Full Text Journal Articles by
Author Mykhaylo Demydchuk

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Single domain shark VNAR antibodies neutralize SARS-CoV-2 infection in vitro.

Aziz Gauhar, Cyril V Privezentzev, Mykhaylo Demydchuk, Tanja Gerlza, Julia Rieger, Andreas J Kungl, Frank S Walsh, J Lynn Rutkowski, Pawel Stocki,

Single domain shark variable domain of new antigen receptor (VNAR) antibodies can offer a viable alternative to conventional Ig-based monoclonal antibodies in treating COVID-19 disease during the current pandemic. Here we report the identification of neutralizing single domain VNAR antibodies selected against the severe acute respiratory syndrome coronavirus 2 spike ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(11):e21970]

Cited: 0 times

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Blood-brain barrier transport using a high affinity, brain-selective VNAR antibody targeting transferrin receptor 1.

Pawel Stocki, Jaroslaw Szary, Charlotte L M Rasmussen, Mykhaylo Demydchuk, Leandra Northall, Diana Bahu Logan, Aziz Gauhar, Laura Thei, Torben Moos, Frank S Walsh, J Lynn Rutkowski,

Transfer across the blood-brain barrier (BBB) remains a significant hurdle for the development of biopharmaceuticals with therapeutic effects within the central nervous system. We established a functional selection method to identify high affinity single domain antibodies to the transferrin receptor 1 (TfR1) with efficient biotherapeutic delivery across the BBB. A ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(2):e21172]

Cited: 6 times

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Blood-brain barrier transport using a high-affinity, brain-selective VNAR (Variable Domain of New Antigen Receptor) antibody targeting transferrin receptor 1

Pawel Stocki, Jaroslaw Szary, Charlotte LM Rasmussen, Mykhaylo Demydchuk, Leandra Northall, Diana Bahu Logan, Aziz Gauhar, Laura Thei, Torben Moos, Frank Walsh, Lynn Rutkowski,

<h4>ABSTRACT</h4> Transfer across the blood-brain barrier (BBB) remains a significant hurdle for the development of biopharmaceuticals with therapeutic effects within the central nervous system. We established a functional selection method to identify high-affinity single domain antibodies to the transferrin receptor 1 (TfR1) with efficient biotherapeutic delivery across the BBB. <h4>Methods</h4> ... Read more >>

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Insights into Hunter syndrome from the structure of iduronate-2-sulfatase.

Mykhaylo Demydchuk, Chris H Hill, Aiwu Zhou, Gábor Bunkóczi, Penelope E Stein, Denis Marchesan, Janet E Deane, Randy J Read,

Hunter syndrome is a rare but devastating childhood disease caused by mutations in the IDS gene encoding iduronate-2-sulfatase, a crucial enzyme in the lysosomal degradation pathway of dermatan sulfate and heparan sulfate. These complex glycosaminoglycans have important roles in cell adhesion, growth, proliferation and repair, and their degradation and recycling ... Read more >>

Nat Commun (Nature communications)
[2017, 8:15786]

Cited: 18 times

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Snapshot of protein structure evolution reveals conservation of functional dimerization through intertwined folding.

Dimitri Y Chirgadze, Mykhaylo Demydchuk, Marion Becker, Stephen Moran, Massimo Paoli,

Protein-protein interactions govern a wide range of cellular processes. Molecular recognition responsible for homodimerization and heterodimerization in the rel/NF-kappaB family of eukaryotic transcription factors relies on a small cluster of hydrophobic residues. We have carried out a structural analysis of six NF-kappaB p50 dimer interface mutants; one of them revealed ... Read more >>

Structure (Structure (London, England : 1993))
[2004, 12(8):1489-1494]

Cited: 9 times

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Engineering of beta-propeller protein scaffolds by multiple gene duplication and fusion of an idealized WD repeat.

Maryam Nikkhah, Zahra Jawad-Alami, Mykhaylo Demydchuk, Duncan Ribbons, Massimo Paoli,

The ability to design specific amino acid sequences that fold into desired structures is central to engineering novel proteins. Protein design is also a good method to assess our understanding of sequence-structure and structure-function relationships. While beta-sheet structures are important elements of protein architecture, it has traditionally been more difficult ... Read more >>

Biomol Eng (Biomolecular engineering)
[2006, 23(4):185-194]

Cited: 15 times

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