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Glycine, the smallest amino acid, confers neuroprotection against D-galactose-induced neurodegeneration and memory impairment by regulating c-Jun N-terminal kinase in the mouse brain.

Rahat Ullah, Myeung Hoon Jo, Muhammad Riaz, Sayed Ibrar Alam, Kamran Saeed, Waqar Ali, Inayat Ur Rehman, Muhammad Ikram, Myeong Ok Kim,

BACKGROUND:Glycine is the smallest nonessential amino acid and has previously unrecognized neurotherapeutic effects. In this study, we examined the mechanism underlying the neuroprotective effect of glycine (Gly) against neuroapoptosis, neuroinflammation, synaptic dysfunction, and memory impairment resulting from D-galactose-induced elevation of reactive oxygen species (ROS) during the onset of neurodegeneration in ... Read more >>

J Neuroinflammation (Journal of neuroinflammation)
[2020, 17(1):303]

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SEATED-IMMOBILITY THROMBOEMBOLISM SYNDROME COMPLICATING CORONAVIRUS DISEASE 2019 OUTBREAK QUARANTINE

Abdulla Ali, Ibrahim Omore, Louisa Asare, Mohanad Gabani, Muhammad Riaz,

Chest (Chest)
[2020, 158(4):A1614-A1614]

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Efficacy of chloroquine or hydroxychloroquine in COVID-19 patients: a systematic review and meta-analysis.

Zakariya Kashour, Muhammad Riaz, Musa A Garbati, Oweida AlDosary, Haytham Tlayjeh, Dana Gerberi, M Hassan Murad, M Rizwan Sohail, Tarek Kashour, Imad M Tleyjeh,

OBJECTIVES:Clinical studies of chloroquine (CQ) and hydroxychloroquine (HCQ) in COVID-19 disease reported conflicting results. We sought to systematically evaluate the effect of CQ and HCQ with or without azithromycin on outcomes of COVID-19 patients. METHODS:We searched multiple databases, preprints and grey literature up to 17 July 2020. We pooled only ... Read more >>

J Antimicrob Chemother (The Journal of antimicrobial chemotherapy)
[2020, :]

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Therapeutic Efficacy of Urinile Against Gouty Arthritis.

Saeed Ahmad, Ejaz Mohiuddin, Syed Muhammad Ali Shah, Muhammad Akram, Muhammad Amjad, Jaweria Nisar, Muhammad Riaz, Naveed Munir, Ghulam Rasool,

Gout is arthritis caused due to Monosodium urate (MSU) crystals deposition occurring particularly in patients with associated comorbidities limiting the use of conventional therapies. This study was planned to evaluate the therapeutic efficacy of urinile (a herbal drug) for the treatment of gouty arthritis. Allopurinol was used as standard drug ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2020, 18(4):1559325820946934]

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Dechlorane Plus as an emerging environmental pollutant in Asia: a review.

Mazhar Iqbal Zafar, Sundas Kali, Mehtabidah Ali, Muhammad Asam Riaz, Tayyaba Naz, Muhammad Mazhar Iqbal, Noshin Masood, Kashif Munawar, Bilal Jan, Sohail Ahmed, Amir Waseem, Muhammad Bilal Khan Niazi,

Dechlorane Plus (DP) is an unregulated, highly chlorinated flame retardant. It has been manufactured from past 40 years but its presence in the environment was initially reported in 2006. Later, it has been found in various biotic and abiotic environmental matrices. However, little attention has been paid to monitor its presence ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2020, :]

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Hantavirus diseases pathophysiology, their diagnostic strategies and therapeutic approaches: A review.

Naveed Munir, Muhammad Jahangeer, Shoukat Hussain, Zahed Mahmood, Mehvish Ashiq, Fatima Ehsan, Muhammad Akram, Syed Muhammad Ali Shah, Muhammad Riaz, Aneezah Sana,

Hantaviruses are enveloped negative (-) single-stranded RNA viruses belongs to Hantaviridae family, hosted by small rodents and entering into the human body through inhalation, causing haemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS) also known as hantavirus cardiopulmonary syndrome (HCPS). Hantaviruses infect approximately more than 200 000 people ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2020, :]

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Short-Term Use of Baclofen Leading to Delirium in a Patient With End Stage Renal Disease Receiving Hemodialysis.

Muhammad Faisal Riaz, Suhaib A Andrabi, Anya Weerasinghe, Maryam Handoo, Sudhanshu Jain,

Baclofen, a muscle relaxant is primarily excreted by the kidneys. We present the case of a 60-year-old male who developed acute delirium, visual hallucinations, and behavioral changes after he took a friend's prescription of baclofen for pain relief. There was immediate improvement after dialysis, and multiple sessions of hemodialysis led ... Read more >>

Cureus (Cureus)
[2020, 12(8):e9778]

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Age-Associated Salivary MicroRNA Biomarkers for Oculopharyngeal Muscular Dystrophy.

Vered Raz, Rosemarie H M J M Kroon, Hailiang Mei, Muhammad Riaz, Henk Buermans, Saskia Lassche, Corinne Horlings, Bert De Swart, Johanna Kalf, Pradeep Harish, John Vissing, Szymon Kielbasa, Baziel G M van Engelen,

Small non-coding microRNAs (miRNAs) are involved in the regulation of mRNA stability. Their features, including high stability and secretion to biofluids, make them attractive as potential biomarkers for diverse pathologies. This is the first study reporting miRNA as potential biomarkers for oculopharyngeal muscular dystrophy (OPMD), an adult-onset myopathy. We hypothesized ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(17):]

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Consensus tracking of nonlinear multi-agent systems under input saturation with applications: A sector-based approach.

Ateeq Ur Rehman, Muhammad Rehan, Muhammad Riaz, Muhammad Abid, Naeem Iqbal,

This paper focuses on the consensus tracking control of nonlinear multi-agent systems by utilizing the quadratic inner-bounded (QIB) and the one-sided Lipschitz (OSL) conditions in the presence of input saturation constraint under a directed communication topology. A novel sector constraint for the saturation function to formulate consensus control of nonlinear ... Read more >>

ISA Trans (ISA transactions)
[2020, :]

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Identification of Lysinibacillus sphaericus Binary toxin binding proteins in a malarial mosquito cell line by proteomics: A novel approach towards improving mosquito control.

Muhammad Asam Riaz, Michael J Adang, Gang Hua, Tatiana Maria Teodoro Rezende, Antonio Mauro Rezende, Guang-Mao Shen,

Bacterial insecticidal proteins, such as the Bin toxin from Lysinibacillus sphaericus, could be used more extensively to control insecticide resistant mosquitoes. This study was aimed at identification of mosquito cell proteins binding Bin toxin. Results showed that purified toxin was toxic to Anopheles gambiae larvae and Ag55 cultured cells. Clathrin ... Read more >>

J Proteomics (Journal of proteomics)
[2020, 227:103918]

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Genome-Wide Transcriptional Analysis Reveals Alternative Splicing Event Profiles in Hepatocellular Carcinoma and Their Prognostic Significance.

Yongfu Xiong, Gang Yang, Kang Wang, Muhammad Riaz, Jian Xu, Zhenbing Lv, He Zhou, Qiang Li, Weinan Li, Ji Sun, Tang Tao, Jingdong Li,

Accumulating evidence indicates an unexpected role of aberrant splicing in hepatocellular carcinoma (HCC) that has been seriously neglected in previous studies. There is a need for a detailed analysis of alternative splicing (AS) and its underlying biological and clinical relevance in HCC. In this study, clinical information and corresponding RNA ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:879]

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Role of iron-lysine on morpho-physiological traits and combating chromium toxicity in rapeseed (Brassica napus L.) plants irrigated with different levels of tannery wastewater.

Ihsan Elahi Zaheer, Shafaqat Ali, Muhammad Hamzah Saleem, Muhammad Imran, Ghalia S H Alnusairi, Basmah M Alharbi, Muhammad Riaz, Zohaib Abbas, Muhammad Rizwan, Mona H Soliman,

Chromium (Cr) is among the most widespread toxic trace elements found in agricultural soils resulting from various anthropogenic activities. However, the role of micronutrient-amino acid chelates in reducing Cr toxicity in crop plants has recently been suggested. The present study was conducted to explore the effect of iron (Fe) chelated ... Read more >>

Plant Physiol Biochem (Plant physiology and biochemistry : PPB)
[2020, 155:70-84]

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Relief Role of Lysine Chelated Zinc (Zn) on 6-Week-Old Maize Plants under Tannery Wastewater Irrigation Stress.

Rehan Ahmad, Wajid Ishaque, Mumtaz Khan, Umair Ashraf, Muhammad Atif Riaz, Said Ghulam, Awais Ahmad, Muhammad Rizwan, Shafaqat Ali, Saad Alkahtani, Mohamed M Abdel-Daim,

Tannery wastewater mainly comes from leather industries. It has high organic load, high salinity, and many other pollutants, including chromium (Cr). Tannery wastewater is generally used for crop irrigation in some areas of Pakistan and worldwide, due to the low availability of good quality of irrigation water. As tannery wastewater ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(14):]

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Effects of cropping system and fertilization regime on soil phosphorous are mediated by rhizosphere-microbial processes in a semi-arid agroecosystem.

Mahnaz Roohi, Muhammad Saleem Arif, Tahira Yasmeen, Muhammad Riaz, Muhammad Rizwan, Sher Muhammad Shahzad, Shafaqat Ali, Luca Bragazza,

In semi-arid regions, soil phosphorus (P) dynamics in cereal-legume intercropping are not yet fully elucidated, particularly in relation to integrated application of fertilizers. To this aim, we investigate the effects of different fertilizers on various P fractions in relation to the rhizosphere-microbial processes in a cowpea/maize intercropping system. Field experiments ... Read more >>

J. Environ. Manage. (Journal of environmental management)
[2020, 271:111033]

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Boron reduces aluminum deposition in alkali-soluble pectin and cytoplasm to release aluminum toxicity.

Lei Yan, Muhammad Riaz, Jiayou Liu, Yalin Liu, Yu Zeng, Cuncang Jiang,

Boron (B) is indispensable for plant growth and has been reported in the mitigation of aluminum (Al) toxicity in different plants. This study focused on the efficacy of B in reducing Al toxicity to trifoliate orange seedlings in a hydroponic experiment. Boron supply had a positive effect on root length ... Read more >>

J. Hazard. Mater. (Journal of hazardous materials)
[2020, 401:123388]

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Optimization of extraction and quantification technique for phenolics content of garlic (Allium sativum): An application for comparative phytochemical evaluation based on cultivar origin.

Rizwan Ahmad, Niyaz Ahmad, Muhammad Riaz, Maria Al-Tarouti, Fatimah Aloufi, Alaa AlDarwish, Bayan Alalaq, Badriah Alhanfoush, Zahid Khan,

A range of conventional, i.e. maceration, percolation, ultrasonic assisted, Soxhlet and Soxtec extraction (STE), to advanced extraction techniques of accelerated solvent extraction (ASE) was utilized for the first time in order to optimize the extract yield and recovery of phenolics-gallic acid (GA), rutin (RT) and quercetin (QT)-quantified via ultra-high performance ... Read more >>

Biomed. Chromatogr. (Biomedical chromatography : BMC)
[2020, :e4942]

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Induction of Erythrocyte Shrinkage by Omeprazole.

Ayesha Naveed, Kashif Jilani, Abu Bakar Siddique, Muhammad Akbar, Muhammad Riaz, Zahid Mushtaq, Muhammad Sikandar, Sajida Ilyas, Ismat Bibi, Asma Asghar, Ghulam Rasool, Muhammad Irfan,

Omeprazole, a proton pump inhibitor blocks the H+/K+-ATPase channels of gastric parietal cells. It is used for the treatment of peptic ulcer. Prolonged use of omeprazole may involve in inducing anemia. The key marker of eryptosis includes membrane blebbing, cell shrinkage and phosphatidylserine (PS) exposure at the cell surface. In ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2020, 18(3):1559325820946941]

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Dissecting the Mechanism of Intracellular Mycobacterium smegmatis Growth Inhibition by Platelet Activating Factor C-16.

Muhammad Suleman Riaz, Anuvinder Kaur, Suha Nadim Shwayat, Shahriar Behboudi, Uday Kishore, Ansar Ahmed Pathan,

Mycobacterium tuberculosis (M.tb) infection results in approximately 1.3 million human deaths each year. M.tb resides primarily inside macrophages, and maintains persistent infection. In response to infection and inflammation, platelet activating factor C-16 (PAF C-16), a phospholipid compound, is released by various cells including neutophils and monocytes. We have recently shown ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2020, 11:1046]

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AI4COVID-19: AI enabled preliminary diagnosis for COVID-19 from cough samples via an app.

Ali Imran, Iryna Posokhova, Haneya N Qureshi, Usama Masood, Muhammad Sajid Riaz, Kamran Ali, Charles N John, Md Iftikhar Hussain, Muhammad Nabeel,

Background:The inability to test at scale has become humanity's Achille's heel in the ongoing war against the COVID-19 pandemic. A scalable screening tool would be a game changer. Building on the prior work on cough-based diagnosis of respiratory diseases, we propose, develop and test an Artificial Intelligence (AI)-powered screening solution ... Read more >>

Inform Med Unlocked (Informatics in medicine unlocked)
[2020, 20:100378]

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Ethnobotany, ethnopharmacology, phytochemistry, biological activities and toxicity of Pistacia chinensis subsp. integerrima: A comprehensive review.

Rizwan Ahmad, Hanine Almubayedh, Niyaz Ahmad, Atta Abbas Naqvi, Muhammad Riaz,

Pistacia chinensis subsp. integerrima (J. L. Stewart ex Brandis) Rech. F. is a valuable medicinal plant used in south Asian communities for the treatment of asthma, diarrhea, diabetes, liver diseases, fever, pain and inflammation. This review critically evaluates the available information on P. integerrima's ethnobotany, ethnopharmacology, phytochemistry, pharmacology and toxicology. ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2020, :]

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Knowledge of obstetric danger signs among Saudi Arabian women.

Amani Abu-Shaheen, Humariya Heena, Abdullah Nofal, Muhammad Riaz, Isamme AlFayyad,

BACKGROUND:In the Middle East, tremendous efforts have been made to promote both maternal and child health. However, there is little information in the literature about maternal knowledge of obstetric danger signs. Thus, this study aims to investigate Saudi Arabian women's knowledge of obstetric danger signs and their determinant factors. METHODS:A ... Read more >>

BMC Public Health (BMC public health)
[2020, 20(1):939]

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Epithelial-Mesenchymal Transition in Endometriosis-When Does It Happen?

Lutz Konrad, Raimund Dietze, Muhammad A Riaz, Georgios Scheiner-Bobis, Judith Behnke, Fabian Horné, Alena Hoerscher, Christoph Reising, Ivo Meinhold-Heerlein,

Epithelial-mesenchymal transition (EMT) is an important process of cell remodeling characterized by the gradual loss of the epithelial phenotype and progressive gain of a mesenchymal phenotype. EMT is not an all-or-nothing process, but instead a transition of epithelial to mesenchymal cells with intermediate cell states. Recently, EMT was described in ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(6):]

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Design Optimization and Non-Linear Buckling Analysis of Spherical Composite Submersible Pressure Hull.

Muhammad Imran, Dongyan Shi, Lili Tong, Hafiz Muhammad Waqas, Riaz Muhammad, Muqeem Uddin, Asghar Khan,

This paper describes an optimization study of a spherical composite submersible pressure hull employing a genetic algorithm (GA) in ANSYS. A total of five lay-up arrangements were optimized for three unidirectional composites carbon/epoxy, glass/epoxy, and boron/epoxy. The minimization of the buoyancy factor (B.F) was selected as the design optimization objective. ... Read more >>

Materials (Basel) (Materials (Basel, Switzerland))
[2020, 13(11):]

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Acute Presentation of Simultaneous Liver Abscesses Caused by Streptococcus constellatus.

Muhammad Faisal Riaz, Alvaro Genao, Ibrahim Omore,

Simultaneous liver abscesses are rarely seen and reported. We are reporting a case of two simultaneous, complex liver abscesses in a patient who had no evidence of liver abscess on cross-sectional imaging close to three months prior to this presentation. These abscesses were 7-8 cm in size, large, and septated. ... Read more >>

Cureus (Cureus)
[2020, 12(6):e8497]

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Nitrogen induced DOC and heavy metals leaching: Effects of nitrogen forms, deposition loads and liming.

Afia Zia, Leon van den Berg, Muhammad Riaz, Muhammad Arif, Dania Zia, Shawana J Khan, Muhammad Nauman Ahmad, Attaullah, Mike Ahsmore,

Atmospheric nitrogen (N) deposition is believed to accelerate dissolved organic carbon (DOC) production and could lead to increased heavy metal mobility into water resources. We sampled intact soil cores from the Isle of Skye with low background N deposition history and having Serpentine rock known for its higher heavy metal ... Read more >>

Environ. Pollut. (Environmental pollution (Barking, Essex : 1987))
[2020, 265(Pt B):114981]

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