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Author Mustafa Caglar Beker

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Physiological and pharmacological roles of melatonin in the pathophysiological components of cellular injury after ischemic stroke.

ErtuĞrul KiliÇ, Berrak ÇaĞlayan, Mustafa Caglar Beker,

Apart from its metabolic or physiological functions, melatonin has a potent cytoprotective activity in the physiological and pathological conditions. It is synthetized by the pineal gland and released into the blood circulation but particularly cerebrospinal fluid in a circadian manner. It can also easily diffuse through cellular membranes due its ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, :]

Cited: 0 times

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Contralateral hemisphere as a lifeguard which is supported by melatonin for molecular and functional recovery after stroke

Ulkan Kilic, Birsen Elibol, Ahmet Burak Caglayan, Mustafa Caglar Beker, Merve Beker, Burcugul Altug-Tasa, Omer Uysal, Bayram Yilmaz, Ertugrul Kilic,

Abstract Successful functional recovery from stroke is crucial in the rehabilitation of patients and mainly depends on several ischemia-induced processes, including cell survival and apoptosis. Melatonin is an interesting candidate for secondary stroke prevention due to its effect on signaling pathways. Therefore, we investigated the coordination of ipsilateral and contralateral ... Read more >>

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Time-of-Day Dependent Neuronal Injury After Ischemic Stroke: Implication of Circadian Clock Transcriptional Factor Bmal1 and Survival Kinase AKT.

Mustafa Caglar Beker, Berrak Caglayan, Esra Yalcin, Ahmet Burak Caglayan, Seyma Turkseven, Busra Gurel, Taha Kelestemur, Elif Sertel, Zafer Sahin, Selim Kutlu, Ulkan Kilic, Ahmet Tarik Baykal, Ertugrul Kilic,

Occurrence of stroke cases displays a time-of-day variation in human. However, the mechanism linking circadian rhythm to the internal response mechanisms against pathophysiological events after ischemic stroke remained largely unknown. To this end, temporal changes in the susceptibility to ischemia/reperfusion (I/R) injury were investigated in mice in which the ischemic ... Read more >>

Mol. Neurobiol. (Molecular neurobiology)
[2018, 55(3):2565-2576]

Cited: 6 times

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Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice.

Ulkan Kilic, Ahmet Burak Caglayan, Mustafa Caglar Beker, Mehmet Yalcin Gunal, Berrak Caglayan, Esra Yalcin, Taha Kelestemur, Reyhan Zeynep Gundogdu, Burak Yulug, Bayram Yılmaz, Bilal Ersen Kerman, Ertugrul Kilic,

Apart from its potent antioxidant property, recent studies have revealed that melatonin promotes PI3K/Akt phosphorylation following focal cerebral ischemia (FCI) in mice. However, it is not clear (i) whether increased PI3K/Akt phosphorylation is a concomitant event or it directly contributes to melatonin's neuroprotective effect, and (ii) how melatonin regulates PI3K/Akt ... Read more >>

Redox Biol (Redox biology)
[2017, 12:657-665]

Cited: 16 times

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Pleiotropic and Renoprotective Effects of Erythropoietin Beta on Experimental Diabetic Nephropathy Model.

Zehra Eren, Mehmet Yalçın Günal, Elif Arı, Jale Çoban, Fulya Çakalağaoğlu, Burak Çağlayan, Mustafa Çağlar Beker, Tuba Akdeniz, Gülderen Yanıkkaya, Ertuğrul Kılıç, Gülçin Kantarcı,

This study aimed at investigating the possible protective effect of erythropoietin beta on experimental diabetic nephropathy (DN) model in rats.Sprague Dawley rats (n = 32) were allocated into 4 equal groups of 8 each, the control (Group C), diabetes (Group D), erythropoietin beta (Group E), and erythropoietin beta treated DN ... Read more >>

Nephron (Nephron)
[2016, 132(4):292-300]

Cited: 4 times

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Time dependent impact of perinatal hypoxia on growth hormone, insulin-like growth factor 1 and insulin-like growth factor binding protein-3.

Ömer Kartal, Seçil Aydınöz, Ayşe Tuğba Kartal, Taha Kelestemur, Ahmet Burak Caglayan, Mustafa Caglar Beker, Ferhan Karademir, Selami Süleymanoğlu, Mustafa Kul, Burak Yulug, Ertugrul Kilic,

Hypoxic-ischemia (HI) is a widely used animal model to mimic the preterm or perinatal sublethal hypoxia, including hypoxic-ischemic encephalopathy. It causes diffuse neurodegeneration in the brain and results in mental retardation, hyperactivity, cerebral palsy, epilepsy and neuroendocrine disturbances. Herein, we examined acute and subacute correlations between neuronal degeneration and serum ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2016, 31(4):827-835]

Cited: 5 times

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Targeting different pathophysiological events after traumatic brain injury in mice: Role of melatonin and memantine.

Taha Kelestemur, Burak Yulug, Ahmet Burak Caglayan, Mustafa Caglar Beker, Ulkan Kilic, Berrak Caglayan, Esra Yalcin, Reyhan Zeynep Gundogdu, Ertugrul Kilic,

The tissue damage that emerges during traumatic brain injury (TBI) is a consequence of a variety of pathophysiological events, including free radical generation and over-activation of N-methyl-d-aspartate-type glutamate receptors (NMDAR). Considering the complex pathophysiology of TBI, we hypothesized that combination of neuroprotective compounds, targeting different events which appear during injury, ... Read more >>

Neurosci. Lett. (Neuroscience letters)
[2016, 612:92-97]

Cited: 10 times

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HMG-CoA Reductase Inhibition Promotes Neurological Recovery, Peri-Lesional Tissue Remodeling, and Contralesional Pyramidal Tract Plasticity after Focal Cerebral Ischemia.

Ertugrul Kilic, Raluca Reitmeir, Ülkan Kilic, Ahmet Burak Caglayan, Mustafa Caglar Beker, Taha Kelestemur, Muhsine Sinem Ethemoglu, Gurkan Ozturk, Dirk M Hermann,

3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors are widely used for secondary stroke prevention. Besides their lipid-lowering activity, pleiotropic effects on neuronal survival, angiogenesis, and neurogenesis have been described. In view of these observations, we were interested whether HMG-CoA reductase inhibition in the post-acute stroke phase promotes neurological recovery, peri-lesional, and contralesional ... Read more >>

(Frontiers in cellular neuroscience)
[2014, 8:422]

Cited: 5 times

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