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Author N McCallion

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Assessing standards for prevention of early onset group B streptococcal (GBS) disease in Ireland.

Alex Dakin, Wendy Ferguson, Richard Drew, Naomi McCallion, Mary F Higgins, Maeve Eogan,

<h4>Background</h4>Early onset group B streptococcal (GBS) disease can cause significant neonatal morbidity and mortality. There is currently no Irish national guideline for GBS screening, and protocols vary across maternity units. Polymerase chain reaction (PCR) testing at induction or labour onset informs triage for antibiotic prophylaxis; however, there are human and ... Read more >>

Ir J Med Sci (Irish journal of medical science)
[2021, :]

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Comparison of medical student performance in summative undergraduate paediatric examinations and a clinician-designed minimum accepted competency (MAC) assessment.

Patrick McCrossan, Dara O'Donoghue, Alf Nicholson, Naomi McCallion,

<h4>Background</h4>It is recognised that newly qualified doctors feel unprepared in many areas of their daily practice and that there is a gap between what students learn during medical school and their clinical responsibilities early in their postgraduate career. This study aimed to assess if undergraduate students and junior paediatric doctors ... Read more >>

BMC Med Educ (BMC medical education)
[2021, 21(1):197]

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Genomic epidemiology of group B streptococci spanning 10 years in an Irish maternity hospital, 2008-2017.

Mary Meehan, Maeve Eogan, Naomi McCallion, Robert Cunney, James E Bray, Keith A Jolley, Anastasia Unitt, Martin C J Maiden, Odile B Harrison, Richard J Drew,

<h4>Objectives</h4>The genomic epidemiology of group b streptococcal (GBS) isolates from the Rotunda maternity hospital, Dublin, 2008-2017, was investigated.<h4>Methods</h4>Whole genome sequences of isolates (invasive, n = 114; non-invasive, n = 76) from infants and women were analysed using the PubMLST database (https://pubmlst.org/sagalactiae/).<h4>Results</h4>Serotypes III (36%), Ia (18%), V (17%), II (11%) and Ib, (9%) and sequence ... Read more >>

J Infect (The Journal of infection)
[2021, :]

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Patent ductus arteriosus shunt elimination results in a reduction in adverse outcomes: a post hoc analysis of the PDA RCT cohort.

Neidín Bussmann, Aisling Smith, Colm R Breatnach, Naomi McCallion, Brian Cleary, Orla Franklin, Patrick J McNamara, Afif El-Khuffash,

<h4>Objective</h4>A post hoc appraisal of the PDA RCT to assess the relationship between early patent ductus arteriosus (PDA) shunt elimination and chronic lung disease or death (CLD/Death).<h4>Study design</h4>Infants <29 weeks were divided into four groups: intervention arm in whom PDA closure was achieved (n = 17); intervention arm in whom PDA closure ... Read more >>

J Perinatol (Journal of perinatology : official journal of the California Perinatal Association)
[2021, 41(5):1134-1141]

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Effect of Gestational Diabetes Mellitus on Neonatal Myocardial Function.

Aisling Smith, Orla Franklin, Naomi McCallion, Fionnouala Breatnach, Afif El-Khuffash,

<h4>Background and aims</h4>Infants born to mothers with gestational diabetes mellitus (GDM) have impaired myocardial performance and are at risk of pulmonary hypertension. We aimed to assess myocardial deformation and left ventricular (LV) rotational mechanics in this population.<h4>Methods</h4>We studied 40 infants of mothers with GDM and 40 control infants. Three echocardiograms ... Read more >>

Neonatology (Neonatology)
[2021, 118(1):64-72]

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Study of performance on a novel paediatric examination to investigate disparity between what undergraduate medical students are taught and what is felt to be essential knowledge in the postgraduate paediatric domain?

Patrick McCrossan, Alf Nicholson, Dara O'Donoghue, Naomi McCallion,

<h4>Background: </h4> It is recognised that newly qualified doctors feel unprepared in many areas of their daily practice and that there is a gap between what students learn during medical school and their clinical responsibilities early in their postgraduate career. This study aimed to assess if undergraduate students and junior ... Read more >>

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Early targeted patent ductus arteriosus treatment in premature neonates using a risk based severity score: study protocol for a randomised controlled trial (PDA RCT)

Afif EL-Khuffash, Neidin Bussmann, Colm Breatnach, Aisling Smith, Elizabeth Tully, Joanna Griffin, Naomi McCallion, John David Corcoran, Elena Fernandez, Claudia Looi, Brian Cleary, Orla Franklin, Patrick McNamara,

A patent ductus arteriosus (PDA) in preterm infants is associated with increased ventilator dependence and chronic lung disease, necrotizing enterocolitis, intraventricular haemorrhage, and poor neurodevelopmental outcome. Randomised controlled trials of early PDA treatment have not established a drop in the aforementioned morbidities. Those trials did not physiologically categorise PDA severity. ... Read more >>

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Comparison of left ventricular rotational mechanics between term and extremely premature infants over the first week of age.

Aisling Smith, Neidin Bussmann, Phillip Levy, Orla Franklin, Naomi McCallion, Afif El-Khuffash,

<h4>Objective</h4>Left ventricle (LV) rotational mechanics is an emerging tool to characterise LV function, but warrants further evaluation in neonates. The aim of this study was to compare LV rotational mechanics between term and extremely preterm babies over the first week of age.<h4>Methods</h4>In this prospective study, we serially assessed LV rotational ... Read more >>

Open Heart (Open heart)
[2021, 8(1):]

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The impact preload on left ventricular three-plane deformation measurements in extremely premature infants.

Neidin Bussmann, Orla Franklin, Naomi McCallion, Patrick J McNamara, Afif El-Khuffash,

<h4>Background</h4>Left Ventricular (LV) deformation analysis using two-dimensional speckle tracking echocardiography (STE) is an emerging modality in premature infants.<h4>Aims</h4>To assess the impact of increased preload on LV deformation in three planes: longitudinal, circumferential and radial in premature infants.<h4>Study design and subjects</h4>Infants recruited to the PDA RCT (ISRCTN 13281214) and survived to ... Read more >>

Early Hum Dev (Early human development)
[2021, 153:105291]

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A Pilot Randomized Controlled Trial of Early Targeted Patent Ductus Arteriosus Treatment Using a Risk Based Severity Score (The PDA RCT).

Afif El-Khuffash, Neidín Bussmann, Colm R Breatnach, Aisling Smith, Elizabeth Tully, Joanna Griffin, Naomi McCallion, John David Corcoran, Elena Fernandez, Claudia Looi, Brian Cleary, Orla Franklin, Patrick J McNamara,

<h4>Objectives</h4>To evaluate the feasibility of recruiting preterm infants to a randomized controlled trial of patent ductus arteriosus (PDA) treatment based on a PDA severity score (PDAsc) and to characterize challenges in obtaining consent, compliance with the protocol, and PDA closure rates.<h4>Study design</h4>This single-center, randomized control pilot study of 60 infants ... Read more >>

J Pediatr (The Journal of pediatrics)
[2021, 229:127-133]

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Impact of an electronic health record on task time distribution in a neonatal intensive care unit.

Joan Devin, Joyce Costello, Naomi McCallion, Eavan Higgins, Brian Kehoe, Brian J Cleary, Shane Cullinan,

<h4>Background</h4>An Electronic Health Record (EHR) has been introduced to four Irish maternity units, with further implementations planned. Previous studies indicate that healthcare professionals are concerned that EHRs may increase time spent on documentation and medication-related tasks.<h4>Objective</h4>To determine the impact of an EHR on task time distribution in a Neonatal Intensive ... Read more >>

Int J Med Inform (International journal of medical informatics)
[2021, 145:104307]

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Trainee's Preparedness for Paediatric Work.

P McCrossan, A Nicholson, N McCallion,

Aim Compare the opinion of paediatric consultants to paediatric Senior House Officers (SHOs) with regards their perceived level of preparedness for starting work in paediatrics. Methods A 5-point Likert scale questionnaire was administered to paediatric consultants and SHOs investigating how well they considered the SHO was performing and how well ... Read more >>

Ir Med J (Irish medical journal)
[2020, 113(7):120]

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Erythromycin compared to amoxicillin and azithromycin for antimicrobial prophylaxis for preterm premature rupture of the membranes: a retrospective study.

Alva Fitzgibbon, Lisa Clooney, Deirdre Broderick, Maeve Eogan, Naomi McCallion, Richard J Drew,

Antimicrobial prophylaxis is widely recommended for pregnant women who have preterm premature rupture of the membranes. Erythromycin prophylaxis was used during an initial period (control) and then changed to intravenous amoxicillin for 48 h, followed by 5 days of oral amoxicillin along with a single dose of azithromycin (case). Healthcare records were ... Read more >>

J Obstet Gynaecol (Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology)
[2020, :1-4]

Cited: 1 time

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Reducing Invasive Screening for Group B Streptococcus (GBS) in Asymptomatic Term Neonates.

M H Tai, R J Drew, N McCallion,

Ir Med J (Irish medical journal)
[2020, 113(5):88]

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Do preterm bones still break? Incidence of rib fracture and osteopenia of prematurity in very low birth weight infants.

Peter O'Reilly, Michela Saviani, Andrea Tou, Ailbhe Tarrant, Louise Capra, Naomi McCallion,

<h4>Aim</h4>Extremely premature babies are at risk of osteopenia of prematurity (OOP) as bone mineralisation in utero increases exponentially after 24 weeks gestation. Our aim was to assess the bone health of very low birth weight (VLBW) infants. We wanted to establish the incidences of OOP and rib fracture. We also looked ... Read more >>

J Paediatr Child Health (Journal of paediatrics and child health)
[2020, 56(6):959-963]

Cited: 2 times

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Circumferential and radial deformation assessment in premature infants: Ready for primetime?

Neidin Bussmann, Aisling Smith, Alessia Cappelleri, Phillip T Levy, Naomi McCallion, Orla Franklin, Afif El-Khuffash,

<h4>Background</h4>Speckle tracking echocardiography (STE) is a validated method to measure longitudinal deformation in premature infants, but there is a paucity of data on STE-derived circumferential and radial strain in this population. We assessed the feasibility and reproducibility of circumferential and radial deformation measurements in premature infants.<h4>Methods</h4>In a prospective study of 40 ... Read more >>

Echocardiography (Echocardiography (Mount Kisco, N.Y.))
[2019, 36(8):1532-1539]

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Alterations in fibrin formation and fibrinolysis in early onset-preeclampsia: Association with disease severity.

Gordon Haire, Karl Egan, Kiran Parmar, Tom McKinnon, Cathy Monteith, Hugh O'Connor, Barry Kevane, Patricia Maguire, Paulina B Szklanna, Marie Galligan, Jennifer C Donnelly, Seamus Allen, Naomi McCallion, Beverley Hunt, Fionnuala Ní Áinle,

<h4>Objective</h4>; Early-onset preeclampsia is a rare pregnancy-specific disorder associated with significantly increased maternal and fetal morbidity and mortality. Whilst it is known that even normotensive pregnancies are associated with changes in clot formation and dissolution, the nature of how these changes differ in those with early onset preeclampsia has not ... Read more >>

Eur J Obstet Gynecol Reprod Biol (European journal of obstetrics, gynecology, and reproductive biology)
[2019, 241:19-23]

Cited: 2 times

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Cardiac mechanics in infants with Down syndrome in the early neonatal period.

Colm R Breatnach, Neidin Bussmann, Aisling Smith, Phil Levy, Naomi McCallion, Orla Franklin, Afif El-Khuffash,

OBJECTIVE:The objective of this study is to test whether myocardial performance is impaired over the first week of age in infants with Down syndrome (DS) without congenital heart disease (CHD). STUDY DESIGN:A prospective cohort study of 20 infants with DS without CHD and 17 healthy term infants comparing echocardiographic measures of ... Read more >>

J Perinatol (Journal of perinatology : official journal of the California Perinatal Association)
[2019, 39(5):626-633]

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Down Syndrome with Transient Neonatal Hepatitis

Q Ali, N McCallion,

Ir Med J (Irish medical journal)
[2019, 112(4):922]

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Postnatal Myocardial Function in Monochorionic Diamniotic Twins with Twin-to-Twin Transfusion Syndrome following Selective Laser Photocoagulation of the Communicating Placental Vessels.

Colm R Breatnach, Neidin Bussmann, Phillip T Levy, Danielle F Vincent, Fergal D Malone, Naomi McCallion, Orla Franklin, Afif El-Khuffash,

BACKGROUND:Monochorionic diamniotic (MCDA) twins are at risk for developing twin-to-twin transfusion syndrome (TTTS) throughout pregnancy. This may lead to myocardial dysfunction in the recipient and/or donor twin that persists beyond delivery. Selective laser photocoagulation of the communicating placental vessels (SLPCV) attempts to mitigate the cardiovascular outcomes. The objective of this ... Read more >>

J Am Soc Echocardiogr (Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography)
[2019, 32(6):774-784.e1]

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A retrospective study (2001-2017) of acute and chronic morbidity and mortality associated with Staphylococcus aureus bacteraemia in a tertiary neonatal intensive care unit.

Daniel O'Reilly, Ciara O'Connor, Naomi McCallion, Richard J Drew,

<h4>Background</h4>Staphylococcus aureus bacteraemia (SAB) in NICU patients can cause significant morbidity and mortality.<h4>Aims</h4>To review early and late neonatal SAB with regard to risk factors, treatment, acute complications and long-term outcomes.<h4>Methods</h4>A retrospective study of laboratory confirmed SAB over a 16-year period (November 2001-January 2017) in a tertiary neonatal unit in Ireland.<h4>Findings</h4>A ... Read more >>

Ir J Med Sci (Irish journal of medical science)
[2019, 188(4):1297-1301]

Cited: 1 time

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Early Onset Neonatal E.Coli Sepsis

M O’Rahelly, A Smith, R Drew, N McCallion,

This was a retrospective case-control study over 14 years comparing characteristics of neonates who developed E.coli bacteraemia with matched infant controls whose mothers were colonised with E.coli on high vaginal swab but who did not develop bacteraemia. Data was obtained from maternal and neonatal charts, the laboratory data-base was analysed ... Read more >>

Ir Med J (Irish medical journal)
[2019, 112(2):868]

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Left ventricular diastolic function influences right ventricular - Pulmonary vascular coupling in premature infants.

Neidin Bussmann, Afif El-Khuffash, Colm R Breatnach, Naomi McCallion, Orla Franklin, Gautam K Singh, Philip T Levy,

<h4>Introduction</h4>Reduced left ventricular (LV) diastolic function can exert significant load to the right ventricle (RV) that can affect RV-pulmonary vasculature (PV) coupling. RV-PV can be assessed with the RV length-force relationship (tricuspid annular plane systolic excursion [TAPSE] to pulmonary artery acceleration time [PAAT] ratio). We aimed to determine the association ... Read more >>

Early Hum Dev (Early human development)
[2019, 128:35-40]

Cited: 1 time

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Early diastolic dysfunction and respiratory morbidity in premature infants: an observational study.

Neidin Bussmann, Colm Breatnach, Philip T Levy, Naomi McCallion, Orla Franklin, Afif El-Khuffash,

<h4>Objective</h4>To test if diastolic dysfunction measured on day one of age is associated with the need for invasive ventilation in preterm infants.<h4>Study design</h4>We conducted a retrospective observational tissue Doppler echocardiographic study over the first 12 h of age for infants born <32 weeks who were invasively ventilated, and infants on continuous ... Read more >>

J Perinatol (Journal of perinatology : official journal of the California Perinatal Association)
[2018, 38(9):1205-1211]

Cited: 2 times

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A Review of the Parenteral Nutrition Supply Service in an Irish Neonatal Unit

A Smith, A C Glynn, A Shankar, C McDermott, N McCallion,

Background Neonatal Intensive Care (NICU) patients have individual nutritional requirements often requiring Patient Specific Parenteral Nutrition (PSPN). From October 2015, the national PSPN compounding service availability changed from 7 days per week service to 5 days per week (i.e. no weekend and limited bank holiday ordering available). The aim of this ... Read more >>

Ir Med J (Irish medical journal)
[2018, 111(6):778]

Cited: 1 time

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