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Sodium-Glucose Cotransporter-2 (SGLT-2) Inhibitors: Benefits in Diabetics With Cardiovascular Disease

Alexander Muacevic, John R Adler, Saba Aftab, Rishwanth Vetrivel Suresh, Nazleen Sherali, Muhammad Daniyal, Nicholas Tsouklidis,

Optimal blood glucose control helps reduce the development of the complications of type II diabetes mellitus (T2DM). T2DM patients usually are at increased risk of cardiovascular (CV) events and mortality. Therapies and strategies to treat diabetes and its related CV outcomes still need more investigation to find the best management ... Read more >>

Cureus (Cureus)
[0, 12(10):]

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Sodium-Glucose Cotransporter-2 (SGLT-2) Inhibitors: Benefits in Diabetics With Cardiovascular Disease.

Saba Aftab, Rishwanth Vetrivel Suresh, Nazleen Sherali, Muhammad Daniyal, Nicholas Tsouklidis,

Optimal blood glucose control helps reduce the development of the complications of type II diabetes mellitus (T2DM). T2DM patients usually are at increased risk of cardiovascular (CV) events and mortality. Therapies and strategies to treat diabetes and its related CV outcomes still need more investigation to find the best management ... Read more >>

Cureus (Cureus)
[2020, 12(10):e10783]

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Flavonoid glycosides from the rhizomes of Pronephrium penangianum.

Bingbing Shen, Shenghuang Chen, Qi Zhou, Yuqing Jian, Muhammad Daniyal, Wenbing Sheng, Limin Gong, Dixian Luo, Bin Liu, Guangming Xu, Wei Wang,

Six flavonoid glycosides jixueqisus A-F, together with nine known flavonoids, were isolated from the rhizomes of the fern Pronephrium penangianum. Among them, two red pigments jixueqisus A and B possess the same rare 6,8-dimethyl-2-phenyl-7H-1-benzopyran-7-one skeleton (a long conjugated system). Jixueqisu Cwas a dihydrochalcone glycoside, jixueqisu D was a chalcone glycoside, ... Read more >>

Phytochemistry (Phytochemistry)
[2020, 179:112500]

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Vicia plants-A comprehensive review on chemical composition and phytopharmacology.

Bahare Salehi, Ibrahim M Abu-Reidah, Farukh Sharopov, Natallia Karazhan, Javad Sharifi-Rad, Muhammad Akram, Muhammad Daniyal, Fahad Said Khan, Wafa Abbaass, Rida Zainab, Katya Carbone, Nouran M Fahmy, Eman Al-Sayed, Mohamed El-Shazly, Massimo Lucarini, Alessandra Durazzo, Antonello Santini, Miquel Martorell, Raffaele Pezzani,

The plants belonging to the genus Vicia are of great interest as a source of many bioactive compounds and micronutrients. A snapshot of their cultivation, habitat, main components, from which essential oils can be obtained, is given. The traditional medicinal uses of Vicia plants are also reported, as well as ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2020, :]

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The flower head of Chrysanthemum morifolium Ramat. (Juhua): A paradigm of flowers serving as Chinese dietary herbal medicine.

Hanwen Yuan, Sai Jiang, Yingkai Liu, Muhammad Daniyal, Yuqing Jian, Caiyun Peng, Jianliang Shen, Shifeng Liu, Wei Wang,

ETHNOPHARMACOLOGICAL RELEVANCE:Dietary herbal medicines are widely used for the prevention and treatment of a variety of diseases due to their pharmacological activities in China. Juhua (the flower head of Chrysanthemum morifolium Ramat.), the most representative flower-derived one, which is mainly used for the treatment of respiratory and cardiovascular diseases, shows ... Read more >>

J Ethnopharmacol (Journal of ethnopharmacology)
[2020, 261:113043]

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DNAzyme and rGO based fluorescence assay for Fpg activity analysis, drug screening, and bacterial imaging.

Yixing Qiu, Wenya Dang, Jialong Fan, Ting Zhou, Bin Li, Yang Liu, Yan Qin, Chunyi Tong, Muhammad Daniyal, Wei Wang, Bin Liu,

Due to the significant role of formamidopyrimidine DNA glycosylase (Fpg) in physiological processes and DNA oxidative damage-related diseases, it is essential to establish sensitive methods for monitoring the Fpg activity in vitro and in vivo so as to illustrate its concrete role in these events. In this work, a sensitive, ... Read more >>

Talanta (Talanta)
[2020, 218:121158]

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Clinical Decision Unit, an extension of emergency department: An experience and advantage in a tertiary care centre.

Irum Qamar Khan, Emaduddin Siddiqui, Shahan Waheed, Munawar Khursheed, Badar Afzal Khan, Sayyeda Ghazala Kazi, Muhammad Daniyal,

Objective:To evaluate the clinical decision unit of a tertiary care health facility and to see the disease pattern. . Methodology:The cross-sectional retrospective study was conducted at the Department of Emergency Medicine, Aga Khan University Hospital, Karachi, from September to October 2011, and comprised data of patients admitted to the clinical ... Read more >>

J Pak Med Assoc (JPMA. The Journal of the Pakistan Medical Association)
[2020, 70(2):293-298]

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Progress and prospects in the management of bacterial infections and developments in Phytotherapeutic modalities.

Muhammad Akram, Muhammad Riaz, Naveed Munir, Akhtar Rasul, Muhammad Daniyal, Muhammad Daniyal, Syed Muhammad Ali Shah, Mohammad Ali Shariati, Ghazala Shaheen, Naheed Akhtar, Farzana Parveen, Naheed Akhter, Aymen Owais Ghauri, Abdul Wadood Chishti, Muhammad Usman Sarwar, Fahad Said Khan,

The advent of antibiotics revolutionized medical care resulting in significantly reduced mortality and morbidity caused by infectious diseases. However, excessive use of antibiotics has led to the development of antibiotic resistance and indeed, the incidence of multidrug-resistant pathogens is considered as a major disadvantage in medication strategy, which has led ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2020, 47(7):1107-1119]

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Development of a nanodrug-delivery system camouflaged by erythrocyte membranes for the chemo/phototherapy of cancer.

Muhammad Daniyal, YuQing Jian, Feng Xiao, Wenbing Sheng, Jialong Fan, Chang Xiao, Zhou Wang, Bin Liu, Caiyun Peng, Qin Yuhui, Wei Wang,

Aim: Development of a new drug-delivery system using a compound derived from Pronephrium penangianum (J5) for the treatment of cervical cancer. Materials & methods: The delivery system was developed using Prussian blue nanoparticles, camouflaged by red blood cell membrane and with folic acid surface modifications. Results: Our results showed the ... Read more >>

Nanomedicine (Lond) (Nanomedicine (London, England))
[2020, 15(7):691-709]

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Endogenous Cys-Assisted [email protected] Nanoprobe for Real-Time Monitoring of Dynamic Change in GSH Levels Regulated by Natural Drug.

Yan Qin, Jialong Fan, Wei Yang, Bingbing Shen, Yupei Yang, Qi Zhou, Wenming Chen, Muhammad Daniyal, Feng Xiao, Wen-Bing Sheng, Huanghe Yu, Jiantao Zhou, Wei Wang, Chunyi Tong, Bin Liu,

Glutathione (GSH) levels are closely related to the homeostasis of redox state which directly affects human disease occurrence by regulating cell apoptosis. Hence, real-time monitoring of dynamic changes in intracellular GSH levels is urgently needed for disease early diagnosis and evaluation of therapy efficiency. In this study, an endogenous cysteine ... Read more >>

Anal. Chem. (Analytical chemistry)
[2020, 92(2):1988-1996]

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Recent Development on Anti-Obesity Compounds and their Mechanisms of Action: A Review.

Yixing Qiu, Huanghe Yu, Rong Zeng, Shiyin Guo, Muhammad Daniyal, Zeyu Deng, Aibing Wang, Wei Wang,

Obesity, associated with a series of complications such as diabetes, hypertension, and heart disease, is a great threat to human health and leads to increased morbidity and mortality. Despite the presence of anti-obesity agents on the market, the application of these drugs is limited because of their typical side effects. ... Read more >>

Curr. Med. Chem. (Current medicinal chemistry)
[2020, 27(21):3577-3597]

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Comprehensive Review on Graphene Oxide for Use in Drug Delivery System.

Muhammad Daniyal, Bin Liu, Wei Wang,

Motivated by the accomplishment of carbon nanotubes (CNTs), graphene and graphene oxide (GO) has been widely investigated in the previous studies as an innovative medication nanocarrier for the loading of a variety of therapeutics as well as anti-cancer medications, poor dissolvable medications, antibiotics, antibodies, peptides, DNA, RNA and genes. Graphene ... Read more >>

Curr. Med. Chem. (Current medicinal chemistry)
[2020, 27(22):3665-3685]

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Chemical constituents, experimental and clinical pharmacology of Rosa damascena: a literature review.

Muhammad Akram, Muhammad Riaz, Naveed Munir, Naheed Akhter, Sadia Zafar, Farhat Jabeen, Mohammad Ali Shariati, Naheed Akhtar, Zarfishan Riaz, Syed Hassan Altaf, Muhammad Daniyal, Muhammad Daniyal, Rabia Zahid, Fahad Said Khan,

CONTEXT:Rosa damascena Mill. is prescribed for the management of chest and abdominal pain, constipation, digestive disorders, menstrual bleeding and liver ailments. OBJECTIVE:The current review compiles up to date and complete information of whole plant of R. damascena with particular emphasis on its numerous scientifically proved pharmacological effects, traditional and folk medicinal ... Read more >>

J. Pharm. Pharmacol. (The Journal of pharmacy and pharmacology)
[2020, 72(2):161-174]

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Clinical outcome of paediatric patients with traumatic brain injury (TBI) receiving 3% hypertonic saline (HTS) in the emergency room of a tertiary care hospital.

Emad Uddin Siddiqui, Shahan Waheed, Feroza Perveen, Muhammad Daniyal, Muhammad Abdul Raffay Khan, Saif Siddiqui, Zain Siddiqui,

OBJECTIVE:To determine the clinical outcome and mean length of hospital stay of paediatric patients with severe blunt traumatic head injury (THI) receiving 3% hypertonic saline (HTS) in the Emergency Department (ED). Methodology:This case series study was conducted at the Department of Emergency Medicine, Aga Khan University Hospital, Karachi, from 2014 ... Read more >>

J Pak Med Assoc (JPMA. The Journal of the Pakistan Medical Association)
[2019, 69(11):1741-1745]

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Medicinal Plants Combating Against Insomnia: A Green Anti-Insomnia Approach.

Muhammad Akram, Muhammad Daniyal, Naveed Munir, Ejaz Mohiuddin, Sabira Sultana,

Insomnia is a state defined as trouble with sleep; it is a chronically disabling condition and is now significantly prevalent, imposing enormous health and economic burdens both on individuals and on society. This state includes trouble in falling asleep, problems staying asleep, fragmented sleep (repeatedly awakening at night), and/or awakening ... Read more >>

J. Nerv. Ment. Dis. (The Journal of nervous and mental disease)
[2019, 207(11):927-935]

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Awareness and current knowledge of epilepsy.

Asmat Ullah Khan, Muhammad Akram, Muhammad Daniyal, Naheed Akhter, Muhammad Riaz, Naheed Akhtar, Mohammad Ali Shariati, Fozia Anjum, Samreen Gul Khan, Abida Parveen, Saeed Ahmad,

Epilepsy is a severe neural disorder that affects approximately fifty million individuals globally. Despite the fact that for most of the people with epilepsy, convulsions are better controlled by current accessible antiepileptic medicines, yet there are more than 30% of individuals affected with medically intractable epilepsy and around 30-40% of ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2020, 35(1):45-63]

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New Lignans from roots of Kadsura coccinea.

Yupei Yang, Yongbei Liu, Muhammad Daniyal, Huanghe Yu, Qingling Xie, Bin Li, Yuqing Jian, Rongyong Man, Sanhu Wang, Xiaoling Zhou, Bin Liu, Wei Wang,

Four new dibenzocyclooctadiene lignans, named heilaohusus A-D (1-4), one new arylnaphthalene lignan named heilaohusu E (5), and seven known analogues (6-12) were isolated from the roots of Kadsura coccinea. Their structures and configurations were elucidated by a combination of HR-ESI-MS, 1H NMR, 13C NMR, HSQC, HMBC, NOESY and CD spectra. ... Read more >>

Fitoterapia (Fitoterapia)
[2019, 139:104368]

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RBC membrane camouflaged prussian blue nanoparticles for gamabutolin loading and combined chemo/photothermal therapy of breast cancer.

Bin Liu, Wenmiao Wang, Jialong Fan, Ying Long, Feng Xiao, Muhammad Daniyal, Chunyi Tong, Qian Xie, Yuqing Jian, Bin Li, Xiaochi Ma, Wei Wang,

Due to the non-targeted release of anti-cancer agent gamabufotalin (CS-6), conventional chemotherapy using this drug can cause serious side effects, which accordingly result in poor therapeutic efficiency. Recently, the development of smart nanodrug systems has attracted more and more attention due to their significant advantages of high loading efficiency, controllable ... Read more >>

Biomaterials (Biomaterials)
[2019, 217:119301]

Cited: 4 times

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Precision Nanomedicine Development Based on Specific Opsonization of Human Cancer Patient-Personalized Protein Coronas.

Jiayu Ren, Rong Cai, Jing Wang, Muhammad Daniyal, Didar Baimanov, Ying Liu, Dongtao Yin, Yang Liu, Qing Miao, Yuliang Zhao, Chunying Chen,

When a nanomedicine is administrated into the human body, biomolecules in biological fluids, particularly proteins, form a layer on the surface of the nanoparticle known as a "personalized protein corona". An understanding of the formation and behavior of the personalized protein corona not only benefits the nanotherapy treatment efficacy but ... Read more >>

Nano Lett. (Nano letters)
[2019, 19(7):4692-4701]

Cited: 1 time

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Two new alkaloids isolated from traditional Chinese medicine Binglang the fruit of Areca catechu.

Mengru Cao, Hanwen Yuan, Muhammad Daniyal, Huanghe Yu, Qingling Xie, Yingkai Liu, Bin Li, Yuqing Jian, Caiyun Peng, Dianbo Tan, Yanmei Peng, M Iqbal Choudhary, Atta-Ur Rahman, Wei Wang,

Binglang, the fruit of Areca catechu L, has a long history as an important Chinese herbal medicine. Two new alkaloids (1 and 2), along with forty-one known compounds (3-43) were isolated from the dried fruit of Areca catechu L. The structures were elucidated on basis of the IR, UV, MS ... Read more >>

Fitoterapia (Fitoterapia)
[2019, 138:104276]

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Awareness and Current Therapeutics of Asthma.

Rida Zainab, Muhammad Akram, Muhammad Daniyal, Muhammad Riaz,

Introduction:Asthma is a serious allergic disorder of the respiratory system. It affects about 300 million people worldwide. This has a great burden on medical treatment. Several medicines are available, but they have many serious side effects. Therefore, there is a need to search for a new therapeutic agent with no ... Read more >>

(Dose-response : a publication of International Hormesis Society)
[2019, 17(3):1559325819870900]

Cited: 1 time

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Therapeutic potential of medicinal plants for the management of urinary tract infection: A systematic review.

Ghazala Shaheen, Muhammad Akram, Farhat Jabeen, Syed Muhammad Ali Shah, Naveed Munir, Muhammad Daniyal, Muhammad Riaz, Imtiaz Mahmood Tahir, Aymen Owais Ghauri, Sabira Sultana, Rida Zainab, Muslim Khan,

Urinary tract infection (UTI) is one of the most severe public health problem affecting both sexes but females are more susceptible due to the differences in urogenital and reproductive anatomy, physiology and lifestyle. As in UTI, different parts of the urinary tract are affected and morbidity due to UTI is ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2019, 46(7):613-624]

Cited: 1 time

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Prevalence and current therapy in chronic liver disorders.

Muhammad Daniyal, Muhammad Akram, Rida Zainab, Naveed Munir, Aamir Sharif, Syed Muhammad Ali Shah, Bin Liu, Wei Wang,

BACKGROUND:Herbal medicine plays an important role in health, particularly in remote parts of developing areas with few health facilities. According to WHO estimates, about three-quarters of the world's population currently use herbs or traditional medicines to treat various ailments, including liver diseases. Several studies have found that the use of ... Read more >>

Inflammopharmacology (Inflammopharmacology)
[2019, 27(2):213-231]

Cited: 1 time

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Determination of oil contents from eight varieties of olea europaea (Olive) grown in Pakistan.

Abdul Khaliq, Syed Muhammad Ali Shah, Muhammad Akram, Naveed Munir, Muhammad Daniyal, Muhammad Irshad, Saeed Ahmad,

The olive (Olea europaea L.) is a worldwide famous tree crop having valuable commercial role due to nutritional as well as therapeutic benefits obtained from its edible oil. Eight varieties of Olea europaea L. fruits were obtained from three Agricultural research institutes located in different areas of Pakistan including Quetta, ... Read more >>

Nat. Prod. Res. (Natural product research)
[2020, 34(13):1951-1955]

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Progress and prospects in the management of psoriasis and developments in phyto-therapeutic modalities.

Muhammad Daniyal, Muhammad Akram, Rida Zainab, Naveed Munir, Syed Muhammad Ali Shah, Bin Liu, Wei Wang, Muhammad Riaz, Farhat Jabeen,

The aim of this study is to review the efficacy of herbal and allopathic drugs used to manage and treat psoriasis. The review has been compiled using reference materials from major databases, Online Journals, Science Direct, Scopus, Open J Gate, Google Scholar and PubMed. Psoriasis is a common skin disease ... Read more >>

Dermatol Ther (Dermatologic therapy)
[2019, 32(3):e12866]

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