Full Text Journal Articles by
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Lessons learned from a progressive supranuclear palsy trial.

Murray Grossman,

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):162-163]

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Association of Mitochondrial DNA Genomic Variation with Risk of Pick's disease.

Rebecca R Valentino, Michael G Heckman, Patrick W Johnson, Matthew C Baker, Alexandra I Soto-Beasley, Ronald L Walton, Shunsuke Koga, Shanu F Roemer, EunRan Suh, Ryan J Uitti, John Q Trojanowski, Murray Grossman, Vivianna M Van Deerlin, Rosa Rademakers, Zbigniew K Wszolek, Dennis W Dickson, Owen A Ross,

<h4>Objective</h4>To determine if stable polymorphisms which define mitochondrial haplogroups in mitochondrial DNA (mtDNA) are associated with Pick's disease risk, we genotyped 52 pathologically confirmed Pick's disease cases and 910 neurologically healthy controls and performed case-control association analysis.<h4>Methods</h4>52 pathologically confirmed Pick's disease cases from Mayo Clinic Florida (N=38) and the University ... Read more >>

Neurology (Neurology)
[2021, :]

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Frontotemporal lobar degeneration proteinopathies have disparate microscopic patterns of white and grey matter pathology.

Lucia A A Giannini, Claire Peterson, Daniel Ohm, Sharon X Xie, Corey T McMillan, Katya Raskovsky, Lauren Massimo, EunRah Suh, Vivianna M Van Deerlin, David A Wolk, John Q Trojanowski, Edward B Lee, Murray Grossman, David J Irwin,

Frontotemporal lobar degeneration proteinopathies with tau inclusions (FTLD-Tau) or TDP-43 inclusions (FTLD-TDP) are associated with clinically similar phenotypes. However, these disparate proteinopathies likely differ in cellular severity and regional distribution of inclusions in white matter (WM) and adjacent grey matter (GM), which have been understudied. We performed a neuropathological study ... Read more >>

Acta Neuropathol Commun (Acta neuropathologica communications)
[2021, 9(1):30]

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Cognitive Profile and Markers of AD-Type Pathology in Patients with Lewy Body Dementias.

Erica Howard, David J Irwin, Katya Rascovsky, Naomi Nevler, Sanjana Shellikeri, Thomas F Tropea, Meredith Spindler, Andres Deik, Alice Chen-Plotkin, Andrew Siderowf, Nabila Dahodwala, Daniel Weintraub, Leslie M Shaw, John Q Trojanowski, Sanjeev N Vaishnavi, David A Wolk, Dawn Mechanic-Hamilton, James F Morley, John E Duda, Murray Grossman, Katheryn Aq Cousins,

<h4>Objective</h4>To determine whether Lewy body dementia (LBD) patients with likely Alzheimer's disease-type (AD-type) co-pathology are more impaired on confrontation naming than those without likely AD-type co-pathology.<h4>Methods</h4>We selected 57 LBD patients (dementia with Lewy bodies, DLB, n=38; Parkinson's disease dementia, PDD, n=19) with available AD CSF biomarkers and neuropsychological data. CSF ... Read more >>

Neurology (Neurology)
[2021, :]

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3D Mapping of Neurofibrillary Tangle Burden in the Human Medial Temporal Lobe

Paul Yushkevich, Mónica Muñoz López, Maria Mercedes Iñiguez de Onzoño Martin, Ranjit Ittyerah, Sydney Lim, Sadhana Ravikumar, Madigan Bedard, Stephen Pickup, Weixia Liu, Jiancong Wang, Ling Yu Hung, Jade Lasserve, Nicolas Vergnet, Long Xie, Mengjin Dong, Salena Cui, Lauren McCollum, John Robinson, Theresa Schuck, Robin de Flores, Murray Grossman, Dylan Tisdall, Karthik Prabhakaran, Gabor Mizsei, Sandhitsu Das, Emilio Artacho-Pérula, María del Mar Arroyo Jiménez, María Pilar Marcos Rabal, Francisco Javier Molina Romero, Sandra Cebada Sánchez, José Carlos Delgado González, Carlos de la Rosa-Prieto, Marta Córcoles Parada, Edward Lee, John Trojanowski, Daniel Ohm, Laura E.M. Wisse, David Wolk, David Irwin, Ricardo Insausti,

Abstract Tau protein neurofibrillary tangles (NFT) are closely linked to neuronal/synaptic loss and cognitive decline in Alzheimer's disease (AD) and related dementias. Our knowledge of the pattern of NFT progression in the human brain, critical to the development of imaging biomarkers and interpretation of in vivo imaging studies in AD, ... Read more >>

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Hippocampal subfield pathologic Burden in Lewy body diseases versus Alzheimer's disease.

David G Coughlin, Murray Grossman, John Q Trojanowski, David J Irwin,

Neuropathol Appl Neurobiol (Neuropathology and applied neurobiology)
[2021, :]

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Lexical and Acoustic Characteristics of Young and Older Healthy Adults.

Sunghye Cho, Naomi Nevler, Sanjana Shellikeri, Natalia Parjane, David J Irwin, Neville Ryant, Sharon Ash, Christopher Cieri, Mark Liberman, Murray Grossman,

Purpose This study examines the effect of age on language use with an automated analysis of digitized speech obtained from semistructured, narrative speech samples. Method We examined the Cookie Theft picture descriptions produced by 37 older and 76 young healthy participants. Using modern natural language processing and automatic speech recognition ... Read more >>

J Speech Lang Hear Res (Journal of speech, language, and hearing research : JSLHR)
[2021, 64(2):302-314]

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An Evaluation of Empirical Approaches for Defining Cognitive Impairment in Amyotrophic Lateral Sclerosis

Corey McMillan, Joanne Wuu, Katya Rascovsky, Stephanie Cosentino, Murray Grossman, Lauren Elman, Colin Quinn, Luis Rosario, Jessica Stark, Volkan Granit, Hannah Briemberg, Sneha Chenji, Annie Dionne, Angela Genge, Wendy Johnston, Lawrence Korngut, Christen Shoesmith, Lorne Zinman, Sanjay Kalra, Michael Benatar, ,

<h4>Importance</h4> Amyotrophic lateral sclerosis (ALS) is a multi-system disorder characterized primarily by motor neuron degeneration, but may be accompanied by cognitive dysfunction. Statistically appropriate criteria for establishing cognitive impairment (CI) in ALS are lacking. <h4>Objective</h4> Define thresholds for CI in ALS using quantile regression (QR) that accounts for age and ... Read more >>

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Frontotemporal lobar degeneration proteinopathies have disparate microscopic patterns of white and grey matter pathology

Lucia A. A. Giannini, Claire Peterson, Daniel Ohm, Sharon X. Xie, Corey T. McMillan, Katya Raskovsky, Lauren Massimo, EunRah Suh, Vivianna M. Van Deerlin, David A. Wolk, John Q. Trojanowski, Edward B. Lee, Murray Grossman, David J. Irwin,

Frontotemporal lobar degeneration proteinopathies with tau inclusions (FTLD-Tau) or TDP-43 inclusions (FTLD-TDP) are associated with clinically similar phenotypes. However, these disparate proteinopathies likely differ in cellular severity and regional distribution of inclusions in white matter (WM) and adjacent grey matter (GM), which have been understudied. We performed a neuropathological study ... Read more >>

Acta Neuropathol Commun (Acta neuropathologica communications)
[2021, 9(1):]

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Brain volumetric deficits in MAPT mutation carriers: a multisite study.

Stephanie A Chu, Taru M Flagan, Adam M Staffaroni, Lize C Jiskoot, Jersey Deng, Salvatore Spina, Liwen Zhang, Virginia E Sturm, Jennifer S Yokoyama, William W Seeley, Janne M Papma, Dan H Geschwind, Howard J Rosen, Bradley F Boeve, Adam L Boxer, Hilary W Heuer, Leah K Forsberg, Danielle E Brushaber, Murray Grossman, Giovanni Coppola, Bradford C Dickerson, Yvette M Bordelon, Kelley Faber, Howard H Feldman, Julie A Fields, Jamie C Fong, Tatiana Foroud, Ralitza H Gavrilova, Nupur Ghoshal, Neill R Graff-Radford, Ging-Yuek Robin Hsiung, Edward D Huey, David J Irwin, Kejal Kantarci, Daniel I Kaufer, Anna M Karydas, David S Knopman, John Kornak, Joel H Kramer, Walter A Kukull, Maria I Lapid, Irene Litvan, Ian R A Mackenzie, Mario F Mendez, Bruce L Miller, Chiadi U Onyike, Alexander Y Pantelyat, Rosa Rademakers, Eliana Marisa Ramos, Erik D Roberson, Maria Carmela Tartaglia, Nadine A Tatton, Arthur W Toga, Ashley Vetor, Sandra Weintraub, Bonnie Wong, Zbigniew K Wszolek, , John C Van Swieten, Suzee E Lee,

<h4>Objective</h4>MAPT mutations typically cause behavioral variant frontotemporal dementia with or without parkinsonism. Previous studies have shown that symptomatic MAPT mutation carriers have frontotemporal atrophy, yet studies have shown mixed results as to whether presymptomatic carriers have low gray matter volumes. To elucidate whether presymptomatic carriers have lower structural brain volumes ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2021, 8(1):95-110]

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Machine learning suggests polygenic risk for cognitive dysfunction in amyotrophic lateral sclerosis.

Katerina Placek, Michael Benatar, Joanne Wuu, Evadnie Rampersaud, Laura Hennessy, Vivianna M Van Deerlin, Murray Grossman, David J Irwin, Lauren Elman, Leo McCluskey, Colin Quinn, Volkan Granit, Jeffrey M Statland, Ted M Burns, John Ravits, Andrea Swenson, Jon Katz, Erik P Pioro, Carlayne Jackson, James Caress, Yuen So, Samuel Maiser, David Walk, Edward B Lee, John Q Trojanowski, Philip Cook, James Gee, Jin Sha, Adam C Naj, Rosa Rademakers, , Wenan Chen, Gang Wu, J Paul Taylor, Corey T McMillan,

Amyotrophic lateral sclerosis (ALS) is a multi-system disease characterized primarily by progressive muscle weakness. Cognitive dysfunction is commonly observed in patients; however, factors influencing risk for cognitive dysfunction remain elusive. Using sparse canonical correlation analysis (sCCA), an unsupervised machine-learning technique, we observed that single nucleotide polymorphisms collectively associate with baseline ... Read more >>

EMBO Mol Med (EMBO molecular medicine)
[2021, 13(1):e12595]

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ATN incorporating cerebrospinal fluid neurofilament light chain detects frontotemporal lobar degeneration.

Katheryn A Q Cousins, Jeffrey S Phillips, David J Irwin, Edward B Lee, David A Wolk, Leslie M Shaw, Henrik Zetterberg, Kaj Blennow, Sarah E Burke, Nikolas G Kinney, Garrett S Gibbons, Corey T McMillan, John Q Trojanowski, Murray Grossman,

<h4>Introduction</h4>The ATN framework provides an in vivo diagnosis of Alzheimer's disease (AD) using cerebrospinal fluid (CSF) biomarkers of pathologic amyloid plaques (A), tangles (T), and neurodegeneration (N). ATN is rarely evaluated in pathologically confirmed patients and its poor sensitivity to suspected non-Alzheimer's pathophysiologies (SNAP), including frontotemporal lobar degeneration (FTLD), leads ... Read more >>

Alzheimers Dement (Alzheimer's & dementia : the journal of the Alzheimer's Association)
[2020, :]

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Cross-sectional and longitudinal medial temporal lobe subregional atrophy patterns in semantic variant primary progressive aphasia.

Laura E M Wisse, Molly B Ungrady, Ranjit Ittyerah, Sydney A Lim, Paul A Yushkevich, David A Wolk, David J Irwin, Sandhitsu R Das, Murray Grossman,

T1-magnetic resonance imaging (MRI) studies report early atrophy in the left anterior temporal lobe, especially the perirhinal cortex, in semantic variant primary progressive aphasia (svPPA). Improved segmentation protocols using high-resolution T2-MRI have enabled fine-grained medial temporal lobe (MTL) subregional measurements, which may provide novel information on the atrophy pattern and ... Read more >>

Neurobiol Aging (Neurobiology of aging)
[2021, 98:231-241]

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Tau pathology associates with in vivo cortical thinning in Lewy body disorders.

Nicola Spotorno, David G Coughlin, Christopher A Olm, David Wolk, Sanjeev N Vaishnavi, Leslie M Shaw, Nabila Dahodwala, James F Morley, John E Duda, Andres F Deik, Meredith A Spindler, Alice Chen-Plotkin, Edward B Lee, John Q Trojanowski, Corey T McMillan, Daniel Weintraub, Murray Grossman, David J Irwin,

<h4>Objectives</h4>To investigate the impact of Alzheimer's disease (AD) co-pathology on an in vivo structural measure of neurodegeneration in Lewy body disorders (LBD).<h4>Methods</h4>We studied 72 LBD patients (Parkinson disease (PD) = 2, PD-MCI = 25, PD with dementia = 10, dementia with Lewy bodies = 35) with either CSF analysis or neuropathological examination and structural MRI during life. The ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2020, 7(12):2342-2355]

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Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau.

Nabil F Darwich, Jessica M Phan, Boram Kim, EunRan Suh, John D Papatriantafyllou, Lakshmi Changolkar, Aivi T Nguyen, Caroline M O'Rourke, Zhuohao He, Sílvia Porta, Garrett S Gibbons, Kelvin C Luk, Sokratis G Papageorgiou, Murray Grossman, Lauren Massimo, David J Irwin, Corey T McMillan, Ilya M Nasrallah, Camilo Toro, Geoffrey K Aguirre, Vivianna M Van Deerlin, Edward B Lee,

Neurodegeneration in Alzheimer's disease (AD) is closely associated with the accumulation of pathologic tau aggregates in the form of neurofibrillary tangles. We found that a p.Asp395Gly mutation in <i>VCP</i> (valosin-containing protein) was associated with dementia characterized neuropathologically by neuronal vacuoles and neurofibrillary tangles. Moreover, VCP appeared to exhibit tau disaggregase ... Read more >>

Science (Science (New York, N.Y.))
[2020, 370(6519):]

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Rates of Brain Atrophy Across Disease Stages in Familial Frontotemporal Dementia Associated With MAPT, GRN, and C9orf72 Pathogenic Variants.

Adam M Staffaroni, Sheng-Yang M Goh, Yann Cobigo, Elise Ong, Suzee E Lee, Kaitlin B Casaletto, Amy Wolf, Leah K Forsberg, Nupur Ghoshal, Neill R Graff-Radford, Murray Grossman, Hilary W Heuer, Ging-Yuek R Hsiung, Kejal Kantarci, David S Knopman, Walter K Kremers, Ian R Mackenzie, Bruce L Miller, Otto Pedraza, Katya Rascovsky, M Carmela Tartaglia, Zbigniew K Wszolek, Joel H Kramer, John Kornak, Bradley F Boeve, Adam L Boxer, Howard J Rosen, ,

<h4>Importance</h4>Several clinical trials are planned for familial forms of frontotemporal lobar degeneration (f-FTLD). Precise modeling of brain atrophy in f-FTLD could improve the power to detect a treatment effect.<h4>Objective</h4>To characterize regions and rates of atrophy in the 3 primary f-FTLD genetic groups (MAPT, GRN, and C9orf72) across all disease stages ... Read more >>

JAMA Netw Open (JAMA network open)
[2020, 3(10):e2022847]

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C9orf72, age at onset, and ancestry help discriminate behavioral from language variants in FTLD cohorts.

Beatrice Costa, Claudia Manzoni, Manuel Bernal-Quiros, Demis A Kia, Miquel Aguilar, Ignacio Alvarez, Victoria Alvarez, Ole Andreassen, Maria Anfossi, Silvia Bagnoli, Luisa Benussi, Livia Bernardi, Giuliano Binetti, Daniel Blackburn, Mercè Boada, Barbara Borroni, Lucy Bowns, Geir Bråthen, Amalia C Bruni, Huei-Hsin Chiang, Jordi Clarimon, Shuna Colville, Maria E Conidi, Tom E Cope, Carlos Cruchaga, Chiara Cupidi, Maria Elena Di Battista, Janine Diehl-Schmid, Monica Diez-Fairen, Oriol Dols-Icardo, Elisabetta Durante, Dušan Flisar, Francesca Frangipane, Daniela Galimberti, Maura Gallo, Maurizio Gallucci, Roberta Ghidoni, Caroline Graff, Jordan H Grafman, Murray Grossman, John Hardy, Isabel Hernández, Guy J T Holloway, Edward D Huey, Ignacio Illán-Gala, Anna Karydas, Behzad Khoshnood, Milica G Kramberger, Mark Kristiansen, Patrick A Lewis, Alberto Lleó, Gaganjit K Madhan, Raffaele Maletta, Aleš Maver, Manuel Menendez-Gonzalez, Graziella Milan, Bruce Miller, Merel O Mol, Parastoo Momeni, Sonia Moreno-Grau, Chris M Morris, Benedetta Nacmias, Christer Nilsson, Valeria Novelli, Linn Öijerstedt, Alessandro Padovani, Suvankar Pal, Yasmin Panchbhaya, Pau Pastor, Borut Peterlin, Irene Piaceri, Stuart Pickering-Brown, Yolande A L Pijnenburg, Annibale A Puca, Innocenzo Rainero, Antonella Rendina, Anna M T Richardson, Ekaterina Rogaeva, Boris Rogelj, Sara Rollinson, Giacomina Rossi, Carola Rossmeier, James B Rowe, Elisa Rubino, Agustín Ruiz, Raquel Sanchez-Valle, Sigrid B Sando, Alexander F Santillo, Jennifer Saxon, Elio Scarpini, Maria Serpente, Nicoletta Smirne, Sandro Sorbi, EunRan Suh, Fabrizio Tagliavini, Jennifer C Thompson, John Q Trojanowski, Vivianna M Van Deerlin, Julie Van der Zee, Christine Van Broeckhoven, Jeroen van Rooij, John C Van Swieten, Arianna Veronesi, Emilia Vitale, Maria L Waldö, Cathy Woodward, Jennifer Yokoyama, Valentina Escott-Price, James M Polke, Raffaele Ferrari, ,

<h4>Objective</h4>We sought to characterize <i>C9orf72</i> expansions in relation to genetic ancestry and age at onset (AAO) and to use these measures to discriminate the behavioral from the language variant syndrome in a large pan-European cohort of frontotemporal lobar degeneration (FTLD) cases.<h4>Methods</h4>We evaluated expansions frequency in the entire cohort (n = ... Read more >>

Neurology (Neurology)
[2020, 95(24):e3288-e3302]

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Automated analysis of lexical features in Frontotemporal Degeneration

Sunghye Cho, Naomi Nevler, Sharon Ash, Sanjana Shellikeri, David Irwin, Lauren Massimo, Katya Rascovsky, Christopher Olm, Murray Grossman, Mark Liberman,

We implemented an automated analysis of lexical aspects of semi-structured speech produced by three patient groups with Frontotemporal degeneration (FTD): behavioral variant FTD (n=74), semantic variant Primary Progressive Aphasia (svPPA, n=42), and nonfluent/agrammatic PPA (naPPA, n=22). With a natural language processing program, we automatically tagged part-of-speech categories of all words ... Read more >>

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Digital Speech Analysis in Progressive Supranuclear Palsy and Corticobasal Syndromes

Natalia Parjane, Sunghye Cho, Sharon Ash, Sanjana Shellikeri, Mark Liberman, Leslie Shaw, David Irwin, Murray Grossman, Naomi Nevler,

<h4>ABSTRACT</h4> <h4>Background</h4> Progressive supranuclear palsy and corticobasal syndromes (PSPS-CBS) as well as nonfluent/agrammatic primary progressive aphasia (naPPA) are often due to misfolded 4-repeat Tau, but the diversity of the associated speech disorders beyond Apraxia of Speech (AoS) is poorly understood. <h4>Objective</h4> Investigate the full range of acoustic and lexical properties ... Read more >>

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More than words: Extra-Sylvian neuroanatomic networks support indirect speech act discourse comprehension in behavioral variant frontotemporal dementia

Meghan Healey, Erica Howard, Molly Ungrady, Christopher Olm, Naomi Nevler, David Irwin, Murray Grossman,

<h4>ABSTRACT</h4> Indirect speech acts— responding “I forgot to wear my watch today” to someone who asked for the time — are ubiquitous in daily conversation, but are understudied in current neurobiological models of language. To comprehend an indirect speech act like this one, listeners must not only decode the lexical-semantic ... Read more >>

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Clinical Conditions "Suggestive of Progressive Supranuclear Palsy"-Diagnostic Performance.

Max-Joseph Grimm, Gesine Respondek, Maria Stamelou, Thomas Arzberger, Leslie Ferguson, Ellen Gelpi, Armin Giese, Murray Grossman, David J Irwin, Alexander Pantelyat, Alex Rajput, Sigrun Roeber, John C van Swieten, Claire Troakes, Wassilios G Meissner, Christer Nilsson, Ines Piot, Yaroslau Compta, James B Rowe, Günter U Höglinger, ,

<h4>Background</h4>The Movement Disorder Society diagnostic criteria for progressive supranuclear palsy introduced the diagnostic certainty level "suggestive of progressive supranuclear palsy" for clinical conditions with subtle signs, suggestive of the disease. This category aims at the early identification of patients, in whom the diagnosis may be confirmed as the disease evolves.<h4>Objective</h4>To ... Read more >>

Mov Disord (Movement disorders : official journal of the Movement Disorder Society)
[2020, 35(12):2301-2313]

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Degeneration of the locus coeruleus is a common feature of tauopathies and distinct from TDP-43 proteinopathies in the frontotemporal lobar degeneration spectrum.

Daniel T Ohm, Claire Peterson, Rebecca Lobrovich, Katheryn A Q Cousins, Garrett S Gibbons, Corey T McMillan, David A Wolk, Vivianna Van Deerlin, Lauren Elman, Meredith Spindler, Andres Deik, Andrew Siderowf, John Q Trojanowski, Edward B Lee, Murray Grossman, David J Irwin,

Neurodegeneration of the locus coeruleus (LC) in age-related neurodegenerative diseases such as Alzheimer's disease (AD) is well documented. However, detailed studies of LC neurodegeneration in the full spectrum of frontotemporal lobar degeneration (FTLD) proteinopathies comparing tauopathies (FTLD-tau) to TDP-43 proteinopathies (FTLD-TDP) are lacking. Here, we tested the hypothesis that there ... Read more >>

Acta Neuropathol (Acta neuropathologica)
[2020, 140(5):675-693]

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Automated analysis of natural speech in amyotrophic lateral sclerosis spectrum disorders.

Naomi Nevler, Sharon Ash, Corey McMillan, Lauren Elman, Leo McCluskey, David J Irwin, Sunghye Cho, Mark Liberman, Murray Grossman,

<h4>Objective</h4>We implemented automated methods to analyze speech and evaluate the hypothesis that cognitive and motor factors impair prosody in partially distinct ways in patients with amyotrophic lateral sclerosis (ALS).<h4>Methods</h4>We recruited 213 participants, including 67 with ALS (44 with motor ALS, 23 with ALS and frontotemporal degeneration [FTD]), 33 healthy controls, ... Read more >>

Neurology (Neurology)
[2020, 95(12):e1629-e1639]

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Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis.

Yixin Gao, Ting Wang, Xinghao Yu, , Huashuo Zhao, Ping Zeng,

We employed Mendelian randomization (MR) to evaluate the causal relationship between leukocyte telomere length (LTL) and amyotrophic lateral sclerosis (ALS) with summary statistics from genome-wide association studies (n = ~ 38,000 for LTL and ~ 81,000 for ALS in the European population; n = ~ 23,000 for LTL and ~ 4,100 for ALS in the Asian population). We ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):12184]

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Quality of life and caregiver burden in familial frontotemporal lobar degeneration: Analyses of symptomatic and asymptomatic individuals within the LEFFTDS cohort.

Melanie T Gentry, Maria I Lapid, Jeremy Syrjanen, Kendrick Calvert, Samantha Hughes, Danielle Brushaber, Walter Kremers, Jessica Bove, Patrick Brannelly, Giovanni Coppola, Christina Dheel, Bradley Dickerson, Susan Dickinson, Kelley Faber, Julie Fields, Jamie Fong, Tatiana Foroud, Leah Forsberg, Ralitza Gavrilova, Deb Gearhart, Nupur Ghoshal, Jill Goldman, Jonathan Graff-Radford, Neill Graff-Radford, Murray Grossman, Dana Haley, Hilary Heuer, Ging-Yuek Hsiung, Edward Huey, David Irwin, David Jones, Lynne Jones, Kejal Kantarci, Anna Karydas, David Knopman, John Kornak, Joel Kramer, Walter Kukull, Diane Lucente, Codrin Lungu, Ian Mackenzie, Masood Manoochehri, Scott McGinnis, Bruce Miller, Rodney Pearlman, Len Petrucelli, Madeline Potter, Rosa Rademakers, Eliana Marisa Ramos, Katherine Rankin, Katya Rascovsky, Pheth Sengdy, Leslie Shaw, Nadine Tatton, Joanne Taylor, Arthur Toga, John Trojanowski, Sandra Weintraub, Bonnie Wong, Zbigniew Wszolek, Bradley F Boeve, Adam Boxer, Howard Rosen, ,

<h4>Objective</h4>The Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects evaluates familial frontotemporal lobar degeneration (FTLD) kindreds with MAPT, GRN, or C9orf72 mutations. Objectives were to examine whether health-related quality of life (HRQoL) correlates with clinical symptoms and caregiver burden, and whether self-rated and informant-rated HRQoL would correlate with each other.<h4>Methods</h4>Individuals were ... Read more >>

Alzheimers Dement (Alzheimer's & dementia : the journal of the Alzheimer's Association)
[2020, 16(8):1115-1124]

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