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Author Naheed Akhter

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Synthesis, characterization, antibacterial, hemolytic and thrombolytic activity evaluation of 5-(3-chlorophenyl)-2-((N-(substituted)-2-acetamoyl)sulfanyl)-1,3,4-oxadiazole derivatives.

- Aziz-Ur-Rehman, Samreen Gul Khan, Tanveer Hussain Bokhari, Fozia Anjum, Naheed Akhter, Shahid Rasool, Syed Adnan Ali Shah, Muhammad Shahid, Aneesa Arshad,

A novel series of 5-(3-Chlorophenyl)-2-((N-(substituted)-2-acetamoyl)sulfanyl)-1,3,4-oxadiazole derivatives was efficiently synthesized and screened for antibacterial, hemolytic and thrombolytic activities. The molecule 7c remained the best inhibitor of all selected bacterial strains and furthermore possessed very low toxicity, 8.52┬▒0.31. Compound 7a 7b and 7f showed very good thrombolytic activity relative to Streptokinase employed ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2020, 33(2(Supplementary)):871-876]

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Autism Cognizance: A dilemma among medical and Allied Medical practitioners.

Naheed Akhter, Nazia Mumtaz, Ghulam Saqulain,

Objectives:To determine the awareness about autism among Medical and Allied-Medical Practitioners. Methods:This cross-sectional survey recruited a sample of n=300 participants including n=150 Medical and n=150 Allied-Medical practitioners using convenience sampling from Benazir Bhutto Hospital and Autism Resource Centre, Rawalpindi, Pakistan between 20th May 2018 to 20th October 2018. Sample included ... Read more >>

Pak J Med Sci (Pakistan journal of medical sciences)
[2020, 36(4):678-682]

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Evaluation of wound healing effects of Syzygium cumini and laser treatment in diabetic rats.

Syed Asif Jahanzeb Kazmi, Azra Riaz, Naheed Akhter, Rafeeq Alam Khan,

This study was aimed to investigate the antioxidant effects of Syzygium cumini (S. cumini) seeds extract along with wound healing score in correlation to glutathione and blood glucose levels in diabetic rats. Sprague-Dawley rats were divided into 8 groups (n=6) and diabetes was induced by a single intraperitoneal injection of ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2020, 33(2(Supplementary)):779-786]

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Progress and prospects in the management of bacterial infections and developments in Phytotherapeutic modalities.

Muhammad Akram, Muhammad Riaz, Naveed Munir, Akhtar Rasul, Muhammad Daniyal, Muhammad Daniyal, Syed Muhammad Ali Shah, Mohammad Ali Shariati, Ghazala Shaheen, Naheed Akhtar, Farzana Parveen, Naheed Akhter, Aymen Owais Ghauri, Abdul Wadood Chishti, Muhammad Usman Sarwar, Fahad Said Khan,

The advent of antibiotics revolutionized medical care resulting in significantly reduced mortality and morbidity caused by infectious diseases. However, excessive use of antibiotics has led to the development of antibiotic resistance and indeed, the incidence of multidrug-resistant pathogens is considered as a major disadvantage in medication strategy, which has led ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2020, 47(7):1107-1119]

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Chemical constituents, experimental and clinical pharmacology of Rosa damascena: a literature review.

Muhammad Akram, Muhammad Riaz, Naveed Munir, Naheed Akhter, Sadia Zafar, Farhat Jabeen, Mohammad Ali Shariati, Naheed Akhtar, Zarfishan Riaz, Syed Hassan Altaf, Muhammad Daniyal, Muhammad Daniyal, Rabia Zahid, Fahad Said Khan,

CONTEXT:Rosa damascena Mill. is prescribed for the management of chest and abdominal pain, constipation, digestive disorders, menstrual bleeding and liver ailments. OBJECTIVE:The current review compiles up to date and complete information of whole plant of R. damascena with particular emphasis on its numerous scientifically proved pharmacological effects, traditional and folk medicinal ... Read more >>

J Pharm Pharmacol (The Journal of pharmacy and pharmacology)
[2020, 72(2):161-174]

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Therapeutic potential of medicinal plants for the management of scabies.

Muhammad Akram, Muhammad Riaz, Sarwat Noreen, Mohammad A Shariati, Ghazala Shaheen, Naheed Akhter, Farzana Parveen, Naheed Akhtar, Sadia Zafar, Aymen Owais Ghauri, Zerfishan Riaz, Fahad S Khan, Shamaila Kausar, Rida Zainab,

Sarcoptes scabiei (S. scabiei), a parasite mite which causes scabies disease resulting in serious public health concern. The long-term scabies disease can lead to complications such as septicemia, acute post-streptococcal glomerulonephritis, heart disease, and secondary infections. Timely treatment to the affected patients is required to control the disease and get ... Read more >>

Dermatol Ther (Dermatologic therapy)
[2020, 33(1):e13186]

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Awareness and current knowledge of epilepsy.

Asmat Ullah Khan, Muhammad Akram, Muhammad Daniyal, Naheed Akhter, Muhammad Riaz, Naheed Akhtar, Mohammad Ali Shariati, Fozia Anjum, Samreen Gul Khan, Abida Parveen, Saeed Ahmad,

Epilepsy is a severe neural disorder that affects approximately fifty million individuals globally. Despite the fact that for most of the people with epilepsy, convulsions are better controlled by current accessible antiepileptic medicines, yet there are more than 30% of individuals affected with medically intractable epilepsy and around 30-40% of ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2020, 35(1):45-63]

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A new approach to design 3(3-sulfamoylbenzamido) benzoic acid containing transition metal complexes: Characterization and Biological activities.

Shagufta Kamal, Naheed Akhter, Razia Noreen, Mahwish Salman, Samreen Gul Khan, Taleeha Roheen, Nazia Yaqoob, Amna Kamal, Waseeq Ahmed Siddique,

Zn, Cu, Co and Ni are biocompatible metals as they are active center of many enzymes in the human body. Incorporation of these biocompatible metals into 3-(o-Sulfamoylphenyl) carbamoylbenzoic acid (I) makes them able to prove an excellent antimicrobial agent. In the present study Ni (II), Co (II), Cu(II) and Zn ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2019, 32(5(Supplementary)):2317-2324]

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Role of medicinal plants in HIV/AIDS therapy.

Umme Laila, Muhammad Akram, Mohammad Ali Shariati, Asif Mehmmod Hashmi, Naheed Akhtar, Imtiaz Mahmood Tahir, Aymen Owais Ghauri, Naveed Munir, Muhammad Riaz, Naheed Akhter, Ghazala Shaheen, Qamar Ullah, Rabia Zahid, Saeed Ahmad,

Human immunodeficiency virus (HIV) causes the potentially life-threatening and chronic disease called acquired immune deficiency syndrome (AIDS). The main target of this viral disease is to suppress the immune system and make the body unresponsive to external stimuli. According to global health observatory data since epidemic, more than 78 million ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2019, 46(12):1063-1073]

Cited: 1 time

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Correlation of metformin with intravenous iodinated contrast media and precautions.

Muhammad Adeel Shah, Samia Gul Niazi, Imtiaz Mahmood Tahir, Ifra Shahid, Abida Parveen, Sadia Sana, Naheed Akhter, Naila Iftikhar, Saba Ashraf, Zafaar Siddique, Yasmin Mushtaq, Muslim Khan, Muhammad Akram,

To discuss metformin and iv-contrast induced acute renal failure with its reported cases worldwide, associated risk factors and precautions that can be taken to reduce this tragedy & to address this sensitive issue to my technologist family working in clinical situations. As these studies were observational studies and just report ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2019, 32(2 (Supplementary)):859-863]

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Determination of Arylamine N-Acetyltransferase 2 Acetylation Genotype by PCR and Phenotyping Using Dapsone Through High-Pressure Liquid Chromatography Assay: A Gender Wise Study.

Naheed Akhter, Tahira Iqbal, Amer Jamil, Muhammad Akram, Imtiaz Mehmood Tahir, Naveed Munir,

The main aim of the study was to establish the acetylation status of local population of Pakistan by N-acetyltransferase 2 (NAT2) enzyme and to find out the concordance between phenotypic and genotypic methods for the determination of NAT2 acetylation. Gender-wise comparison of selected healthy male and female volunteers aged greater ... Read more >>

(Dose-response : a publication of International Hormesis Society)
[2019, 17(2):1559325819855537]

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Prevalence and co-infection of Malaria and Typhoid in the local population of Faisalabad, Pakistan.

Hasan Abdaal Jalani, Syed Muhammad Ali Shah, Fozia Anjum, Samreen Gul Khan, Naheed Akhter, Muslim Khan, Muhammad Akram, Imtiaz Mahmood Tahir, Naveed Munir,

Malaria and typhoid fever are among the major infectious diseases which impose significant health and socioeconomic burden on affected populations. Further, co-infection and resembling symptomatology in both infections, mostly leads to misdiagnosis and mistreatment. So co-infection of malaria and typhoid fever is becoming a major issue in tropical and subtropical ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2019, 32(1(Supplementary)):323-326]

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The evaluation ofefficacy and safety of Cough (EMA) granules used for upper respiratory disorders.

Muhammad Faizan Khan, Muhammad Akram, Naheed Akhter, Muhammad Mukhtiar, Rabia Zahid, Fahad Said Khan, Muhammad Daniyal, Imtiaz Mahmood Tahir, Khalil Ahmed, Aamir Sharif, Shamaila Kausar, Syed Muhammad Ali Shah, Khan Usmanghani,

Ivy leaf is used for the treatment of respiratory diseases with the intensive mucus formation, respiratory infections, and irritating cough coming from the common cold. Conferring to clinical trials, the efficacy, and tolerability of ivy leaf is good. The main compounds accountable for biological activity are triterpene and saponins. Ivy ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2018, 31(6 (Supplementary):2617-2622]

Cited: 1 time

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Effects of methanolic and aqueous extracts of Ipomoea batatas L on mineral contents level (calcium and magnesium) in alloxan-induced diabetic rats.

Imtiaz Mahmood Tahir, Naheed Akhter, Abida Parveen, Huma Mehboob, Sadaf Saleem, Naveed Munir, Syed Muhammad-Ali Shah, Jawad Zaheer, Fahad Said Khan, Sabira Sultana, Muhammad Akram,

In diabetic patients, electrolyte disorders frequently occur with the characteristic changes in minerals like calcium and magnesium etc. Several medicines are used to manage diabetes mellitus but they exert adverse effects. Plants are a valuable alternative to synthetic medicines because they are easily available, economical and have fewer side effects. ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2018, 31(5(Supplementary)):2077-2083]

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Enhanced production of Lovastatin by filamentous fungi through solid state fermentation.

Shagufta Kamal, Naheed Akhter, Samreen Gul Khan, Shumaila Kiran, Tahir Farooq, Muhammad Akram, Syed Muhammad Ali Shah, Imtiaz Mahmood Tahir, Muhammad Akhlaq, Fahad Said, Jawad Zaheer,

Lovastatin is a natural competitive inhibitor of 3-hydroxy-3-methyl glutaryl coenzyme-A (HMG-CoA) reductase and inhibits specifically rate limiting step in cholesterol biosynthesis. Further, lovastatin in comparison with synthetic drugs has no well-reported side effects. Four pure isolated filamentous fungal strains including Aspergillus niger IBL, Aspergillus terreus FFCBP-1053, Aspergillus flavus PML and ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2018, 31(4(Supplementary)):1583-1589]

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Anti-diabetic activity of aqueous extract of Ipomoea batatas L. in alloxan induced diabetic Wistar rats and its effects on biochemical parameters in diabetic rats.

Shagufta Kamal, Naheed Akhter, Samreen Gul Khan, Shumaila Kiran, Tahir Farooq, Muhammad Akram, Syed Muhammad Ali Shah, Imtiaz Mahmood Tahir, Muhammad Akhlaq, Fahad Said, Jawad Zaheer,

Diabetes is a condition where the fasting blood glucose level elevated above the normal range (80-120mg/dL). This increase in blood glucose level may be due to the insulin deficiency i.e. insulin dependent diabetes mellitus (IDDM or type I) or due to insulin resistance i.e. non-insulin dependent diabetes mellitus (NIDDM or ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2018, 31(4(Supplementary)):1539-1548]

Cited: 1 time

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Association of serum leptin with serum estradiol in relation to breast carcinogenesis: a comparative case-control study between pre- and postmenopausal women

Syed Danish Haseen Ahmed, Farah Idrees, Muhammad Ahsan, Aziza Khanam, Naheed Sultan, Naheed Akhter,

Background/aim: The aims of this study were to observe the interhormonal relationship of serum leptin with serum estradiol and to compare pre- and postmenopausal women for possible implications in breast carcinogenesis. Materials and methods: This comparative case-control study encompasses 175 breast ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2018, 48(2):305-310]

Cited: 2 times

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Recent trends on gellan gum blends with natural and synthetic polymers: A review.

Khalid Mahmood Zia, Shazia Tabasum, Muhammad Faris Khan, Nadia Akram, Naheed Akhter, Aqdas Noreen, Mohammad Zuber,

Gellan gum (GG), a linear negatively charged exopolysaccharide,is biodegradable and non-toxic in nature. It produces hard and translucent gel in the presence of metallic ions which is stable at low pH. However, GG has poor mechanical strength, poor stability in physiological conditions, high gelling temperature and small temperature window.Therefore,it is ... Read more >>

Int J Biol Macromol (International journal of biological macromolecules)
[2018, 109:1068-1087]

Cited: 6 times

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Pharmacokinetic behavior of montelukast in indigenous healthy male volunteers.

Amtul Fayyaz, Junaid Ali Khan, Muhammad Mudassar Ashraf, Naheed Akhter, Bilal Aslam, Muhammad Fiaz Khalid, Sidra Altaf, Rana Dawood Naseer, Muhammad Akram, Syed Muhammad Ali Shah, Muhammad Waqas Khadam, Imtiaz Mahmood Tahir,

Aim of present study was to investigate the pharmacokinetic behavior of Montelukast in the healthy male volunteers under indigenous conditions. One tablet of montelukast 10 mg was administered in each subject and blood at different time intervals. Concentration of montelukast in plasma samples was analyzed by high performance liquid chromatography ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2017, 30(6(Supplementary)):2435-2439]

Cited: 0 times

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Review-Medicinal plants and management of Diabetes Mellitus: A review.

Sodah Bint Mustafa, Zahid Mehmood, Naheed Akhter, Abida Kauser, Iqbal Hussain, Abid Rashid, Muhammad Akram, Imtiaz Mahmood Tahir, Naveed Munir, Muhammad Riaz, Samia Gul Niazi, Abid Ali, Muhammad Mudassar Ashraf, Umbreen Naz, Hammad Ahmed, S M Ali Shah, Khan Usmanghani,

Diabetes is a metabolic disorder characterized by chronic hyperglycemia and associated with dysfunction and failure of various body organs. Alarming increase in prevalence rate has made this disorder a major health problem globally. The available treatment modalities are not sufficient to combat diabetes and associated complications. A number of medicinal ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2016, 29(5 Suppl):1885-1891]

Cited: 2 times

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Serum Adiponectin Level Association with Breast Cancer Risk: Evidence from a Case-Control Study.

Syed Danish Haseen Ahmed, Aziza Khanam, Naheed Sultan, Farah Idrees, Naheed Akhter,

Adiponectin is a protein, synthesized by adipose tissue, which has a questionable role in breast cancer pathogenesis. This study focused on serum levels of adiponectin among cases and controls, and its possible association with breast cancer risk.This case-control study covered 175 diagnosed breast cancer patients with positive histopathology from Breast ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2015, 16(12):4945-4948]

Cited: 4 times

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