Full Text Journal Articles by
Author Muhammad Khalid

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CRISPR-Cas13a mediated targeting of hepatitis C virus internal-ribosomal entry site (IRES) as an effective antiviral strategy.

Muhammad Usman Ashraf, Hafiz Muhammad Salman, Muhammad Farhan Khalid, Muhammad Haider Farooq Khan, Saima Anwar, Samia Afzal, Muhammad Idrees, Safee Ullah Chaudhary,

Hepatitis C is an inflammatory liver disease caused by the single-stranded RNA (ssRNA) hepatitis C virus (HCV). The genetic diversity of the virus and quasispecies produced during replication have resulted in viral resistance to direct-acting antivirals (DAAs) as well as impediments in vaccine development. The recent adaptation of CRISPR-Cas as ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2021, 136:111239]

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Psychometric properties of the Urdu version of the Geriatric Oral Health Assessment Index (GOHAI) and oral health-related quality of life in the elder Pakistani population.

Farooq Ahmad Chaudhary, Yasir Dilshad Siddiqui, Muhammad Azeem Yaqoob, Muhammad Danial Khalid, Danial Qasim Butt, Shoaib Hameed,

<h4>Objective</h4>The study aimed to translate the English version of the Geriatric Oral Health Assessment Index, assess its reliability and validity, and demonstrate its psychometric properties with regard to OHRQoL in the elder Pakistani population.<h4>Material and methods</h4>In this cross-sectional study, 408 elder people were randomly recruited from three day-care centres. In ... Read more >>

Gerodontology (Gerodontology)
[2021, :]

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Exploring the optoelectronic and third-order nonlinear optical susceptibility of cross-shaped molecules: insights from molecule to material level.

Rao Aqil Shehzad, Shabbir Muhammad, Javed Iqbal, Abdullah G Al-Sehemi, Muhammad Yaseen, Zouhaier Aloui, Muhammad Khalid,

In the present investigation, we use a dual computational approach (at single molecular and solid-state levels) to explore the optoelectronic and nonlinear optical (NLO) properties of cross-shaped derivatives. The solid-state electronic band structures of the compounds 1-3 (the derivatives of tetracarboxylic acid in cross-shaped having the core of benzene (1), ... Read more >>

J Mol Model (Journal of molecular modeling)
[2021, 27(1):12]

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Vascular inflammation in cardiovascular disease: Is Immune system protective or bystander.

Khalid Muhammad, Mohammed Akli Ayoub, Rabah Iratni,

Cardiovascular disease (CVD) is one of the leading cause of death worldwide. Chronic atherosclerosis induced vascular inflammation and perturbation of lipid metabolism is believed to be a major cause of CVD. Interplay of innate and adaptive Immune system has been interwined with various risk factors associated with the initiation and ... Read more >>

Curr Pharm Des (Current pharmaceutical design)
[2021, :]

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Outcomes of rotational atherectomy versus orbital atherectomy for the treatment of heavily calcified coronary stenosis: A systematic review and meta-analysis.

Abdul Ahad Khan, Ghulam Murtaza, Muhammad Faisal Khalid, Christopher J White, Mamas A Mamas, Debabrata Mukherjee, Hani Jneid, Madhan Shanmugasundaram, Harsha S Nagarajarao, Timir K Paul,

<h4>Introduction</h4>The optimal approach to deal with severe coronary artery calcification (CAC) during percutaneous coronary intervention (PCI) remains ill-defined.<h4>Methods</h4>We conducted an electronic database search of all published studies comparing Orbital versus Rotational Atherectomy in patients undergoing PCI.<h4>Results</h4>Eight observational studies were included in the analysis. Overall, there were no significant differences in ... Read more >>

Catheter Cardiovasc Interv (Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions)
[2020, :]

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Intricate Relationship Between Adaptive and Innate Immune System in Allergic Contact Dermatitis.

Muhammad Azeem, Hidaya Kader, Andreas Kerstan, Helal F Hetta, Edgar Serfling, Matthias Goebeler, Khalid Muhammad,

Allergic contact dermatitis (ACD) is a complex immunological allergic disease characterized by the interplay between the innate and adaptive immune system. Initially, the role of the innate immune system was believed to be confined to the initial sensitization phase, while adaptive immune reactions were linked with the advanced elicitation phase. ... Read more >>

Yale J Biol Med (The Yale journal of biology and medicine)
[2020, 93(5):699-709]

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Discovery and Protein Modeling Studies of Novel Compound Mutations Causing Resistance to Multiple Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia.

Zafar Iqbal, Muhammad Absar, Amer Mahmood, Aamer Aleem, Mudassar Iqbal, Abid Jameel, Tanveer Akhtar, Sajjad Karim, Mahmood Rasool, Zeenat Mirza, Muhammad Khalid, Afia Muhammad Akram, Muhammad Farooq Sabar, Ahmad M Khalid, Khalid Aljarrah, Janhangir Iqbal, Muhammad Khalid, Ijaz H Shah, Nawaf Alanazi,

<h4>Objective</h4>BCR-ABL fusion oncogene is the hallmark of chronic myeloid leukemia (CML), causing genomic instability which leads to accumulation of mutations in BCR-ABL as well as other genes. BCR-ABL mutations are the cause of tyrosine kinase inhibitors (TKIs) resistance in CML. Recently, compound BCR-ABL mutations have been reported to resist all ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2020, 21(12):3517-3526]

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A cyanobacterial photorespiratory bypass model to enhance photosynthesis by rerouting photorespiratory pathway in C3 plants.

Ghazal Khurshid, Anum Zeb Abbassi, Muhammad Farhan Khalid, Mahnoor Naseer Gondal, Tatheer Alam Naqvi, Mohammad Maroof Shah, Safee Ullah Chaudhary, Raza Ahmad,

Plants employ photosynthesis to produce sugars for supporting their growth. During photosynthesis, an enzyme Ribulose 1,5 bisphosphate carboxylase/oxygenase (Rubisco) combines its substrate Ribulose 1,5 bisphosphate (RuBP) with CO<sub>2</sub> to produce phosphoglycerate (PGA). Alongside, Rubisco also takes up O<sub>2</sub> and produce 2-phosphoglycolate (2-PG), a toxic compound broken down into PGA through ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):20879]

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The potential role of dietary plant ingredients against mammary cancer: a comprehensive review.

Amjad Hussain, Marie-Lise Bourguet-Kondracki, Farhad Hussain, Abdur Rauf, Muhammad Ibrahim, Muhammad Khalid, Hidayat Hussain, Javid Hussain, Iftikhar Ali, Anees Ahmed Khalil, Fahad A Alhumaydhi, Muhammad Khan, Riaz Hussain, Kannan R R Rengasamy,

Breast cancer is known as the most devastating cancer in the global female community and is considered as one of the severe health care burdens in both developed and developing countries. In many cases, breast cancer has shown resistance to chemotherapy, radiotherapy and hormonal therapy. Keeping in view these limitations, ... Read more >>

Crit Rev Food Sci Nutr (Critical reviews in food science and nutrition)
[2020, :1-26]

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Finite Element Simulation Technique for Evaluation of Opening Stresses Under High Plasticity

Ans Al Rashid, Ramsha Imran, Muhammad Yasir Khalid,

The mechanical behavior of materials plays a vital role in the structural performance of designed structures. Therefore, significant resources are devoted globally towards experimental characterization of material behavior, especially for the experiments requiring particular protocols. Contrary, finite element analysis tools have made a substantial contribution to the design of structural ... Read more >>

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Tensile Properties characterization of Glass and Jute Fabric-based Hybrid Composites and Applications in Engineering

Muhammad Yasir Khalid, Zia Ullah Arif, Muhammad Fahad Sheikh, Hassan Arshad, Muhammad Ali Nasir,

Composites have an exceptional prospective to replace traditional metals like steel and aluminium by offering low weight, high strength, excellent damping characteristics and outstanding performance at elevated temperatures. Jute composites are emerging significantly and are being used in the formation of green composites materials. In this study, glass-jute hybrid composites, ... Read more >>

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Multiepitope Subunit Vaccine Design against COVID-19 Based on the Spike Protein of SARS-CoV-2: An In Silico Analysis.

Hamza Arshad Dar, Yasir Waheed, Muzammil Hasan Najmi, Saba Ismail, Helal F Hetta, Amjad Ali, Khalid Muhammad,

The global health crisis caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal agent of COVID-19, has resulted in a negative impact on human health and on social and economic activities worldwide. Researchers around the globe need to design and develop successful therapeutics as well as vaccines against ... Read more >>

J Immunol Res (Journal of immunology research)
[2020, 2020:8893483]

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Gall Bladder Wall Thickening in Dengue Fever - Aid in Labelling Dengue Hemorrhagic Fever and a Marker of Severity.

Benish Adil, Arshad Rabbani, Sualeha Ahmed, Imran Arshad, Muhammad Ali Khalid,

Introduction Dengue fever is a mosquito-borne viral disease spread by the bite of the <i>Aedes aegypti</i> mosquito. Dengue epidemics have contributed to a great economic burden, especially in South-East Asia. This study aimed to determine gall bladder wall thickness (GBWT) in patients with dengue fever, assess its sensitivity and specificity to identify ... Read more >>

Cureus (Cureus)
[2020, 12(11):e11331]

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Exploration of Chromone-Based Thiosemicarbazone Derivatives: SC-XRD/DFT, Spectral (IR, UV-Vis) Characterization, and Quantum Chemical Analysis.

Rabia Basri, Muhammad Khalid, Zahid Shafiq, Muhammad Suleman Tahir, Muhammad Usman Khan, Muhammad Nawaz Tahir, Muhammad Moazzam Naseer, Ataualpa Albert Carmo Braga,

By the condensation of thiosemicarbazide with coumarin aldehyde, two novel substituted thiosemicarbazones with chemical formulae C<sub>24</sub>H<sub>25</sub>N<sub>3</sub>O<sub>3</sub>S (<b>3a</b>) and C<sub>26</sub>H<sub>23</sub>N<sub>3</sub>O<sub>3</sub>S (<b>3b</b>) have been synthesized. The synthesized compounds were resolved using SC-XRD, and structure elucidation was carried out using <sup>1</sup>H NMR, <sup>13</sup>C NMR, UV-visible, and FT-IR spectroscopic analyses. Computational calculations at the ... Read more >>

ACS Omega (ACS omega)
[2020, 5(46):30176-30188]

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Share Patients, Not Ventilators: Lessons From an Academic Center With a Low Admission Rate of COVID-19 Patients.

Ravi Patel, Ami DeWaters, Muhammad Khalid, Margaret Wojnar, Philippe Haouzi,

Chest (Chest)
[2020, 158(5):2235-2236]

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Modal decompositions of the kinematics of Crevalle Jack and the fluid-caudal fin interaction.

Muhammad Saif Ullah Khalid, Junshi Wang, Imran Akhtar, Haibo Dong, Moubin Liu,

To understand the governing mechanisms of bio-inspired swimming has always been challenging due to intense interactions between flexible bodies of natural aquatic species and water around them. Advanced modal decomposition techniques provide us with tools to develop more in-depth understating about these complex dynamical systems. In this paper, we employ ... Read more >>

Bioinspir Biomim (Bioinspiration & biomimetics)
[2020, :]

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Identification, Association of Natural Variation and Expression Analysis of ZmNAC9 Gene Response to Low Phosphorus in Maize Seedling Stage.

Javed Hussain Sahito, Bowen Luo, Muhammad Hayder Bin Khalid, Hakim Ali Sahito, Asif Ali, Zeeshan Ghulam Nabi Gishkori, Xiao Zhang, Xuan He, Haixu Zhong, Chen Zhen, Peng Ma, Dan Liu, Ling Wu, Shibin Gao,

Phosphorus (P) is an essential macroelement supporting maize productivity and low-P stress is a limiting factor of maize growth and yield. Improving maize plant tolerance to low P through molecular breeding is an effective alternative to increase crop productivity. In this study, a total of 111 diverse maize inbred lines ... Read more >>

Plants (Basel) (Plants (Basel, Switzerland))
[2020, 9(11):]

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In Silico Modeling of New "Y-Series"-Based Near-Infrared Sensitive Non-Fullerene Acceptors for Efficient Organic Solar Cells.

Muhammad Usman Khan, Riaz Hussain, Muhammad Yasir Mehboob, Muhammad Khalid, Zahid Shafiq, Muhammad Aslam, Abdulaziz A Al-Saadi, Saba Jamil, Muhammad Ramzan Saeed Ashraf Janjua,

This work was inspired by a previous report [Janjua, M. R. S. A. Inorg. Chem. 2012, 51, 11306-11314] in which the optoelectronic properties were improved with an acceptor bearing heteroaromatic rings. Herein, we have designed four novel Y-series non-fullerene acceptors (NFAs) by end-capped acceptor modifications of a recently synthesized 15% ... Read more >>

ACS Omega (ACS omega)
[2020, 5(37):24125-24137]

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First theoretical framework of Z-shaped acceptor materials with fused-chrysene core for high performance organic solar cells.

Muhammad Usman Khan, Riaz Hussain, Muhammad Yasir Mehboob, Muhammad Khalid, Muhammad Ali Ehsan, Abdul Rehman, Muhammad Ramzan Saeed Ashraf Janjua,

Chrysene core containing fused ring acceptor materials have remarkable efficiency for high performance organic solar cells. Therefore, present study has been carried out with the aim to design chrysene based novel Z-shaped electron acceptor molecules (Z1-Z6) from famous Z-shaped photovoltaic material FCIC (R) for organic photovoltaic applications. End-capped engineering at ... Read more >>

Spectrochim Acta A Mol Biomol Spectrosc (Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy)
[2021, 245:118938]

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Outcomes of Percutaneous Coronary Intervention Versus Optimal Medical Treatment for Chronic Total Occlusion: A Comprehensive Meta-analysis.

Abdul A Khan, Muhammad F Khalid, Muhammad T Ayub, Ghulam Murtaza, Rizwan Sardar, Christopher J White, Debabrata Mukherjee, Aravinda Nanjundappa, Timir K Paul,

The presence of concurrent chronic total occlusion (CTO) is a strong predictor for both short-term and long-term mortality. Successful percutaneous coronary intervention (PCI) of CTO has been associated with clinical benefit. We sought to perform a meta-analysis comparing CTO-PCI versus optimal medical therapy. PubMed, ClinicalTrials.gov, Google scholar and the Cochrane Central Register of Controlled Trials ... Read more >>

Curr Probl Cardiol (Current problems in cardiology)
[2020, :100695]

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Superior Mesenteric Artery Syndrome: A Classic Presentation of a Rare Entity.

Sunraj Tharu, Biswaraj Tharu, Mohammed Mahgoub, Muhammad Umar Khalid, Arooj Ahmed,

A 32-year-old female with a past medical history of constipation (predominant irritable bowel syndrome (IBS) and gastro-esophageal reflux disease (GERD)) presented with a complaint of pain in the lower abdomen. She lost 20 pounds in three months with a current body mass index (BMI) of 19.5 kg/m2 (ref: normal level ... Read more >>

Cureus (Cureus)
[2020, 12(8):e9990]

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Therapeutic Cytokine Inhibition Modulates Activation and Homing Receptors of Peripheral Memory B Cell Subsets in Rheumatoid Arthritis Patients.

Zafar Mahmood, Marc Schmalzing, Thomas Dörner, Hans-Peter Tony, Khalid Muhammad,

Memory B cells have known to play an important role in the pathogenesis of rheumatoid arthritis (RA). With the emergence of B cell-targeted therapies, the modulation of memory B cells appears to be a key therapeutic target. Human peripheral memory B cells can be distinguished based on the phenotypic expression ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:572475]

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Frequency of autoimmune thyroiditis in children with Celiac disease and effect of gluten free diet.

Javaria Rasheed, Rushan Hassan, Muhammad Khalid, Fauzia Zafar,

<h4>Objective</h4>To determine the frequency of autoimmune thyroiditis in children with Celiac disease and the effect of gluten free diet on autoimmune thyroiditis.<h4>Methods</h4>We enrolled 100 patients, age 1-12 years of either gender diagnosed as Celiac disease (CD) in this prospective observational study in the Department of Pediatric Medicine, from 1<sup>st</sup> January ... Read more >>

Pak J Med Sci (Pakistan journal of medical sciences)
[2020, 36(6):1280-1284]

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Scleroderma-associated cutaneous calcinosis: a remarkable regression post stem cell transplantation.

Abuelmagd Abdalla, Muhammad Khalid, Qasim Ishaq, Suzanne Donnelly,

Clin Rheumatol (Clinical rheumatology)
[2021, 40(2):789-790]

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Designing Star-Shaped Subphthalocyanine-Based Acceptor Materials with Promising Photovoltaic Parameters for Non-fullerene Solar Cells.

Muhammad Usman Khan, Muhammad Khalid, Muhammad Nadeem Arshad, Muhammad Naeem Khan, Muhammad Usman, Akbar Ali, Bullo Saifullah,

Star-shaped three-dimensional (3D) twisted configured acceptors are a type of nonfullerene acceptors (NFAs) which are getting considerable attention of chemists and physicists on account of their promising photovoltaic properties and manifestly promoted the rapid progress of organic solar cells (OSCs). This report describes the peripheral substitution of the recently reported ... Read more >>

ACS Omega (ACS omega)
[2020, 5(36):23039-23052]

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