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Author Myung Chul Kim

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Natural and Synthetic Estrogens in Chronic Inflammation and Breast Cancer.

Chandra K Maharjan, Jiao Mo, Lei Wang, Myung-Chul Kim, Sameul Wang, Nicholas Borcherding, Praveen Vikas, Weizhou Zhang,

The oncogenic role of estrogen receptor (ER) signaling in breast cancer has long been established. Interaction of estrogen with estrogen receptor (ER) in the nucleus activates genomic pathways of estrogen signaling. In contrast, estrogen interaction with the cell membrane-bound G-protein-coupled estrogen receptor (GPER) activates the rapid receptor-mediated signaling transduction cascades. ... Read more >>

Cancers (Basel) (Cancers)
[2021, 14(1):]

Cited: 1 time

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Updates on Immunotherapy and Immune Landscape in Renal Clear Cell Carcinoma.

Myung-Chul Kim, Zeng Jin, Ryan Kolb, Nicholas Borcherding, Jonathan Alexander Chatzkel, Sara Moscovita Falzarano, Weizhou Zhang,

Several clinicopathological features of clear cell renal cell carcinomas (ccRCC) contribute to make an "atypical" cancer, including resistance to chemotherapy, sensitivity to anti-angiogenesis therapy and ICIs despite a low mutational burden, and CD8<sup>+</sup> T cell infiltration being the predictor for poor prognosis-normally CD8<sup>+</sup> T cell infiltration is a good prognostic ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(22):]

Cited: 0 times

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CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells.

Myung-Chul Kim, Nicholas Borcherding, Kawther K Ahmed, Andrew P Voigt, Ajaykumar Vishwakarma, Ryan Kolb, Paige N Kluz, Gaurav Pandey, Umasankar De, Theodore Drashansky, Eric Y Helm, Xin Zhang, Katherine N Gibson-Corley, Julia Klesney-Tait, Yuwen Zhu, Jinglu Lu, Jinsong Lu, Xian Huang, Hongrui Xiang, Jinke Cheng, Dongyang Wang, Zheng Wang, Jian Tang, Jiajia Hu, Zhengting Wang, Hua Liu, Mingjia Li, Haoyang Zhuang, Dorina Avram, Daohong Zhou, Rhonda Bacher, Song Guo Zheng, Xuefeng Wu, Yousef Zakharia, Weizhou Zhang,

Regulatory T (Treg) cells are one of the major immunosuppressive cell types in cancer and a potential target for immunotherapy, but targeting tumor-infiltrating (TI) Treg cells has been challenging. Here, using single-cell RNA sequencing of immune cells from renal clear cell carcinoma (ccRCC) patients, we identify two distinct transcriptional fates ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):5764]

Cited: 1 time

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Reduction in mitochondrial oxidative stress mediates hypoxia-induced resistance to cisplatin in human transitional cell carcinoma cells.

Myung-Chul Kim, Sung-Hyun Hwang, Yeseul Yang, Na-Yon Kim, Yongbaek Kim,

Tumor hypoxia is known to promote the acquisition of more aggressive phenotypes in human transitional cell carcinoma (TCC), including drug resistance. Accumulating evidence suggests that mitochondria play a central role in the chemoresistance of TCC. However, the role of mitochondria in the hypoxia-induced drug resistance in TCC remains elusive. The ... Read more >>

Neoplasia (Neoplasia (New York, N.Y.))
[2021, 23(7):653-662]

Cited: 1 time

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Clinical Practice Guideline for Postoperative Rehabilitation in Older Patients With Hip Fractures.

Kyunghoon Min, Jaewon Beom, Bo Ryun Kim, Sang Yoon Lee, Goo Joo Lee, Jung Hwan Lee, Seung Yeol Lee, Sun Jae Won, Sangwoo Ahn, Heui Je Bang, Yonghan Cha, Min Cheol Chang, Jung-Yeon Choi, Jong Geol Do, Kyung Hee Do, Jae-Young Han, Il-Young Jang, Youri Jin, Dong Hwan Kim, Du Hwan Kim, In Jong Kim, Myung Chul Kim, Won Kim, Yun Jung Lee, In Seok Lee, In-Sik Lee, JungSoo Lee, Chang-Hyung Lee, Seong Hoon Lim, Donghwi Park, Jung Hyun Park, Myungsook Park, Yongsoon Park, Ju Seok Ryu, Young Jin Song, Seoyon Yang, Hee Seung Yang, Ji Sung Yoo, Jun-Il Yoo, Seung Don Yoo, Kyoung Hyo Choi, Jae-Young Lim,

<h4>Objective</h4>The incidence of hip fractures is increasing worldwide with the aging population, causing a challenge to healthcare systems due to the associated morbidities and high risk of mortality. After hip fractures in frail geriatric patients, existing comorbidities worsen and new complications are prone to occur. Comprehensive rehabilitation is essential for ... Read more >>

Ann Rehabil Med (Annals of rehabilitation medicine)
[2021, 45(3):225-259]

Cited: 1 time

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Proteolysis-targeting chimera against BCL-XL destroys tumor-infiltrating regulatory T cells.

Ryan Kolb, Umasankar De, Sajid Khan, Yuewan Luo, Myung-Chul Kim, Haijun Yu, Chaoyan Wu, Jiao Mo, Xin Zhang, Peiyi Zhang, Xuan Zhang, Nicholas Borcherding, Daniel Koppel, Yang-Xin Fu, Song Guo Zheng, Dorina Avram, Guangrong Zheng, Daohong Zhou, Weizhou Zhang,

Regulatory T cells (Tregs) play an important role in maintaining immune homeostasis and, within tumors, their upregulation is common and promotes an immunosuppressive microenvironment. Therapeutic strategies that can eliminate Tregs in the tumor (i.e., therapies that do not run the risk of affecting normal tissues), are urgently needed for the ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):1281]

Cited: 8 times

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Glucose starvation induces resistance to metformin through the elevation of mitochondrial multidrug resistance protein 1.

Sung-Hyun Hwang, Myung-Chul Kim, Sumin Ji, Yeseul Yang, Yeji Jeong, Yongbaek Kim,

Metformin, a drug for type 2 diabetes mellitus, has shown therapeutic effects for various cancers. However, it had no beneficial effects on the survival rate of human malignant mesothelioma (HMM) patients. The present study was performed to elucidate the underlying mechanism of metformin resistance in HMM cells. Glucose-starved HMM cells ... Read more >>

Cancer Sci (Cancer science)
[2019, 110(4):1256-1267]

Cited: 1 time

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Evaluation of a human glycated hemoglobin test in canine diabetes mellitus.

Na-Yon Kim, Jaehoon An, Jae-Kyung Jeong, Sumin Ji, Sung-Hyun Hwang, Hong-Seok Lee, Myung-Chul Kim, Hyun-Wook Kim, Sungho Won, Yongbaek Kim,

Glycated hemoglobin A1c (HbA1c) is widely used for monitoring and diagnosing human diabetes mellitus, but is rarely used in veterinary clinics. The goal of our study was to validate the commercial HbA1c testing system SD A1cCare analyzer (Bionote, Gyeoggi-do, South Korea) for use in dogs. Dogs were recruited with owner's ... Read more >>

J Vet Diagn Invest (Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc)
[2019, 31(3):408-414]

Cited: 1 time

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Association of the Anxiety/Depression with Nutrition Intake in Stroke Patients.

Yoonji Kim, Myung-Chul Kim, Hang-Sik Park, Il-Hoon Cho, Jean Kyung Paik,

Stroke patients often experience a walking dysfunction caused by decreased mobility, weakened muscular strength, abnormal posture control, and cognitive dysfunction. Anxiety/depression is the most important and prevalent neuropsychiatric complication of stroke survivors. Brain injury and the presence of malnutrition after stroke contribute to metabolic status and clinical outcome of patients. ... Read more >>

Clin Nutr Res (Clinical nutrition research)
[2018, 7(1):11-20]

Cited: 4 times

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Hypoxia promotes acquisition of aggressive phenotypes in human malignant mesothelioma.

Myung-Chul Kim, Sung-Hyun Hwang, Na-Yon Kim, Hong-Seok Lee, Sumin Ji, Yeseul Yang, Yongbaek Kim,

<h4>Background</h4>Hypoxia is a hallmark of the solid tumor microenvironment and is associated with poor outcomes in cancer patients. The present study was performed to investigate mechanisms underlying the hypoxia-induced phenotypic changes using human malignant mesothelioma (HMM) cells.<h4>Methods</h4>Hypoxic conditions were achieved by incubating HMM cells in the air chamber. The effect of ... Read more >>

BMC Cancer (BMC cancer)
[2018, 18(1):819]

Cited: 20 times

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Integrated analysis of microRNA and mRNA expressions in peripheral blood leukocytes of Warmblood horses before and after exercise.

Hang-Ah Kim, Myung-Chul Kim, Na-Yon Kim, Doug-Young Ryu, Hong-Seok Lee, Yongbaek Kim,

Exercise capacity is a valuable trait in horses, and it has been used as a horse selection criterion. Although exercise affects molecular homeostasis and adaptation in horses, the mechanisms underlying these effects are not fully described. This study was carried out to identify changes in the blood profiles of microRNAs ... Read more >>

J Vet Sci (Journal of veterinary science)
[2018, 19(1):99-106]

Cited: 3 times

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A subset of microRNAs defining the side population of a human malignant mesothelioma cell line.

Myung-Chul Kim, Na-Yon Kim, Yu-Ri Seo, Yongbaek Kim,

This study was performed to investigate the global expression profile of microRNAs in distinct subpopulations of a human malignant mesothelioma cell line. Total RNAs were isolated from the sorted side population and non-side population of MS1. The RNAs were subjected to analysis using Affymetrix GeneChip microRNA Arrays. After data extraction ... Read more >>

Oncotarget (Oncotarget)
[2017, 8(26):42847-42856]

Cited: 2 times

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Systemic infection of Mycobacterium avium subspecies hominissuis and fungus in a pet dog.

Myung-Chul Kim, JaeMyung Kim, WoonKi Kang, Yunho Jang, Yongbaek Kim,

A 3-year-old neutered female poodle with a long history of dermatophytic skin disease was presented with lethargy, anorexia and progressive weight loss. Abdominal ultrasonography revealed markedly enlarged mesenteric lymph nodes and multiple hypoechoic foci in the spleen. Cytology of the mesenteric lymph nodes and spleen showed granulomatous inflammation with fungal ... Read more >>

J Vet Med Sci (The Journal of veterinary medical science)
[2016, 78(1):157-160]

Cited: 4 times

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An Integrated Analysis of the Genome-Wide Profiles of DNA Methylation and mRNA Expression Defining the Side Population of a Human Malignant Mesothelioma Cell Line.

Myung-Chul Kim, Na-Yon Kim, Yu-Ri Seo, Yongbaek Kim,

Intratumoral heterogeneity is a hallmark of all cancers and functions as the major barrier against effective cancer therapy. In contrast to genetic mutations, the role of epigenetic modifications in the generation and maintenance of heterogeneous cancer cells remains largely undetermined. This study was performed to evaluate the epigenetic mechanisms involved ... Read more >>

J Cancer (Journal of Cancer)
[2016, 7(12):1668-1679]

Cited: 15 times

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Improved Secretory Production of the Sweet-Tasting Protein, Brazzein, in Kluyveromyces lactis.

Cho-Rong Yun, Ji-Na Kong, Ju-Hee Chung, Myung-Chul Kim, Kwang-Hoon Kong,

Brazzein is an intensely sweet protein with high stability over a wide range of pH values and temperatures, due to its four disulfide bridges. Recombinant brazzein production through secretory expression in Kluyveromyces lactis is reported, but is inefficient due to incorrect disulfide formation, which is crucial for achieving the final ... Read more >>

J Agric Food Chem (Journal of agricultural and food chemistry)
[2016, 64(32):6312-6316]

Cited: 5 times

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Changes in the Range of Motion of the Hip Joint and the Muscle Activity of the Rectus Femoris and Biceps Femoris of Stroke Patients during Obstacles Crossing on the Ground and Underwater.

Myung-Chul Kim, Seul-Ki Han, Seung-Kyun Kim,

[Purpose] The purpose of this study was to examine range of motion (ROM) and the muscle activity of stroke patients during obstacle task on the ground and underwater. [Subjects] The subjects of this study were seven stroke patients in a hospital located in Daejeon, South Korea. [Methods] The measurements in ... Read more >>

J Phys Ther Sci (Journal of physical therapy science)
[2014, 26(8):1143-1146]

Cited: 4 times

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Expression of microRNAs in Horse Plasma and Their Characteristic Nucleotide Composition.

Seungwoo Lee, Seungwoo Hwang, Hee Jeong Yu, Dayoung Oh, Yu Jung Choi, Myung-Chul Kim, Yongbaek Kim, Doug-Young Ryu,

MicroRNAs (miRNAs) in blood plasma are stable under high levels of ribonuclease activity and could function in tissue-to-tissue communication, suggesting that they may have distinctive structural characteristics compared with non-circulating miRNAs. In this study, the expression of miRNAs in horse plasma and their characteristic nucleotide composition were examined and compared ... Read more >>

PLoS One (PloS one)
[2016, 11(1):e0146374]

Cited: 11 times

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Importance of Glu53 in the C-terminal region of brazzein, a sweet-tasting protein.

Jin-Kyung Lim, Jin-Chul Jang, Ji-Na Kong, Myung-Chul Kim, Kwang-Hoon Kong,

<h4>Background</h4>The sweetness of brazzein, one of the known sweet proteins, is dependent on charges and/or structures of its specific amino acid side chains. As the residues in the C-terminus of brazzein are known to play a critical role in sweetness, the currently unknown function of Glu53 requires further study.<h4>Results</h4>To identify ... Read more >>

J Sci Food Agric (Journal of the science of food and agriculture)
[2016, 96(9):3202-3206]

Cited: 1 time

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The affect on delayed onset muscle soreness recovery for ultrasound with bee venom.

Seung Kyun Kim, Myung Chul Kim,

[Purpose] The purpose of this study was to evaluate whether ultrasound alone or ultrasound with bee venom is effective in treating delayed onset muscle soreness of the biceps brachii muscle, using the visual analogue scale, range of motion test (flexion and extension), and serum creatine kinase level. [Subjects] Twenty women ... Read more >>

J Phys Ther Sci (Journal of physical therapy science)
[2014, 26(9):1419-1421]

Cited: 9 times

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Effects of C18 Fatty Acids on Intracellular Ca(2+) Mobilization and Histamine Release in RBL-2H3 Cells.

Myung Chul Kim, Min Gyu Kim, Young Soo Jo, Ho Sun Song, Tae In Eom, Sang Soo Sim,

To investigate the underlying mechanisms of C18 fatty acids (stearic acid, oleic acid, linoleic acid and α-linolenic acid) on mast cells, we measured the effect of C18 fatty acids on intracellular Ca(2+) mobilization and histamine release in RBL-2H3 mast cells. Stearic acid rapidly increased initial peak of intracellular Ca(2+) mobilization, ... Read more >>

Korean J Physiol Pharmacol (The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology)
[2014, 18(3):241-247]

Cited: 4 times

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Identification and characterization of microRNAs in normal equine tissues by Next Generation Sequencing.

Myung-Chul Kim, Seung-Woo Lee, Doug-Young Ryu, Feng-Ji Cui, Jong Bhak, Yongbaek Kim,

The role of microRNAs (miRNAs) as a post-transcriptional gene regulator has been elucidated in a broad range of organisms including domestic animals. Characterization of miRNAs in normal tissues is an important step to investigate the functions of miRNAs in various physiological and pathological conditions. Using Illumina Next Generation Sequencing (NGS) ... Read more >>

PLoS One (PloS one)
[2014, 9(4):e93662]

Cited: 17 times

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Comparison of effects of a proprioceptive exercise program in water and on land the balance of chronic stroke patients.

Seul Ki Han, Myung Chul Kim, Chang Sik An,

[Purpose] The purpose of this study was to compare changes in balance ability of land exercise and underwater exercise on chronic stroke patients. [Subjects] A total of 60 patients received exercise for 40 minutes, three times a week, for 6 weeks. [Methods] Subjects from both groups performed general conventional treatment ... Read more >>

J Phys Ther Sci (Journal of physical therapy science)
[2013, 25(10):1219-1222]

Cited: 7 times

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Evaluation of a side population of canine lymphoma cells using Hoechst 33342 dye.

Myung-Chul Kim, Susan D'Costa, Steven Suter, Yongbaek Kim,

Cancer stem cell (CSC) research has increased exponentially to gain further insight into the mechanisms underlying both carcinogenesis and chemotherapy resistance. The present study was performed to explore the potential value of a side population (SP) assay for identifying and characterizing putative CSCs among canine lymphoma cells. Canine lymphoma cells ... Read more >>

J Vet Sci (Journal of veterinary science)
[2013, 14(4):481-486]

Cited: 8 times

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Effect of Lutein on L-NAME-Induced Hypertensive Rats.

Ji Hoon Sung, Young Soo Jo, Su Jin Kim, Jeong Soo Ryu, Myung Chul Kim, Hyun Ju Ko, Sang Soo Sim,

We investigated the antihypertensive effect of lutein on N(G) -nitro-L-arginine methyl ester hydrochloride (L-NAME)-induced hypertensive rats. Daily oral administration of L-NAME (40 mg/kg)-induced a rapid progressive increase in mean arterial pressure (MAP). L-NAME significantly increased MAP from the first week compared to that in the control and reached 193.3±9.6 mmHg ... Read more >>

Korean J Physiol Pharmacol (The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology)
[2013, 17(4):339-345]

Cited: 10 times

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The effect of acteoside on intracellular Ca(2+) mobilization and phospholipase C activity in RBL-2H3 cells stimulated by melittin.

Jeong Soo Ryu, Beom Hyeon Jang, Young Soo Jo, Su Jin Kim, Tae In Eom, Myung Chul Kim, Hyun Ju Ko, Sang Soo Sim,

This study was performed to investigate the effects of acteoside on various cellular functions such as, intracellular Ca(2+) mobilization, phospholipase C activity, and exocytosis induced by melittin. Melittin (0.1-1 μM) dose-dependently increased intracellular Ca(2+) mobilization in the presence of extracellular Ca(2+), but was not affected by 1 μM U73122, a specific PLC ... Read more >>

Arch Pharm Res (Archives of pharmacal research)
[2014, 37(2):239-244]

Cited: 3 times

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