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Author N McCallion

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Early targeted patent ductus arteriosus treatment in premature neonates using a risk based severity score: study protocol for a randomised controlled trial (PDA RCT)

Afif EL-Khuffash, Neidin Bussmann, Colm Breatnach, Aisling Smith, Elizabeth Tully, Joanna Griffin, Naomi McCallion, John David Corcoran, Elena Fernandez, Claudia Looi, Brian Cleary, Orla Franklin, Patrick McNamara,

<ns5:p>A patent ductus arteriosus (PDA) in preterm infants is associated with increased ventilator dependence and chronic lung disease, necrotizing enterocolitis, intraventricular haemorrhage, and poor neurodevelopmental outcome. Randomised controlled trials of early PDA treatment have not established a drop in the aforementioned morbidities. Those trials did not physiologically categorise PDA severity. ... Read more >>

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A Pilot Randomized Controlled Trial of Early Targeted Patent Ductus Arteriosus Treatment Using a Risk Based Severity Score (The PDA RCT).

Afif El-Khuffash, Neidín Bussmann, Colm R Breatnach, Aisling Smith, Elizabeth Tully, Joanna Griffin, Naomi McCallion, John David Corcoran, Elena Fernandez, Claudia Looi, Brian Cleary, Orla Franklin, Patrick J McNamara,

OBJECTIVES:To evaluate the feasibility of recruiting preterm infants to a randomized controlled trial of patent ductus arteriosus (PDA) treatment based on a PDA severity score (PDAsc) and to characterize challenges in obtaining consent, compliance with the protocol, and PDA closure rates. STUDY DESIGN:This single-center, randomized control pilot study of 60 ... Read more >>

J Pediatr (The Journal of pediatrics)
[2020, :]

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Impact of an electronic health record on task time distribution in a neonatal intensive care unit.

Joan Devin, Joyce Costello, Naomi McCallion, Eavan Higgins, Brian Kehoe, Brian J Cleary, Shane Cullinan,

BACKGROUND:An Electronic Health Record (EHR) has been introduced to four Irish maternity units, with further implementations planned. Previous studies indicate that healthcare professionals are concerned that EHRs may increase time spent on documentation and medication-related tasks. OBJECTIVE:To determine the impact of an EHR on task time distribution in a Neonatal ... Read more >>

Int J Med Inform (International journal of medical informatics)
[2020, 145:104307]

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Trainee's Preparedness for Paediatric Work.

P McCrossan, A Nicholson, N McCallion,

Aim Compare the opinion of paediatric consultants to paediatric Senior House Officers (SHOs) with regards their perceived level of preparedness for starting work in paediatrics. Methods A 5-point Likert scale questionnaire was administered to paediatric consultants and SHOs investigating how well they considered the SHO was performing and how well ... Read more >>

Ir Med J (Irish medical journal)
[2020, 113(7):120]

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Preparedness for practice: Is there a disparity between what undergraduate medical students are taught and what is felt to be essential knowledge in the postgraduate paediatric domain?

Patrick McCrossan, Alf Nicholson, Dara O'Donoghue, Naomi McCallion,

Abstract BackgroundThis study aimed to evaluate how undergraduate students and junior paediatric doctors performed against an examination of knowledge set by non-academic consultants at a “must –know “ level for starting in paediatrics. We named this the Minimum Accepeted Competency (MAC) examination.MethodsExamination (comprised of 30 MCQ questions) was delivered to ... Read more >>

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Erythromycin compared to amoxicillin and azithromycin for antimicrobial prophylaxis for preterm premature rupture of the membranes: a retrospective study.

Alva Fitzgibbon, Lisa Clooney, Deirdre Broderick, Maeve Eogan, Naomi McCallion, Richard J Drew,

Antimicrobial prophylaxis is widely recommended for pregnant women who have preterm premature rupture of the membranes. Erythromycin prophylaxis was used during an initial period (control) and then changed to intravenous amoxicillin for 48 h, followed by 5 days of oral amoxicillin along with a single dose of azithromycin (case). Healthcare records were ... Read more >>

J Obstet Gynaecol (Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology)
[2020, :1-4]

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Reducing Invasive Screening for Group B Streptococcus (GBS) in Asymptomatic Term Neonates.

M H Tai, R J Drew, N McCallion,

Ir Med J (Irish medical journal)
[2020, 113(5):88]

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Do preterm bones still break? Incidence of rib fracture and osteopenia of prematurity in very low birth weight infants.

Peter O'Reilly, Michela Saviani, Andrea Tou, Ailbhe Tarrant, Louise Capra, Naomi McCallion,

AIM:Extremely premature babies are at risk of osteopenia of prematurity (OOP) as bone mineralisation in utero increases exponentially after 24 weeks gestation. Our aim was to assess the bone health of very low birth weight (VLBW) infants. We wanted to establish the incidences of OOP and rib fracture. We also looked ... Read more >>

J Paediatr Child Health (Journal of paediatrics and child health)
[2020, 56(6):959-963]

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Circumferential and radial deformation assessment in premature infants: Ready for primetime?

Neidin Bussmann, Aisling Smith, Alessia Cappelleri, Phillip T Levy, Naomi McCallion, Orla Franklin, Afif El-Khuffash,

BACKGROUND:Speckle tracking echocardiography (STE) is a validated method to measure longitudinal deformation in premature infants, but there is a paucity of data on STE-derived circumferential and radial strain in this population. We assessed the feasibility and reproducibility of circumferential and radial deformation measurements in premature infants. METHODS:In a prospective study of ... Read more >>

Echocardiography (Echocardiography (Mount Kisco, N.Y.))
[2019, 36(8):1532-1539]

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Alterations in fibrin formation and fibrinolysis in early onset-preeclampsia: Association with disease severity.

Gordon Haire, Karl Egan, Kiran Parmar, Tom McKinnon, Cathy Monteith, Hugh O'Connor, Barry Kevane, Patricia Maguire, Paulina B Szklanna, Marie Galligan, Jennifer C Donnelly, Seamus Allen, Naomi McCallion, Beverley Hunt, Fionnuala Ní Áinle,

OBJECTIVE:; Early-onset preeclampsia is a rare pregnancy-specific disorder associated with significantly increased maternal and fetal morbidity and mortality. Whilst it is known that even normotensive pregnancies are associated with changes in clot formation and dissolution, the nature of how these changes differ in those with early onset preeclampsia has not ... Read more >>

Eur J Obstet Gynecol Reprod Biol (European journal of obstetrics, gynecology, and reproductive biology)
[2019, 241:19-23]

Cited: 2 times

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Down Syndrome with Transient Neonatal Hepatitis

Q Ali, N McCallion,

Ir Med J (Irish medical journal)
[2019, 112(4):922]

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Cardiac mechanics in infants with Down syndrome in the early neonatal period.

Colm R Breatnach, Neidin Bussmann, Aisling Smith, Phil Levy, Naomi McCallion, Orla Franklin, Afif El-Khuffash,

OBJECTIVE:The objective of this study is to test whether myocardial performance is impaired over the first week of age in infants with Down syndrome (DS) without congenital heart disease (CHD). STUDY DESIGN:A prospective cohort study of 20 infants with DS without CHD and 17 healthy term infants comparing echocardiographic measures of ... Read more >>

J Perinatol (Journal of perinatology : official journal of the California Perinatal Association)
[2019, 39(5):626-633]

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A retrospective study (2001-2017) of acute and chronic morbidity and mortality associated with Staphylococcus aureus bacteraemia in a tertiary neonatal intensive care unit.

Daniel O'Reilly, Ciara O'Connor, Naomi McCallion, Richard J Drew,

BACKGROUND:Staphylococcus aureus bacteraemia (SAB) in NICU patients can cause significant morbidity and mortality. AIMS:To review early and late neonatal SAB with regard to risk factors, treatment, acute complications and long-term outcomes. METHODS:A retrospective study of laboratory confirmed SAB over a 16-year period (November 2001-January 2017) in a tertiary neonatal unit ... Read more >>

Ir J Med Sci (Irish journal of medical science)
[2019, 188(4):1297-1301]

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Postnatal Myocardial Function in Monochorionic Diamniotic Twins with Twin-to-Twin Transfusion Syndrome following Selective Laser Photocoagulation of the Communicating Placental Vessels.

Colm R Breatnach, Neidin Bussmann, Phillip T Levy, Danielle F Vincent, Fergal D Malone, Naomi McCallion, Orla Franklin, Afif El-Khuffash,

BACKGROUND:Monochorionic diamniotic (MCDA) twins are at risk for developing twin-to-twin transfusion syndrome (TTTS) throughout pregnancy. This may lead to myocardial dysfunction in the recipient and/or donor twin that persists beyond delivery. Selective laser photocoagulation of the communicating placental vessels (SLPCV) attempts to mitigate the cardiovascular outcomes. The objective of this ... Read more >>

J Am Soc Echocardiogr (Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography)
[2019, 32(6):774-784.e1]

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Early Onset Neonatal E.Coli Sepsis

M O’Rahelly, A Smith, R Drew, N McCallion,

This was a retrospective case-control study over 14 years comparing characteristics of neonates who developed E.coli bacteraemia with matched infant controls whose mothers were colonised with E.coli on high vaginal swab but who did not develop bacteraemia. Data was obtained from maternal and neonatal charts, the laboratory data-base was analysed ... Read more >>

Ir Med J (Irish medical journal)
[2019, 112(2):868]

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Left ventricular diastolic function influences right ventricular - Pulmonary vascular coupling in premature infants.

Neidin Bussmann, Afif El-Khuffash, Colm R Breatnach, Naomi McCallion, Orla Franklin, Gautam K Singh, Philip T Levy,

INTRODUCTION:Reduced left ventricular (LV) diastolic function can exert significant load to the right ventricle (RV) that can affect RV-pulmonary vasculature (PV) coupling. RV-PV can be assessed with the RV length-force relationship (tricuspid annular plane systolic excursion [TAPSE] to pulmonary artery acceleration time [PAAT] ratio). We aimed to determine the association ... Read more >>

Early Hum Dev (Early human development)
[2019, 128:35-40]

Cited: 1 time

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Early diastolic dysfunction and respiratory morbidity in premature infants: an observational study.

Neidin Bussmann, Colm Breatnach, Philip T Levy, Naomi McCallion, Orla Franklin, Afif El-Khuffash,

OBJECTIVE:To test if diastolic dysfunction measured on day one of age is associated with the need for invasive ventilation in preterm infants. STUDY DESIGN:We conducted a retrospective observational tissue Doppler echocardiographic study over the first 12 h of age for infants born <32 weeks who were invasively ventilated, and infants on ... Read more >>

J Perinatol (Journal of perinatology : official journal of the California Perinatal Association)
[2018, 38(9):1205-1211]

Cited: 1 time

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A Review of the Parenteral Nutrition Supply Service in an Irish Neonatal Unit

A Smith, A C Glynn, A Shankar, C McDermott, N McCallion,

Background Neonatal Intensive Care (NICU) patients have individual nutritional requirements often requiring Patient Specific Parenteral Nutrition (PSPN). From October 2015, the national PSPN compounding service availability changed from 7 days per week service to 5 days per week (i.e. no weekend and limited bank holiday ordering available). The aim of this ... Read more >>

Ir Med J (Irish medical journal)
[2018, 111(6):778]

Cited: 1 time

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Volume-targeted versus pressure-limited ventilation in neonates.

Claus Klingenberg, Kevin I Wheeler, Naomi McCallion, Colin J Morley, Peter G Davis,

BACKGROUND:Damage caused by lung overdistension (volutrauma) has been implicated in the development of bronchopulmonary dysplasia (BPD). Modern neonatal ventilation modes can target a set tidal volume as an alternative to traditional pressure-limited ventilation (PLV) using a fixed inflation pressure. Volume-targeted ventilation (VTV) aims to produce a more stable tidal volume ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2017, 10:CD003666]

Cited: 25 times

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Impact of a rapid molecular test for positive blood cultures from neonatal intensive care patients on clinical management: a retrospective audit.

L L Koh, S O'Rourke, M Brennan, L Clooney, M Cafferkey, N McCallion, R J Drew,

Both Staphylococcus aureus and coagulase negative Staphylococci are common causes of late-onset neonatal sepsis in the neonatal intensive care unit (NICU), usually relating to intravascular access device infections.This project aimed to review the impact on antimicrobial treatment and clinical outcome in the NICU setting, of the introduction of the Xpert ... Read more >>

Ir J Med Sci (Irish journal of medical science)
[2018, 187(2):423-427]

Cited: 1 time

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Screening for group B Streptococcus (GBS) at labour onset using PCR: accuracy and potential impact - a pilot study.

Sandhya Ramesh Babu, Rachel McDermott, Irum Farooq, David Le Blanc, Wendy Ferguson, Naomi McCallion, Richard Drew, Maeve Eogan,

This pilot study assessed the diagnostic accuracy and potential impact of a rapid PCR-based screening test for the detection of group B Streptococcus (GBS) at the onset of labour for the purpose of optimising intrapartum antibiotic prophylaxis (IAP). Vaginal and rectal swabs from a convenience sample of 158 women were ... Read more >>

J Obstet Gynaecol (Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology)
[2018, 38(1):49-54]

Cited: 1 time

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Congenital hypofibrinogenaemia: a presymptomatic detection of an extremely rare bleeding disorder in preterm twins.

Catherine Mary Breen, Muhammad I Riazat, Naomi McCallion, Michael A Boyle,

Twenty-eight-week-old preterm monochorionic-diamniotic twins were admitted to the neonatal intensive care unit secondary to low birth weight and mild respiratory distress syndrome. A low fibrinogen level of less than 0.5 g/L was detected following an abnormal full blood count. They required fibrinogen transfusions until 32 weeks corrected gestation to maintain adequate ... Read more >>

BMJ Case Rep (BMJ case reports)
[2017, 2017:]

Cited: 2 times

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Elevated plasma TFPI activity causes attenuated TF-dependent thrombin generation in early onset preeclampsia.

Karl Egan, Hugh O'Connor, Barry Kevane, Fergal Malone, Aine Lennon, Amani Al Zadjali, Sharon Cooley, Cathy Monteith, Patricia Maguire, Paulina B Szklanna, Seamus Allen, Naomi McCallion, Fionnuala Ní Áinle,

Early onset preeclampsia (EOP) is a pregnancy-specific proinflammatory disorder that is characterised by competing thrombotic and bleeding risks. It was the aim of this study to characterise thrombin generation, a major determinant of thrombotic and bleeding risk, in order to better understand the haemostatic balance in patients with EOP. Patients ... Read more >>

Thromb Haemost (Thrombosis and haemostasis)
[2017, 117(8):1549-1557]

Cited: 1 time

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Serial measures of cardiac performance using tissue Doppler imaging velocity in preterm infants <29weeks gestations.

Colm R Breatnach, Afif El-Khuffash, Adam James, Naomi McCallion, Orla Franklin,

Tissue Doppler imaging (TDI) is a useful marker of myocardial performance in preterm infants. We aimed to demonstrate serial changes in TDI velocity in preterm infants <29weeks gestation, to assess the impact of inotropes and a haemodynamically significant patent ductus arteriosus (hsPDA).This was a prospective observational study of preterm infants ... Read more >>

Early Hum. Dev. (Early human development)
[2017, 108:33-39]

Cited: 6 times

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The impact of a hyperdynamic left ventricle on right ventricular function measurements in preterm infants with a patent ductus arteriosus.

Colm R Breatnach, Orla Franklin, Adam T James, Naomi McCallion, Afif El-Khuffash,

Right ventricular (RV) functional assessment in premature infants includes basal longitudinal strain (RV BLS), RV systolic tissue Doppler velocity (RV s'), tricuspid annular plane systolic excursion (TAPSE) and RV fractional area change (FAC). A hyperdynamic left ventricle (LV) may influence RV measures of displacement (TAPSE) and velocity (RV s') but ... Read more >>

Arch Dis Child Fetal Neonatal Ed (Archives of disease in childhood. Fetal and neonatal edition)
[2017, 102(5):F446-F450]

Cited: 0 times

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