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Beneficial effects of combination therapy of phloretin and metformin in streptozotocin-induced diabetic rats and improved insulin sensitivity in vitro.

Xin Shen, Libin Wang, Nan Zhou, Shouchang Gai, Xueying Liu, Shengyong Zhang,

The GLUT4 and PI3K/AKT signaling pathways are the key sensors of energy status and they regulate glucose and lipid metabolism. Phloretin activates the PI3K/AKT pathway by promoting GLUT4 translocation and expression, thereby improving glucose consumption and tolerance. As metformin can regulate glucose metabolism, we hypothesized that phloretin can amplify its ... Read more >>

Food Funct (Food & function)
[2020, 11(1):392-403]

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CIRDES: an efficient genome-wide method for in vivo RNA-RNA interactome analysis.

Yao-Ting Li, Nan Zhou, Wei-Xi Deng, Xue-Zhen Zeng, Xiao-Juan Wang, Jing-Wen Peng, Bing Yang, Yan-Jie Wang, Jian-You Liao, Dong Yin,

Complex RNA-RNA interactions underlie fundamental biological processes. However, a large number of RNA-RNA interactions remain unknown. Most existing methods used to map RNA-RNA interactions are based on proximity ligation, but these strategies also capture a huge amount of intramolecular RNA secondary structures, making it almost impossible to detect most RNA-RNA ... Read more >>

Analyst (The Analyst)
[2019, 144(21):6197-6206]

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A role for the right dorsolateral prefrontal cortex in enhancing regulation of both craving and negative emotions in internet gaming disorder: A randomized trial.

Lu-Lu Wu, Marc N Potenza, Nan Zhou, Hedy Kober, Xin-Hui Shi, Sarah W Yip, Jia-Hua Xu, Lei Zhu, Rui Wang, Guan-Qun Liu, Jin-Tao Zhang,

Reward-seeking and relief from negative emotions are two central motivational drives underlying addictions. Impaired executive control over craving and negative emotions contributes to compulsive addictive behaviors. Neuroimaging evidence has implicated the prefrontal cortex (PFC) in regulating craving or emotions. This study aims at examining whether anodal transcranial direct current stimulation ... Read more >>

Eur Neuropsychopharmacol (European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology)
[2020, :]

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The etiology of maternal postpartum depressive symptoms: Childhood emotional maltreatment, couple relationship satisfaction, and genes.

Hongjian Cao, Nan Zhou, Esther M Leerkes, Jinni Su,

There is a call for integrative studies examining the roles of biological and psychosocial factors and their interrelations in shaping maternal postpartum psychopathology. Using longitudinal data from 198 primiparous mothers, we tested a biopsychosocial model for the etiology of maternal postpartum depressive symptoms that integrated childhood emotional maltreatment, couple relationship ... Read more >>

J Fam Psychol (Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43))
[2020, :]

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Mothers' feeding profiles among overweight, normal weight and underweight Chinese preschoolers.

Nan Zhou, Charissa S L Cheah, Guangheng Wang, Tony Xing Tan,

We adopted a person-centered approach to identify maternal feeding profiles among urban Chinese mothers of preschoolers, including two previously unexamined culturally-emphasized practices, and examine the associations between these feeding profiles and child and parent characteristics. Participants included 167 mothers and their preschoolers residing in Shanghai, China. Mothers reported on their ... Read more >>

Appetite (Appetite)
[2020, :104726]

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Pathology features and the results of treatment of two cases of posterior choroidal leiomyoma.

Nan Zhou, Wenbin Wei, Xiaolin Xu,

BACKGROUND:Posterior choroidal leiomyoma is an extremely rare tumor, to our knowledge, less than 10 cases reported in the literature. The definite diagnosis can be confirmed by immunohistochemistry, and local resection is preferable to enucleation for the posterior choroidal leiomyoma. CASE PRESENTATION:Two adult Asian women presented with progressive vision loss in ... Read more >>

BMC Ophthalmol (BMC ophthalmology)
[2020, 20(1):198]

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FBXW7 triggers degradation of KMT2D to favor growth of diffuse large B-cell lymphoma cells.

Rizwan Saffie, Nan Zhou, Delphine Rolland, Özlem Önder, Venkatesha Basrur, Sydney Campbell, Kathryn E Wellen, Kojo S J Elenitoba-Johnson, Brian C Capell, Luca Busino,

Mature B-cell neoplasms are the fifth most common neoplasm. Due to significant heterogeneity at the clinical and genetic levels, current therapies for these cancers fail to provide long-term cures. The clinical success of proteasome inhibition for the treatment of multiple myeloma and B-cell lymphomas has made the ubiquitin pathway an ... Read more >>

Cancer Res. (Cancer research)
[2020, :]

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PapA, a peptidoglycan-associated protein, interacts with OmpC and maintains cell envelope integrity.

Yun-Hao Wang, Hong-He Chen, Zhou Huang, Xiao-Jing Li, Nan Zhou, Chang Liu, Cheng-Ying Jiang, De-Feng Li, Shuang-Jiang Liu,

The bacterial cell envelope is critical to support and maintain cellular life. In Gram-negative bacterial cells, the outer membrane and the peptidoglycan layer are two important parts of the cell envelope and they harbour abundant proteins. Here, we report the identification and characterization of a previously unknown peptidoglycan-associated protein, PapA, ... Read more >>

Environ. Microbiol. (Environmental microbiology)
[2020, :]

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A brand-new generation of fluorescent nano-neural tracers: biotinylated dextran amine conjugated carbonized polymer dots.

Yang Liu, Junjun Liu, Jiayi Zhang, Xiucun Li, Fangsiyu Lin, Nan Zhou, Bai Yang, Laijin Lu,

The anterograde neuroanatomical tracing technique plays a crucial role in studying and charting the complex interconnections of the nervous system. But there are several major limitations for traditional neural tracers, such as complex immunohistochemical staining procedures, low fluorescence intensity and quick fluorescence quenching. Carbon dots (CDs) as fluorescent bio-probes have ... Read more >>

Biomater Sci (Biomaterials science)
[2019, 7(4):1574-1583]

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Early home learning environment predicts early adolescents' adjustment through cognitive abilities in middle childhood.

Yue Liang, Hongjian Cao, Nan Zhou, Jiayao Li, Limin Zhang,

This study tested the potential mediating roles of various cognitive abilities in middle childhood (i.e., short-term memory [STM], sustained attention, and inhibitory control) in the associations between home learning environment in early childhood and child adjustment in multiple domains during early adolescence (i.e., internalizing and externalizing problems, language skills, and ... Read more >>

J Fam Psychol (Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43))
[2020, :]

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Effect of lime mud on the reaction kinetics and thermodynamics of biomass pyrolysis.

Hui Li, Nan Zhou, Leilei Dai, Yanling Cheng, Kirk Cobb, Paul Chen, Roger Ruan,

The solid waste from papermaking factory, lime mud (LM), was previously demonstrated as an effective catalyst in biomass pyrolysis. Since understanding the kinetics and thermodynamics is the critical step for pyrolysis development, thereby the effect of LM on the kinetics and thermodynamics for biomass pyrolysis was systematically investigated in this ... Read more >>

Bioresour. Technol. (Bioresource technology)
[2020, 310:123475]

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Assessment of the prevention and control effects on the outbreak of COVID-19  in Hunan, China: Based on a SEIAR Dynamic Model

Wen-ting ZHA, Nan ZHOU, Guoqun LI, Weitong LI, Siyu ZHANG, Heng ZHANG, Mengxiang CHEN, Ruihua FENG, Tong LI, Yi Su, yuan lv,

Abstract Background A new infectious disease, Coronavirus disease 2019 (COVID-19) has been first reported during December 2019 in Wuhan, China, cases have been exported to other cities and abroad rapidly. Hunan is the neighboring province of Wuhan, a series of preventive and control measures were taken to control the outbreak ... Read more >>

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Complete Mitogenomic Structure and Phylogenetic Implications of the Genus Ostrinia (Lepidoptera: Crambidae).

Nan Zhou, Yanling Dong, Pingping Qiao, Zhaofu Yang,

To understand mitogenome characteristics and reveal phylogenetic relationships of the genus Ostrinia, including several notorious pests of great importance for crops, we sequenced the complete mitogenomes of four species: Ostrinia furnacalis (Guenée, 1854), Ostrinia nubilalis (Hübner, 1796), Ostrinia scapulalis (Walker, 1859) and Ostrinia zealis (Guenée, 1854). Results indicate that the ... Read more >>

Insects (Insects)
[2020, 11(4):]

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CNTF-STAT3-IL-6 Axis Mediates Neuroinflammatory Cascade across Schwann Cell-Neuron-Microglia.

Zhongsheng Hu, Nan Deng, Kaili Liu, Nan Zhou, Yue Sun, Wenwen Zeng,

Neuroinflammation is a crucial mechanism in many neurological disorders. Injury to the peripheral sensory nerves leads to a neuroinflammatory response in the somatosensory pathway, from dorsal root ganglia (DRG) to the spinal cord, contributing to neuropathic pain. How the immune reaction is initiated peripherally and propagated to the spinal cord ... Read more >>

Cell Rep (Cell reports)
[2020, 31(7):107657]

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Digitized subwavelength surface structure on silicon platform for wavelength-/polarization-/charge-diverse optical vortex generation

Xiaoping Cao, Nan Zhou, Shuang Zheng, Shengqian Gao, Yuntao Zhu, Mingbo He, Xinlun Cai, Jian Wang,

Abstract Optical vortices carrying orbital angular momentum (OAM) have recently attracted increasing interest for providing an additional degree of freedom for capacity scaling in optical communications. The optical vortex generator is an essential component to facilitate OAM-enabled optical communications. Traditional devices face challenges of limited compactness, narrow bandwidth and first-order ... Read more >>

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Effects of Increasing the Negativity of Implicit Outcome Expectancies on Internet Gaming Impulsivity.

Shumeng Hou, Xiaoyi Fang, Nan Zhou, Pengpeng Cai,

Outcome expectancies have been found to play important roles in addictive behaviors. Research has shown that implicit outcome expectancies (OE) were significantly correlated with Internet gaming behaviors among players with Internet gaming disorder (IGD). However, few empirical studies have further examined the relationship between implicit OE and players with IGD. ... Read more >>

Front Psychiatry (Frontiers in psychiatry)
[2020, 11:336]

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Metformin Prevents H₂O₂-Induced Senescence in Human Lens Epithelial B3 Cells.

Chunmei Zhang, Mengmeng Chen, Nan Zhou, Yanhua Qi,

BACKGROUND The primary purpose of this study was to investigate the protective effect of metformin against hydrogen peroxide (H₂O₂)-induced cellular senescence and to explore the underlying molecular mechanism of lens epithelial cell senescence. MATERIAL AND METHODS We used H₂O₂ to establish senescence in human lens epithelial B3 cells. The cells ... Read more >>

Med Sci Monit Basic Res (Medical science monitor basic research)
[2020, 26:e923391]

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Spatial-temporal analysis and visualization of scarlet fever in mainland China from 2004 to 2017.

Wei-Tong Li, Rui-Hua Feng, Tong Li, Yan-Bing Du, Nan Zhou, Xiu-Qin Hong, Shang-Hui Yi, Wen-Ting Zha, Yuan Lv,

This study retrospectively analyzed the spatio-temporal distribution and spatial clustering of scarlet fever in mainland China from 2004 to 2017. In recent years, the incidence of scarlet fever is increasing. Previous studies on the spatial distribution of scarlet fever in China are mainly focused at the provincial and municipal levels, ... Read more >>

Geospat Health (Geospatial health)
[2020, 15(1):]

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Characterizing relevant microRNA editing sites in Parkinson's disease

Chenyu Lu, Shuchao Ren, Zhigang Zhao, Xinwan Wu, Angbaji Suo, Nan Zhou, Jun Yang, Tianqing Li, Chao Peng, Yun Zheng,

MicroRNAs (miRNAs) are extensively edited in human brains. However, the functional relevance of miRNA editome is largely unknown in Parkinson's disease (PD). By analyzed small RNA sequencing profiles of brain tissues of 43 PD patients and 88 normal controls, we totally identified 421 miRNA editing sites with significantly different editing ... Read more >>

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Auto-flocculation microalgae species Tribonema sp. and Synechocystis sp. with T-IPL pretreatment to improve swine wastewater nutrient removal.

Pengfei Cheng, Dongjie Chen, Wei Liu, Kirk Cobb, Nan Zhou, Yuhuan Liu, Hui Liu, Qin Wang, Paul Chen, Chengxu Zhou, Roger Ruan,

It is recognized coupling microalgae, which is rich in lipids or protein with wastewater treatment offers extra economic benefits that can potentially make microalgal production feasible by reducing production costs and providing environmental benefits. However, the pretreatment of high concentration nutrients such as ammonia nitrogen (NH3-N), total phosphorus (TP) and ... Read more >>

Sci. Total Environ. (The Science of the total environment)
[2020, 725:138263]

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2π-space uniform-backscattering metasurfaces enabled with geometric phase and magnetic resonance in visible light.

Kuixian Chen, Juan Deng, Nan Zhou, Congling Liang, Renyuan Ren, Liangui Deng, Zhou Zhou, Jin Tao, Zile Li, Guoxing Zheng,

Metasurfaces have shown unusual abilities to modulate the phase, amplitude and polarization of an incident lightwave with spatial resolution at the subwavelength scale. Here, we experimentally demonstrate a dielectric metasurface enabled with both geometric phase and magnetic resonance that scatters an incident light beam filling the full reflective 2π-space with ... Read more >>

Opt Express (Optics express)
[2020, 28(8):12331-12341]

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Compact high-efficiency four-mode vortex beam generator within the telecom C-band: publisher's note.

Yuntao Zhu, Heyun Tan, Nan Zhou, Lifeng Chen, Jian Wang, Xinlun Cai,

This publisher's note contains corrections to Opt. Lett.45, 1607 (2020)OPLEDP0146-959210.1364/OL.385878. ... Read more >>

Opt Lett (Optics letters)
[2020, 45(7):2127]

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Childhood emotional maltreatment and couple functioning among women across transition to parenthood: A process model.

Hongjian Cao, Nan Zhou, Esther M Leerkes,

Research on the implications of childhood emotional maltreatment for later romantic relationship well-being has been accumulating. More efforts are needed to systematically delineate the etiological chains of the more proximal processes explaining why childhood emotional maltreatment, as a more distal risk factor, might ultimately result in later romantic relationship malfunctioning. ... Read more >>

J Fam Psychol (Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43))
[2020, :]

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Compact high-efficiency four-mode vortex beam generator within the telecom C-band.

Yuntao Zhu, Heyun Tan, Nan Zhou, Lifeng Chen, Jian Wang, Xinlun Cai,

Vortex beams carrying orbital angular momentum have attracted a great deal of attention over the past few years. An integrated vortex beam generator with high efficiency is desirable for wide-ranging applications. Here we demonstrate a highly efficient silicon photonic integrated vortex beam generator based on superposed holographic fork gratings. A ... Read more >>

Opt Lett (Optics letters)
[2020, 45(7):1607-1610]

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Biodegradation of bisphenol compounds in the surface water of Taihu Lake and the effect of humic acids.

Nan Zhou, Yanhua Liu, Siqi Cao, Ruixin Guo, Yini Ma, Jianqiu Chen,

Bisphenol analogues (BPs) pollution in the aquatic environment is increasingly a worldwide concern. There is an urgent need to understand the fate of BPs in the aquatic environment. In this study, we studied the biodegradation of eight BPs in Taihu Lake and discussed the effect of humic acid (HA), which ... Read more >>

Sci. Total Environ. (The Science of the total environment)
[2020, 723:138164]

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