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Author Musa Sekikubo

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"What are you carrying?" Experiences of mothers with preterm babies in low-resource setting neonatal intensive care unit: a qualitative study.

Fatuma Namusoke, Musa Sekikubo, Flavia Namiiro, Janet Nakigudde,

<h4>Introduction</h4>Babies born preterm often have challenges in feeding, temperature control and breathing difficulty and are prone to infection during the neonatal period. These usually necessitate admission to the neonatal intensive care unit (NICU). Admission to NICU disrupts the mother-baby bonding.<h4>Objective</h4>This study explored the lived experiences of mothers with preterm babies ... Read more >>

BMJ Open (BMJ open)
[2021, 11(9):e043989]

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Indirect effects of COVID-19 on maternal, neonatal, child, sexual and reproductive health services in Kampala, Uganda.

Jessica Florence Burt, Joseph Ouma, Lawrence Lubyayi, Alexander Amone, Lorna Aol, Musa Sekikubo, Annettee Nakimuli, Eve Nakabembe, Robert Mboizi, Philippa Musoke, Mary Kyohere, Emily Namara Lugolobi, Asma Khalil, Kirsty Le Doare,

<h4>Background</h4>COVID-19 impacted global maternal, neonatal and child health outcomes. We hypothesised that the early, strict lockdown that restricted individuals' movements in Uganda limited access to services.<h4>Methods</h4>An observational study, using routinely collected data from Electronic Medical Records, was carried out, in Kawempe district, Kampala. An interrupted time series analysis assessed the ... Read more >>

BMJ Glob Health (BMJ global health)
[2021, 6(8):]

Cited: 1 time

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Level of and factors associated with awareness of gestational diabetes mellitus among pregnant women attending antenatal care at Kawempe National Referral Hospital: a cross sectional study.

Elizabeth Byakwaga, Musa Sekikubo, Annettee Nakimuli,

<h4>Background</h4>The burden of Gestational diabetes mellitus (GDM) is significantly increasing worldwide and the disorder causes substantial short term and long-term adverse effects both to the mother and the unborn baby. Public health measures to increase awareness of GDM among pregnant women may aid in prevention of the disease through life ... Read more >>

BMC Pregnancy Childbirth (BMC pregnancy and childbirth)
[2021, 21(1):467]

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Adverse pregnancy outcomes associated with moderate elevations in blood pressure or blood glucose in Ugandan women; a prospective cohort study.

Jack Milln, Betty Nakabuye, Barnabas Natamba, Isaac Sekitoleko, Michael Mubiru, Arthur Namara, Samuel Tumwesigire, Tino Salome, Mandy Mirembe, Ayoub Kakanda, Brian Agaba, Faridah Nansubuga, Daniel Zaake, Ben Ayiko, Herbert Kalema, Sarah Nakubulwa, Musa Sekikubo, Annettee Nakimuli, Emily L Webb, Moffat J Nyirenda,

<h4>Background</h4>The association between overt hypertension and diabetes and adverse pregnancy outcomes is well documented. Recent evidence suggests that even moderate elevations in blood pressure or blood glucose may confer a significant risk in a dose-dependent manner. However, these studies have primarily been undertaken in white populations in high-income settings. Hypertension ... Read more >>

AJOG Glob Rep (AJOG global reports)
[2021, 1(2):100007]

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Antenatal management and maternal/fetal outcomes associated with hyperglycaemia in pregnancy (HIP) in Uganda; a prospective cohort study.

Jack Milln, Betty Nakabuye, Barnabas Kahiira Natamba, Isaac Sekitoleko, Michael Mubiru, Arthur Araali Namara, Samuel Tumwesigire, Salome Tino, Mandy Mirembe, Ayoub Kakande, Brian Agaba, Faridah Nansubuga, Daniel Zaake, Ben Ayiko, Herbert Kalema, Sarah Nakubulwa, Musa Sekikubo, Annettee Nakimuli, Emily L Webb, Moffat J Nyirenda,

<h4>Background</h4>Hyperglycaemia in pregnancy (HIP) is associated with complications for both mother and baby. The prevalence of the condition is likely to increase across Africa as the continent undergoes a rapid demographic transition. However, little is known about the management and pregnancy outcomes associated with HIP in the region, particularly less ... Read more >>

BMC Pregnancy Childbirth (BMC pregnancy and childbirth)
[2021, 21(1):386]

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Indirect Effects of COVID-19 on Maternal, Neonatal, Child, Sexual and Reproductive Health Services in Kampala, Uganda

Jessica Florence Burt, Joseph Ouma, Lawrence Lubyayi, Alexander Amone, Lorna Aol, Musa Sekikubo, Annettee Nakimuli, Eve Nakabembe, Robert Mboizi, Philippa Musoke, Mary Kyohere, Emily Namara, Asma Khalil, Kirsty Le Doare,

<h4>Background: </h4> COVID-19 has impacted global maternal, neonatal and child health outcomes. We hypothesised that the early, strict lockdown which severely limited the movements of individuals in Uganda will have impacted access to services. <h4>Methods:</h4> An observational study, using routinely collected health data from Electronic Medical Records was carried out, ... Read more >>

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Diversity of Vaginal Microbiota Affects Epithelial Barrier Permeability Among African Pregnant Women

Lois Bayigga BBLT, Rose Nabatanzi, Emilie Mausser, David Kateete, Musa Sekikubo, Deborah Anderson, Damalie Nakanjako,

<h4>Background: </h4> Women with diverse genital anaerobic bacterial communities, are at over 4-fold higher risk of HIV acquisition than women with a Lactobacillus -rich vaginal microbiome. The mechanisms underlying this are poorly understood. We set out to examine how vaginal microbiota diversity affects epithelial integrity in HIV sero-negative pregnant women. ... Read more >>

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Effect of SARS-CoV-2 Infection in Pregnancy on Maternal and Neonatal Outcomes in Africa: An AFREhealth Call for Evidence through Multicountry Research Collaboration.

Jean B Nachega, Nadia A Sam-Agudu, Samantha Budhram, Taha E Taha, Valerie Vannevel, Priya Somapillay, Daniel Katuashi Ishoso, Michel Tshiasuma Pipo, Christian Bongo-Pasi Nswe, John Ditekemena, Birhanu T Ayele, Rhoderick N Machekano, Onesmus W Gachuno, John Kinuthia, Nancy Mwongeli, Musa Sekikubo, Philippa Musoke, Evans Kofi Agbeno, Lawal W Umar, Mukanire Ntakwinja, Denis M Mukwege, Emily R Smith, Eduard J Mills, John Otokoye Otshudiema, Placide Mbala-Kingebeni, Jean-Marie N Kayembe, Don Jethro Mavungu Landu, Jean-Jacques Muyembe Tamfum, Alimuddin Zumla, Eduard J Langenegger, Lynne M Mofenson, For The AFREhealth Covid-Research Collaboration Working Group,

In the African context, there is a paucity of data on SARS-CoV-2 infection and associated COVID-19 in pregnancy. Given the endemicity of infections such as malaria, HIV, and tuberculosis (TB) in sub-Saharan Africa (SSA), it is important to evaluate coinfections with SARS-CoV-2 and their impact on maternal/infant outcomes. Robust research ... Read more >>

Am J Trop Med Hyg (The American journal of tropical medicine and hygiene)
[2020, :]

Cited: 4 times

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Seroepidemiology of maternally-derived antibody against Group B Streptococcus (GBS) in Mulago/Kawempe Hospitals Uganda - PROGRESS GBS.

Mary Kyohere, Hannah Georgia Davies, Philippa Musoke, Annettee Nakimuli, Valerie Tusubira, Hannington Baluku Tasimwa, Juliet Sendagala Nsimire, Paul Heath, Stephen Cose, Carol Baker, Kirsty Le Doare, Musa Sekikubo,

<b>Background</b>: Group B <i>Streptococcus</i> (GBS) is a major contributor to the high burden of neonatal and young infant infectious disease in resource- limited settings. As disease protection during the first six months of life is provided via placental transfer of maternal antibodies, a maternal GBS vaccine may provide an effective ... Read more >>

Gates Open Res (Gates open research)
[2020, 4:155]

Cited: 1 time

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Seroepidemiology of maternally-derived antibody against Group B Streptococcus (GBS) in Mulago/Kawempe Hospitals Uganda - PROGRESS GBS

Mary Kyohere, Hannah Georgia Davies, Philippa Musoke, Annettee Nakimuli, Valerie Tusubira, Hannington Baluku Tasimwa, Juliet Sendagala Nsimire, Paul Heath, Stephen Cose, Carol Baker, Kirsty Le Doare, Musa Sekikubo,

<ns3:p> <h4>Background: </h4> Group B <ns3:italic>Streptococcus</ns3:italic> (GBS) is a major contributor to the high burden of neonatal and young infant infectious disease in resource- limited settings. As disease protection during the first six months of life is provided via placental transfer of maternal antibodies, a maternal GBS vaccine may provide ... Read more >>

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SARS-CoV-2 Infection in Pregnant Women and Their Newborns.

Melanie Etti, Musa Sekikubo, Victoria Nankabirwa, Halvor Sommerfelt, Bridget Freyne, Kondwani Kawaza, Gladys Gadama, Kondwani Jambo, Esperança Sevene, Marleen Temmerman, Laura A Magee, Peter von Dadelszen, Asma Khalil, Kirsty Le Doare, ,

There remain a number of uncertainties globally about the risks posed to women who are infected with SARS-CoV-2 during pregnancy. Furthermore, our understanding of the spread of COVID-19 in Sub-Saharan Africa is limited, owing to low testing rates in many parts of the continent. PeriCOVID Africa, in conjunction with the ... Read more >>

Ann Glob Health (Annals of global health)
[2020, 86(1):132]

Cited: 1 time

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Decision-to-delivery interval of emergency cesarean section in Uganda: a retrospective cohort study.

Noemi J Hughes, Imelda Namagembe, Annettee Nakimuli, Musa Sekikubo, Ashley Moffett, Charlotte J Patient, Catherine E Aiken,

<h4>Background</h4>In many low and medium human development index countries, the rate of maternal and neonatal morbidity and mortality is high. One factor which may influence this is the decision-to-delivery interval of emergency cesarean section. We aimed to investigate the maternal risk factors, indications and decision-to-delivery interval of emergency cesarean section ... Read more >>

BMC Pregnancy Childbirth (BMC pregnancy and childbirth)
[2020, 20(1):324]

Cited: 5 times

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Relative impact of pre-eclampsia on birth weight in a low resource setting: A prospective cohort study.

Annettee Nakimuli, Jennifer E Starling, Sarah Nakubulwa, Imelda Namagembe, Musa Sekikubo, Eve Nakabembe, James G Scott, Ashley Moffett, Catherine E Aiken,

<h4>Objectives</h4>Low birth-weight is a major risk factor for perinatal death in sub-Saharan Africa, but the relative contribution of determinants of birth-weight are difficult to disentangle in low resource settings. We sought to delineate the relationship between birth-weight and maternal pre-eclampsia across gestation in a low-resource obstetric setting.<h4>Study design</h4>Prospective cohort study ... Read more >>

Pregnancy Hypertens (Pregnancy hypertension)
[2020, 21:1-6]

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Decision-to-delivery interval of emergency cesarean section in Uganda: a retrospective cohort study

Noemi Hughes, Imelda Namagembe, Annettee Nakimuli, Musa Sekikubo, Ashley Moffett, Charlotte Patient, Catherine Aiken,

<h4>Background: </h4> In many low and medium human development index countries, the rate of maternal and neonatal morbidity and mortality is high. One factor which may influence this is the decision-to-delivery interval of emergency cesarean section. We aimed to investigate the maternal risk factors, indications and decision-to-delivery interval of emergency ... Read more >>

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Understanding Men's Perceptions of Human Papillomavirus and Cervical Cancer Screening in Kampala, Uganda.

Erin Moses, Heather N Pedersen, Emily C Wagner, Musa Sekikubo, Deborah M Money, Gina S Ogilvie, Sheona M Mitchell-Foster,

<h4>Purpose</h4>This preliminary study explores Ugandan men's knowledge and attitudes about human papillomavirus (HPV), cervical cancer, and screening.<h4>Methods</h4>A local physician led an education session about cervical cancer for 62 men in Kisenyi, Kampala in Uganda. Trained nurse midwives administered surveys to assess knowledge and attitudes before and after the education session.<h4>Results</h4>From ... Read more >>

J Glob Oncol (Journal of global oncology)
[2018, 4:1-9]

Cited: 1 time

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Diversity of vaginal microbiota in sub-Saharan Africa and its effects on HIV transmission and prevention.

Lois Bayigga, David P Kateete, Deborah J Anderson, Musa Sekikubo, Damalie Nakanjako,

The vaginal microbial community ("microbiota") is a key component of the reproductive health of women, providing protection against urogenital infections. In sub-Saharan Africa, there is a high prevalence of bacterial vaginosis, a condition defined by bacterial overgrowth and a shift away from a Lactobacillus-dominated profile toward increased percentages of strict ... Read more >>

Am J Obstet Gynecol (American journal of obstetrics and gynecology)
[2019, 220(2):155-166]

Cited: 15 times

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Community-based HPV self-collection versus visual inspection with acetic acid in Uganda: a cost-effectiveness analysis of the ASPIRE trial.

Alex K Mezei, Heather N Pedersen, Stephen Sy, Catherine Regan, Sheona M Mitchell-Foster, Josaphat Byamugisha, Musa Sekikubo, Heather Armstrong, Angeli Rawat, Joel Singer, Gina S Ogilvie, Jane J Kim, Nicole G Campos,

BACKGROUND:Cervical cancer is the leading cause of cancer death for women in Uganda, despite the potential for prevention through organised screening. Community-based self-collected human papillomavirus (HPV) testing has been proposed to reduce barriers to screening. OBJECTIVE:Our objective was to evaluate the cost-effectiveness of the Advances in Screening and Prevention of ... Read more >>

BMJ Open (BMJ open)
[2018, 8(6):e020484]

Cited: 8 times

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Antibiotic Overconsumption in Pregnant Women With Urinary Tract Symptoms in Uganda.

Musa Sekikubo, Karolina Hedman, Florence Mirembe, Annelie Brauner,

<h4>Background</h4>Urinary tract infections (UTIs) are one of the most common bacterial infections in women. During pregnancy physiological changes, like frequency, mimic UTI symptoms, and therefore bacteriological cultures are needed to confirm the diagnosis. However, in developing countries antibiotic therapy is commonly initiated without culture confirmation.<h4>Methods</h4>We investigated the prevalence of bacteriuria ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2017, 65(4):544-550]

Cited: 6 times

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Cost-effectiveness of cervical cancer screening methods in low- and middle-income countries: A systematic review.

Alex K Mezei, Heather L Armstrong, Heather N Pedersen, Nicole G Campos, Sheona M Mitchell, Musa Sekikubo, Josaphat K Byamugisha, Jane J Kim, Stirling Bryan, Gina S Ogilvie,

The incidence of cervical cancer in low- and middle-income countries (LMICs) is five times higher than that observed in high-income countries (HICs). This discrepancy is largely attributed to the implementation of cytology-based screening programmes in HICs. However, due to reduced health system infrastructure requirements, HPV testing (self- and provider-collected) and ... Read more >>

Int J Cancer (International journal of cancer)
[2017, 141(3):437-446]

Cited: 30 times

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Self-collection based HPV testing for cervical cancer screening among women living with HIV in Uganda: a descriptive analysis of knowledge, intentions to screen and factors associated with HPV positivity.

Sheona M Mitchell, Heather N Pedersen, Evelyn Eng Stime, Musa Sekikubo, Erin Moses, David Mwesigwa, Christine Biryabarema, Jan Christilaw, Josaphat K Byamugisha, Deborah M Money, Gina S Ogilvie,

<h4>Background</h4>Women living with HIV (WHIV) are disproportionately impacted by cervical dysplasia and cancer. The burden is greatest in low-income countries where limited or no access to screening exists. The goal of this study was to describe knowledge and intentions of WHIV towards HPV self-collection for cervical cancer screening, and to ... Read more >>

BMC Womens Health (BMC women's health)
[2017, 17(1):4]

Cited: 6 times

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A phase 2b randomized, controlled trial of the efficacy of the GMZ2 malaria vaccine in African children.

Sodiomon B Sirima, Benjamin Mordmüller, Paul Milligan, Ulysse Ateba Ngoa, Fred Kironde, Frank Atuguba, Alfred B Tiono, Saadou Issifou, Mark Kaddumukasa, Oscar Bangre, Clare Flach, Clare Flach, Michael Christiansen, Peter Bang, Roma Chilengi, Søren Jepsen, Peter G Kremsner, Michael Theisen, ,

<h4>Background</h4>GMZ2 is a recombinant protein malaria vaccine, comprising two blood-stage antigens of Plasmodium falciparum, glutamate-rich protein and merozoite surface protein 3. We assessed efficacy of GMZ2 in children in Burkina Faso, Gabon, Ghana and Uganda.<h4>Methods</h4>Children 12-60months old were randomized to receive three injections of either 100μg GMZ2 adjuvanted with aluminum ... Read more >>

Vaccine (Vaccine)
[2016, 34(38):4536-4542]

Cited: 35 times

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Strategies for Community Education Prior to Clinical Trial Recruitment for a Cervical Cancer Screening Intervention in Uganda.

Sheona M Mitchell, Heather N Pedersen, Musa Sekikubo, Christine Biryabarema, Josaphat J K Byamugisha, David Mwesigwa, Malcolm Steinberg, Deborah M Money, Gina S Ogilvie,

<h4>Introduction</h4>Community engagement and education can improve acceptability and participation in clinical trials conducted in Kisenyi, Uganda. In preparation for a randomized controlled trial exploring different methods for cervical cancer screening, we explored optimal engagement strategies from the perspective of community members and health professionals.<h4>Methods</h4>We conducted key informant interviews followed by ... Read more >>

Front Oncol (Frontiers in oncology)
[2016, 6:90]

Cited: 1 time

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Uptake of community-based, self-collected HPV testing vs. visual inspection with acetic acid for cervical cancer screening in Kampala, Uganda: preliminary results of a randomised controlled trial.

Erin Moses, Heather N Pedersen, Sheona M Mitchell, Musa Sekikubo, David Mwesigwa, Joel Singer, Christine Biryabarema, Josaphat K Byamugisha, Deborah M Money, Gina S Ogilvie,

<h4>Objectives</h4>To compare two cervical cancer screening methods: community-based self-collection of high-risk human papillomavirus (HR-HPV) testing and visual inspection with acetic acid (VIA).<h4>Methods</h4>Pilot randomised controlled trial of 500 women aged 30-65 in the community of Kisenyi, Uganda. Women randomised to self-collection-based HR-HPV testing provided a cervico-vaginal swab for HR-HPV, and results ... Read more >>

Trop Med Int Health (Tropical medicine & international health : TM & IH)
[2015, 20(10):1355-1367]

Cited: 30 times

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Antibiotic prophylaxis for caesarean section at a Ugandan hospital: a randomised clinical trial evaluating the effect of administration time on the incidence of postoperative infections.

Lomangisi D Dlamini, Musa Sekikubo, Janat Tumukunde, Charles Kojjo, Davidson Ocen, Agnes Wabule, Arthur Kwizera,

<h4>Background</h4>Prophylactic antibiotics are used to prevent postoperative infections after caesarean section. Studies have suggested that the timing of prophylaxis plays an important role. Over the years, the role of the anaesthesiologist in the administration of prophylactic antibiotics has become prominent. Therefore, there is an increasing need for anaesthesia providers to ... Read more >>

BMC Pregnancy Childbirth (BMC pregnancy and childbirth)
[2015, 15:91]

Cited: 7 times

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Malariometric indices from Iganga, Uganda: baseline characterization in preparation of GMZ2 vaccine trial.

Mark Kaddumukasa, William Buwembo, Musa Sekikubo, Halima Naiwumbwe, Fatuma Namusoke, Stephen Kiwuwa, Brenda Oketch, Ramadhani Noor, Roma Chilengi, Edison Mworozi, Fred Kironde,

<h4>Background</h4>Malaria still remains the leading cause of childhood morbidity and mortality in Uganda. Interventions like malaria vaccines which reduce the malaria burden are needed in malaria endemic communities. There is need to establish baseline characteristics in vaccine trial study sites. This study determined the following baseline malariometric indices: spleen rates, ... Read more >>

BMC Res Notes (BMC research notes)
[2014, 7:793]

Cited: 2 times

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