Full Text Journal Articles by
Author Muhammad Akhlaq

Advertisement

Find full text journal articles








Targeted Delivery of Methotrexate through pH-sensitive Hydrogel: To Treat Colon Pathology

Muhammad Akhlaq, Inam Ullah, Asif Nawaz, Muhammad Safdar, Abul Kalam Azad, Syed Atif Abbas, Abul Bashar Mohammed Helaluddin,

The purpose of current research work was to formulate and typify gelatin and poly(vinyl) alcohol (Gel/PVA) hydrogel which would be highly pH-responsive and can able to accomplish targeted delivery of methotrexate in order to treat the colo-rectal pathologies. The primed gel/pva hydrogel discs were subjected to various physicochemical techniques i.e. ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Hexose monophosphate shunt, the role of its metabolites and associated disorders: A review.

Muhammad Akram, Syed Muhammad Ali Shah, Naveed Munir, Muhammad Daniyal, Imtiaz Mahmood Tahir, Zahed Mahmood, Muhammad Irshad, Muhammad Akhlaq, Sabira Sultana, Rida Zainab,

The hexose monophosphate (HMP) shunt acts as an essential component of cellular metabolism in maintaining carbon homeostasis. The HMP shunt comprises two phases viz. oxidative and nonoxidative, which provide different intermediates for the synthesis of biomolecules like nucleotides, DNA, RNA, amino acids, and so forth; reducing molecules for anabolism and detoxifying the reactive oxygen species ... Read more >>

J Cell Physiol (Journal of cellular physiology)
[2019, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

Comparison of clinico-pathological characteristics and survival of recurrent ovarian cancer patients on seven different chemo-protocols.

Saima Sattar, Mobasher Ahmad, Hamid Saeed, Zikria Saleem, Zeeshan Danish, Muhammad Akhlaq,

Despite growing prevalence of ovarian cancer (OC) in Pakistan, no literature evidence exists regarding its clinic-pathological characteristics, survival and compliance of patients with recurrent ovarian cancer on various chemo-protocols. An observational study was conducted by enrolling 251 recurrent OC patients on 7 different chemo-protocols, from a specialized cancer care hospital, ... Read more >>

Acta Pharm (Acta pharmaceutica (Zagreb, Croatia))
[2019, 69(1):87-97]

Cited: 0 times

View full text PDF listing >>



Pharmacokinetic evaluation of quetiapine fumarate controlled release hybrid hydrogel: a healthier treatment of schizophrenia.

Muhammad Akhlaq, Faiza Maryam, Abdelhamid Elaissari, Hashmat Ullah, Muhammad Adeel, Abid Hussain, Muhammad Ramzan, Obaid Ullah, Muhammad Zeeshan Danish, Shehla Iftikhar, Nighat Aziz,

The current study aimed to rationally develop and characterize pH-sensitive controlled release hydrogels by graft polymerization of gelatin (Gel) and hydroxypropyl methyl cellulose (HPMC) in the presence of glutaraldehyde (GA) using quetiapine fumarate for the treatment of schizophrenia. The prepared hydrogels discs were subjected to various physicochemical studies including: swelling, ... Read more >>

Drug Deliv (Drug delivery)
[2018, 25(1):916-927]

Cited: 0 times

View full text PDF listing >>



Anti-diabetic activity of aqueous extract of Ipomoea batatas L. in alloxan induced diabetic Wistar rats and its effects on biochemical parameters in diabetic rats.

Shagufta Kamal, Naheed Akhter, Samreen Gul Khan, Shumaila Kiran, Tahir Farooq, Muhammad Akram, Syed Muhammad Ali Shah, Imtiaz Mahmood Tahir, Muhammad Akhlaq, Fahad Said, Jawad Zaheer,

Diabetes is a condition where the fasting blood glucose level elevated above the normal range (80-120mg/dL). This increase in blood glucose level may be due to the insulin deficiency i.e. insulin dependent diabetes mellitus (IDDM or type I) or due to insulin resistance i.e. non-insulin dependent diabetes mellitus (NIDDM or ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2018, 31(4(Supplementary)):1539-1548]

Cited: 1 time

View full text PDF listing >>



Enhanced production of Lovastatin by filamentous fungi through solid state fermentation.

Shagufta Kamal, Naheed Akhter, Samreen Gul Khan, Shumaila Kiran, Tahir Farooq, Muhammad Akram, Syed Muhammad Ali Shah, Imtiaz Mahmood Tahir, Muhammad Akhlaq, Fahad Said, Jawad Zaheer,

Lovastatin is a natural competitive inhibitor of 3-hydroxy-3-methyl glutaryl coenzyme-A (HMG-CoA) reductase and inhibits specifically rate limiting step in cholesterol biosynthesis. Further, lovastatin in comparison with synthetic drugs has no well-reported side effects. Four pure isolated filamentous fungal strains including Aspergillus niger IBL, Aspergillus terreus FFCBP-1053, Aspergillus flavus PML and ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2018, 31(4(Supplementary)):1583-1589]

Cited: 0 times

View full text PDF listing >>



Development of an ANN optimized mucoadhesive buccal tablet containing flurbiprofen and lidocaine for dental pain.

Amjad Hussain, Muhammad Ali Syed, Nasir Abbas, Sana Hanif, Muhammad Sohail Arshad, Nadeem Irfan Bukhari, Khalid Hussain, Muhammad Akhlaq, Zeeshan Ahmad,

A novel mucoadhesive buccal tablet containing flurbiprofen (FLB) and lidocaine HCl (LID) was prepared to relieve dental pain. Tablet formulations (F1-F9) were prepared using variable quantities of mucoadhesive agents, hydroxypropyl methyl cellulose (HPMC) and sodium alginate (SA). The formulations were evaluated for their physicochemical properties, mucoadhesive strength and mucoadhesion time, ... Read more >>

Acta Pharm (Acta pharmaceutica (Zagreb, Croatia))
[2016, 66(2):245-256]

Cited: 2 times

View full text PDF listing >>



Controlled release matrix tablets of glipizide: Influence of different grades of ethocel and Co-excipient on drug release.

Saif Ullah Mehsud, Gul Majid Khan, Abid Hussain, Muhammad Akram, Muhammad Akhlaq, Kamran Ahmad Khan, Abdul Shakoor,

The aim of the current study was to formulate and evaluate glipizide controlled release matrix tablets by means of different grades of polymer Ethoceland different co-excipients in order to evaluate their effect on drug release profiles during in vitro dissolution studies. Type II diabetes mellitus is usually treated with Glipizide. ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2016, 29(3):779-787]

Cited: 0 times

View full text PDF listing >>



Formulation and evaluation of anti-rheumatic dexibuprofen transdermal patches: a quality-by-design approach.

Muhammad Akhlaq, Muhammad Sohail Arshad, Abdul Mughees Mudassir, Amjad Hussain, Israfil Kucuk, Rita Haj-Ahmad, Manoochehr Rasekh, Zeeshan Ahmad,

Dexibuprofen (DXIBN) transdermal patches were formulated using various concentrations of selected polymeric excipients (matrix material; ethyl cellulose and polyvinylpyrrolidone, plasticizer (di-N-butyl phthalate), and a conventional permeation enhancer (almond oil)). Initial patch formulations were evaluated for their physiochemical properties (thickness, moisture uptake, final moisture content, and DXIBN content). Also, impact of ... Read more >>

J Drug Target (Journal of drug targeting)
[2016, 24(7):603-612]

Cited: 4 times

View full text PDF listing >>



A simple and rapid approach to evaluate the in vitro in vivo role of release controlling agent ethyl cellulose ether derivative polymer.

Muhammad Akhlaq, Gul Majid Khan, Syed Umer Jan, Abdul Wahab, Abid Hussain, Asif Nawaz, Hamdy Abdelkader,

Diclofenac sodium (DCL-Na) conventional oral tablets exhibit serious side effects when given for a longer period leading to noncompliance. Controlled release matrix tablets of diclofenac sodium were formulated using simple blending (F-1), solvent evaporation (F-2) and co-precipitation techniques (F-3). Ethocel® Standard 7 FP Premium Polymer (15%) was used as a ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2014, 27(6):1789-1798]

Cited: 0 times

View full text PDF listing >>



Effect of olive oil on transdermal penetration of flurbiprofen from topical gel as enhancer.

Abid Hussain, Gul Majid Khan, Syed Umer Jan, Shefaatullah Shah, Kifayatullah Shah, Muhammad Akhlaq, Nouman Rahim, Asif Nawaz, Abdul Wahab,

The present study was conducted to formulate and evaluate flurbiprofen transdermal gel. A standard calibration curve was constructed to obtain a regression line equation to be used for finding out the concentration of drug in samples. Olive oil was used as penetration enhancer and was added in different concentrations to ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2012, 25(2):365-369]

Cited: 1 time

View full text PDF listing >>



A simple high-performance liquid chromatographic practical approach for determination of flurbiprofen.

Muhammad Akhlaq, Gul Majid Khan, Abdul Wahab, Arshad Khan, Abid Hussain, Asif Nawaz, Hamdy Abdelkader,

A simple, rapid, sensitive, and specific high-performance liquid chromatography (HPLC) assay for flurbiprofen has been developed and validated practically. The chromatography was conducted using Gemini C18 column (5 μm; 4.6 mm × 250 mm, Phenomenex, California, USA). The mobile phase containing disodium hydrogen phosphate solution (30 mM) pH 7.0 and ... Read more >>

J Adv Pharm Technol Res (Journal of advanced pharmaceutical technology & research)
[2011, 2(3):151-155]

Cited: 7 times

View full text PDF listing >>





Advertisement

Disclaimer
0.7794 s