Full Text Journal Articles by
Author Natalia I Dmitrieva

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Impaired angiogenesis and extracellular matrix metabolism in autosomal-dominant hyper-IgE syndrome.

Natalia I Dmitrieva, Avram D Walts, Dai Phuong Nguyen, Alex Grubb, Xue Zhang, Xujing Wang, Xianfeng Ping, Hui Jin, Zhen Yu, Zu-Xi Yu, Dan Yang, Robin Schwartzbeck, Clifton L Dalgard, Beth A Kozel, Mark D Levin, Russell H Knutsen, Delong Liu, Joshua D Milner, Diego B López, Michael P O'Connell, Chyi-Chia Richard Lee, Ian A Myles, Amy P Hsu, Alexandra F Freeman, Steven M Holland, Guibin Chen, Manfred Boehm,

There are more than 7000 described rare diseases, most lacking specific treatment. Autosomal-dominant hyper-IgE syndrome (AD-HIES, also known as Job's syndrome) is caused by mutations in STAT3. These patients present with immunodeficiency accompanied by severe nonimmunological features, including skeletal, connective tissue, and vascular abnormalities, poor postinfection lung healing, and subsequent ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2020, 130(8):4167-4181]

Cited: 4 times

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Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease.

Najoua Lalaoui, Steven E Boyden, Hirotsugu Oda, Geryl M Wood, Deborah L Stone, Diep Chau, Lin Liu, Monique Stoffels, Tobias Kratina, Kate E Lawlor, Kristien J M Zaal, Patrycja M Hoffmann, Nima Etemadi, Kristy Shield-Artin, Christine Biben, Wanxia Li Tsai, Mary D Blake, Hye Sun Kuehn, Dan Yang, Holly Anderton, Natasha Silke, Laurens Wachsmuth, Lixin Zheng, Natalia Sampaio Moura, David B Beck, Gustavo Gutierrez-Cruz, Amanda K Ombrello, Gineth P Pinto-Patarroyo, Andrew J Kueh, Marco J Herold, Cathrine Hall, Hongying Wang, Jae Jin Chae, Natalia I Dmitrieva, Mark McKenzie, Amanda Light, Beverly K Barham, Anne Jones, Tina M Romeo, Qing Zhou, Ivona Aksentijevich, James C Mullikin, Andrew J Gross, Anthony K Shum, Edwin D Hawkins, Seth L Masters, Michael J Lenardo, Manfred Boehm, Sergio D Rosenzweig, Manolis Pasparakis, Anne K Voss, Massimo Gadina, Daniel L Kastner, John Silke,

RIPK1 is a key regulator of innate immune signalling pathways. To ensure an optimal inflammatory response, RIPK1 is regulated post-translationally by well-characterized ubiquitylation and phosphorylation events, as well as by caspase-8-mediated cleavage<sup>1-7</sup>. The physiological relevance of this cleavage event remains unclear, although it is thought to inhibit activation of RIPK3 ... Read more >>

Nature (Nature)
[2020, 577(7788):103-108]

Cited: 42 times

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Suboptimal hydration remodels metabolism, promotes degenerative diseases, and shortens life.

Michele D Allen, Danielle A Springer, Maurice B Burg, Manfred Boehm, Natalia I Dmitrieva,

With increased life expectancy worldwide, there is an urgent need for improving preventive measures that delay the development of age-related degenerative diseases. Here, we report evidence from mouse and human studies that this goal can be achieved by maintaining optimal hydration throughout life. We demonstrate that restricting the amount of ... Read more >>

JCI Insight (JCI insight)
[2019, 4(17):]

Cited: 5 times

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Cross-Sectional Positive Association of Serum Lipids and Blood Pressure With Serum Sodium Within the Normal Reference Range of 135-145 mmol/L.

Shouguo Gao, Xiangqin Cui, Xujing Wang, Maurice B Burg, Natalia I Dmitrieva,

<h4>Objective</h4>Serum sodium concentration is maintained by osmoregulation within normal range of 135 to 145 mmol/L. Previous analysis of data from the ARIC study (Atherosclerosis Risk in Communities) showed association of serum sodium with the 10-year risk scores of coronary heart disease and stroke. Current study evaluated the association of within-normal-range ... Read more >>

Arterioscler Thromb Vasc Biol (Arteriosclerosis, thrombosis, and vascular biology)
[2017, 37(3):598-606]

Cited: 11 times

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Increased activity of TNAP compensates for reduced adenosine production and promotes ectopic calcification in the genetic disease ACDC.

Hui Jin, Cynthia St Hilaire, Yuting Huang, Dan Yang, Natalia I Dmitrieva, Alejandra Negro, Robin Schwartzbeck, Yangtengyu Liu, Zhen Yu, Avram Walts, Jean-Michel Davaine, Duck-Yeon Lee, Danielle Donahue, Kevin S Hsu, Jessica Chen, Tao Cheng, William Gahl, Guibin Chen, Manfred Boehm,

ACDC (arterial calcification due to deficiency of CD73) is an autosomal recessive disease resulting from loss-of-function mutations in NT5E, which encodes CD73, a 5'-ectonucleotidase that converts extracellular adenosine monophosphate to adenosine. ACDC patients display progressive calcification of lower extremity arteries, causing limb ischemia. Tissue-nonspecific alkaline phosphatase (TNAP), which converts pyrophosphate ... Read more >>

Sci Signal (Science signaling)
[2016, 9(458):ra121]

Cited: 23 times

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Elevated sodium and dehydration stimulate inflammatory signaling in endothelial cells and promote atherosclerosis.

Natalia I Dmitrieva, Maurice B Burg,

Cardiovascular diseases (CVDs) are a leading health problem worldwide. Epidemiologic studies link high salt intake and conditions predisposing to dehydration such as low water intake, diabetes and old age to increased risk of CVD. Previously, we demonstrated that elevation of extracellular sodium, which is a common consequence of these conditions, ... Read more >>

PLoS One (PloS one)
[2015, 10(6):e0128870]

Cited: 27 times

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Secretion of von Willebrand factor by endothelial cells links sodium to hypercoagulability and thrombosis.

Natalia I Dmitrieva, Maurice B Burg,

Hypercoagulability increases risk of thrombi that cause cardiovascular events. Here we identify plasma sodium concentration as a factor that modulates blood coagulability by affecting the production of von Willebrand factor (vWF), a key initiator of the clotting cascade. We find that elevation of salt over a range from the lower ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2014, 111(17):6485-6490]

Cited: 35 times

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DNA double-strand breaks induced by high NaCl occur predominantly in gene deserts.

Natalia I Dmitrieva, Kairong Cui, Daniil A Kitchaev, Keji Zhao, Maurice B Burg,

High concentration of NaCl increases DNA breaks both in cell culture and in vivo. The breaks remain elevated as long as NaCl concentration remains high and are rapidly repaired when the concentration is lowered. The exact nature of the breaks, and their location, has not been entirely clear, and it ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2011, 108(51):20796-20801]

Cited: 17 times

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Increased insensible water loss contributes to aging related dehydration.

Natalia I Dmitrieva, Maurice B Burg,

Dehydration with aging is attributed to decreased urine concentrating ability and thirst. We further investigated by comparing urine concentration and water balance in 3, 18 and 27 month old mice, consuming equal amounts of water. During water restriction, 3 month old mice concentrate their urine sufficiently to maintain water balance ... Read more >>

PLoS One (PloS one)
[2011, 6(5):e20691]

Cited: 9 times

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Mediator of DNA damage checkpoint 1 (MDC1) contributes to high NaCl-induced activation of the osmoprotective transcription factor TonEBP/OREBP.

Margarita Kunin, Natalia I Dmitrieva, Morgan Gallazzini, Rong-Fong Shen, Guanghui Wang, Maurice B Burg, Joan D Ferraris,

<h4>Background</h4>Hypertonicity, such as induced by high NaCl, increases the activity of the transcription factor TonEBP/OREBP whose target genes increase osmoprotective organic osmolytes and heat shock proteins.<h4>Methodology</h4>We used mass spectrometry to analyze proteins that coimmunoprecipitate with TonEBP/OREBP in order to identify ones that might contribute to its high NaCl-induced activation.<h4>Principal findings</h4>We ... Read more >>

PLoS One (PloS one)
[2010, 5(8):e12108]

Cited: 7 times

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Knockout of Ku86 accelerates cellular senescence induced by high NaCl.

Natalia I Dmitrieva, Hua Tang Chen, André Nussenzweig, Maurice B Burg,

NaCl induces DNA breaks, thus leading to cellular senescence. Here we showed that Ku86 deficiency accelerated the high NaCl-induced cellular senescence. We find that 1) high NaCl induces rapid cellular senescence in Ku86 deficient(xrs5) cells, 2) Ku86 deficiency shortens lifespan of C. elegans in high NaCl, and 3) cellular senescence ... Read more >>

Aging (Albany NY) (Aging)
[2009, 1(2):245-253]

Cited: 3 times

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Analysis of DNA breaks, DNA damage response, and apoptosis produced by high NaCl.

Natalia I Dmitrieva, Maurice B Burg,

We previously reported that, both in cell culture and in the renal inner medulla in vivo, elevating NaCl increased the number of DNA breaks, which persisted as long as NaCl remained high but were rapidly repaired when NaCl was lowered. Furthermore, those breaks did not induce the DNA repair protein ... Read more >>

Am J Physiol Renal Physiol (American journal of physiology. Renal physiology)
[2008, 295(6):F1678-88]

Cited: 15 times

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Cellular response to hyperosmotic stresses.

Maurice B Burg, Joan D Ferraris, Natalia I Dmitrieva,

Cells in the renal inner medulla are normally exposed to extraordinarily high levels of NaCl and urea. The osmotic stress causes numerous perturbations because of the hypertonic effect of high NaCl and the direct denaturation of cellular macromolecules by high urea. High NaCl and urea elevate reactive oxygen species, cause ... Read more >>

Physiol Rev (Physiological reviews)
[2007, 87(4):1441-1474]

Cited: 348 times

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High NaCl promotes cellular senescence.

Natalia I Dmitrieva, Maurice B Burg,

High extracellular NaCl was previously shown to increase the number of DNA breaks in mammalian cells in tissue culture, renal medullary cells in vivo, C. elegans and marine invertebrates. It was also shown to increase reactive oxygen species in renal cells, resulting in oxidation of proteins and DNA. Cellular senescence ... Read more >>

Cell Cycle (Cell cycle (Georgetown, Tex.))
[2007, 6(24):3108-3113]

Cited: 19 times

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MKP-1 inhibits high NaCl-induced activation of p38 but does not inhibit the activation of TonEBP/OREBP: opposite roles of p38alpha and p38delta.

Xiaoming Zhou, Joan D Ferraris, Natalia I Dmitrieva, Yusen Liu, Maurice B Burg,

High NaCl rapidly activates p38 MAPK by phosphorylating it, the phosphorylation presumably being regulated by a balance of kinases and phosphatases. Kinases are known, but the phosphatases are uncertain. Our initial purpose was to identify the phosphatases. We find that in HEK293 cells transient overexpression of MAPK phosphatase-1 (MKP-1), a ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2008, 105(14):5620-5625]

Cited: 30 times

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Helper B cells promote cytotoxic T cell survival and proliferation independently of antigen presentation through CD27/CD70 interactions.

Sara Deola, Monica C Panelli, Dragan Maric, Silvia Selleri, Natalia I Dmitrieva, Ching Y Voss, Harvey Klein, David Stroncek, Ena Wang, Francesco M Marincola,

CD8-expressing cytotoxic T cell (CTL) interactions with APCs and helper T cells determine their function and ability to survive. In this study, we describe a novel interaction independent of Ag presentation between activated CTLs and bystander CD19-expressing B lymphocytes. Ag-stimulated CTLs serially engage autologous B lymphocytes through CD27/CD70 contact that ... Read more >>

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2008, 180(3):1362-1372]

Cited: 37 times

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The saltiness of the sea breaks DNA in marine invertebrates: possible implications for animal evolution.

Natalia I Dmitrieva, Joan D Ferraris, Jon L Norenburg, Maurice B Burg,

More than 97 percent of the world's water is ocean and its average osmolality of 1000 mosmol/kg is much higher than the 300 mosmol/kg found in most of the intercellular fluids of vertebrates. Many marine invertebrates are osmoconformers, meaning that the osmolality of their extracellular fluid is the same as ... Read more >>

Cell Cycle (Cell cycle (Georgetown, Tex.))
[2006, 5(12):1320-1323]

Cited: 12 times

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Osmotic stress and DNA damage.

Natalia I Dmitrieva, Maurice B Burg,

Mammalian renal inner medullary cells are normally exposed to extremely high NaCl concentrations. The interstitial NaCl concentration in parts of a normal renal medulla can be 500 mM or more, depending on the species. Remarkably, under these normal conditions, the high NaCl causes DNA damage, yet the cells survive and ... Read more >>

Methods Enzymol (Methods in enzymology)
[2007, 428:241-252]

Cited: 9 times

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Ku86 preserves chromatin integrity in cells adapted to high NaCl.

Natalia I Dmitrieva, Arkady Celeste, André Nussenzweig, Maurice B Burg,

Cells adapted to high NaCl have many DNA breaks both in cell culture and in the renal inner medulla in vivo; yet they survive, function, and even proliferate. Here, we show that Ku86 is important for maintaining chromosomal integrity despite the continued presence of DNA breaks. The Ku heterodimer is ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2005, 102(30):10730-10735]

Cited: 22 times

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DNA damage and osmotic regulation in the kidney.

Natalia I Dmitrieva, Maurice B Burg, Joan D Ferraris,

Renal medullary cells normally are exposed to extraordinarily high interstitial NaCl concentration as part of the urinary concentrating mechanism, yet they survive and function. Acute elevation of NaCl to a moderate level causes transient cell cycle arrest in culture. Higher levels of NaCl, within the range found in the inner ... Read more >>

Am J Physiol Renal Physiol (American journal of physiology. Renal physiology)
[2005, 289(1):F2-7]

Cited: 15 times

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Effects of expression of p53 and Gadd45 on osmotic tolerance of renal inner medullary cells.

Qi Cai, Natalia I Dmitrieva, Joan D Ferraris, Luis F Michea, Jesus M Salvador, M Christine Hollander, Albert J Fornace, Robert A Fenton, Maurice B Burg,

The response of renal inner medullary (IM) collecting duct cells (mIMCD3) to high NaCl involves increased expression of Gadd45 and p53, both of which have important effects on growth and survival of the cells. However, mIMCD3 cells, being immortalized by SV40, proliferate rapidly, which is known to sensitize cells to ... Read more >>

Am J Physiol Renal Physiol (American journal of physiology. Renal physiology)
[2006, 291(2):F341-9]

Cited: 7 times

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Ataxia telangiectasia-mutated, a DNA damage-inducible kinase, contributes to high NaCl-induced nuclear localization of transcription factor TonEBP/OREBP.

Zheng Zhang, Joan D Ferraris, Carlos E Irarrazabal, Natalia I Dmitrieva, Jong-Hwan Park, Maurice B Burg,

High NaCl activates the transcription factor tonicity-responsive enhancer/osmotic response element binding protein (TonEBP/OREBP) by increasing its abundance and transactivation, the latter signaled by a variety of protein kinases. In addition, high NaCl causes TonEBP/OREBP to translocate into the nucleus, but little is known about the signals directing this translocation. The ... Read more >>

Am J Physiol Renal Physiol (American journal of physiology. Renal physiology)
[2005, 289(3):F506-11]

Cited: 27 times

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Hypertonic stress response.

Natalia I Dmitrieva, Maurice B Burg,

Mammalian renal inner medullary cells are normally exposed to extremely high NaCl concentrations. Remarkably, under these normal conditions, the high NaCl causes DNA damage and inhibits its repair, yet the cells survive and function both in cell culture and in vivo. The interstitial NaCl concentration in parts of a normal ... Read more >>

Mutat Res (Mutation research)
[2005, 569(1-2):65-74]

Cited: 45 times

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Pax2 expression occurs in renal medullary epithelial cells in vivo and in cell culture, is osmoregulated, and promotes osmotic tolerance.

Qi Cai, Natalia I Dmitrieva, Joan D Ferraris, Heddwen L Brooks, Bas W M van Balkom, Maurice Burg,

Pax2 is a transcription factor that is crucial for kidney development, and it is also expressed in the normal adult kidney, where its physiological function is unknown. In the present study, we find by cDNA microarray analysis that Pax2 expression in second-passage mouse inner-medullary epithelial cells is increased by a ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2005, 102(2):503-508]

Cited: 43 times

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High urea and NaCl carbonylate proteins in renal cells in culture and in vivo, and high urea causes 8-oxoguanine lesions in their DNA.

Zheng Zhang, Natalia I Dmitrieva, Jong-Hwan Park, Rodney L Levine, Maurice B Burg,

<h4>Unlabelled</h4>Urea and NaCl are elevated in the renal inner medulla. We now find that a high concentration of urea or NaCl increases reactive oxygen species (ROS) in mouse renal inner medullary (mIMCD3) cells in culture. Previously, high NaCl, but not high urea, was found to cause DNA double-strand breaks. We ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2004, 101(25):9491-9496]

Cited: 86 times

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