Full Text Journal Articles by
Author Mushi Matjila

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Placental pathology in women with HIV.

Nadia M Ikumi, Mushi Matjila, Clive M Gray, Dilly Anumba, Komala Pillay,

Recognizing the importance of placental features and their unique functions can provide insight into maternal health, the uterine environment during the course of pregnancy, birth outcomes and neonatal health. In the context of HIV and antiretroviral therapy (ART), there have been great strides in the prevention of mother to child ... Read more >>

Placenta (Placenta)
[2021, 115:27-36]

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Maternal characteristics and pregnancy outcomes of hospitalized pregnant women with SARS-CoV-2 infection in South Africa: An International Network of Obstetric Survey Systems-based cohort study.

Samantha Budhram, Valerie Vannevel, Tanita Botha, Lawrence Chauke, Shastra Bhoora, Gaynor M Balie, Natalie Odell, Hennie Lombaard, Amy Wise, Chrysanthi Georgiou, Nondumiso Ngxola, Emma Wynne, Unati Mbewu, Mfundo Mabenge, Sibusiso Phinzi, Nontsikelelo Gubu-Ntaba, Gareth Goldman, Kay Tunkyi, Sudhir Prithipal, Keshree Naidoo, Santhi Venkatachalam, Terence Moodley, Sean Mould, Mzuvele Hlabisa, Logie Govender, Charlene Maistry, John P Habineza, Priya Israel, Serantha Foolchand, Nomandla V Tsibiyane, Mala Panday, Priya Soma-Pillay, Sumaiya Adam, Felicia Molokoane, Matthew S Mojela, Elizabeth J van Rensburg, Tshililo Mashamba, Mushi Matjila, Sue Fawcus, Ayesha Osman, Mareli Venter, Gregory Petro, Ahminah Fakier, Eduard Langenegger, Catherine A Cluver, Adrie Bekker, Liesl de Waard, Chantal Stewart, Nnabuike C Ngene, Ongombe Lunda, Sylvia N Cebekhulu, Siva Moodley, Mama-Asu Koranteng-Peprah, Emmanuel M C Ati, Salome Maswime, Laura M Yates,

<h4>Objective</h4>To describe risk factors and outcomes of pregnant women infected with SARS-CoV-2 admitted to South African healthcare facilities.<h4>Methods</h4>A population-based cohort study was conducted utilizing an amended International Obstetric Surveillance System protocol. Data on pregnant women with SARS-CoV-2 infection, hospitalized between April 14, 2020, and November 24, 2020, were analyzed.<h4>Results</h4>A total ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, :]

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The effects of mode of delivery on causes of postpartum haemorrhage.

Nnabuike Chibuoke Ngene, Jagidesa Moodley, Lameck Chinula, Mushi Matjila,

Eur J Obstet Gynecol Reprod Biol (European journal of obstetrics, gynecology, and reproductive biology)
[2021, 264:388]

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Differential impact of antiretroviral therapy initiated before or during pregnancy on placenta pathology in HIV-positive women.

Nadia M Ikumi, Thokozile R Malaba, Komala Pillay, Marta C Cohen, Hlengiwe P Madlala, Mushi Matjila, Dilly Anumba, Landon Myer, Marie-Louise Newell, Clive M Gray, ,

<h4>Objective</h4>To examine the association between timing of antiretroviral treatment (ART) initiation in HIV-infected women and placental histopathology.<h4>Design</h4>A nested substudy in a larger cohort of HIV-infected women which examined the association between ART status and birth outcomes.<h4>Methods</h4>Placentas (n = 130) were examined for histopathology from two ART groups: stable (n = 53), who initiated ART ... Read more >>

AIDS (AIDS (London, England))
[2021, 35(5):717-726]

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Kisspeptins and Glucose Homeostasis in Pregnancy: Implications for Gestational Diabetes Mellitus-a Review Article.

Ezekiel Musa, Mushi Matjila, Naomi S Levitt,

Gestational diabetes mellitus (GDM) is becoming an increasingly common complication of pregnancy with the global rise of obesity. The precise pathophysiological mechanisms underpinning GDM are yet to be fully elucidated. Kisspeptin, a peptide encoded by the KISS1 gene, is mainly expressed by placental syncytiotrophoblasts during pregnancy. It is an essential ... Read more >>

Reprod Sci (Reproductive sciences (Thousand Oaks, Calif.))
[2021, :]

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The effect of COVID-19 on maternal newborn and child health (MNCH) services in Bangladesh, Nigeria and South Africa: call for a contextualised pandemic response in LMICs.

Tanvir Ahmed, Ahmed Ehsanur Rahman, Taiwo Gboluwaga Amole, Hadiza Galadanci, Mushi Matjila, Priya Soma-Pillay, Bronwen M Gillespie, Shams El Arifeen, Dilly O C Anumba,

Global response to COVID-19 pandemic has inadvertently undermined the achievement of existing public health priorities and laregely overlooked local context. Recent evidence suggests that this will cause additional maternal and childhood mortality and morbidity especially in low- and middle-income countries (LMICs). Here we have explored the contextual factors influencing maternal, neonatal ... Read more >>

Int J Equity Health (International journal for equity in health)
[2021, 20(1):77]

Cited: 1 time

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Blood pressure trajectories during pregnancy and associations with adverse birth outcomes among HIV-infected and HIV-uninfected women in South Africa: a group-based trajectory modelling approach.

Thokozile R Malaba, Annibale Cois, Hlengiwe P Madlala, Mushi Matjila, Landon Myer, Marie-Louise Newell, ,

<h4>Background</h4>High blood pressure (BP) late in pregnancy is associated with preterm delivery (PTD); BP has also been associated with HIV and antiretroviral therapy (ART), but whether the relationship between BP assessed longitudinally over pregnancy and PTD and low birthweight (LBW) is modified by HIV/ART is unclear. We hypothesise the presence ... Read more >>

BMC Pregnancy Childbirth (BMC pregnancy and childbirth)
[2020, 20(1):742]

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Outcomes of hyperglycaemia in pregnancy in Africa: systematic review study protocol.

Ezekiel Musa, Tawanda Chivese, Mahmoud Werfalli, Mushi Matjila, Shane A Norris, Naomi Levitt,

<h4>Introduction</h4>The prevalence of diabetes mellitus globally has increased considerably over the past decades with a resultant increase in the incidence of diabetes-complicated pregnancies. Hyperglycaemia in pregnancy is the most common metabolic complication encountered during pregnancy and is associated with adverse maternal and fetal outcomes. This systematic review aims to examine ... Read more >>

BMJ Open (BMJ open)
[2021, 11(2):e040921]

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Associating antiretroviral therapy initiated before or during pregnancy with placenta pathology in HIV infected women

Nadia Ikumi, Thokozile Malaba, Komala Pillay, Marta Cohen, Hlengiwe Madlala, Mushi Matjila, Dilly Anumba, Landon Myer, Marie-Louise Newell, Clive Gray, ,

<h4>ABSTRACT</h4> <h4>Background</h4> Antiretroviral therapy (ART) is universally recommended for all HIV-infected pregnant women to improve survival and to reduce mother-to-child HIV transmission. With widespread use of ART in areas of high HIV prevalence, there is concern that prolonged in-utero ART exposure may result in adverse birth outcomes, such as preterm ... Read more >>

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Medical conditions associated with recurrent miscarriage-Is BMI the tip of the iceberg?

Mushi J Matjila, Anne Hoffman, Zephne M van der Spuy,

<h4>Background</h4>In contrast to sporadic miscarriage, recurrent miscarriage (RM) is a rare entity which affects 1% of couples attempting conception. It is distressing for couples and healthcare professionals as the aetiology is unclear with limited treatment options. Apart from anti-phospholipid syndrome (APS), the strength of associations between RM and commonly investigated ... Read more >>

Eur J Obstet Gynecol Reprod Biol (European journal of obstetrics, gynecology, and reproductive biology)
[2017, 214:91-96]

Cited: 7 times

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Preeclampsia in 2017: Obstetric and Anaesthesia Management.

Ross Hofmeyr, Mushi Matjila, Robert Dyer,

In many centres, anaesthesia now incorporates perioperative medicine. Preeclampsia is a perioperative medical challenge requiring a multi-disciplinary team. New definitions stress the rapid progression of the disease and highlight the importance of early detection. Anaesthesiologists should understand the pathophysiology of the disease and develop the ultrasound skills required to assist ... Read more >>

Best Pract Res Clin Anaesthesiol (Best practice & research. Clinical anaesthesiology)
[2017, 31(1):125-138]

Cited: 5 times

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Elevated placental expression at the maternal-fetal interface but diminished maternal circulatory kisspeptin in preeclamptic pregnancies.

Mushi Matjila, Robert Millar, Zephne van der Spuy, Arieh Katz,

<h4>Objective</h4>To investigate the placental mRNA and protein expression of metastasis suppressor gene Kiss-1 and the transcript expression of its receptor GPR-54 across the maternal-fetal interface of healthy and preeclamptic pregnancies. To furthermore compare placental tissue kisspeptin expression to circulatory kisspeptin levels in these pregnancies.<h4>Setting</h4>Secondary and Tertiary Hospital Setting in Cape ... Read more >>

Pregnancy Hypertens (Pregnancy hypertension)
[2016, 6(1):79-87]

Cited: 6 times

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Antiretrovirals causing severe pre-eclampsia.

Lloyd Tooke, Linda Riemer, Mushi Matjila, Michael Harrison,

<h4>Background</h4>Extremely low birth weight infants (ELBW) (⩽1000g) at our tertiary hospital have a much higher HIV exposure rate than bigger babies and are mainly delivered due to complications of pre-eclampsia. Studies investigating the effect of HIV or antiretroviral therapy on pre-eclampsia, a partially immune-mediated disease have produced contradictory results.<h4>Objective</h4>To determine ... Read more >>

Pregnancy Hypertens (Pregnancy hypertension)
[2016, 6(4):266-268]

Cited: 10 times

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Stevens Johnson Syndrome and Toxic Epidermal Necrolysis: Maternal and Foetal Outcomes in Twenty-Two Consecutive Pregnant HIV Infected Women.

Lauren Knight, Gail Todd, Rudzani Muloiwa, Mushi Matjila, Rannakoe J Lehloenya,

<h4>Introduction</h4>Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) form a spectrum of a rare and life-threatening cutaneous drug reaction. SJS/TEN in pregnancy poses largely unknown risk factors and outcomes for both the mother and foetus compared to the general population.<h4>Methods</h4>We conducted a study of consecutive pregnant women admitted to single ... Read more >>

PLoS One (PloS one)
[2015, 10(8):e0135501]

Cited: 7 times

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Kisspeptin regulation of genes involved in cell invasion and angiogenesis in first trimester human trophoblast cells.

Víctor A Francis, Aron B Abera, Mushi Matjila, Robert P Millar, Arieh A Katz,

The precise regulation of extravillous trophoblast invasion of the uterine wall is a key process in successful pregnancies. Kisspeptin (KP) has been shown to inhibit cancer cell metastasis and placental trophoblast cell migration. In this study primary cultures of first trimester human trophoblast cells have been utilized in order to ... Read more >>

PLoS One (PloS one)
[2014, 9(6):e99680]

Cited: 20 times

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The differential expression of Kiss1, MMP9 and angiogenic regulators across the feto-maternal interface of healthy human pregnancies: implications for trophoblast invasion and vessel development.

Mushi Matjila, Robert Millar, Zephne van der Spuy, Arieh Katz,

Genes involved in invasion of trophoblast cells and angiogenesis are crucial in determining pregnancy outcome. We therefore studied expression profiles of these genes in both fetal and maternal tissues to enhance our understanding of feto-maternal dialogue. We investigated the expression of genes involved in trophoblast invasion, namely Kiss1, Kiss1 Receptor ... Read more >>

PLoS One (PloS one)
[2013, 8(5):e63574]

Cited: 14 times

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