Full Text Journal Articles by
Author Nancy Krucher


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Targeting retinoblastoma protein phosphorylation in combination with EGFR inhibition in pancreatic cancer cells.

Nimmi A Thomas, Rita G Abraham, Brixhilda Dedi, Nancy A Krucher,

Pancreatic ductal adenocarcinoma (PDAC) remains a particularly lethal disease that is resistant to targeted therapies. Tyrosine kinase inhibitors (TKIs), including erlotinib and gefitinib, which block the action of the human epidermal growth factor receptor type 1 receptor, provide small increases in patient survival when administered with gemcitabine. The retinoblastoma (Rb) tumor ... Read more >>

Int J Oncol (International journal of oncology)
[2019, 54(2):527-536]

Cited: 4 times

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Dephosphorylation of the Retinoblastoma protein (Rb) inhibits cancer cell EMT via Zeb.

Jacklynn V Egger, Maria V Lane, Lisa A Antonucci, Brixhilda Dedi, Nancy A Krucher,

The tumor suppressor Retinoblastoma (Rb) protein is highly phosphorylated in cancer cells largely due to the overexpression of cyclins or the loss of expression of cyclin dependent kinase inhibitors (cdki). Hyperphosphorylation of Rb promotes proliferation, and plays a role in the regulation of apoptosis. Recently, inhibition of cyclin dependent activity ... Read more >>

Cancer Biol Ther (Cancer biology & therapy)
[2016, 17(11):1197-1205]

Cited: 8 times

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Genetically divergent Symbiodinium sp. display distinct molecular responses to pathogenic Vibrio and thermal stress.

Briana Hauff, James M Cervino, Joshua A Haslun, Nancy Krucher, Andrew M Wier, Alexandra L Mannix, Konrad Hughen, Kevin B Strychar,

Global climate change and anthropogenic activities are threatening the future survival of coral reef ecosystems. The ability of reef-building zooxanthellate coral to survive these stressors may be determined through fundamental differences within their symbiotic dinoflagellates (Symbiodinium sp.). We define the in vitro apoptotic response of 2 evolutionarily distant Symbiodinium sp., ... Read more >>

Dis Aquat Organ (Diseases of aquatic organisms)
[2014, 112(2):149-159]

Cited: 1 time

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Phosphorylation of the Retinoblastoma protein (Rb) on serine-807 is required for association with Bax.

Lisa A Antonucci, Jacklynn V Egger, Nancy A Krucher,

The recent finding that the Retinoblastoma protein (Rb) is able to regulate apoptosis in a non-transcriptional manner directly at the mitochondria by interaction with the pro-apoptotic protein Bax prompted this investigation of the complex formed between Rb and Bax. Because the function of Rb in the cellular processes of proliferation, ... Read more >>

Cell Cycle (Cell cycle (Georgetown, Tex.))
[2014, 13(22):3611-3617]

Cited: 14 times

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Dephosphorylation of threonine-821 of the retinoblastoma tumor suppressor protein (Rb) is required for apoptosis induced by UV and Cdk inhibition.

Brandon Lentine, Lisa Antonucci, Ray Hunce, Justina Edwards, Valerie Marallano, Nancy A Krucher,

The Retinoblastoma protein (Rb) is important in the control of cell proliferation and apoptosis. Its activity is controlled by reversible phosphorylation on several serine and threonine residues. When Rb is hypophosphorylated, it inhibits proliferation by preventing passage through the G 1- S phase transition. Hyperphosphorylated Rb promotes cell cycle progression. ... Read more >>

Cell Cycle (Cell cycle (Georgetown, Tex.))
[2012, 11(17):3324-3330]

Cited: 10 times

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PNUTS knockdown potentiates the apoptotic effect of Roscovitine in breast and colon cancer cells.

Gabriel De Leon, Margaret Cavino, Mikilyn D'Angelo, Nancy A Krucher,

The phosphorylation state of Retinoblastoma protein (Rb) plays a role in cell proliferation and apoptosis. Within cells, cyclin dependent kinases (cdks) phosphorylate Rb in response to growth stimulatory signals, whereas protein phosphatase 1 (PP1) dephosphorylates Rb when cells stop proliferating or undergo apoptosis in response to anti-proliferative or stress signals. ... Read more >>

Int J Oncol (International journal of oncology)
[2010, 36(5):1269-1275]

Cited: 8 times

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Reduced expression of PNUTS leads to activation of Rb-phosphatase and caspase-mediated apoptosis.

Gabriel De Leon, Tara C Sherry, Nancy A Krucher,

There is abundant evidence that Retinoblastoma (Rb) activity is important in the control of cell proliferation and apoptosis. Reversible phosphorylation of the Rb protein that is carried out by cyclin dependent kinases and Protein phosphatase 1 (PP1) regulates its functions. A PP1 interacting protein, PNUTS (Phosphatase Nuclear Targeting Subunit) is ... Read more >>

Cancer Biol Ther (Cancer biology & therapy)
[2008, 7(6):833-841]

Cited: 26 times

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Dephosphorylation of Rb (Thr-821) in response to cell stress.

Nancy A Krucher, Ethel Rubin, Vivienne C Tedesco, Michael H Roberts, Tara C Sherry, Gabriel De Leon,

The retinoblastoma tumor suppressor Rb is regulated by reversible phosphorylation that is dependent upon cyclin-dependent kinase (CDK) and protein phosphatase type 1 (PP1) activity in replicating cells. Hyperphosphorylated Rb allows cells to proliferate, whereas the hypophosphorylated isoform of Rb inhibits proliferation. Of the many phosphorylation sites of Rb, there is ... Read more >>

Exp Cell Res (Experimental cell research)
[2006, 312(15):2757-2763]

Cited: 24 times

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PNUTS (phosphatase nuclear targeting subunit) inhibits retinoblastoma-directed PP1 activity.

Eshwar Udho, Vivienne C Tedesco, Adam Zygmunt, Nancy A Krucher,

Protein phosphatase type 1 catalytic subunit (PP1c) is a serine/threonine phosphatase involved in the dephosphorylation of many proteins in eukaryotic cells. It associates with several known targeting or regulatory subunits that directly regulate PP1c activity toward specific substrates. The recently identified Phosphatase Nuclear Targeting Subunit (PNUTS) binds to PP1c and ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2002, 297(3):463-467]

Cited: 21 times

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Hypoxia stimulates p16 expression and association with cdk4.

Adam Zygmunt, Vivienne C Tedesco, Eshwar Udho, Nancy A Krucher,

Exposure of CV-1P cells to hypoxic conditions causes cell proliferation inhibition concomitant with the accumulation of pRb in the hypophosphorylated, growth suppressive form. This is in part due to inhibition of pRb-directed cdk4 and cdk2 activity. In this study we attempted to elucidate the mechanism by which cdk4 is inactivated ... Read more >>

Exp Cell Res (Experimental cell research)
[2002, 278(1):53-60]

Cited: 16 times

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