Full Text Journal Articles by
Author Mukund Seshadri

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Ultra-high frequency ultrasound as a clinical adjunct for imaging the oral cavity: added value of quantitative analysis.

Celia R DeJohn, Mukund Seshadri,

Dentomaxillofac Radiol (Dento maxillo facial radiology)
[2020, 49(7):20200314]

Cited: 0 times

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Managing the Oral Health of Cancer Patients During the COVID-19 Pandemic: Perspective of a Dental Clinic in a Cancer Center.

Sunita Manuballa, Marym Abdelmaseh, Nirmala Tasgaonkar, Vladimir Frias, Michael Hess, Heidi Crow, Sebastiano Andreana, Vishal Gupta, Kimberly E Wooten, Michael R Markiewicz, Anurag K Singh, Wesley L Hicks, Mukund Seshadri,

The practice of dentistry has been dramatically altered by the coronavirus disease 2019 (COVID-19) pandemic. Given the close person-to-person contact involved in delivering dental care and treatment procedures that produce aerosols, dental healthcare professionals including dentists, dental assistants and dental hygienists are at high risk of exposure. As a dental ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(10):]

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Excretable, ultrasmall hexagonal NaGdF4:Yb50% Nanoparticles for bimodal imaging and radiosensitization

Jossana Abcede Damasco, Tymish Ohulchanskyy, Supriya Mahajan, Guanying Chen, Ajay Singh, Hilliard Kutscher, Haoyuan Huang, Steven Turowski, Joseph Spernyak, Anurag Singh, Jonathan Lovell, Mukund Seshadri, Paras Prasad,

Abstract Background In this study, we report on the synthesis, imaging properties and radiosensitizing properties of β-NaGdF 4 :Yb50% nanoparticles as a multifunctional theranostic platform. The synthesized nanoparticles act as potent bimodal contrast agents with superior imaging properties compared to existing agents used for magnetic resonance imaging (MRI) and ... Read more >>

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Linear Oral Lichen Planus: A Rare Presentation

Prashanth Panta, David Felix, Dimitrios Andreadis, Mukund Seshadri,

Mucosal irritation caused by cusps of upper and lower teeth represents a source of persistent, low grade mechanical trauma. This type of trauma can initiate and/or perpetuate oral lichen planus in a few susceptible patients. Here, we report a rare case of bilateral white linear striations in the buccal mucosa ... Read more >>

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Targeting dual signalling pathways in concert with immune checkpoints for the treatment of pancreatic cancer.

Erik S Knudsen, Vishnu Kumarasamy, Sejin Chung, Amanda Ruiz, Paris Vail, Stephanie Tzetzo, Jin Wu, Ram Nambiar, Jared Sivinski, Shailender S Chauhan, Mukund Seshadri, Scott I Abrams, Jianmin Wang, Agnieszka K Witkiewicz,

OBJECTIVE:This study exploits the intersection between molecular-targeted therapies and immune-checkpoint inhibition to define new means to treat pancreatic cancer. DESIGN:Patient-derived cell lines and xenograft models were used to define the response to CDK4/6 and MEK inhibition in the tumour compartment. Impacts relative to immunotherapy were performed using subcutaneous and orthotopic ... Read more >>

Gut (Gut)
[2020, :]

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Development and Radiation Response Assessment in A Novel Syngeneic Mouse Model of Tongue Cancer: 2D Culture, 3D Organoids and Orthotopic Allografts.

Vui King Vincent-Chong, Mukund Seshadri,

Oral squamous cell carcinoma (OSCC) are aggressive cancers that contribute to significant morbidity and mortality in humans. Although numerous human xenograft models of OSCC have been developed, only a few syngeneic models of OSCC exist. Here, we report on a novel murine model of OSCC, RP-MOC1, derived from a tongue ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(3):]

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Vitamin D3 Metabolites Demonstrate Prognostic Value in EGFR-Mutant Lung Adenocarcinoma and Can be Deployed to Oppose Acquired Therapeutic Resistance.

Tatiana Shaurova, Grace K Dy, Sebastiano Battaglia, Alan Hutson, Letian Zhang, Yunkai Zhang, Christine M Lovly, Mukund Seshadri, David W Goodrich, Candace S Johnson, Pamela A Hershberger,

EGFR tyrosine kinase inhibitors (EGFR TKIs) are the standard of care treatment for patients with EGFR-mutant lung adenocarcinoma (LUAD). Although initially effective, EGFR TKIs are not curative. Disease inevitably relapses due to acquired drug resistance. We hypothesized that vitamin D metabolites could be used with EGFR TKIs to prevent therapeutic ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(3):]

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Impact of dietary vitamin D on initiation and progression of oral cancer.

Aparajita Verma, Vui King Vincent-Chong, Hendrik DeJong, Pamela A Hershberger, Mukund Seshadri,

Calcitriol, the active metabolite of vitamin D, has been widely studied for its preventive and therapeutic activity against several cancers including oral squamous cell carcinoma (OSCC). However, the impact of dietary vitamin D supplementation on initiation and progression of OSCC is unclear. To address this gap in knowledge, we conducted ... Read more >>

J Steroid Biochem Mol Biol (The Journal of steroid biochemistry and molecular biology)
[2020, 199:105603]

Cited: 0 times

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Targeting dual signaling pathways in concert with immune checkpoints for the treatment of pancreatic cancer

Erik Knudsen, Vishnu Kumarasamy, Sejin Chung, Paris Vail, Stephanie Tzetzo, Amanda Ruiz, Mukund Seshadri, Scott Abrams, Jianmin Wang, Agnieszka Witkiewicz,

ABSTRACT Pancreatic cancer harbors a poor prognosis due to the lack of effective systemic therapies. Here we interrogated means to target key effector pathways down-stream from KRAS. We found that combination treatment with MEK and CDK4/6 inhibitors was effective across a broad range of PDX models in delaying tumor progression. ... Read more >>

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Performance Characteristics of Photoacoustic Imaging Probes with Varying Frequencies and Light-delivery Schemes.

Laurie J Rich, Sarah R Chamberlain, Daniela R Falcone, Robert Bruce, Andrew Heinmiller, Jun Xia, Mukund Seshadri,

Photoacoustic imaging (PAI) is an emerging biomedical imaging technique that utilizes a combination of light and ultrasound to detect photoabsorbers embedded within tissues. While the clinical utility of PAI has been widely explored for several applications, limitations in light penetration and detector sensitivity have restricted these studies to mostly superficial ... Read more >>

Ultrason Imaging (Ultrasonic imaging)
[2019, 41(6):319-335]

Cited: 1 time

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Dynamic photoacoustic imaging of neurovascular coupling in salivary glands.

Laurie J Rich, Eftekhar Rajab Bolookat, Mukund Seshadri,

The purpose of this study was to apply photoacoustic imaging (PAI), a relatively new imaging method, to non-invasively map neurovascular dynamics in salivary glands. Dynamic PAI with co-registered ultrasound (US) was performed in mice to monitor salivary gland hemodynamics in response to exogenous muscarinic receptor stimulation (pilocarpine) and blockade (atropine). ... Read more >>

J Oral Biosci (Journal of oral biosciences)
[2019, 61(4):236-241]

Cited: 0 times

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Profiling the Stromal and Vascular Heterogeneity in Patient-derived Xenograft Models of Head and Neck Cancer: Impact on Therapeutic Response.

Margaret Folaron, Mihai Merzianu, Umamaheswar Duvvuri, Robert L Ferris, Mukund Seshadri,

Head and neck squamous cell carcinomas (HNSCC) represent a group of epithelial neoplasms that exhibit considerable heterogeneity in clinical behavior. Here, we examined the stromal and vascular heterogeneity in a panel of patient-derived xenograft (PDX) models of HNSCC and the impact on therapeutic response. Tumor sections from established tumors were ... Read more >>

Cancers (Basel) (Cancers)
[2019, 11(7):]

Cited: 1 time

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Oncolytic Maraba virus armed with tumor antigen boosts vaccine priming and reveals diverse therapeutic response patterns when combined with checkpoint blockade in ovarian cancer.

A J Robert McGray, Ruea-Yea Huang, Sebastiano Battaglia, Cheryl Eppolito, Anthony Miliotto, Kyle B Stephenson, Amit A Lugade, Gill Webster, Brian D Lichty, Mukund Seshadri, Danuta Kozbor, Kunle Odunsi,

BACKGROUND:Cancer immunotherapies are emerging as promising treatment strategies for ovarian cancer patients that experience disease relapse following first line therapy. As such, identifying strategies to bolster anti-tumor immunity and limit immune suppression, while recognizing diverse patterns of tumor response to immunotherapy is critical to selecting treatment combinations that lead to ... Read more >>

J Immunother Cancer (Journal for immunotherapy of cancer)
[2019, 7(1):189]

Cited: 6 times

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Ultrasound guided generation of PDOX models of adenoid cystic carcinoma.

Mukund Seshadri, Laurie J Rich,

EBioMedicine (EBioMedicine)
[2019, 42:38]

Cited: 0 times

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Concurrent oropharyngeal squamous cell carcinomas in couples.

Prashanth Panta, Mukund Seshadri,

Oral Oncol (Oral oncology)
[2019, 93:127-128]

Cited: 0 times

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Preclinical Prevention Trial of Calcitriol: Impact of Stage of Intervention and Duration of Treatment on Oral Carcinogenesis.

Vui King Vincent-Chong, Hendrik DeJong, Kristopher Attwood, Pamela A Hershberger, Mukund Seshadri,

The anticancer activity of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3 or calcitriol) has been widely reported in preclinical models. However, systematic investigation into the chemopreventive potential of calcitriol against the spectrum of oral carcinogenesis has not been performed. To address this gap in knowledge, we conducted a preclinical prevention trial of calcitriol in ... Read more >>

Neoplasia (Neoplasia (New York, N.Y.))
[2019, 21(4):376-388]

Cited: 2 times

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IFN regulatory factor-8 expression in macrophages governs an antimetastatic program.

Danielle Yf Twum, Sean H Colligan, Nicholas C Hoffend, Eriko Katsuta, Eduardo Cortes Gomez, Mary Lynn Hensen, Mukund Seshadri, Michael J Nemeth, Scott I Abrams,

High macrophage infiltration in cancer is associated with reduced survival in animal models and in patients. This reflects a shift in the macrophage response from a tumor-suppressive to tumor-supportive program governed by transcriptional events regulated by the inflammatory milieu. Although several transcription factors are known to drive a prometastatic program, ... Read more >>

JCI Insight (JCI insight)
[2019, 4(3):]

Cited: 3 times

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Tumor-derived thymic stromal lymphopoietin enhances lung metastasis through an alveolar macrophage-dependent mechanism.

Lauren Burkard-Mandel, Rachel O'Neill, Sean Colligan, Mukund Seshadri, Scott I Abrams,

It is well-recognized that macrophages, which arise from circulating precursors, enhance tumor progression in patients and animal models. However, less is known regarding the role of tissue-resident macrophages in metastasis. Moreover, the identification of tumor factors which influence macrophage function in the metastatic niche remains incomplete. Here, we investigated one ... Read more >>

Oncoimmunology (Oncoimmunology)
[2018, 7(5):e1419115]

Cited: 3 times

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Visualizing the effects of metformin on tumor growth, vascularity, and metabolism in head and neck cancer.

Aparajita Verma, Laurie J Rich, Vui King Vincent-Chong, Mukund Seshadri,

BACKGROUND:The antidiabetic drug metformin (Met) is believed to inhibit tumor proliferation by altering the metabolism of cancer cells. In this study, we examined the effects of Met on tumor oxygenation, metabolism, and growth in head and neck squamous cell carcinoma (HNSCC) using non-invasive multimodal imaging. MATERIALS AND METHODS:Severe combined immunodeficient ... Read more >>

J Oral Pathol Med (Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology)
[2018, 47(5):484-491]

Cited: 3 times

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Photoacoustic Imaging as an Early Biomarker of Radio Therapeutic Efficacy in Head and Neck Cancer.

Laurie J Rich, Austin Miller, Anurag K Singh, Mukund Seshadri,

The negative impact of tumor hypoxia on radiotherapeutic efficacy is well recognized. However, an easy to use, reliable imaging method for assessment of tumor oxygenation in routine clinical practice remains elusive. Photoacoustic imaging (PAI) is a relatively new imaging technique that utilizes a combination of light and ultrasound (US) to ... Read more >>

Theranostics (Theranostics)
[2018, 8(8):2064-2078]

Cited: 8 times

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Spatiotemporal Optoacoustic Mapping of Tumor Hemodynamics in a Clinically Relevant Orthotopic Rabbit Model of Head and Neck Cancer.

Laurie J Rich, Sandra Sexton, Leslie Curtin, Mukund Seshadri,

The purpose of this study was to investigate the usefulness of photoacoustic imaging (PAI) for spatiotemporal mapping of tumor hemodynamics in a rabbit model of head and neck carcinoma. Shope cottontail rabbit papilloma virus associated VX2 carcinomas were established in adult male New Zealand White rabbits (n = 9) by ... Read more >>

Transl Oncol (Translational oncology)
[2017, 10(5):839-845]

Cited: 3 times

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EZH2 Modifies Sunitinib Resistance in Renal Cell Carcinoma by Kinome Reprogramming.

Remi Adelaiye-Ogala, Justin Budka, Nur P Damayanti, Justine Arrington, Mary Ferris, Chuan-Chih Hsu, Sreenivasulu Chintala, Ashley Orillion, Kiersten Marie Miles, Li Shen, May Elbanna, Eric Ciamporcero, Sreevani Arisa, Piergiorgio Pettazzoni, Giulio F Draetta, Mukund Seshadri, Bradley Hancock, Milan Radovich, Janaiah Kota, Michael Buck, Heike Keilhack, Brian P McCarthy, Scott A Persohn, Paul R Territo, Yong Zang, Joseph Irudayaraj, W Andy Tao, Peter Hollenhorst, Roberto Pili,

Acquired and intrinsic resistance to receptor tyrosine kinase inhibitors (RTKi) represents a major hurdle in improving the management of clear cell renal cell carcinoma (ccRCC). Recent reports suggest that drug resistance is driven by tumor adaptation via epigenetic mechanisms that activate alternative survival pathways. The histone methyl transferase EZH2 is ... Read more >>

Cancer Res (Cancer research)
[2017, 77(23):6651-6666]

Cited: 14 times

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Curcumin and metformin-mediated chemoprevention of oral cancer is associated with inhibition of cancer stem cells.

Gangotri Siddappa, Safeena Kulsum, Doddathimmasandra Ramanjanappa Ravindra, Vinay V Kumar, Nalini Raju, Nisheena Raghavan, Holalugunda Vittalamurthy Sudheendra, Anupam Sharma, Sumsum P Sunny, Tina Jacob, Binu T Kuruvilla, Merina Benny, Benny Antony, Mukund Seshadri, Padma Lakshminarayan, Wesley Hicks, Amritha Suresh, Moni A Kuriakose,

Effective chemoprevention is critical for improving outcomes of oral cancer. As single agents, curcumin and metformin are reported to exhibit chemopreventive properties, in vitro as well as in patients with oral cancer. In this study, the chemopreventive efficacy of this drug combination was tested in a 4-nitro quinoline-1-oxide (4NQO) induced ... Read more >>

Mol. Carcinog. (Molecular carcinogenesis)
[2017, 56(11):2446-2460]

Cited: 12 times

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Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance.

Sheng Yu Ku, Spencer Rosario, Yanqing Wang, Ping Mu, Mukund Seshadri, Zachary W Goodrich, Maxwell M Goodrich, David P Labbé, Eduardo Cortes Gomez, Jianmin Wang, Henry W Long, Bo Xu, Myles Brown, Massimo Loda, Charles L Sawyers, Leigh Ellis, David W Goodrich,

Prostate cancer relapsing from antiandrogen therapies can exhibit variant histology with altered lineage marker expression, suggesting that lineage plasticity facilitates therapeutic resistance. The mechanisms underlying prostate cancer lineage plasticity are incompletely understood. Studying mouse models, we demonstrate that Rb1 loss facilitates lineage plasticity and metastasis of prostate adenocarcinoma initiated by ... Read more >>

Science (Science (New York, N.Y.))
[2017, 355(6320):78-83]

Cited: 203 times

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Enhanced tumour perfusion following treatment with water-filtered IR-A radiation to the thorax in a patient with head and neck cancer.

Laurie J Rich, Timothy B Winslow, Ronald A Alberico, Elizabeth A Repasky, Mukund Seshadri, Anurag K Singh,

Int J Hyperthermia (International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group)
[2016, 32(5):539-542]

Cited: 2 times

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