Full Text Journal Articles by
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Autism in Australia: Community Knowledge and Autistic People's Experiences.

Sandra C Jones, Muhammad Akram, Chloe S Gordon, Nicole Murphy, Fiona Sharkie,

This paper presents two studies that explored community attitudes to autism in Australia; and autistic people and their families' perspectives of community attitudes. In Study One 2424 (primarily non-autistic) people completed a survey on autism-related knowledge and attitudes; identifying a number of misperceptions and knowledge gaps in the general community. ... Read more >>

J Autism Dev Disord (Journal of autism and developmental disorders)
[2021, :]

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Molecular targets for the management of cancer using Curcuma longa Linn. phytoconstituents: A Review.

Sabira Sultana, Naveed Munir, Zahed Mahmood, Muhammad Riaz, Muhammad Akram, Maksim Rebezov, Nazira Kuderinova, Zhanar Moldabayeva, Mohammad Ali Shariati, Abdur Rauf, Kannan R R Rengasamy,

Medicinal plants are being used for therapeutic purposes since the dawn of human civilization. The therapeutic efficacy of medicinal plants is due to the presence of wide range phytochemical constituents or secondary metabolites. The medicinal plants are traditionally used for several types of ailments. Even in those pathological conditions where ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2021, 135:111078]

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RAG-FW: A Hybrid Convolutional Framework for the Automated Extraction of Retinal Lesions and Lesion-Influenced Grading of Human Retinal Pathology.

Taimur Hassan, Muhammad Usman Akram, Naoufel Werghi, Muhammad Noman Nazir,

The identification of retinal lesions plays a vital role in accurately classifying and grading retinopathy. Many researchers have presented studies on optical coherence tomography (OCT) based retinal image analysis over the past. However, to the best of our knowledge, there is no framework yet available that can extract retinal lesions ... Read more >>

IEEE J Biomed Health Inform (IEEE journal of biomedical and health informatics)
[2021, 25(1):108-120]

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Family, school and individual characteristics associated with adolescents' physical activity at school in Hong Kong: the iHealt(H) study.

Alison Carver, Muhammad Akram, Anthony Barnett, Wendy Yajun Huang, Gemma Yang Gao, Robin R Mellecker, Ester Cerin,

<h4>Background</h4>Adolescents (11-18-year-olds) are at risk of physical inactivity. There is limited knowledge of physical activity (PA) levels among adolescents in the school setting in Hong Kong. We developed and tested a novel theoretical model of how household/family characteristics, school-level social and physical environmental factors and individual adolescent's characteristics impact on ... Read more >>

Int J Behav Nutr Phys Act (The international journal of behavioral nutrition and physical activity)
[2021, 18(1):14]

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Anti-anxiety properties of selected medicinal plants.

Asmatullah Khan, Muhammad Akram, Muthu Thiruvengadam, Muhammad Daniyal, Shahbaz Ahmad Zakki, Naveed Munir, Rida Zainab, Mojtaba Heydari, Seyed Hamdollah Mosavat, Maksim Rebezov, Mohammad Ali Shariati,

Exploration of new drugs targeting anxiety treatment is a major concern worldwide. Medicinal plants are being used as a potential source of novel drugs for anxiety disorders. The objective of this review is to provide information about the healing outcomes of anxiety treatment with natural products. Valeriana officinalis, Citrus aurantium, ... Read more >>

Curr Pharm Biotechnol (Current pharmaceutical biotechnology)
[2021, :]

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Type I IFNs: A Blessing in Disguise or Partner in Crime in MERS-CoV-, SARS-CoV-, and SARS-CoV-2-Induced Pathology and Potential Use of Type I IFNs in Synergism with IFN-γ as a Novel Antiviral Approach Against COVID-19.

Faisal Rasheed Anjum, Sidra Anam, Ghazanfar Abbas, Muhammad Shahid Mahmood, Sajjad Ur Rahman, Mohsan Ullah Goraya, Rana Muhammad Abdullah, Muhammad Luqman, Ashiq Ali, Muhammad Kamran Akram, Tamoor Hamid Chaudhry,

Since the end of 2019, the emergence of novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has accelerated the research on host immune responses toward the coronaviruses. When there is no approved drug or vaccine to use against these culprits, host immunity is the ... Read more >>

Viral Immunol (Viral immunology)
[2020, :]

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Serratia sp. CP-13 alleviates Cd toxicity by morpho-physio-biochemical improvements, antioxidative potential and diminished Cd uptake in Zea mays L. cultivars differing in Cd tolerance.

Kashif Tanwir, Muhammad Tariq Javed, Saghir Abbas, Muhammad Shahid, Muhammad Sohail Akram, Hassan Javed Chaudhary, Muhammad Iqbal,

Cadmium (Cd) is highly toxic for plant metabolic processes even in low concentration due to higher retention rates, longer half-life and non-biodegradable nature. The current study was designed to assess the bioremediation potential of Cd tolerant PGPR, Serratia sp. CP-13 together with two differentially Cd tolerant maize cultivars (MMRI-Yellow, Sahiwal-2002) ... Read more >>

Ecotoxicol Environ Saf (Ecotoxicology and environmental safety)
[2021, 208:111584]

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Plant growth-promoting Bacillus sp. strain SDA-4 confers Cd tolerance by physio-biochemical improvements, better nutrient acquisition and diminished Cd uptake in Spinacia oleracea L.

Muhammad Shahid, Muhammad Tariq Javed, Kashif Tanwir, Muhammad Sohail Akram, Syeda Khola Tazeen, Muhammad Hamzah Saleem, Sajid Masood, Sadia Mujtaba, Hassan Javed Chaudhary,

Cadmium (Cd) is highly toxic metal for plant metabolic processes even in low concentration due to its longer half-life and non-biodegradable nature. The current study was designed to assess the bioremediation potential of a Cd-tolerant phytobeneficial bacterial strain <i>Bacillus</i> sp. SDA-4, isolated, characterized and identified from Chakera wastewater reservoir, Faisalabad, ... Read more >>

Physiol Mol Biol Plants (Physiology and molecular biology of plants : an international journal of functional plant biology)
[2020, 26(12):2417-2433]

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Traditional and modern management strategies for rheumatoid arthritis.

Muhammad Akram, Muhammad Daniyal, Sabira Sultana, Aymen Owais, Naheed Akhtar, Rabia Zahid, Fahad Said, Abdelhakim Bouyahya, Evgeny Ponomarev, Mohammad Ali Shariat, Muthu Thiruvengadam,

Rheumatoid arthritis (RA) is a serious disorder of the joints affecting 1 or 2% of the population aged between 20 and 50 years worldwide. RA is the foremost cause of disability in developing and Western populations. It is an autoimmune disease-causing inflammation and pain involving synovial joints. Pro-inflammatory markers, including cytokines, ... Read more >>

Clin Chim Acta (Clinica chimica acta; international journal of clinical chemistry)
[2021, 512:142-155]

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Is it safe to consume traditional medicinal plants during pregnancy?

Nirit Bernstein, Muhammad Akram, Zohara Yaniv-Bachrach, Muhammad Daniyal,

The popularity of natural medicine is growing worldwide. Unlike conventional licensed medicines, herbal medicine practices are usually not supported by effectiveness, efficacy, or safety studies, which raise concerns about potential risks involved in their usage, particularly in high-risk patients such as pregnant women where teratogenicity is a concern. Despite a ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2020, :]

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sEMG dataset of routine activities.

Asad Mansoor Khan, Sajid Gul Khawaja, Muhammad Usman Akram, Ali Saeed Khan,

In this paper, we present the data set of surface electromyography (sEMG) and an Inertial Measurement Unit (IMU) against human muscle activity during routine activities. The Myo Thalamic Armband is used to acquire the signals from muscles below the elbow. The dataset comprises of raw sEMG, accelerometer, gyro and derived ... Read more >>

Data Brief (Data in brief)
[2020, 33:106543]

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Selection and validation of optimal endogenous reference genes for analysis of quantitative PCR in four tissues pathologically associated with Kidney-yang deficiency syndrome following influenza A infection.

Yepei Fu, Jia Yang, Shanshan Fan, Shaozhe Zhao, Ruikun Du, Syed Muhammad Ali Shah, Muhammad Akram, Rong Rong, Yong Yang,

Kidney-yang deficiency syndrome (KYDS) infected with the influenza virus is a suitable model to imitate a population at high-risk to influenza infection with a high rate of morbidity and mortality. However, the specific molecular mechanisms underlying this disease remain unclear. A stable reference gene is essential as an internal control ... Read more >>

Exp Ther Med (Experimental and therapeutic medicine)
[2020, 20(6):244]

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Phytosynthesized nanoparticles as a potential cancer therapeutic agent.

Jaison Jeevanandam, Prabir Kumar Kulabhusan, Godfred Sabbih, Muhammad Akram, Michael K Danquah,

Plants are the well-known sources for the hyper-accumulation and reduction of metallic ions. Analysis of various plant extracts has justified the presence of different types of phytochemicals that possess the stabilization and reduction functionalities of precursors to form nanoparticles. Such characteristics make plants as an attractive source for synthesizing eco-friendly ... Read more >>

3 Biotech (3 Biotech)
[2020, 10(12):535]

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Attenuation of Spatial Memory in 5xFAD Mice by Halting Cholinesterases, Oxidative Stress and Neuroinflammation Using a Cyclopentanone Derivative.

Rahim Ullah, Gowhar Ali, Nisar Ahmad, Muhammad Akram, Geeta Kumari, Muhammad Usman Amin, Muhammad Naveed Umar,

Alzheimer's disease (AD) is an irreversible and chronic neurological disorder that gradually destroys memory and thinking skills. The research study was designed to investigate the underlying molecular signaling involved in the neuroprotective effects of cyclopentanone derivative i.e., 2-(hydroxyl-(3-nitrophenyl)methyl)cyclopentanone (3NCP) as a therapeutic agent for AD. In this study, In vivo ... Read more >>

Pharmaceuticals (Basel) (Pharmaceuticals (Basel, Switzerland))
[2020, 13(10):]

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Foliar Applied Acetylsalicylic Acid Induced Growth and Key-Biochemical Changes in Chickpea (Cicer arietinum L.) Under Drought Stress.

Iqbal Hussain, Rizwan Rasheed, Muhammad Arslan Ashraf, Muhammad Mohsin, Syed Muhammad Ali Shah, Dr Abid Rashid, Muhammad Akram, Jaweria Nisar, Muhammad Riaz,

The exogenous application of acetylsalicylic acid (ASA) is stated to increase tolerance of plants against different environmental stresses. Therefore, the present study was planned to get insight into ASA-mediated regulation of growth, secondary metabolism, and oxidative defense in 2 chickpea varieties. Ten seeds of 2 chickpea varieties (DG-89 and Bittle-98) ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2020, 18(4):1559325820956801]

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Honey and Nigella sativa against COVID-19 in Pakistan (HNS-COVID-PK): A multi-center placebo-controlled randomized clinical trial

Sohaib Ashraf, Shoaib Ashraf, Moneeb Ashraf, Muhammad Ahmad Imran, Larab Kalsoom, Uzma Nasim Siddiqui, Iqra Farooq, Zaighum Habib, Sidra Ashraf, Muhammad Ghufran, Muhammad Kiwan Akram, Nighat Majeed, Zain-ul-Abdin, Rutaba Akmal, Sundas Rafique, Khawar Nawaz, Muhammad Ismail Yousaf, Sohail Ahmad, Muhammad Sarmad Shahab, Muhammad Faisal Nadeem, Muhammad Azam, Hui Zheng, Amber Malik, Mahmood Ayyaz, Talha Mahmud, Qazi Abdul Saboor, Ali Ahmad, Muhammad Ashraf, Mateen Izhar, Abubakar Hilal, Arz Muhammad, Zeeshan Shaukat, Ayesha Khaqan, Kanwal Hayat, Shahroze Arshad, Muhammad Hassan, Abeer-bin-Awais, Ammara Ahmad, Tayyab Mughal, Abdur Rehman Virk, Muhammad Umer, Muhammad Suhail, Sibgha Zulfiqar, Saulat Sarfraz, Muhammad Imran Anwar, Ayesha Humayun, Khokhar, Siddique, ,

<h4>SUMMARY</h4> <h4>BACKGROUND</h4> No definitive treatment exists for Coronavirus Disease 2019 (COVID-19). Honey and Nigella sativa (HNS) have established antiviral, antibacterial, anti-inflammatory and immunomodulatory properties. Hence, we investigated efficacy of HNS against COVID-19. wide <h4>METHODS</h4> We conducted a multicenter, placebo-controlled, randomized clinical trial at 4 centers in Pakistan. RT-PCR confirmed COVID-19 ... Read more >>

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Therapeutic Efficacy of Urinile Against Gouty Arthritis.

Saeed Ahmad, Ejaz Mohiuddin, Syed Muhammad Ali Shah, Muhammad Akram, Muhammad Amjad, Jaweria Nisar, Muhammad Riaz, Naveed Munir, Ghulam Rasool,

Gout is arthritis caused due to Monosodium urate (MSU) crystals deposition occurring particularly in patients with associated comorbidities limiting the use of conventional therapies. This study was planned to evaluate the therapeutic efficacy of urinile (a herbal drug) for the treatment of gouty arthritis. Allopurinol was used as standard drug ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2020, 18(4):1559325820946934]

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Method for efficient soluble expression and purification of recombinant human interleukin-15.

Nadeem Ahmed, Bakht Afroze, Rabia Abbas, Mohsin Ahmed Khan, Muhammad Akram, Saad Tahir, Shehman Bakht, Ayesha Munir, Ahmad Ali Shahid,

Periplasmic expression of recombinant proteins ensures the production of biologically active proteins in a correctly folded state with several key advantages. This research focused on the in-frame cloning of rhIL-15 in pET-20 (+) vector with pelB-leader sequence to direct the protein to the bacterial periplasm. The target construct periplasmic expression ... Read more >>

Protein Expr Purif (Protein expression and purification)
[2021, 177:105746]

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The Diagnostic Utility and Clinical Implications of Bronchoalveolar Lavage in Cancer Patients With Febrile Neutropenia and Lung Infiltrates.

Usman Khalid, Muhammad J Akram, Faheem M Butt, Mohammad B Ashraf, Faheem Khan,

Introduction Febrile neutropenia (FN) is a dreaded complication of cancer chemotherapy and frequently associated with respiratory infections. Flexible bronchoscopy (FB) serves as a useful diagnostic tool in this regard. Objective To determine the diagnostic yield, safety and clinical implications of bronchoalveolar lavage (BAL) in cancer patients with FN, having lung infiltrates ... Read more >>

Cureus (Cureus)
[2020, 12(9):e10268]

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Clinically Verified Hybrid Deep Learning System for Retinal Ganglion Cells Aware Grading of Glaucomatous Progression.

Hina Raja, Taimur Hassan, Muhammad Usman Akram, Naoufel Werghi,

<h4>Objective</h4>Glaucoma is the second leading cause of blindness worldwide. Glaucomatous progression can be easily monitored by analyzing the degeneration of retinal ganglion cells (RGCs). Many researchers have screened glaucoma by measuring cup-to-disc ratios from fundus and optical coherence tomography scans. However, this paper presents a novel strategy that pays attention ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
[2020, PP:]

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Challenges for biosimilars: focus on rheumatoid arthritis.

Muhammad Safwan Akram, Neelam Pery, Lucy Butler, Muhammad Imtiaz Shafiq, Nayab Batool, Muhammad Fayyaz Ur Rehman, Luke G Grahame-Dunn, Ali K Yetisen,

Healthcare systems worldwide are struggling to find ways to fund the cost of innovative treatments such as gene therapies, regenerative medicine, and monoclonal antibodies (mAbs). As the world's best known mAbs are close to facing patent expirations, the biosimilars market is poised to grow with the hope of bringing prices ... Read more >>

Crit Rev Biotechnol (Critical reviews in biotechnology)
[2021, 41(1):121-153]

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The Diagnostic Utility and Clinical Implications of Bronchoalveolar Lavage in Cancer Patients With Febrile Neutropenia and Lung Infiltrates

Alexander Muacevic, John R Adler, Usman Khalid, Muhammad J Akram, Faheem M Butt, Mohammad B Ashraf, Faheem Khan,

Introduction Febrile neutropenia (FN) is a dreaded complication of cancer chemotherapy and frequently associated with respiratory infections. Flexible bronchoscopy (FB) serves as a useful diagnostic tool in this regard. Objective To determine the diagnostic yield, safety and clinical implications of bronchoalveolar lavage (BAL) in cancer patients with FN, having lung infiltrates ... Read more >>

Cureus (Cureus)
[0, 12(9):]

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A Prospective Cohort Analysis of COVID-19 Positive and Negative Patients Admitted to a Single Centre in the North-East of England During the Peak of a Pandemic

Anjan Dhar, Alexander Newman, Keryn Hall, Christopher Pexton, Satyasheel Ramful, Alison Carter, Whajong Lee, Sarath Bethapud, Anthony Allan, Muhammad Safwan Akram, Vikki Rand,

Objectives: To investigate the clinical haematological, radiological and biochemical factors associated with outcome in COVID-19 positive patients in North East England (NEE) where mortality rates were higher during the peak of the pandemic.<br><br>Design: Prospective single-centre cohort study.<br><br>Setting: Acute Medical Admissions service at Darlington Memorial Hospital in North East England.<br><br>Participants: 275 ... Read more >>

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Predicting the survival in patients with malignant pleural effusion undergoing indwelling pleural catheter insertion.

Muhammad Junaid Akram, Usman Khalid, Mohammad Bilal Ashraf, Muhammad Abu Bakar, Faheem Mahmood Butt, Faheem Khan,

<h4>Context</h4>Malignant pleural effusion (MPE) is a common comorbid condition in advanced malignancies with variable survival.<h4>Aims</h4>The aim of this study was to predict the survival in patients with MPE undergoing indwelling pleural catheter (IPC) insertion.<h4>Settings and design</h4>This was a cross-sectional study conducted at Shaukat Khanum Memorial Cancer Hospital and Research Centre, ... Read more >>

Ann Thorac Med (Annals of thoracic medicine)
[2020, 15(4):223-229]

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CuO Hollow Cubic Caves Wrapped with Biogenic N-Rich Graphitic C for Simultaneous Monitoring of Uric Acid and Xanthine.

Khizer Hayat, Aqsa Munawar, Anam Zulfiqar, Mahmood Hassan Akhtar, Hafiz Badaruddin Ahmad, Zahid Shafiq, Muhammad Akram, Awais Siddique Saleemi, Naeem Akhtar,

Herein, we synthesized hollow cubic caves of CuO (HC) and wrapped it with N-rich graphitic C (NC), derived from a novel biogenic mixture composed of dopamine (DA) and purine. The synthesized NC wrapped HC ([email protected]) sensor shows enhanced electrocatalytic efficacy compared to unwrapped CuO with shapes including HC, sponge (SP), ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, 12(42):47320-47329]

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