Full Text Journal Articles by
Author Mubeen F Rafay

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Association of outcomes in acute flaccid myelitis with identification of enterovirus at presentation: a Canadian, nationwide, longitudinal study.

Carmen Yea, Ari Bitnun, Helen M Branson, Beyza Ciftci-Kavaklioglu, Mubeen F Rafay, Olivier Fortin, Paola Moresoli, Guillaume Sébire, Myriam Srour, Hélène Decaluwe, Louis Marois, Félixe Pelletier, Michelle Barton, Maryam Nabavi Nouri, Jason Brophy, Sunita Venkateswaran, Daniela Pohl, Kathryn Selby, Kevin Jones, Joan Robinson, Aleksandra Mineyko, Christoph Licht, Birgit Ertl-Wagner, E Ann Yeh,

BACKGROUND:Acute flaccid myelitis (AFM) is characterised by rapid onset of limb weakness with spinal cord grey-matter abnormalities on MRI scan. We aimed to assess whether detection of enterovirus in respiratory or other specimens can help predict prognosis in children with AFM. METHODS:In this nationwide, longitudinal study, we evaluated the significance ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, 4(11):828-836]

Cited: 0 times

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Teaching NeuroImages: Early imaging of sulfite oxidase deficiency mimics severe hypoxic ischemic encephalopathy.

Carly Scramstad, Hayley Moffatt, Mubeen F Rafay,

Neurology (Neurology)
[2020, 95(13):e1913-e1914]

Cited: 0 times

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Reply to Letter to the Editor "Predicting Recovery and Outcome after Pediatric Stroke: Results from the International Pediatric Stroke Study".

Ryan J Felling, Mubeen F Rafay, Mahmoud Slim, Gabrielle de Veber,

Ann Neurol (Annals of neurology)
[2020, 88(1):202-203]

Cited: 0 times

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Spectrum of cerebral arteriopathies in children with arterial ischemic stroke.

Mubeen F Rafay, Kevin A Shapiro, Ann-Marie Surmava, Gabrielle A deVeber, Adam Kirton, Heather J Fullerton, Catherine Amlie-Lefond, Bernhard Weschke, Nomazulu Dlamini, Jessica L Carpenter, Mark T Mackay, Michael Rivkin, Alexandra Linds, Timothy J Bernard, ,

OBJECTIVE:To determine that children with arterial ischemic stroke (AIS) due to an identifiable arteriopathy are distinct from those without arteriopathy and that each arteriopathy subtype has unique and recognizable clinical features. METHODS:We report a large, observational, multicenter cohort of children with AIS, age 1 month to 18 years, enrolled in ... Read more >>

Neurology (Neurology)
[2020, 94(23):e2479-e2490]

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Predicting Recovery and Outcome after Pediatric Stroke: Results from the International Pediatric Stroke Study.

Ryan J Felling, Mubeen F Rafay, Timothy J Bernard, Jessica L Carpenter, Nomazulu Dlamini, Sahar M A Hassanein, Lori C Jordan, Michael J Noetzel, Michael J Rivkin, Kevin A Shapiro, Mahmoud Slim, Gabrielle deVeber, ,

OBJECTIVE:To characterize predictors of recovery and outcome following pediatric arterial ischemic stroke, hypothesizing that age influences recovery after stroke. METHODS:We studied children enrolled in the International Pediatric Stroke Study between January 1, 2003 and July 31, 2014 with 2-year follow-up after arterial ischemic stroke. Outcomes were defined at discharge by ... Read more >>

Ann Neurol (Annals of neurology)
[2020, 87(6):840-852]

Cited: 0 times

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Comparative study of posterior and anterior circulation stroke in childhood: Results from the International Pediatric Stroke Study.

Barbara Goeggel Simonetti, Mubeen F Rafay, Melissa Chung, Warren D Lo, Lauren A Beslow, Lori L Billinghurst, Christine K Fox, Alberto Pagnamenta, Maja Steinlin, Mark T Mackay, ,

OBJECTIVE:To compare risk factors, clinical presentation, and outcomes after posterior circulation arterial ischemic stroke (PCAIS) and anterior circulation arterial ischemic stroke (ACAIS) in neonates and children. METHODS:In this international multicenter observational study including neonates and children up to 18 years of age with arterial ischemic stroke (AIS), we compared clinical ... Read more >>

Neurology (Neurology)
[2020, 94(4):e337-e344]

Cited: 0 times

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Arterial Ischemic Stroke Secondary to Cardiac Disease in Neonates and Children.

Melissa G Chung, Kristin P Guilliams, Jenny L Wilson, Lauren A Beslow, Michael M Dowling, Neil R Friedman, Sahar M A Hassanein, Rebecca Ichord, Lori C Jordan, Mark T Mackay, Mubeen F Rafay, Michael Rivkin, Marcela Torres, Dimitrios Zafeiriou, Gabrielle deVeber, Christine K Fox, ,

OBJECTIVE:We describe the risk factors for peri-procedural and spontaneous arterial ischemic stroke (AIS) in children with cardiac disease. METHODS:We identified children with cardiac causes of AIS enrolled in the International Pediatric Stroke Study registry from January 2003 to July 2014. Isolated patent foramen ovale was excluded. Peri-procedural AIS (those occurring ... Read more >>

Pediatr Neurol (Pediatric neurology)
[2019, 100:35-41]

Cited: 0 times

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Craniocervical Arterial Dissection in Children: Pathophysiology and Management.

Monica Nash, Mubeen F Rafay,

BACKGROUND:Craniocervical arterial dissection is a commonly reported arteriopathy associated with stroke in children. It is characterized by a high stroke recurrence rate and variable outcomes. Here we review the pathophysiology, clinical presentation, and diagnostic neuroimaging approaches that are helpful in accurate diagnosis and follow-up of children with arterial dissection. METHODS:MEDLINE ... Read more >>

Pediatr Neurol (Pediatric neurology)
[2019, 95:9-18]

Cited: 0 times

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Focal Cerebral Arteriopathy of Childhood: Novel Severity Score and Natural History.

Heather J Fullerton, Nicholas Stence, Nancy K Hills, Bin Jiang, Catherine Amlie-Lefond, Timothy J Bernard, Neil R Friedman, Rebecca Ichord, Mark T Mackay, Mubeen F Rafay, Stéphane Chabrier, Maja Steinlin, Mitchell S V Elkind, Gabrielle A deVeber, Max Wintermark, ,

Background and Purpose- Focal cerebral arteriopathy (FCA)-a common cause of arterial ischemic stroke in previously healthy children-often progresses over days to weeks, increasing the risk of recurrent stroke. We developed a novel severity scoring system designed to quantify FCA progression and correlate with clinical outcomes. Methods- The VIPS study (Vascular ... Read more >>

Stroke (Stroke)
[2018, 49(11):2590-2596]

Cited: 5 times

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Clinical and Imaging Characteristics of Arteriopathy Subtypes in Children with Arterial Ischemic Stroke: Results of the VIPS Study.

M Wintermark, N K Hills, G A DeVeber, A J Barkovich, T J Bernard, N R Friedman, M T Mackay, A Kirton, G Zhu, C Leiva-Salinas, Q Hou, H J Fullerton, ,

Childhood arteriopathies are rare but heterogenous, and difficult to diagnose and classify, especially by nonexperts. We quantified clinical and imaging characteristics associated with childhood arteriopathy subtypes to facilitate their diagnosis and classification in research and clinical settings.The Vascular Effects of Infection in Pediatric Stroke (VIPS) study prospectively enrolled 355 children ... Read more >>

AJNR Am J Neuroradiol (AJNR. American journal of neuroradiology)
[2017, 38(11):2172-2179]

Cited: 10 times

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Child- and parent-reported quality of life trajectories in children with epilepsy: A prospective cohort study.

Mark A Ferro, Lisa Avery, Nora Fayed, David L Streiner, Charles E Cunningham, Michael H Boyle, Lucyna Lach, Gina Glidden, Peter L Rosenbaum, Gabriel M Ronen, ,

To describe the developmental trajectories of quality of life (QoL) in a large cohort of children with epilepsy, and to assess the relative contribution of clinical, psychosocial, and sociodemographic variables on QoL trajectories.Five assessments during a 28-month prospective cohort study were used to model trajectories of QoL. Participants were recruited ... Read more >>

Epilepsia (Epilepsia)
[2017, 58(7):1277-1286]

Cited: 3 times

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Epidemiology, Clinical Presentation, and Prognosis of Posterior Circulation Ischemic Stroke in Children.

Samantha Carey, Jens Wrogemann, Frances A Booth, Mubeen F Rafay,

Anterior and posterior circulation strokes are often different in terms of presentation and recurrence risk, but there are few studies that focused on posterior circulation stroke.We performed a longitudinal retrospective study of children, birth to 18 years, with posterior circulation ischemic stroke at the Children's Hospital Winnipeg from January 1992 to December 2012. ... Read more >>

Pediatr. Neurol. (Pediatric neurology)
[2017, 74:41-50]

Cited: 2 times

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Longitudinal Outcomes in the 2014 Acute Flaccid Paralysis Cluster in Canada.

Carmen Yea, Ari Bitnun, Joan Robinson, Aleksandra Mineyko, Michelle Barton, Jean K Mah, Jiri Vajsar, Susan Richardson, Christoph Licht, Jason Brophy, Megan Crone, Shalini Desai, Juliette Hukin, Kevin Jones, Katherine Muir, Jeffrey M Pernica, Robert Pless, Daniela Pohl, Mubeen F Rafay, Kathryn Selby, Sunita Venkateswaran, Geneviève Bernard, E Ann Yeh,

We describe the presenting features and long-term outcome of an unusual cluster of pediatric acute flaccid paralysis cases that occurred in Canada during the 2014 enterovirus D68 outbreak. Children (n = 25; median age 7.8 years) presenting to Canadian centers between July 1 and October 31, 2014, and who met ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2017, 32(3):301-307]

Cited: 13 times

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Inflammatory Biomarkers in Childhood Arterial Ischemic Stroke: Correlates of Stroke Cause and Recurrence.

Heather J Fullerton, Gabrielle A deVeber, Nancy K Hills, Michael M Dowling, Christine K Fox, Mark T Mackay, Adam Kirton, Jerome Y Yager, Timothy J Bernard, Eldad A Hod, Max Wintermark, Mitchell S V Elkind, ,

Among children with arterial ischemic stroke (AIS), those with arteriopathy have the highest recurrence risk. We hypothesized that arteriopathy progression is an inflammatory process and that inflammatory biomarkers would predict recurrent AIS.In an international study of childhood AIS, we selected cases classified into 1 of the 3 most common childhood ... Read more >>

Stroke (Stroke)
[2016, 47(9):2221-2228]

Cited: 15 times

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A pediatric institutional acute stroke protocol improves timely access to stroke treatment.

Melissa Shack, Andrea Andrade, Priyanka P Shah-Basak, Manohar Shroff, Mahendranath Moharir, Ivanna Yau, Rand Askalan, Daune MacGregor, Mubeen F Rafay, Gabrielle A deVeber, ,

We aimed to evaluate whether an institutional acute stroke protocol (ASP) could accelerate the diagnosis and secondary treatment of pediatric stroke.We initiated an ASP in 2005. We compared 209 children (125 males, 84 females; median age 4.8y, interquartile range [IQR] 1.2-9.3y, range 0.09-17.7y) diagnosed with arterial ischemic stroke 'pre-protocol' (1992-2004) ... Read more >>

Dev Med Child Neurol (Developmental medicine and child neurology)
[2017, 59(1):31-37]

Cited: 6 times

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Risk of Recurrent Arterial Ischemic Stroke in Childhood: A Prospective International Study.

Heather J Fullerton, Max Wintermark, Nancy K Hills, Michael M Dowling, Marilyn Tan, Mubeen F Rafay, Mitchell S V Elkind, A James Barkovich, Gabrielle A deVeber, ,

Published cohorts of children with arterial ischemic stroke (AIS) in the 1990s to early 2000s reported 5-year cumulative recurrence rates approaching 20%. Since then, utilization of antithrombotic agents for secondary stroke prevention in children has increased. We sought to determine rates and predictors of recurrent stroke in the current era.The ... Read more >>

Stroke (Stroke)
[2016, 47(1):53-59]

Cited: 38 times

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Patterns of cerebral ischemia in children with moyamoya.

Mubeen F Rafay, Derek Armstrong, Peter Dirks, Daune L MacGregor, Gabrielle deVeber,

BACKGROUND: Moyamoya disease is characterized by progressive cerebrovascular stenosis with recurrent cerebral ischemic events. Transient ischemic attacks are often associated with hyperventilation in children with moyamoya, suggesting hypoperfusion rather than thrombotic vaso-occlusion as a prominent mechanism. The patterns of ischemia and severity of steno-occlusive disease in such children may elucidate ... Read more >>

Pediatr. Neurol. (Pediatric neurology)
[2015, 52(1):65-72]

Cited: 8 times

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Cardioembolic stroke in children: a clinical presentation and outcome study.

Markus T Ziesmann, Monica Nash, Frances A Booth, Mubeen F Rafay,

Cardiac disease is a common cause of ischemic stroke in children. Limited information is available about its incidence and long-term outcome.We undertook a retrospective study of children (age 0-17 years) with cardioembolic arterial ischemic stroke, occurring between 1992 and December 2007. Study subjects were observed at the Winnipeg Children's Hospital ... Read more >>

Pediatr Neurol (Pediatric neurology)
[2014, 51(4):494-502]

Cited: 5 times

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Outcomes trajectories in children with epilepsy: hypotheses and methodology of a Canadian longitudinal observational study.

Gabriel M Ronen, David L Streiner, Michael H Boyle, Charles E Cunningham, Lucyna Lach, Leonard H Verhey, Nora Fayed, Karen Chen, Peter L Rosenbaum, , Mary Connolly, Luis E Bello-Espinosa, Mubeen F Rafay, Juan Pablo Appendino, Michael Shevell, Lionel Carmant,

BACKGROUND: The impact of childhood epilepsy can only be appreciated by understanding that epilepsy comprises a set of complex neurobehavioral conditions with significant social consequences, and not simply disorders of recurrent seizures. Our objective is to describe the hypotheses and methodology behind a large prospective longitudinal study that is based ... Read more >>

Pediatr Neurol (Pediatric neurology)
[2014, 50(1):38-48]

Cited: 7 times

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SCN1A mutation associated with intractable myoclonic epilepsy and migraine headache.

Patrick Frosk, Aizeddin A Mhanni, Mubeen F Rafay,

Mutations in the SCN1A gene are associated with a variety of epilepsy syndromes and more recently with familial hemiplegic migraine. The spectrum of phenotypes can be quite broad even within the same family and with the same mutation. Here we describe a child with intractable myoclonic epilepsy and autism spectrum ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2013, 28(3):389-391]

Cited: 8 times

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Arterial ischemic stroke in an adolescent with presumed perinatal ischemic stroke.

Kristin Hamilton, Michael S Salman, Ilan Schwartz, Patricia J McCusker, Jens Wrogemann, Mubeen F Rafay,

The risk of recurrent ischemic stroke after presumed perinatal stroke and the risk factors for such recurrence are rarely reported. Here, we present an adolescent with a history of presumed perinatal stroke who presented with arterial ischemic stroke recurrence at the age of 15 years. Hereditary thrombophilia screening performed at ... Read more >>

J Child Neurol (Journal of child neurology)
[2012, 27(1):94-98]

Cited: 0 times

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Antithrombotic treatment in neonatal cerebral sinovenous thrombosis: results of the International Pediatric Stroke Study.

Lori C Jordan, Mubeen F Rafay, Sabrina E Smith, Rand Askalan, Khaled M Zamel, Gabrielle deVeber, Stephen Ashwal, ,

To identify predictors of antithrombotic treatment in neonates with cerebral sinovenous thrombosis (CSVT) in a large multinational study.Neonates with CSVT from 10 countries were enrolled in the International Pediatric Stroke Study from 2003 through 2007. Term neonates with CSVT who presented with neurologic symptoms or signs of systemic illness and ... Read more >>

J Pediatr (The Journal of pediatrics)
[2010, 156(5):704-10, 710.e1-710.e2]

Cited: 33 times

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Ischemic perinatal stroke secondary to chorioamnionitis: a histopathological case presentation.

Christine C Dueck, David Grynspan, David D Eisenstat, Rebecca Caces, Mubeen F Rafay,

Ischemic perinatal stroke is a serious potential complication of delivery. In utero infection may be responsible for an underestimated proportion of perinatal stroke. Limited literature identifies objective evidence of ischemic perinatal stroke as a consequence of uterine infection. The authors report a neonate with ischemic stroke and documented findings of ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2009, 24(12):1557-1560]

Cited: 6 times

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Recurrent posterior circulation stroke in an infant with basilar artery aneurysm.

Patrick Frosk, Michael S Salman, Jens Wrogemann, Namrata Shah, Mubeen F Rafay,

Arterial ischemic stroke involving the posterior circulation is uncommon in children. The underlying etiologies and risk factors predisposing to posterior circulation stroke include vasculopathies, intracranial trauma, cardiac disease, infection, and hematologic disorders. However, in many children with posterior circulation stroke, the underlying mechanisms are poorly understood. We describe a 14-month-old ... Read more >>

J Child Neurol (Journal of child neurology)
[2009, 24(8):1019-1020]

Cited: 1 time

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Predictive value of clinical and EEG features in the diagnosis of stroke and hypoxic ischemic encephalopathy in neonates with seizures.

Mubeen F Rafay, Miguel A Cortez, Gabrielle A de Veber, Cherrie Tan-Dy, Amna Al-Futaisi, Woojin Yoon, Shafagh Fallah, Aideen M Moore,

In neonates, the differentiation of stroke and hypoxic ischemic encephalopathy (HIE) is important. Neuroimaging presents technical challenges in unstable neonates, resulting in frequently delayed or missed diagnosis of stroke. Differentiating clinical and electroencephalographic (EEG) features would assist physicians in the timely diagnosis. We sought to determine, in neonates with seizures, ... Read more >>

Stroke (Stroke)
[2009, 40(7):2402-2407]

Cited: 16 times

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