Full Text Journal Articles by
Author Mussarat Ashraf

Advertisement

Find full text journal articles








Association of trinucleotide repeat polymorphisms CAG and GGC in exon 1 of the Androgen Receptor gene with male infertility: a cross-sectional study.

Mussarat Ashraf, Dr Shahana Urooj Kazmi, Hemaila Tariq, Adnan Munir, Rehana Rehman,

BACKGROUND:Infertility is a global problem that brings with serious sexual and social consequences that strain the health sector and society. The expansion of CAG & GGC repeats in androgen receptor (AR) gene Ensembl number; ENSG00000169083 may leads to reduced fertility. Our objective was to determine association of CAG and GGC ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Role of oxidative stress and altered thyroid hormones in unexplained infertility.

Rehana Rehman, Hiba Ismail Rajpar, Mussarat Ashraf, Najeeha Talat Iqbal, Salima Lalani, Faiza Alam,

OBJECTIVE:To explore the link between altered thyroid profile and oxidative stress marker in females with unexplained infertility. METHODS:The cross-sectional case-control study was carried out at the Islamabad Clinic Serving Infertile Couples, Islamabad, Pakistan, from June 2016 to August 2017, and comprised women aged 18-40 years regardless of ethnic background who ... Read more >>

J Pak Med Assoc (JPMA. The Journal of the Pakistan Medical Association)
[2020, 70(8):1345-1349]

Cited: 0 times

View full text PDF listing >>



Advertisement

Association of polymorphism c.-124G>A and c.-16 C>T in the promoter region of human INHA gene with altered sperm parameters; A pilot study.

Wardah Rafaqat, Muhammad Rohan Kayani, Tasneem Fatima, Saeeda Shaharyar, Shagufta Khan, Mussarat Ashraf, Usman Afzal, Rehana Rehman,

OBJECTIVE:The objective of this was to demonstrate the association of Inhibin α (INHα) c.-124G>A and INHα-c.-16 C>T polymorphisms with altered sperm parameters in a selected male population of Karachi, Pakistan. STUDY DESIGN & SETTINGS:In this pilot study, male subjects were stratified on the basis of the WHO criteria for altered ... Read more >>

Int J Clin Pract (International journal of clinical practice)
[2020, 74(10):e13595]

Cited: 0 times

View full text PDF listing >>



Oxidative stress and male infertility: a cross sectional study.

Rehana Rehman, Sofia Amjad, Hemaila Tariq, Nida Zahid, Masnoon Akhter, Mussarat Ashraf,

OBJECTIVE:To compare stress markers and antioxidants in fertile and infertile males, and to explore their effects on reproductive hormones and fertility. METHODS:The cross-sectional case-control study was conducted from July 2017 to July 2018 at the Islamabad Clinic Serving Infertile Couples, Islamabad, Pakistan, and comprised male subjects aged 25-55 years. Infertile ... Read more >>

J Pak Med Assoc (JPMA. The Journal of the Pakistan Medical Association)
[2020, 70(3):461-466]

Cited: 1 time

View full text PDF listing >>



Single nucleotide polymorphisms in Renalase and KCNQ1 genes and female infertility: A cross-sectional study in Pakistan.

Syeda Sadia Fatima, Rehana Rehman, Russell Seth Martins, Faiza Alam, Mussarat Ashraf,

A global increase in the incidence of subfertility is observed, and research suggests strong genetic influences that might restrict fertility directly or indirectly. It therefore becomes important to rule out the existence of genetic causes and counsel infertile couples before offering "Advanced Infertility Treatment Techniques." This cross-sectional study aimed to ... Read more >>

Andrologia (Andrologia)
[2019, 51(10):e13434]

Cited: 0 times

View full text PDF listing >>



Kisspeptin and attributes of infertile males and females: A cross-sectional study in a subset of Pakistani population.

Rehana Rehman, Syeda S Fatima, Faiza Alam, Mussarat Ashraf, Shaheen Zafar,

Kisspeptin, a peptide hormone, plays a pivotal role in fertility and neuroendocrine regulation of hypothalamo-pituitary-gonadal axis. Increased kisspeptin and reproductive hormones are responsible for fertility in male and females. This study aimed to explore the role of kisspeptin on hypothalamo-pituitary-gonadal axis by comparing the levels of kisspeptin in fertile and ... Read more >>

Andrologia (Andrologia)
[2019, 51(9):e13370]

Cited: 0 times

View full text PDF listing >>



Longer trinucleotide repeats of androgen Receptor Gene: Infertility in males.

Mussarat Ashraf, Hemaila Tariq, Rehana Rehman,

J Pak Med Assoc (JPMA. The Journal of the Pakistan Medical Association)
[2019, 69(3):446-447]

Cited: 1 time

View full text PDF listing >>



Integration of therapies in autistic children; a survey based in Karachi, Pakistan.

Masnoon Akhter, Mussarat Ashraf, Adnan Ali, Irum Rizwan, Rehana Rehman,

A cross-sectional study was conducted from January to June 2016 on autistic children at the Autism Unit of Dow University of Health Sciences to compare speech therapy, occupational therapy and combination of both for rehabilitation of autistic children in the selected population. A total of 55 children with autism age ... Read more >>

J Pak Med Assoc (JPMA. The Journal of the Pakistan Medical Association)
[2018, 68(10):1508-1512]

Cited: 0 times

View full text PDF listing >>



Cytokines and endometrial receptivity after intracytoplasmic sperm injection - A cohort study at Islamabad.

Rehana Rehman, Mussarat Ashraf, Anila Jasmine, Karishma Lal, Faiza Alam,

OBJECTIVE:To evaluate the role of tumour necrosis factor alpha and interleukin-6 in conception after assisted reproductive treatment. METHODS:The longitudinal cohort study was conducted from August 2014 to May 2015 and comprised patients undergoing intracytoplasmic sperm injection at the Islamabad Clinic Serving Infertile Couples, Islamabad, Pakistan. During the procedure, endometrial thickness ... Read more >>

J Pak Med Assoc (JPMA. The Journal of the Pakistan Medical Association)
[2018, 68(6):862-866]

Cited: 0 times

View full text PDF listing >>



Serum tumour necrosis factor alpha in osteopenic and osteoporotic postmenopausal females: A cross-sectional study in Pakistan.

Rafat Murad, Zahra Shezad, Saara Ahmed, Mussarat Ashraf, Murad Qadir, Rehana Rehman,

OBJECTIVE:To compare biochemical parameters serum tumour necrosis factor alpha, calcium, magnesium, bone-specific alkaline phosphatase and vitamin D in postmenopausal women. METHODS:This cross-sectional study was carried out from June 2015 to July 2016 at Jinnah Medical and Dental College, Karachi, and comprised postmenopausal women. Bone mineral density done by dual energy ... Read more >>

J Pak Med Assoc (JPMA. The Journal of the Pakistan Medical Association)
[2018, 68(3):428-431]

Cited: 0 times

View full text PDF listing >>



Alternate efflux pump mechanism may contribute to drug resistance in extensively drug-resistant isolates of Mycobacterium tuberculosis.

Akbar Kanji, Rumina Hasan, Ambreen Zaver, Asho Ali, Kehkashan Imtiaz, Mussarat Ashraf, Taane G Clark, Ruth McNerney, Samreen Shafiq, Zahra Hasan,

INTRODUCTION:Extensively drug-resistant tuberculosis (XDR-TB) has emerged as one of the biggest threats to public health and TB control programs worldwide. XDR-TB is caused by Mycobacterium tuberculosis (MTB) strains resistant to rifampin and isoniazid, as well as to a fluoroquinolone and to at least one injectable aminoglycoside. Drug resistance in MTB ... Read more >>

Int J Mycobacteriol (International journal of mycobacteriology)
[2016, 5 Suppl 1:S97-S98]

Cited: 4 times

View full text PDF listing >>



Effective testing for pulmonary tuberculosis using Xpert MTB/RIF assay for stool specimens in immunocompetent Pakistani children.

Zahra Hasan, Fehmina Arif, Sadia Shakoor, Aisha Mehnaz, Alnoor Akber, Akbar Kanji, Mussarat Ashraf, Rumina Hasan,

Childhood tuberculosis (TB) is largely a paucibacillary disease and difficult to diagnose. It is difficult to obtain a sputum or gastric aspirate (GA) sample, and patients are often undiagnosed and treated empirically. Stool is a noninvasive specimen not usually used for TB testing in Pakistan. We investigated the value of ... Read more >>

Int J Mycobacteriol (International journal of mycobacteriology)
[2016, 5 Suppl 1:S8-S9]

Cited: 1 time

View full text PDF listing >>



Measurement of ESAT6-induced IFNγ responses adjunct with CXCL9 increases the rate of diagnosis of active tuberculosis in an endemic region.

Zahra Hasan, Nisar Rao, Naseem Salahuddin, Mussarat Ashraf, Muniba Islam, Bushra Jamil,

Due to difficulties in direct diagnosis of Mycobacterium tuberculosis infection where site-specific specimens are not available, indirect methods of testing for infection are required. M. tuberculosis early secreted antigen target-6 (ESAT6) induced IFN-γ responses are specific, but do not differentiate between latent and active TB. The use of adjunct biomarkers ... Read more >>

Int J Mycobacteriol (International journal of mycobacteriology)
[2013, 2(3):135-140]

Cited: 0 times

View full text PDF listing >>



BCG vaccination is associated with decreased severity of tuberculosis in Pakistan.

Zahra Hasan, Muhammad Irfan, Javaid A Khan, Shehryar Khaliqdina Jahangir, Muhammad Haris, Mussarat Ashraf, Naseem Salahuddin, Bushra Jamil, Nisar A Rao,

Vaccination with Bacille Calmette-Guérin (BCG) is given at birth to protect against tuberculosis (TB) in Pakistan. The country ranks 6th amongst high-burden countries worldwide and has an incidence of 231/100,000 pyopulation. This was a cross-sectional multi-center hospital-based study. TB patients (n=218) with pulmonary (PTB, n=120) or extrapulmonary (ETB, 98) were ... Read more >>

Int J Mycobacteriol (International journal of mycobacteriology)
[2012, 1(4):201-206]

Cited: 1 time

View full text PDF listing >>



Bleeding disorders in obstetrics and gynaecological practice.

Mussarat Ashraf, Zaiba Sher, Nabila Irum,

The objective of the study was to determine the frequency, types, presenting symptoms and management options in patients with bleeding disorders in the local obstetric and gynaecological practice. This was a descriptive study of oneyear duration conducted at the Pakistan Atomic Energy Commission General Hospital, Islamabad. Types of bleeding disorders ... Read more >>

J Coll Physicians Surg Pak (Journal of the College of Physicians and Surgeons--Pakistan : JCPSP)
[2012, 22(3):192-193]

Cited: 0 times

View full text PDF listing >>



Differential live Mycobacterium tuberculosis-, M. bovis BCG-, recombinant ESAT6-, and culture filtrate protein 10-induced immunity in tuberculosis.

Zahra Hasan, Bushra Jamil, Mussarat Ashraf, Muniba Islam, Maqboola Dojki, Muhammad Irfan, Rabia Hussain,

The high prevalence of Mycobacterium tuberculosis makes it imperative that immune responses to evaluate could be predictive of infection. We investigated live Mycobacterium- and recombinant antigen-induced cytokine and chemokine responses in patients with active tuberculosis (TB) compared with those of healthy controls from an area where TB is endemic (ECs). ... Read more >>

Clin. Vaccine Immunol. (Clinical and vaccine immunology : CVI)
[2009, 16(7):991-998]

Cited: 16 times

View full text PDF listing >>



CCL2 responses to Mycobacterium tuberculosis are associated with disease severity in tuberculosis.

Zahra Hasan, Jacqueline M Cliff, Hazel M Dockrell, Bushra Jamil, Muhammad Irfan, Mussarat Ashraf, Rabia Hussain,

BACKGROUND: Leucocyte activating chemokines such as CCL2, CCL3, and CXCL8 together with proinflammatory IFNgamma, TNFalpha and downmodulatory IL10 play a central role in the restriction of M. tuberculosis infections, but is unclear whether these markers are indicative of tuberculosis disease severity. METHODOLOGY: We investigated live M. tuberculosis- and M. bovis ... Read more >>

PLoS ONE (PloS one)
[2009, 4(12):e8459]

Cited: 36 times

View full text PDF listing >>



ESAT6-induced IFNgamma and CXCL9 can differentiate severity of tuberculosis.

Zahra Hasan, Bushra Jamil, Mussarat Ashraf, Muniba Islam, Muhammad S Yusuf, Javaid A Khan, Rabia Hussain,

BACKGROUND: Protective responses against Mycobacterium tuberculosis are dependent on appropriate T cell and macrophage activation. Mycobacterial antigen six kDa early secreted antigenic target (ESAT6) and culture filtrate protein 10 (CFP10) can detect M. tuberculosis specific IFNgamma responses. However, most studies have been performed in non-endemic regions and to study pulmonary ... Read more >>

PLoS One (PloS one)
[2009, 4(4):e5158]

Cited: 18 times

View full text PDF listing >>



M. leprae inhibits apoptosis in THP-1 cells by downregulation of Bad and Bak and upregulation of Mcl-1 gene expression.

Zahra Hasan, Mussarat Ashraf, Ali Tayyebi, Rabia Hussain,

BACKGROUND: Virulent Mycobacterium leprae interfere with host defense mechanisms such as cytokine activation and apoptosis. The mitochondrial pathway of apoptosis is regulated by the Bcl-2 family of proteins. Expression of Fas ligand and apoptotic proteins is found in leprosy lesions and M. leprae has been shown to activate pro-apoptotic Bcl-2 ... Read more >>

BMC Microbiol. (BMC microbiology)
[2006, 6:78]

Cited: 20 times

View full text PDF listing >>





Advertisement

Disclaimer
1.0663 s