Full Text Journal Articles by
Author Muhammad Naeem

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Microbe-EDTA mediated approach in the phytoremediation of lead-contaminated soils using maize (Zea mays L.) plants.

Saiqa Menhas, Kashif Hayat, Nabeel Khan Niazi, Pei Zhou, Amna, Jochen Bundschuh, Muhammad Naeem, Muhammad Farooq Hussain Munis, Xijia Yang, Hassan Javed Chaudhary,

In the current study, we investigated the potential of Cronobacter sakazakii- ethylenediaminetetraacetic acid (EDTA) assisted phytoremediation potential of Zea mays L. to remediate lead (Pb)-contaminated soils. The C. sakazakii exhibited various stress tolerance mechanisms via plant growth promoting (PGP) traits, intrinsic extracellular enzyme production and antibiotic resistance. A greenhouse experiment ... Read more >>

Int J Phytoremediation (International journal of phytoremediation)
[2020, :1-12]

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Stealth Strategies of Mycobacterium tuberculosis for Immune Evasion.

Muhammad Ahsan Naeem, Waqas Ahmad, Rohit Tyagi, Qaiser Akram, Muhammad Younus, Xilin Liu,

Tuberculosis is a devastating disease causing high mortality all over the world, especially in the developing countries. Mycobacterium tuberculosis (M. tb) is the causative agent of tuberculosis which replicates in the intracellular environment of host macrophages. Although the host immune system is capable of completely eliminating the pathogen, co-evolution of ... Read more >>

Curr Issues Mol Biol (Current issues in molecular biology)
[2020, 41:597-616]

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Development and characterization of orodispersible film containing cefixime trihydrate.

Qurrat-Ul-Ain Khan, Muhammad Irfan Siddique, Fatima Rasool, Muhammad Naeem, Muhammad Usman, Muhammad Zaman,

Patients suffering from dysphagia have trouble in swallowing conventional oral dosage forms and there is also risk of choking, which may cause patient noncompliance. This study aimed to develop an orodispersible film (ODF) containing cefixime trihydrate (CFX) to cope with the above-mentioned problems as well as to enhance water solubility ... Read more >>

Drug Dev Ind Pharm (Drug development and industrial pharmacy)
[2020, :1-11]

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Effect of Cadmium-Tolerant Rhizobacteria on Growth Attributes and Chlorophyll Contents of Bitter Gourd under Cadmium Toxicity.

Muhammad Zafar-Ul-Hye, Muhammad Naeem, Subhan Danish, Muhammad Jamil Khan, Shah Fahad, Rahul Datta, Martin Brtnicky, Antonin Kintl, Ghulam Sabir Hussain, Mohamed A El-Esawi,

Cadmium (Cd) is one of the heavy metals that negatively affects the growth of plants. High solubilization in water leads Cd to enter into plants quite easily, thus decreasing seed germination, photosynthesis, and transpiration. It also shows an antagonistic effect with many of the plants' nutrients like Mn, Ca, K, ... Read more >>

Plants (Basel) (Plants (Basel, Switzerland))
[2020, 9(10):]

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In-Vitro Assessment Of The Therapeutic Potential Of Polymyxins And Tigecycline Against Multidrugresistant Acinetobacter Isolates From Infected Wounds.

Mohsin Khurshid, Abid Rashid, Muhammad Husnain, Muhammad Hidayat Rasool, Umair Waqas, Muhammad Saeed, Muhammad Naeem, Muhammad Sohail,

BACKGROUND:The incidence of multidrug-resistant (MDR), extreme drug resistant (XDR), and pan drug-resistant (PDR) Acinetobacter are increasing throughout the world. The therapeutic management and control of Acinetobacter are difficult due to the emergence of drug resistance and its enduring capacity to survive in the environment. The present study was designed to ... Read more >>

J Ayub Med Coll Abbottabad (Journal of Ayub Medical College, Abbottabad : JAMC)
[2020, 32(4):459-464]

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Risk Stratification of 18F-Fluorodeoxyglucose-Avid Thyroid Nodules Based on ACR Thyroid Imaging Reporting and Data System.

Malak Itani, Gabriel Felder, Muhammad Naeem, Waleed Shady, Anup S Shetty, Tyler J Fraum,

OBJECTIVE:Fine needle aspiration (FNA) of thyroid nodules is often requested based on 18F-fluorodeoxyglucose (FDG) uptake regardless of sonographic features. The purpose of this study is to determine the risk of malignancy in FDG-avid thyroid nodules when stratified according to the ACR Thyroid Imaging Reporting and Data System (TI-RADS). METHODS:This retrospective ... Read more >>

J Am Coll Radiol (Journal of the American College of Radiology : JACR)
[2020, :]

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Humanin: A mitochondrial-derived peptide in the treatment of apoptosis-related diseases.

Abu Hazafa, Ammara Batool, Saeed Ahmad, Muhammad Amjad, Sundas Nasir Chaudhry, Jamal Asad, Hasham Feroz Ghuman, Hafiza Madeeha Khan, Muhammad Naeem, Usman Ghani,

Humanin (HN) is a small mitochondrial-derived cytoprotective polypeptide encoded by mtDNA. HN exhibits protective effects in several cell types, including leukocytes, germ cells, neurons, tissues against cellular stress conditions and apoptosis through regulating various signaling mechanisms, such as JAK/STAT pathway and interaction of BCL-2 family of protein. HN is an ... Read more >>

Life Sci (Life sciences)
[2020, :118679]

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Genetic Epidemiology Reveals 3 Chronic Reservoir Areas With Recurrent Population Mobility Challenging Poliovirus Eradication in Pakistan.

Ribqa Akhtar, Nayab Mahmood, Muhammad Masroor Alam, Muhammad Naeem, Syed Sohail Zahoor Zaidi, Salmaan Sharif, Zainab Khattak, Yasir Arshad, Adnan Khurshid, Ghulam Mujtaba, Lubna Rehman, Mehar Angez, Shehzad Shaukat, Nighat Mushtaq, Massab Umair, Aamer Ikram, Muhammad Salman,

BACKGROUND:Pakistan is among 3 countries endemic for wild poliovirus type 1 (WPV1) circulation that are still struggling for eradication of poliomyelitis. Active clinical and environmental surveillance with meticulous laboratory investigations provide insights into poliovirus transmission patterns and genomic diversity to inform decisions for strategic operations required to achieve eradication. METHODS:We ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 71(7):e58-e67]

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Acute sensorineural hearing loss as atypical presentation of typhoid fever in adult patient.

Khaled Al Khodari, Tehniyat Baig, Mohammad Husni Alkhateeb, Muhammad Naeem,

Salmonella Typhi is the main cause of an acute febrile, sometimes fatal, multisystemic illness called typhoid fever. The diverse presentations of this disease make it a diagnostic challenge in some patients. Involvement of the neurological system, including cochleovestibular system, is very rare with less than a handful of reported cases. ... Read more >>

SAGE Open Med Case Rep (SAGE open medical case reports)
[2020, 8:2050313X20958548]

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Whole genome sequencing data of multiple individuals of Pakistani descent.

Shahid Y Khan, Muhammad Ali, Mei-Chong W Lee, Zhiwei Ma, Pooja Biswas, Asma A Khan, Muhammad Asif Naeem, Saima Riazuddin, Sheikh Riazuddin, Radha Ayyagari, J Fielding Hejtmancik, S Amer Riazuddin,

Here we report whole genome sequencing of four individuals (H3, H4, H5, and H6) from a family of Pakistani descent. Whole genome sequencing yielded 1084.92, 894.73, 1068.62, and 1005.77 million mapped reads corresponding to 162.73, 134.21, 160.29, and 150.86 Gb sequence data and 52.49x, 43.29x, 51.70x, and 48.66x average coverage for ... Read more >>

Sci Data (Scientific data)
[2020, 7(1):350]

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Apparent Missense Variant in COL7A1 Causes a Severe Form of Recessive Dystrophic Epidermolysis Bullosa via Effects on Splicing.

Syed Ashraf Uddin, Nicole Cesarato, Aytaj Humbatova, Axel Schmidt, Fazal urRehman, Muhammad Naeem, Abdul Samad Tareen, Sabrina Wolf, Muhammad Anwar Panezai, Holger Thiele, Abdul Wali, Regina Fölster-Holst, Sulman Basit, Muhammad Ayub, Regina C Betz,

Dystrophic epidermolysis bullosa is an inherited skin disorder characterized by fragile skin that is prone to blistering. We report here a consanguineous Pakistani family with two siblings, in whom a severe recessive dystrophic epidermolysis bullosa was suspected. Using whole-exome sequencing for one sibling, the homozygous base substitution c.7249C>G in COL7A1 ... Read more >>

Acta Derm Venereol (Acta dermato-venereologica)
[2020, 100(16):adv00275]

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Colitis-targeted hybrid nanoparticles-in-microparticles system for the treatment of ulcerative colitis.

Muhammad Naeem, Juho Lee, Murtada A Oshi, Jiafu Cao, Shwe Phyu Hlaing, Eunok Im, Yunjin Jung, Jin-Wook Yoo,

Nanoparticle (NP)-based drug delivery systems accumulate in the disrupted epithelium of inflamed colon tissue in ulcerative colitis. However, premature early drug release and uptake or degradation of NPs during their passage through the harsh gastric or intestinal environment compromise their therapeutic outcomes. This study aimed to develop an advanced colitis-targeted ... Read more >>

Acta Biomater (Acta biomaterialia)
[2020, 116:368-382]

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Do social media platforms develop consumer panic buying during the fear of Covid-19 pandemic

Muhammad Naeem,

There is inadequate understanding of how social media can shape fear and consumer responses in the manner of consumer panic buying while Covid-19 is spreading across the world. Through taking a social constructionism position this research focused on what people think and feel at an individual and collective level on ... Read more >>

(Journal of Retailing and Consumer Services)
[2020, 58:102226-102226]

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Unraveling the toxic effects of iron oxide nanoparticles on nitrogen cycling through manure-soil-plant continuum.

Muhammad Kamran, Hifsa Ali, Muhammad Farhan Saeed, Hafiz Faiq Bakhat, Zeshan Hassan, Muhammad Tahir, Ghulam Abbas, Muhammad Asif Naeem, Muhammad Imtiaz Rashid, Ghulam Mustafa Shah,

Soil contamination with metallic nanoparticles is increasing due to their increased use in industrial and domestic settings. These nanoparticles are potentially toxic to soil microbes and may affect their associated functions and thereby the nutrient cycling in agro-ecosystems. This study examined the effects of iron oxides nanoparticles (IONPs) on carbon ... Read more >>

Ecotoxicol Environ Saf (Ecotoxicology and environmental safety)
[2020, 205:111099]

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De Novo Transcriptomic and Metabolomic Analyses Reveal the Ecological Adaptation of High-Altitude Bombus pyrosoma.

Yanjie Liu, Huiyue Zhao, Qihua Luo, Yadong Yang, Guangshuo Zhang, Zhiyong Zhou, Muhammad Naeem, Jiandong An,

Bombus pyrosoma is one of the most abundant bumblebee species in China, with a distribution range of very varied geomorphology and vegetation, which makes it an ideal pollinator species for research into high-altitude adaptation. Here, we sequenced and assembled transcriptomes of B. pyrosoma from the low-altitude North China Plain and ... Read more >>

Insects (Insects)
[2020, 11(9):]

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Utility of the FebriDx point-of-care test for rapid triage and identification of possible coronavirus disease 2019 (COVID-19).

Nawazish Karim, Muhammad Zubair Ashraf, Muhammad Naeem, Tahir Anwar, Hnin Aung, Srikumar Mallik, Eleni Avraam, Sidra Kiran, Sareesh Bandapaati, Faisal Khan, Georgios Tsaknis, Raja Reddy,

OBJECTIVES:The Coronavirus disease 2019 (COVID-19) pandemic is straining healthcare resources. Molecular testing turnaround time precludes having results at the point-of-care (POC) thereby exposing COVID-19/Non-COVID-19 patients while awaiting diagnosis. We evaluated the utility of a triage strategy including FebriDx, a 10-minute POC finger-stick blood test that differentiates viral from bacterial acute ... Read more >>

Int J Clin Pract (International journal of clinical practice)
[2020, :e13702]

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Sustainability and COVID-19: Recycling and Reusing N95's.

Maria Sabahat, Muhammad Talha Naeem, Anusha Sultan Meo,

(Pakistan journal of medical sciences)
[2020, 36(6):1412-1413]

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Curcumin Nanocrystal/pH-Responsive Polyelectrolyte Multilayer Core-Shell Nanoparticles for Inflammation-Targeted Alleviation of Ulcerative Colitis.

Murtada A Oshi, Juho Lee, Muhammad Naeem, Nurhasni Hasan, Jihyun Kim, Hak Jin Kim, Eun Hee Lee, Yunjin Jung, Jin-Wook Yoo,

In this study, we developed oral core-shell nanoparticles composed of curcumin nanocrystals in the core and chitosan/alginate multilayers in the shell for inflammation-targeted alleviation of ulcerative colitis (UC). The release rate of curcumin from the core-shell nanoparticles was low at a pH mimicking the stomach and small intestine, whereas it ... Read more >>

Biomacromolecules (Biomacromolecules)
[2020, 21(9):3571-3581]

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Nitric oxide regulates water status and associated enzymatic pathways to inhibit nutrients imbalance in maize (Zea mays L.) under drought stress.

Sadia Majeed, Fahim Nawaz, Muhammad Naeem, Muhammad Yasin Ashraf, Samina Ejaz, Khawaja Shafique Ahmad, Saba Tauseef, Ghulam Farid, Iqra Khalid, Kinza Mehmood,

Nitric oxide (NO) is a key signaling molecule that instigates significant changes in plant metabolic processes and promotes tolerance against various environmental stresses including drought. In this study, we focused on NO-mediated physiological mechanisms and enzymatic activities that influence the nutrient concentrations and yield in maize under drought stress. The ... Read more >>

Plant Physiol Biochem (Plant physiology and biochemistry : PPB)
[2020, 155:147-160]

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Agro-morphological, yield, and genotyping-by-sequencing data of selected wheat germplasm

Madiha Islam, Abdullah, Bibi Zubaida, Nosheen Shafqat, Rabia Masood, Uzma Khan, Shahid Waseem, Mohammad Tahir Waheed, Waseem Haider, Jibran Tahir, Ibrar Ahmed, Muhammad Naeem, Habib Ahmad,

Abstract Wheat ( Triticum aestivum ) is the most important staple food in Pakistan. Knowledge of its genetic diversity is critical for designing effective crop breeding programs. Here we report agro-morphological and yield data for 112 genotypes (including 7 duplicates) of wheat ( Triticum aestivum ) cultivars, advance lines, landraces ... Read more >>

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Latest Developed Strategies to Minimize the Off-Target Effects in CRISPR-Cas-Mediated Genome Editing.

Muhammad Naeem, Saman Majeed, Mubasher Zahir Hoque, Irshad Ahmad,

Gene editing that makes target gene modification in the genome by deletion or addition has revolutionized the era of biomedicine. Clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 emerged as a substantial tool due to its simplicity in use, less cost and extraordinary efficiency than the conventional gene-editing tools, including zinc ... Read more >>

Cells (Cells)
[2020, 9(7):]

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Neurological and cognitive significance of probiotics: a holy grail deciding individual personality.

Muhammad Afzal, Sayyeda Farwa Mazhar, Sadia Sana, Muhammad Naeem, Muhammad Hidayat Rasool, Muhammad Saqalein, Muhammad Atif Nisar, Maria Rasool, Muhammad Bilal, Abdul Arif Khan, Mohsin Khurshid,

The role of the human microbiome in the brain and behavioral development is an area of increasing attention. Recent investigations have found that diverse mechanisms and signals including the immune, endocrine and neural associations are responsible for the communication between gut microbiota and the brain. The studies have suggested that alteration ... Read more >>

Future Microbiol (Future microbiology)
[2020, 15:1059-1074]

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Evidence of a Recessively Inherited CCN3 Mutation as a Rare Cause of Early-Onset Parkinsonism.

Steven R Bentley, Suliman Khan, Marco Öchsner, Susitha Premarathne, Zain Aslam, Javed Y Fowdar, Jamila Iqbal, Muhammad Naeem, Christopher A Love, Stephen A Wood, George D Mellick, Alex M Sykes,

The study of consanguineous families has provided novel insights into genetic causes of monogenic parkinsonism. Here, we present a family from the rural Khyber Pakhtunkhwa province, Pakistan, where three siblings were diagnosed with early-onset parkinsonism. Homozygosity mapping of two affected siblings and three unaffected family members identified two candidate autozygous ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:331]

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First Report on Molecular Characterization of Anaplasmosis in Small Ruminants in Pakistan.

Awais Ghaffar, Muhammad Ijaz, Ahmad Ali, Shahid Hussain Farooqi, Abdul Rehman, Muhammad Muddassir Ali, Muhammad Zeeshan Zafar, Muhammad Anas Naeem,

Anaplasmosis is caused by a Gram-negative obligate intracellular bacterium of the genus Anaplasma with the pathogen having a zoonotic impact. The study aimed to estimate the prevalence of anaplasmosis in Pakistan, to unravel the association of potential risk factors, and to investigate the effect on hematological parameters in affected small ... Read more >>

J Parasitol (The Journal of parasitology)
[2020, 106(3):360-368]

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Noninfectious Granulomatous Diseases of the Chest.

Muhammad Naeem, David H Ballard, Hamza Jawad, Constantine Raptis, Sanjeev Bhalla,

Granulomas are pathologically defined as focal aggregations of activated macrophages, Langerhans cells, and lymphocytes. Granulomas form in the lungs when the immune system barricades the substances it perceives as foreign but is unable to remove. Granulomas manifest with numerous imaging appearances in thoracic radiology, and their presence is a nonspecific ... Read more >>

Radiographics (Radiographics : a review publication of the Radiological Society of North America, Inc)
[2020, 40(4):1003-1019]

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