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Author Nagarajan Selvamurugan

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Advancements in nucleic acids-based techniques for bone regeneration.

Dharmaraj Saleth Sidharthan, Ranganathan Abhinandan, Kalimuthu Balagangadharan, Nagarajan Selvamurugan,

The dynamic biology of bone involving an enormous magnitude of cellular interactions and signaling transduction provides ample biomolecular targets, which can be enhanced or repressed to mediate a rapid regeneration of the impaired bone tissue. The delivery of nucleic acids such as DNA and RNA can enhance the expression of ... Read more >>

Biotechnol J (Biotechnology journal)
[2021, :e2100570]

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Regulation of transforming growth factor-β1-stimulation of Runx2 acetylation for matrix metalloproteinase 13 expression in osteoblastic cells.

Kanagaraj Gomathi, Muthukumar Rohini, Nicola C Partridge, Nagarajan Selvamurugan,

Transforming growth factor beta 1 (TGF-β1) functions as a coupling factor between bone development and resorption. Matrix metalloproteinase 13 (MMP13) is important in bone remodeling, and skeletal dysplasia is caused by a deficiency in MMP13 expre-ssion. Runx2, a transcription factor is essential for bone development, and MMP13 is one of ... Read more >>

Biol Chem (Biological chemistry)
[2021, :]

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Three-dimensional-poly(lactic acid) scaffolds coated with gelatin/magnesium-doped nano-hydroxyapatite for bone tissue engineering.

Sampath Swetha, Kalimuthu Balagangadharan, Krishnaraj Lavanya, Nagarajan Selvamurugan,

<h4>Background</h4>Treatment of critical-sized bone defects has progressively evolved over the years from metallic implants to more ingenious three-dimensional-based scaffolds. The use of three-dimensional scaffolds for bone regeneration from biodegradable polymers like poly(lactic acid) (PLA) is gaining popularity. Scaffolds with surface functionalization using gelatin (Gel) have the advantages of biocompatibility and ... Read more >>

Biotechnol J (Biotechnology journal)
[2021, :e2100282]

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Regulation of Runx2 and Its Signaling Pathways by MicroRNAs in Breast Cancer Metastasis.

Shivashankar Pranavkrishna, Ganesh Sanjeev, Ravishkumar L Akshaya, Muthukumar Rohini, Nagarajan Selvamurugan,

As a major threat among women globally, breast cancer (BC) emerges as a primary research focus for several researchers. Although various therapeutic regimens are available, there is an increased chance of metastasis of BC cells, which raises the severity of this malignancy. Of multiple preferred secondary targets, metastasis to bone ... Read more >>

Curr Protein Pept Sci (Current protein & peptide science)
[2021, 22(7):534-547]

Cited: 1 time

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Valproic acid, A Potential Inducer of Osteogenesis in Mouse Mesenchymal Stem Cells.

Narayanan Akshaya, Prakash Prasith, Balakrishnan Abinaya, Badrinath Ashwin, S V Chandran, Nagarajan Selvamurugan,

<h4>Background</h4>Recent reports have unveiled the potential of flavonoids to enhance bone formation and assuage bone resorption due to their involvement in cell signaling pathways. They also act as an effective alternative to circumvent the disadvantages associated with existing treatment methods, which has increased their scope in orthopedic research. Valproic acid ... Read more >>

Curr Mol Pharmacol (Current molecular pharmacology)
[2021, 14(1):27-35]

Cited: 2 times

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Polycaprolactone fibrous electrospun scaffolds reinforced with copper doped wollastonite for bone tissue engineering applications.

Mohamed Abudhahir, Azeena Saleem, Pragyan Paramita, Sukumar Dinesh Kumar, Chung Tze-Wen, Nagarajan Selvamurugan, Ambigapathi Moorthi,

The bone defects healing are always associated with post implantation infections; hence biomaterials rules significant role for orchestration of defective bone. In this study, we synthesized biocomposite scaffold by combining polycaprolactone (PCL), wollastonite (Ws) and metal ions (Cu) by electrospinning technique. The manufactured scaffolds (PCL/Ws andPCL/Cu-Ws) were subjected to physio-chemical ... Read more >>

J Biomed Mater Res B Appl Biomater (Journal of biomedical materials research. Part B, Applied biomaterials)
[2021, 109(5):654-664]

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The Functional Significance of Endocrine-immune Interactions in Health and Disease.

Sridhar Muthusami, Balasubramanian Vidya, Esaki M Shankar, Jamuna Vadivelu, Ilangovan Ramachandran, Jone A Stanley, Nagarajan Selvamurugan,

Hormones are known to influence various body systems that include skeletal, cardiac, digestive, excretory, and immune systems. Emerging investigations suggest the key role played by secretions of endocrine glands in immune cell differentiation, proliferation, activation, and memory attributes of the immune system. The link between steroid hormones such as glucocorticoids ... Read more >>

Curr Protein Pept Sci (Current protein & peptide science)
[2020, 21(1):52-65]

Cited: 2 times

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miR-873-3p targets HDAC4 to stimulate matrix metalloproteinase-13 expression upon parathyroid hormone exposure in rat osteoblasts.

Desai Malavika, Srinivasan Shreya, Vembar Raj Priya, Muthukumar Rohini, Zhiming He, Nicola C Partridge, Nagarajan Selvamurugan,

Matrix metalloproteinase-13 (MMP-13) plays a predominant role in endochondral bone formation and bone remodeling. Parathyroid hormone (PTH) stimulates the expression of MMP-13 via Runx2, a bone transcription factor in rat osteoblastic cells (UMR106-01), and histone deacetylase 4 (HDAC4) acts as a corepressor of Runx2. Moreover, microRNAs (miRNAs) play an important ... Read more >>

J Cell Physiol (Journal of cellular physiology)
[2020, 235(11):7996-8009]

Cited: 1 time

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Chitosan in Surface Modification for Bone Tissue Engineering Applications.

Balakrishnan Abinaya, Tandiakkal Prakash Prasith, Badrinath Ashwin, Syamala Viji Chandran, Nagarajan Selvamurugan,

Traditional methods of bone defect repair include autografts, allografts, surgical reconstruction, and metal implants that have several disadvantages such as donor site morbidity, rejection, risk of disease transmission, and repetitive surgery. Biomaterial-based bone reconstructions can, therefore, be an efficient alternative due to the inherent properties of the materials. Chitosan (CS), ... Read more >>

Biotechnol J (Biotechnology journal)
[2019, 14(12):e1900171]

Cited: 1 time

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Regulation of Breast Cancer Progression by Noncoding RNAs.

Ravishkumar L Akshaya, Muthukumar Rohini, Nagarajan Selvamurugan,

<h4>Background</h4>Breast cancer (BC) is the cardinal cause of cancer-related deaths among women across the globe. Our understanding of the molecular mechanisms underlying BC invasion and metastasis remains insufficient. Recent studies provide compelling evidence on the prospective contribution of noncoding RNAs (ncRNAs) and the association of different interactive mechanisms between these ... Read more >>

Curr Cancer Drug Targets (Current cancer drug targets)
[2020, 20(10):757-767]

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Sinapic acid-loaded chitosan nanoparticles in polycaprolactone electrospun fibers for bone regeneration in vitro and in vivo

Kalimuthu Balagangadharan, Ritu Trivedi, Mariappanadar Vairamani, Nagarajan Selvamurugan,

Sinapic acid (SA) is a plant-derived phenolic compound known for its multiple biological properties, but its role in the promotion of bone formation is not yet well-studied. Moreover, the delivery of SA is hindered by its complex hydrophobic nature, limiting its bioavailability. In this study, we fabricated a drug delivery ... Read more >>

(Carbohydrate polymers.)
[2019, 216:1-16]

Cited: 3 times

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Sinapic acid-loaded chitosan nanoparticles in polycaprolactone electrospun fibers for bone regeneration in vitro and in vivo.

Kalimuthu Balagangadharan, Ritu Trivedi, Mariappanadar Vairamani, Nagarajan Selvamurugan,

Sinapic acid (SA) is a plant-derived phenolic compound known for its multiple biological properties, but its role in the promotion of bone formation is not yet well-studied. Moreover, the delivery of SA is hindered by its complex hydrophobic nature, limiting its bioavailability. In this study, we fabricated a drug delivery ... Read more >>

Carbohydr Polym (Carbohydrate polymers)
[2019, 216:1-16]

Cited: 5 times

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Osteogenic potential of zingerone, a phenolic compound in mouse mesenchymal stem cells.

Narasimhan Srinaath, Kalimuthu Balagangadharan, Vikraman Pooja, Udhaykumar Paarkavi, Adhikari Trishla, Nagarajan Selvamurugan,

Zingerone, 4-(4-hydroxy-3-methoxyphenyl)-2-butanone (Zg), a phenolic compound isolated from ginger is reported to have anti-inflammatory and antidiabetic properties. However, its role in the promotion of osteogenesis is not known. In this study, we investigated the therapeutic effect of Zg on osteogenesis at the cellular and molecular levels. Zg treatment was nontoxic ... Read more >>

Biofactors (BioFactors (Oxford, England))
[2019, 45(4):575-582]

Cited: 2 times

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Chitosan and gelatin-based electrospun fibers for bone tissue engineering.

Sruthi Ranganathan, Kalimuthu Balagangadharan, Nagarajan Selvamurugan,

Fractures and injuries pertaining to bone tissue usually take prolonged periods for its natural healing. To overcome this problem, the field of bone tissue engineering (BTE) has acquired an efficient designing mechanism that incorporates cells, biomaterials and the corresponding growth factors to promote both osteogenesis as well as mineralization of ... Read more >>

Int J Biol Macromol (International journal of biological macromolecules)
[2019, 133:354-364]

Cited: 20 times

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Parathyroid hormone-induced down-regulation of miR-532-5p for matrix metalloproteinase-13 expression in rat osteoblasts.

Vishal Mohanakrishnan, Arumugam Balasubramanian, Gokulnath Mahalingam, Nicola Chennell Partridge, Ilangovan Ramachandran, Nagarajan Selvamurugan,

Parathyroid hormone (PTH) acts on osteoblasts and functions as an essential regulator of calcium homeostasis and as a mediator of bone remodeling. We previously reported that PTH stimulates the expression of matrix metalloproteinase-13 (MMP-13) in rat osteoblasts and that MMP-13 plays a key role in bone remodeling, endochondral bone formation, ... Read more >>

J Cell Biochem (Journal of cellular biochemistry)
[2018, 119(7):6181-6193]

Cited: 2 times

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Pulsed electromagnetic fields inhibit human osteoclast formation and gene expression via osteoblasts.

Zhiming He, Nagarajan Selvamurugan, Johanna Warshaw, Nicola C Partridge,

Pulsed electromagnetic fields (PEMFs) can be effective in promoting the healing of delayed union or nonunion fractures. We previously reported that PEMF (Spinal-Stim® by Orthofix, Inc., Lewisville, TX) stimulated proliferation, differentiation and mineralization of rat calvarial osteoblastic cells in culture. In the present work we investigated the effects of PEMF ... Read more >>

Bone (Bone)
[2018, 106:194-203]

Cited: 18 times

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Characterization of Runx2 phosphorylation sites required for TGF-β1-mediated stimulation of matrix metalloproteinase-13 expression in osteoblastic cells.

Balasubramanian Arumugam, Mariappanadar Vairamani, Nicola C Partridge, Nagarajan Selvamurugan,

Transforming growth factor-beta1 (TGF-β1), a highly abundant growth factor in skeletal tissues, stimulates matrix metalloproteinase-13 (MMP-13) expression in osteoblastic cells. MMP-13 plays a critical role in bone remodeling. Runx2, a bone transcription factor, is required for TGF-β1-mediated stimulation of MMP-13 expression in osteoblastic cells. In this study, the molecular mechanism ... Read more >>

J Cell Physiol (Journal of cellular physiology)
[2018, 233(2):1082-1094]

Cited: 4 times

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Nanoceramics on osteoblast proliferation and differentiation in bone tissue engineering.

Sai Nievethitha Sethu, Subhapradha Namashivayam, Saravanan Devendran, Selvamurugan Nagarajan, Wei-Bor Tsai, Srinivasan Narashiman, Murugesan Ramachandran, Moorthi Ambigapathi,

Bone, a highly dynamic connective tissue, consist of a bioorganic phase comprising osteogenic cells and proteins which lies over an inorganic phase predominantly made of CaPO<sub>4</sub> (biological apatite). Injury to bone can be due to mechanical, metabolic or inflammatory agents also owing pathological conditions like fractures, osteomyelitis, osteolysis or cysts ... Read more >>

Int J Biol Macromol (International journal of biological macromolecules)
[2017, 98:67-74]

Cited: 11 times

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Regulation of Runx2 by Histone Deacetylases in Bone.

Mohanakrishnan Vishal, Ramachandran Ajeetha, Rajendran Keerthana, Nagarajan Selvamurugan,

Osteogenesis involves a cascade of processes wherein mesenchymal stem cells differentiate towards osteoblasts, strictly controlled by a number of regulatory factors. Runx2 protein is a key transcription factor which serves as a master regulator for osteogenesis by activating the promoters of various osteoblastic genes. Runx2 is regulated by several cofactors, ... Read more >>

Curr Protein Pept Sci (Current protein & peptide science)
[2016, 17(4):343-351]

Cited: 8 times

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A novel injectable temperature-sensitive zinc doped chitosan/β-glycerophosphate hydrogel for bone tissue engineering.

Ramesh Niranjan, Chandru Koushik, Sekaran Saravanan, Ambigapathi Moorthi, Mariappanadar Vairamani, Nagarajan Selvamurugan,

Hydrogels are hydrophilic polymers that have a wide range of biomedical applications including bone tissue engineering. In this study we report preparation and characterization of a thermosensitive hydrogel (Zn-CS/β-GP) containing zinc (Zn), chitosan (CS) and beta-glycerophosphate (β-GP) for bone tissue engineering. The prepared hydrogel exhibited a liquid state at room ... Read more >>

Int J Biol Macromol (International journal of biological macromolecules)
[2013, 54:24-29]

Cited: 43 times

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Expression of matrix metalloproteinases in human breast cancer tissues.

Chellakkan Selvanesan Benson, Somasundaram Dinesh Babu, Selvi Radhakrishna, Nagarajan Selvamurugan, Bhaskaran Ravi Sankar,

<h4>Background</h4>Breast cancer is the most common cancer affecting women in the world today. Matrix metalloproteinases (MMPs) are a family of endopeptidases that can degrade extracellular matrix proteins and promote cell invasion and metastasis. MMPs are differentially expressed and their expressions are often associated with a poor prognosis for patients.<h4>Objective</h4>The aim ... Read more >>

Dis Markers (Disease markers)
[2013, 34(6):395-405]

Cited: 26 times

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Bio-composite scaffolds containing chitosan/nano-hydroxyapatite/nano-copper-zinc for bone tissue engineering.

Anjali Tripathi, Sekaran Saravanan, Soumitri Pattnaik, Ambigapathi Moorthi, Nicola C Partridge, Nagarajan Selvamurugan,

The current study involves fabrication and characterization of bio-composite scaffolds containing chitosan (CS), nano-hydroxyapatite (nHAp) and Cu-Zn alloy nanoparticles (nCu-Zn) by freeze drying technique. The fabricated composite scaffolds (CS/nHAp and CS/nHAp/nCu-Zn) were characterized by SEM, EDX, XRD and FT-IR studies. The addition of nCu-Zn in the CS/nHAp scaffolds significantly increased ... Read more >>

Int J Biol Macromol (International journal of biological macromolecules)
[2012, 50(1):294-299]

Cited: 41 times

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Effects of Cissus quadrangularis on the proliferation, differentiation and matrix mineralization of human osteoblast like SaOS-2 cells.

Sridhar Muthusami, Krishnamoorthy Senthilkumar, Chandragandan Vignesh, Ramachandran Ilangovan, Jone Stanley, Nagarajan Selvamurugan, Narasimhan Srinivasan,

Osteoporosis is a public health problem which is associated with significant morbidity and mortality. The repair of bone defect is still a big challenge for orthopedic surgeons. Traditional use of Cissus quadrangularis (C. quadrangularis) in the treatment of bone disorders has been documented. The present study was employed to delineate ... Read more >>

J Cell Biochem (Journal of cellular biochemistry)
[2011, 112(4):1035-1045]

Cited: 28 times

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HDAC4 represses matrix metalloproteinase-13 transcription in osteoblastic cells, and parathyroid hormone controls this repression.

Emi Shimizu, Nagarajan Selvamurugan, Jennifer J Westendorf, Eric N Olson, Nicola C Partridge,

Parathyroid hormone (PTH) is a hormone regulating bone remodeling through its actions on both bone formation and bone resorption. Previously we reported that PTH induces matrix metalloproteinase-13 (MMP-13) transcription in osteoblastic cells. Here, we show that histone deacetylase 4 (HDAC4) interacts with Runx2, binds the MMP-13 promoter, and suppresses MMP-13 ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2010, 285(13):9616-9626]

Cited: 47 times

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Polymeric composites containing carbon nanotubes for bone tissue engineering.

Kolli Sahithi, Maddela Swetha, Kumarasamy Ramasamy, Narasimhan Srinivasan, Nagarajan Selvamurugan,

Several natural and synthetic polymers are now available for bone tissue engineering applications but they may lack mechanical integrity. In recent years, there are reports emphasizing the importance of carbon nanotubes (CNTs) in supporting bone growth. CNTs possess exceptional mechanical, thermal, and electrical properties, facilitating their use as reinforcements or ... Read more >>

Int J Biol Macromol (International journal of biological macromolecules)
[2010, 46(3):281-283]

Cited: 36 times

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