Full Text Journal Articles by
Author Muhammad Mukhtiar

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Ex-vivo abortifacient activity of Androsace foliosa n-hexane leaves extract on isolated rabbit uterus.

Jawad Zaheer, Qazi Najam-Us-Saqib, Asif Mehmmod Hashmi, Muhammad Mukhtiar, Sadia Zafar, Muhammad Riaz, Ghulam Rasool, Muhammad Akram, Syed Muhammad-Ali Shah, Saher Rahat, Faid Said Khan,

Androsace foliosa is a medicinal herb utilized in different areas of Pakistan for abortifacient, diabetic and liver complications. In the current research, the possible action of the n-hexane leaves extract of the Androsace foliosa on isolated rabbit uterus was examined. Abortifacient activity was examined in the existence of standard antagonist ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2019, 32(5(Supplementary)):2333-2339]

Cited: 0 times

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The evaluation ofefficacy and safety of Cough (EMA) granules used for upper respiratory disorders.

Muhammad Faizan Khan, Muhammad Akram, Naheed Akhter, Muhammad Mukhtiar, Rabia Zahid, Fahad Said Khan, Muhammad Daniyal, Imtiaz Mahmood Tahir, Khalil Ahmed, Aamir Sharif, Shamaila Kausar, Syed Muhammad Ali Shah, Khan Usmanghani,

Ivy leaf is used for the treatment of respiratory diseases with the intensive mucus formation, respiratory infections, and irritating cough coming from the common cold. Conferring to clinical trials, the efficacy, and tolerability of ivy leaf is good. The main compounds accountable for biological activity are triterpene and saponins. Ivy ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2018, 31(6 (Supplementary):2617-2622]

Cited: 1 time

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Spectrophotometric investigation of Glutathione modulation by Thallium chloride in aqueous medium.

Muhammad Jalil Khan, Muhammad Mukhtiar, Muhammad Murtaza Qureshi, Syed Umer Jan, - IzharUllah, Abid Hussain, Muhammad Farid Khan, Rahman Gul, Nisar Ahmad Shahwani, Imran Rabbani,

Thallium has been shown to significantly influence various tissues of living organisms; Exposure to Thallium can disturb mitochondrial function, degenerate neurons, and interfere with the function of critical metabolic enzymes and co-enzymes. Glutathione (GSH) an essential biomarker is considered a key factor in harnessing the thallium toxicity. In the present ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2018, 31(4(Supplementary)):1463-1467]

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Report: Palladium glutathione, N-acetylcysteine, D-penicillamine conjugation chemistry.

Muhammad Mukhtiar, Syed Umer Jan, Muhammad Farid Khan, Naseem Ullah, Abid Hussain, Saifur Rehman, Muhammad Murtaza Qureshi,

The metalloelement Palladium has a number of potential Pharmaco-clinical advantages. Palladium compounds have antiviral, antibacterial, neuroprotective and antitumor properties. However studies have also indicated some mild to serious toxic effects of Palladium metalloelements. Biothiols are important antioxidants that provide protection against metals toxicity. The interaction of metalloelements with biothiols can ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2018, 31(1):213-219]

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Synthesis, characterization and antihypertensive activity of 2-phenyl substituted benzimidazoles.

Muhammad Tariq Khan, Muhammad Tahir Razi, Syed Umer Jan, Muhammad Mukhtiar, Rahman Gul, - IzharUllah, Abid Hussain, Asif Mehmood Hashmi, Muhammad Taufiq Ahmad, Nisar Ahmed Shahwani, Imran Rabbani,

Hypertension is one of cardiovascular disease that is not sufficiently prevented and controlled at both hospital and community levels. Hypertension resulted in significant morbidity and mortality. The benz-imidazole ring is very important pharmacophore in modern drug discovery. The substituted benzimidazoles are the important for medicinal research. Researchers have reported that ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2018, 31(3(Supplementary)):1067-1074]

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Interaction of palladium inorganic salt and organic complex with glutathione content of liver homogenate.

Muhammad Mukhtiar, Syed Umer Jan, - IhsanUllah, Rahman Gul, Abid Hussain, Essa Ali, - IzharUllah, Abdul Jabbar, Muhammad Akram, Sibghat Mansoor, Muhammad Farid Khan,

Glutathione is an essential antioxidant of living organism that provides a primary protection against metals toxicity. A significant amount of glutathione is present in blood erythrocytes, plasma and liver hepatocytes to protect them from oxidative damage from both external and internal oxidants. Metalo-element palladium has numerous pharmacological, clinical and toxicological ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2018, 31(2(Suppl.)):727-731]

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The role of Glutathione, Cysteine and D-Penicillamine in exchanging Palladium and Vanadium metals from albumin metal complex.

Muhammad Mukhtiar, Syed Umer Jan, Ihsan Ullah, Abid Hussain, Izhar Ullah, Rahman Gul, Essa Ali, Abdul Jabbar, Zulfiqar Hussan Kuthu, Muhammad Wasim, Muhammad Farid Khan,

Thiol groups are extensively present across biological systems being found in range of small molecules (e.g. Glutathione, Homo-cysteine) and proteins (e.g. albumin, haemo-globin). Albumin is considered to be a major thiol containing protein present in circulating Plasma. Albumin contains a single thiolate group located at cysteine-34(cys-34) at its active site. ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2017, 30(6(Supplementary)):2405-2410]

Cited: 1 time

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Study of the effect of inorganic and organic complexes of arsenic metal on the status of GSH in T. cells and B. cells of blood.

Naseem Ullah, Muhammad Farid Khan, Syed Umer Jan, Muhammad Mukhtiar, Haroon Khan, Asim-ur Rehman,

Arsenic is a major threat to large part of the population due to its carcinogenic nature. The toxicity of Arsenic varies with its chemical form and oxidation states. Glutathione (GSH), a major intra-cellular tripeptide plays a major role in arsenic detoxification. The present study was designed to provide insight into ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2015, 28(2):457-464]

Cited: 4 times

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Change in metabolic status of glutathione by palladium nitrate in blood components.

Muhammad Mukhtiar, Muhammad Farid Khan, Syed Umer Jan, Haroon Khan, Naseem Ullah, Amir Badshah,

This piece of research work present the toxicological impact of varied concentrations of palladium nitrate [Pd (NO3)2] by changing the chemical status of glutathione and the way how glutathione plays its role in detoxification and conjugation processes of [Pd (NO(3))(2))] in whole blood components (plasma and cytosolic fraction). The impact ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2013, 26(1):131-135]

Cited: 1 time

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Evaluation of the interaction of vanadium with glutathione in human blood components.

Muhammad Mukhtiar, Muhammad Farid Khan, Syed Umer Jan, Haroon Khan, Naseem Ullah, Asim-ur-Rehman,

Metallo-elements including Vanadium (V) have strong affinity for sulfhydryl (-SH) groups in biological molecules including Glutathione (GSH) in tissues. Because of this fact it was of interest to further investigate the interaction of Ammonium Vanadate [NH(4)VO(3)] with Glutathione as a biomarker of toxicity and the role of Glutathione in the ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2012, 25(3):549-553]

Cited: 1 time

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Role of Glutathione in protection against mercury induced poisoning.

Haroon Khan, Muhammad Farid Khan, Syed Umer Jan, Muhammad Mukhtiar, Naseem Ullah, Naveed Anwar,

Mercury is harmless in an insoluble form, such as mercuric sulfide, but it is poisonous in soluble forms such as mercuric chloride or methylmercury. Mercury is a neurotoxin. Outbreaks of mercuric chloride poisonings have made it clear that adults, children, and developing fetuses are at risk from ingestion exposure to ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2012, 25(2):395-400]

Cited: 3 times

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