicians how to perform a transabdominal cerclage.

Natalie Suff, Katy Kuhrt, Manju Chandiramani, Ertan Saridogan, Anna David, Andrew H Shennan,

<h4>Background</h4>A transabdominal cerclage has been shown in a recent randomized controlled trial to be superior to a low vaginal cerclage in reducing the risk of early preterm birth (8% [3/39] vs 33% [11/33]; relative risk, 0.23; 95% confidence interval, 0.07-0.76; P=.01570) and fetal loss (3% [1/39] vs 21% [7/33]; relative ... Read more >>

Am J Obstet Gynecol MFM (American journal of obstetrics & gynecology MFM)
[2020, 2(4):100238]

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CRAFT (Cerclage after full dilatation caesarean section): protocol of a mixed methods study investigating the role of previous in-labour caesarean section in preterm birth risk.

Naomi Carlisle, Agnieszka Glazewska-Hallin, Lisa Story, Jenny Carter, Paul T Seed, Natalie Suff, Lucie Giblin, Jana Hutter, Raffaele Napolitano, Mary Rutherford, Daniel C Alexander, Nigel Simpson, Amrita Banerjee, Anna L David, Andrew H Shennan,

<h4>Background</h4>Full dilatation caesarean sections are associated with recurrent early spontaneous preterm birth and late miscarriage. The risk following first stage caesarean sections, are less well defined, but appears to be increased in late-first stage of labour. The mechanism for this increased risk of late miscarriage and early spontaneous preterm birth ... Read more >>

BMC Pregnancy Childbirth (BMC pregnancy and childbirth)
[2020, 20(1):698]

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Efficacy of transvaginal cervical cerclage in women at risk of preterm birth following previous emergency cesarean section.

Maria M Hickland, Lisa Story, Agnieszka Glazewska-Hallin, Natalie Suff, Matthew Cauldwell, Helena A Watson, Jenny Carter, Kate E Duhig, Andrew H Shennan,

<h4>Introduction</h4>Emergency cesarean sections (EMCS) are associated with subsequent preterm birth, particularly at full dilation (FDCS), which is a cause of both second trimester miscarriages and early, recurrent spontaneous preterm birth (sPTB). The optimal management for these women in subsequent pregnancies is currently unknown. This study aims to assess efficacy of ... Read more >>

Acta Obstet Gynecol Scand (Acta obstetricia et gynecologica Scandinavica)
[2020, 99(11):1486-1491]

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Generation of light-producing somatic-transgenic mice using adeno-associated virus vectors.

Rajvinder Karda, Ahad A Rahim, Andrew M S Wong, Natalie Suff, Juan Antinao Diaz, Dany P Perocheau, Maha Tijani, Joanne Ng, Julien Baruteau, Nuria Palomar Martin, Michael Hughes, Juliette M K M Delhove, John R Counsell, Jonathan D Cooper, Els Henckaerts, Tristan R Mckay, Suzanne M K Buckley, Simon N Waddington,

We have previously designed a library of lentiviral vectors to generate somatic-transgenic rodents to monitor signalling pathways in diseased organs using whole-body bioluminescence imaging, in conscious, freely moving rodents. We have now expanded this technology to adeno-associated viral vectors. We first explored bio-distribution by assessing GFP expression after neonatal intravenous ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):2121]

Cited: 1 time

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Cervical Gene Delivery of the Antimicrobial Peptide, Human β-Defensin (HBD)-3, in a Mouse Model of Ascending Infection-Related Preterm Birth.

Natalie Suff, Rajvinder Karda, Juan Antinao Diaz, Joanne Ng, Julien Baruteau, Dany Perocheau, Peter W Taylor, Dagmar Alber, Suzanne M K Buckley, Mona Bajaj-Elliott, Simon N Waddington, Donald Peebles,

Approximately 40% of preterm births are preceded by microbial invasion of the intrauterine space; ascent from the vagina being the most common pathway. Within the cervical canal, antimicrobial peptides and proteins (AMPs) are important components of the cervical barrier which help to prevent ascending vaginal infection. We investigated whether expression ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:106]

Cited: 1 time

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The use of quantitative fetal fibronectin for the prediction of preterm birth in women with exposed fetal membranes undergoing emergency cervical cerclage.

Natalie Suff, Megan Hall, Andrew Shennan, Manju Chandiramani,

<h4>Objective</h4>Emergency cervical cerclage is often considered a controversial salvage measure for those pregnancies at high risk of mid-trimester loss or early preterm birth. To determine the efficacy and benefit of emergency cerclage insertion, we assessed the predictive value of quantitative fetal fibronectin (fFN) concentration in cervicovaginal fluid for spontaneous preterm ... Read more >>

Eur J Obstet Gynecol Reprod Biol (European journal of obstetrics, gynecology, and reproductive biology)
[2020, 246:19-22]

Cited: 1 time

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Cervical gene delivery of the antimicrobial peptide, Human β-defensin (HBD)-3, in a mouse model of ascending infection-related preterm birth

Natalie Suff, Rajvinder Karda, Juan Antinao Diaz, Joanne Ng, Julien Baruteau, Dany Perocheau, Peter Taylor, Dagmar Alber, Suzanne M.K. Buckley, Mona Bajaj-Elliott, Simon Waddington, Donald Peebles,

Approximately 40% of preterm births are preceded by microbial invasion of the intrauterine space: ascent from the vagina is the most common pathway. Within the cervical canal, antimicrobial peptides and proteins (AMPs) help to constitute a barrier which prevents ascending infection. We investigated whether expression of the AMP, human β-defensin-3 ... Read more >>

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The prediction of preterm delivery: What is new?

Natalie Suff, Lisa Story, Andrew Shennan,

Preterm birth, defined as birth occurring prior to 37 weeks gestation, is a serious obstetric problem accounting for 11% of pregnancies worldwide. It is associated with significant neonatal morbidity and mortality. Predictive tests for preterm birth are incredibly important, given the huge personal, economic, and health impacts of preterm birth. ... Read more >>

Semin Fetal Neonatal Med (Seminars in fetal & neonatal medicine)
[2019, 24(1):27-32]

Cited: 14 times

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Argininosuccinic aciduria fosters neuronal nitrosative stress reversed by Asl gene transfer.

Julien Baruteau, Dany P Perocheau, Joanna Hanley, Maëlle Lorvellec, Eridan Rocha-Ferreira, Rajvinder Karda, Joanne Ng, Natalie Suff, Juan Antinao Diaz, Ahad A Rahim, Michael P Hughes, Blerida Banushi, Helen Prunty, Mariya Hristova, Deborah A Ridout, Alex Virasami, Simon Heales, Stewen J Howe, Suzanne M K Buckley, Philippa B Mills, Paul Gissen, Simon N Waddington,

Argininosuccinate lyase (ASL) belongs to the hepatic urea cycle detoxifying ammonia, and the citrulline-nitric oxide (NO) cycle producing NO. ASL-deficient patients present argininosuccinic aciduria characterised by hyperammonaemia, multiorgan disease and neurocognitive impairment despite treatment aiming to normalise ammonaemia without considering NO imbalance. Here we show that cerebral disease in argininosuccinic ... Read more >>

Nat Commun (Nature communications)
[2018, 9(1):3505]

Cited: 12 times

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Generation of light-producing somatic-transgenic mice using adeno-associated virus vectors

Rajvinder Karda, Ahad Rahim, Andrew M.S. Wong, Natalie Suff, Juan Antinao Diaz, Dany Perocheau, Nuria Palomar Martin, Michael Hughes, Juliette M.K.M. Delhove, John Counsell, Jonathan Cooper, Els Henckaerts, Tristan Mckay, Suzanne M.K. Buckley, Simon Waddington,

We have previously designed a library of lentiviral vectors to generate somatic-transgenic rodents to monitor signalling pathways in diseased organs using whole-body bioluminescence imaging, in conscious, freely moving rodents. We have now expanded this technology to adeno-associated viral vectors. We first explored bio-distribution by assessing GFP expression after neonatal intravenous ... Read more >>

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Ascending Vaginal Infection Using Bioluminescent Bacteria Evokes Intrauterine Inflammation, Preterm Birth, and Neonatal Brain Injury in Pregnant Mice.

Natalie Suff, Rajvinder Karda, Juan A Diaz, Joanne Ng, Julien Baruteau, Dany Perocheau, Mark Tangney, Peter W Taylor, Donald Peebles, Suzanne M K Buckley, Simon N Waddington,

Preterm birth is a serious global health problem and the leading cause of infant death before 5 years of age. At least 40% of cases are associated with infection. The most common way for pathogens to access the uterine cavity is by ascending from the vagina. Bioluminescent pathogens have revolutionized ... Read more >>

Am J Pathol (The American journal of pathology)
[2018, 188(10):2164-2176]

Cited: 12 times

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The power of bioluminescence imaging in understanding host-pathogen interactions.

Natalie Suff, Simon N Waddington,

Infectious diseases are one of the leading causes of death worldwide. Modelling and understanding human infection is imperative to developing treatments to reduce the global burden of infectious disease. Bioluminescence imaging is a highly sensitive, non-invasive technique based on the detection of light, produced by luciferase-catalysed reactions. In the study ... Read more >>

Methods (Methods (San Diego, Calif.))
[2017, 127:69-78]

Cited: 3 times

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Schistosomiasis presenting in travellers: a 15 year observational study at the Hospital for Tropical Diseases, London.

Cordelia E M Coltart, Anastasia Chew, Neill Storrar, Margaret Armstrong, Natalie Suff, Leila Morris, Peter L Chiodini, Christopher J M Whitty,

<h4>Background</h4>Schistosomiasis in returning travellers is one of the most common imported tropical infections with potentially serious complications, which are preventable if diagnosed early.<h4>Methods</h4>A review was undertaken of consecutive cases of schistosomiasis presenting at the Hospital for Tropical Diseases, London, UK from 1997 to 2012.<h4>Results</h4>All 1020 schistosomiasis cases were from Africa ... Read more >>

Trans R Soc Trop Med Hyg (Transactions of the Royal Society of Tropical Medicine and Hygiene)
[2015, 109(3):214-220]

Cited: 23 times

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OS078. Fetal growth restriction: A marker of severity of early-onset pre-eclampsia?

A Khalil, Natalie Suff, Alice Grande, Anna David, Asma Khalil,

<h4>Introduction</h4>Pre-eclampsia (PE), particularly early-onset PE (PE requiring delivery before 34 weeks), is commonly associated with fetal growth restriction (FGR). The evidence for an association between FGR and a more severe PE phenotype is controversial.<h4>Objectives</h4>The main aim of this study was to investigate whether the presence of FGR in women with ... Read more >>

Pregnancy Hypertens (Pregnancy hypertension)
[2012, 2(3):220]

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