Full Text Journal Articles by
Author Nadia Cummins


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A stress-free stress response.

Nadia Cummins, Rebecca C Taylor,

Nat Chem Biol (Nature chemical biology)
[2020, 16(10):1038-1039]

Cited: 0 times

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PINK1 and parkin shape the organism-wide distribution of a deleterious mitochondrial genome

Arnaud Ahier, Nadia Cummins, Chuan-Yang Dai, Jürgen Götz, Steven Zuryn,

Abstract In multiple species, certain tissue types are prone to acquiring greater loads of mitochondrial genome (mtDNA) mutations relative to others, however the mechanisms that drive these heteroplasmy differences are unknown. We found that the conserved PTEN-induced putative kinase (PINK1/PINK-1) and the E3 ubiquitin-protein ligase parkin (PDR-1), which are required ... Read more >>

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Cited: 1 time

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Disease-associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria.

Nadia Cummins, Andrea Tweedie, Steven Zuryn, Jesus Bertran-Gonzalez, Jürgen Götz,

Accumulation of the protein tau characterises Alzheimer's disease and other tauopathies, including familial forms of frontotemporal dementia (FTD) that carry pathogenic tau mutations. Another hallmark feature of these diseases is the accumulation of dysfunctional mitochondria. Although disease-associated tau is known to impair several aspects of mitochondrial function, it is still ... Read more >>

EMBO J. (The EMBO journal)
[2019, 38(3):]

Cited: 13 times

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Local Oxidative Damage in the Soma and Dendrites Quarantines Neuronal Mitochondria at the Site of Insult.

Amandine Grimm, Nadia Cummins, Jürgen Götz,

Neurons are highly dependent on mitochondria, but little is known about how they react to a local mitochondrial oxidative insult. We therefore developed a protocol in primary hippocampal cultures that combines the photosensitizer mito-KillerRed with fluorescent biosensors and photoactivatable GFP. We found in both the soma and dendrites that neurons ... Read more >>

iScience (iScience)
[2018, 6:114-127]

Cited: 3 times

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Shedding light on mitophagy in neurons: what is the evidence for PINK1/Parkin mitophagy in vivo?

Nadia Cummins, Jürgen Götz,

Neurons are highly specialised cells with a large bioenergetic demand, and so require a healthy mitochondrial network to function effectively. This network is compromised in many neurological disorders, in which damaged mitochondria accumulate. Dysfunctional mitochondria can be removed via an organelle-specific autophagic pathway, a process known as mitophagy. The canonical ... Read more >>

Cell. Mol. Life Sci. (Cellular and molecular life sciences : CMLS)
[2018, 75(7):1151-1162]

Cited: 17 times

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Changes to mitochondrial ultrastructure in optic nerve vulnerable to secondary degeneration in vivo are limited by irradiation at 670 nm.

Nadia Cummins, Carole A Bartlett, Michael Archer, Elora Bartlett, Jan M Hemmi, Alan R Harvey, Sarah A Dunlop, Melinda Fitzgerald,

BACKGROUND: Traumatic injury to the central nervous system results in damage to tissue beyond the primary injury, termed secondary degeneration. Key events thought to be associated with secondary degeneration involve aspects of mitochondrial function which may be modulated by red/near-infrared irradiation therapy (R/NIR-IT), but precisely how mitochondria are affected in ... Read more >>

BMC Neurosci (BMC neuroscience)
[2013, 14:98]

Cited: 11 times

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Paranode Abnormalities and Oxidative Stress in Optic Nerve Vulnerable to Secondary Degeneration: Modulation by 670 nm Light Treatment.

Charis R Szymanski, Wissam Chiha, Natalie Morellini, Nadia Cummins, Carole A Bartlett, Ryan L O'Hare Doig, Donna L Savigni, Sophie C Payne, Alan R Harvey, Sarah A Dunlop, Melinda Fitzgerald,

Secondary degeneration of nerve tissue adjacent to a traumatic injury results in further loss of neurons, glia and function, via mechanisms that may involve oxidative stress. However, changes in indicators of oxidative stress have not yet been demonstrated in oligodendrocytes vulnerable to secondary degeneration in vivo. We show increases in ... Read more >>

PLoS One (PloS one)
[2013, 8(6):e66448]

Cited: 18 times

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