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Francesco Santoro, Ivan J Núñez-Gil, Natale Daniele Brunetti,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1183-e1184]

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Antiplatelet therapy and outcome in COVID-19: the Health Outcome Predictive Evaluation Registry.

Francesco Santoro, Ivan Javier Nuñez-Gil, Enrica Vitale, Maria C Viana-Llamas, Begoña Reche-Martinez, Rodolfo Romero-Pareja, Gisela Feltez Guzman, Inmaculada Fernandez Rozas, Aitor Uribarri, Víctor Manuel Becerra-Muñoz, Emilio Alfonso-Rodriguez, Marcos Garcia-Aguado, Jia Huang, María Elizabeth Ortega-Armas, Juan F Garcia Prieto, Eva Maria Corral Rubio, Fabrizio Ugo, Matteo Bianco, Alba Mulet, Sergio Raposeiras-Roubin, Jorge Luis Jativa Mendez, Carolina Espejo Paeres, Adrián Rodríguez Albarrán, Francisco Marín, Federico Guerra, Ibrahim Akin, Bernardo Cortese, Harish Ramakrishna, Carlos Macaya, Antonio Fernandez-Ortiz, Natale Daniele Brunetti,

<h4>Background</h4>Standard therapy for COVID-19 is continuously evolving. Autopsy studies showed high prevalence of platelet-fibrin-rich microthrombi in several organs. The aim of the study was therefore to evaluate the safety and efficacy of antiplatelet therapy (APT) in hospitalised patients with COVID-19 and its impact on survival.<h4>Methods</h4>7824 consecutive patients with COVID-19 were ... Read more >>

Heart (Heart (British Cardiac Society))
[2021, :]

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Predictors of right ventricular function improvement with sacubitril/valsartan in a real-life population of patients with chronic heart failure.

Michele Correale, Pietro Mazzeo, Michele Magnesa, Martino Fortunato, Lucia Tricarico, Alessandra Leopizzi, Adriana Mallardi, Raffaele Mennella, Salvatore Tucci, Natale Daniele Brunetti,

<h4>Background</h4>Observational studies have demonstrated that treatment with sacubitril/valsartan may improve left ventricular (LV) systolic and diastolic function in subjects with reduced LV ejection fraction (LVEF) in real-world studies. Subjects with heart failure and reduced EF (HFrEF), however, are also characterized by an impaired right ventricular (RV) function. We therefore aimed ... Read more >>

Clin Physiol Funct Imaging (Clinical physiology and functional imaging)
[2021, 41(6):505-513]

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Safety and heart rate changes in Covid-19 patients treated with Remdesivir.

Natale Daniele Brunetti, Mariacristina Poliseno, Irene Francesca Bottalico, Antonio Centola, Laura Montemurro, Salvatore Sica, Teresa Santantonio, Sergio Lo Caputo,

Objectives Limited data are available regarding the occurrence and the extent of cardiac rhythm disturbances in patients with COVID-19 treated with Remdesivir. Methods Here we present a case series of 52 patients who underwent daily electrocardiogram (ECG) examination after Remdesivir administration. Results Compared to baseline, a significant heart rate reduction ... Read more >>

Int J Infect Dis (International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases)
[2021, :]

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Switch to SGLT2 Inhibitors and Improved Endothelial Function in Diabetic Patients with Chronic Heart Failure.

Michele Correale, Pietro Mazzeo, Adriana Mallardi, Alessandra Leopizzi, Lucia Tricarico, Martino Fortunato, Michele Magnesa, Salvatore Tucci, Pasquale Maiellaro, Giuseppe Pastore, Olga Lamacchia, Massimo Iacoviello, Matteo Di Biase, Natale Daniele Brunetti,

<h4>Purpose</h4>The use of sodium-glucose-cotransporter-type-2 inhibitors (SGLT2i) was associated in previous studies with an improved vascular function in non-human experimental models. We therefore sought to evaluate possible changes in endothelial function assessed by flow-mediated dilation (FMD) in patients with chronic heart failure (CHF) and type-2 diabetes mellitus (T2DM), switching from other ... Read more >>

Cardiovasc Drugs Ther (Cardiovascular drugs and therapy)
[2021, :]

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Prognostic role of neoplastic markers in Takotsubo syndrome.

Francesco Santoro, Tecla Zimotti, Adriana Mallardi, Alessandra Leopizzi, Enrica Vitale, Nicola Tarantino, Armando Ferraretti, Antonio Giovanni Solimando, Vito Racanelli, Massimo Iacoviello, Michele Cannone, Matteo Di Biase, Natale Daniele Brunetti,

Takotsubo syndrome (TTS) is an acute heart failure syndrome with significant rates of in and out-of-hospital mayor cardiac adverse events (MACE). To evaluate the possible role of neoplastic biomarkers [CA-15.3, CA-19.9 and Carcinoembryonic Antigen (CEA)] as prognostic marker at short- and long-term follow-up in subjects with TTS. Ninety consecutive subjects ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):16548]

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Biomarkers in Cardiorenal Syndrome.

Giovanni Goffredo, Roberta Barone, Vito Di Terlizzi, Michele Correale, Natale Daniele Brunetti, Massimo Iacoviello,

Cardiorenal syndrome is a clinical manifestation of the bidirectional interaction between the heart and kidney diseases. Over the last years, in patients with cardiovascular diseases, several biomarkers have been studied in order to better assess renal function as well as to identify patients prone to experiencing chronic or acute worsening ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(15):]

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Vascular and metabolic effects of SGLT2i and GLP-1 in heart failure patients.

Michele Correale, Olga Lamacchia, Michele Ciccarelli, Giuseppe Dattilo, Lucia Tricarico, Natale Daniele Brunetti,

Alterations of endothelial function, inflammatory activation, and nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathway are involved in the pathophysiology of heart failure. Metabolic alterations have been studied in the myocardium of heart failure (HF) patients; alterations in ketone body and amino acid/protein metabolism have been described in patients affected by HF, ... Read more >>

Heart Fail Rev (Heart failure reviews)
[2021, :]

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Remodelling is inversely proportional to left ventricular dimensions in a real-life population of patients with chronic heart failure after therapy with sacubitril/valsartan.

Michele Correale, Adriana Mallardi, Lucia Tricarico, Pietro Mazzeo, Armando Ferraretti, Claudia Diella, Valentina Romano, Giuseppina Merolla, Massimo Iacoviello, Matteo Di Biase, Natale Daniele Brunetti,

<h4>Background</h4>Left ventricular (LV) remodelling is a major mechanism underlying disease progression in patients with heart failure (HF) with reduced ejection fraction (EF). Previous studies that LVEF improvement and reverse remodelling can be achieved after therapy with Sacubitril/Valsartan in real-world settings. Therefore, we sought to investigate possible predictors of LV remodelling, ... Read more >>

Acta Cardiol (Acta cardiologica)
[2021, :1-6]

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The Evolving Phenotypes of Cardiovascular Disease during COVID-19 Pandemic.

Michele Correale, Francesca Croella, Alessandra Leopizzi, Pietro Mazzeo, Lucia Tricarico, Adriana Mallardi, Martino Fortunato, Michele Magnesa, Vincenzo Ceci, Alessandra Puteo, Massimo Iacoviello, Matteo Di Biase, Natale Daniele Brunetti,

COVID-19 pandemic has negatively impacted the management of patients with acute and chronic cardiovascular disease: acute coronary syndrome patients were often not timely reperfused, heart failure patients not adequately followed up and titrated, atrial arrhythmias not efficaciously treated and became chronic. New phenotypes of cardiovascular patients were more and more ... Read more >>

Cardiovasc Drugs Ther (Cardiovascular drugs and therapy)
[2021, :]

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Disease-modifier Drugs in Patients with Advanced Heart Failure: How to Optimize Their Use?

Massimo Iacoviello, Enrica Vitale, Maria Delia Corbo, Michele Correale, Natale Daniele Brunetti,

Therapy based on disease-modifier drugs is among the required criteria to diagnose advanced heart failure (AdvHF). Nevertheless, several conditions, such as hospitalization, hypotension, renal dysfunction, electrolyte abnormalities, medical inertia, and patients' adherence, can make the maintenance of optimal medical therapy in patients with AdvHF challenging. Moreover, in recent years, new ... Read more >>

Heart Fail Clin (Heart failure clinics)
[2021, 17(4):561-573]

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Effect of SAcubitril/Valsartan on left vEntricular ejection fraction and on the potential indication for Implantable Cardioverter Defibrillator in primary prevention: the SAVE-ICD study.

Federico Guerra, Ernesto Ammendola, Matteo Ziacchi, Vittorio Aspromonte, Pier Luigi Pellegrino, Giuseppe Del Giorno, Gabriele Dell'Era, Lorenzo Pimpini, Francesco Santoro, Roberto Floris, Giulia Stronati, Gerardo Nigro, Pasquale Paolisso, Alessandro Guido, Giampiero Maglia, Natale Daniele Brunetti, Angelo Carbone, Miriam Gravellone, Roberto Antonicelli, Michele Cannone, Michele Accogli, Antonio Dello Russo, Pietro Palmisano,

<h4>Purpose</h4>Sacubitril/valsartan has been associated with a positive reverse left ventricular remodelling in patients with heart failure with reduced ejection fraction (HFrEF). These patients may also benefit from an ICD implant. We aimed to assess EF improvement after 6 months of treatment with sacubitril/valsartan, evaluating when ICD as primary prevention was no ... Read more >>

Eur J Clin Pharmacol (European journal of clinical pharmacology)
[2021, :]

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Multivessel spontaneous coronary artery dissection and Crohn's disease.

Maria Delia Corbo, Antonio Centola, Martino Fortunato, Pietro Mazzeo, Enrica Vitale, Davide Della Monica, Michele Magnesa, Riccardo Ieva, Andrea Cuculo, Massimo Iacoviello, Natale Daniele Brunetti,

Spontaneous coronary artery dissection (SCAD) may be a cause of up to 1-4% of acute coronary syndrome overall, occurring mainly in young women, less than 50 years old, with no classical risk factor for CAD, especially during the postpartum period or associated with inflammatory disease. The clinical presentation varies from ... Read more >>

J Cardiovasc Med (Hagerstown) (Journal of cardiovascular medicine (Hagerstown, Md.))
[2021, :]

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Anticoagulation Therapy in Patients With Coronavirus Disease 2019: Results From a Multicenter International Prospective Registry (Health Outcome Predictive Evaluation for Corona Virus Disease 2019 [HOPE-COVID19]).

Francesco Santoro, Ivan J Núñez-Gil, María C Viana-Llamas, Charbel Maroun Eid, Rodolfo Romero, Inmaculada Fernández Rozas, Alvaro Aparisi, Victor Manuel Becerra-Muñoz, Marcos García Aguado, Jia Huang, Ludovica Maltese, Enrico Cerrato, Emilio Alfonso-Rodriguez, Alex Fernando Castro Mejía, Francisco Marin, Sergio Raposeiras Roubin, Martino Pepe, Victor H Moreno Munguia, Gisela Feltes, Jesus Varas Navas, Bernardo Cortese, Luis Buzón, Cristoph Liebetrau, Raquel Ramos-Martinez, Antonio Fernandez-Ortiz, Vicente Estrada, Natale Daniele Brunetti,

<h4>Objectives</h4>No standard therapy, including anticoagulation regimens, is currently recommended for coronavirus disease 2019. Aim of this study was to evaluate the efficacy of anticoagulation in coronavirus disease 2019 hospitalized patients and its impact on survival.<h4>Design</h4>Multicenter international prospective registry (Health Outcome Predictive Evaluation for Corona Virus Disease 2019).<h4>Setting</h4>Hospitalized patients with coronavirus ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(6):e624-e633]

Cited: 3 times

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Predictors of clinical improvement with sacubitril/valsartan in a real world population with chronic heart failure.

Michele Correale, Lucia Tricarico, Armando Ferraretti, Ennio S Formica, Giuseppina Padovano, Ilenia Monaco, Giuseppina Merolla, Valeria Tozzi, Matteo Di Biase, Massimo Iacoviello, Natale Daniele Brunetti,

J Cardiovasc Med (Hagerstown) (Journal of cardiovascular medicine (Hagerstown, Md.))
[2021, 22(6):508-510]

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Incidence and Clinical Impact of Right Ventricular Involvement (Biventricular Ballooning) in Takotsubo Syndrome: Results From the GEIST Registry.

Ibrahim El-Battrawy, Francesco Santoro, Thomas Stiermaier, Christian Möller, Francesca Guastafierro, Giuseppina Novo, Salvatore Novo, Enrica Mariano, Francesco Romeo, Fabiana Romeo, Holger Thiele, Federico Guerra, Alessandro Capucci, Irene Giannini, Natale Daniele Brunetti, Ingo Eitel, Ibrahim Akin,

<h4>Background</h4>The short- and long-term prognosis of Takotsubo syndrome (TTS) presenting with right ventricular (RV) involvement remains poorly understood.<h4>Research question</h4>What is the incidence and clinical outcome of RV involvement in TTS?<h4>Study design and methods</h4>This study analyzed 839 consecutive patients with TTS (758 female subjects and 81 male subjects) in a multicenter ... Read more >>

Chest (Chest)
[2021, 160(4):1433-1441]

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Eligibility of outpatients with chronic heart failure for sodium-glucose co-transporter-2 inhibitors.

Gianmarco Angelini, Miriam Albanese, Raffaella Ursi, Francesco Lisi, Maria Consiglia Bellino, Luca Amato, Margherita Ilaria Gioia, Giuseppe Parisi, Natale Daniele Brunetti, Giuseppina Piazzolla, Marco Matteo Ciccone, Massimo Iacoviello,

<h4>Aims</h4>Sodium-glucose co-transporter-2 inhibitors (SGLT2i) have been shown to have a relevant role in the prevention of hospitalizations for heart failure and improvement in the life expectancy of patients with diabetes and outpatients with chronic heart failure (CHF) with reduced left ventricular ejection fraction, independently from the presence of type 2 ... Read more >>

ESC Heart Fail (ESC heart failure)
[2021, 8(4):2951-2958]

Cited: 1 time

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New Targets in Heart Failure Drug Therapy.

Michele Correale, Lucia Tricarico, Martino Fortunato, Pietro Mazzeo, Savina Nodari, Matteo Di Biase, Natale Daniele Brunetti,

Despite recent advances in chronic heart failure management (either pharmacological or non-pharmacological), the prognosis of heart failure (HF) patients remains poor. This poor prognosis emphasizes the need for developing novel pathways for testing new HF drugs, beyond neurohumoral and hemodynamic modulation approaches. The development of new drugs for HF therapy ... Read more >>

Front Cardiovasc Med (Frontiers in cardiovascular medicine)
[2021, 8:665797]

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TSH variations in chronic heart failure outpatients: clinical correlates and outcomes.

Paola Terlizzese, Miriam Albanese, Dario Grande, Giuseppe Parisi, Margherita Ilaria Gioia, Natale Daniele Brunetti, Francesco Lisi, Giuseppe Lisco, Francesca Di Serio, Marco Matteo Ciccone, Vincenzo Triggiani, Massimo Iacoviello,

<h4>Background</h4>Hypothyroidism is a frequently observed comorbidity in patients with chronic heart failure (CHF), possibly giving rise to unfavorable outcomes.<h4>Aim</h4>The aim of the study was to evaluate the impact of TSH changes over time on cardiac function and prognosis of outpatients with CHF.<h4>Methods</h4>Patients underwent clinical, electrocardiographic, and echocardiographic evaluations at baseline ... Read more >>

Endocr Metab Immune Disord Drug Targets (Endocrine, metabolic & immune disorders drug targets)
[2021, :]

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Safety and Efficacy of Cryoballoon Ablation for the Treatment of Atrial Fibrillation in Diabetic Patients.

Abdin Amr, Heeger Christian-H, Yalin Kivanc, Santoro Francesco, Brunetti Natale Daniele, Fink Thomas, Liosis Spyridon, Brueggemann Ben, Keelani Ahmad, Phan Huong Lan, Sano Makoto, Sciacca Vanessa, Lyan Evgeny, A N Dong, Meyer-Saraei Roza, Ouyang Feifan, Kuck Karl-Heinz, Eitel Charlotte, Vogler Julia, Tilz Roland Richard,

<h4>Background</h4>Cryoballoon based catheter ablation (CB-CA) is an established therapy for treatment of symptomatic atrial fibrillation (AF). However, data about AF ablation using the CB in the diabetic population is sparse. The aim of this single center retrospective study is to evaluate the safety and efficacy of CB ablation in patients ... Read more >>

J Atr Fibrillation (Journal of atrial fibrillation)
[2020, 12(6):2285]

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Revascularization rates with coronary angioplasty and mortality in type 2 myocardial infarction: A meta-regression analysis.

Marco Mele, Lucia Tricarico, Grazia Casavecchia, Riccardo Ieva, Massimo Iacoviello, Matteo Di Biase, Michele Magnesa, Maria Delia Corbo, Enrica Vitale, Natale Daniele Brunetti,

<h4>Background</h4>Percutaneous coronary intervention (PCI) represents the best therapeutic option for type-1 myocardial infarction (T1MI) in the majority of clinical settings; its role in the treatment of type-2 myocardial infarction (T2MI), however, remains unclear. We therefore sought to assess in a meta-regression analysis the impact of PCI rates on mortality in ... Read more >>

Am J Emerg Med (The American journal of emergency medicine)
[2021, 47:145-148]

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mTOR inhibition improves mitochondria function/biogenesis and delays cardiovascular aging in kidney transplant recipients with chronic graft dysfunction.

Barbara Infante, Francesco Bellanti, Michele Correale, Paola Pontrelli, Rossana Franzin, Serena Leo, Martina Calvaruso, Silvia Mercuri, Giuseppe Stefano Netti, Elena Ranieri, Natale Daniele Brunetti, Giuseppe Grandaliano, Loreto Gesualdo, Gaetano Serviddio, Giuseppe Castellano, Giovanni Stallone,

CVD remains the major cause of mortality with graft functioning in Kidney transplant recipients (KTRs), with an estimated risk of CV events about 50-fold higher than in the general population. Many strategies have been considered to reduce the CV risk such as the use of mTOR inhibitors. We evaluate whether ... Read more >>

Aging (Albany NY) (Aging)
[2021, 13(6):8026-8039]

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Incidence of cardiovascular events in patients with chronic myeloid leukaemia treated with tyrosine kinase inhibitors.

Grazia Casavecchia, Giuseppina Spinosa, Luisa De Gennaro, Stefano Zicchino, Matteo Gravina, Michele Magnesa, Matteo Di Biase, Natale Daniele Brunetti,

<h4>Background</h4>The introduction of imatinib and tyrosine kinase inhibitors as therapeutic strategy for Philadelphia chromosome-positive chronic myeloid leukaemia (CML) has represented an important step forward for treatment of this disease. The aim of this study was therefore to evaluate the incidence of cardiovascular adverse events (CVEs) in patients affected by CML ... Read more >>

Acta Cardiol (Acta cardiologica)
[2021, :1-6]

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Leadless implantation as alternative for pacemaker replacement in infiltrative breast cancer.

Girolamo D'Arienzo, Monica Sicuranza, Luigi Ziccardi, Matteo Di Biase, Natale Daniele Brunetti,

J Cardiovasc Med (Hagerstown) (Journal of cardiovascular medicine (Hagerstown, Md.))
[2021, 22(3):222-224]

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Risk Reduction and Hemodynamics with Initial Combination Therapy in Pulmonary Arterial Hypertension.

Roberto Badagliacca, Michele D'Alto, Stefano Ghio, Paola Argiento, Vincenzo Bellomo, Natale Daniele Brunetti, Gavino Casu, Marco Confalonieri, Marco Corda, Michele Correale, Carlo D'Agostino, Lucrezia De Michele, Giuseppe Galgano, Alessandra Greco, Carlo Lombardi, Giovanna Manzi, Valentina Mercurio, Massimiliano Mulè, Giuseppe Paciocco, Silvia Papa, Emanuele Romeo, Laura Scelsi, Davide Stolfo, Patrizio Vitulo, Robert Naeije, Carmine Dario Vizza,

<b>Rationale:</b> An initial oral combination of drugs is being recommended in pulmonary arterial hypertension (PAH), but the effects of this approach on risk reduction and pulmonary vascular resistance (PVR) are not known.<b>Objectives:</b> To test the hypothesis that a low-risk status would be determined by the reduction of PVR in patients ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2021, 203(4):484-492]

Cited: 6 times

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