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Privileged Quinolylnitrones for the Combined Therapy of Ischemic Stroke and Alzheimer's Disease.

José M Alonso, Alejandro Escobar-Peso, Alejandra Palomino-Antolín, Daniel Diez-Iriepa, Mourad Chioua, Emma Martínez-Alonso, Isabel Iriepa, Javier Egea, Alberto Alcázar, José Marco-Contelles,

Cerebrovascular diseases such as ischemic stroke are known to exacerbate dementia caused by neurodegenerative pathologies such as Alzheimer's disease (AD). Besides, the increasing number of patients surviving stroke makes it necessary to treat the co-occurrence of these two diseases with a single and combined therapy. For the development of new ... Read more >>

Pharmaceuticals (Basel) (Pharmaceuticals (Basel, Switzerland))
[2021, 14(9):]

Cited: 0 times

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Synthesis, Neuroprotection, and Antioxidant Activity of 1,1'-Biphenylnitrones as α-Phenyl-N-tert-butylnitrone Analogues in In Vitro Ischemia Models.

Beatriz Chamorro, David García-Vieira, Daniel Diez-Iriepa, Estíbaliz Garagarza, Mourad Chioua, Dimitra Hadjipavlou-Litina, Francisco López-Muñoz, José Marco-Contelles, María Jesús Oset-Gasque,

Herein, we report the neuroprotective and antioxidant activity of 1,1'-biphenyl nitrones (<b>BPNs</b>) <b>1</b>-<b>5</b> as α-phenyl-<i>N</i>-<i>tert</i>-butylnitrone analogues prepared from commercially available [1,1'-biphenyl]-4-carbaldehyde and [1,1'-biphenyl]-4,4'-dicarbaldehyde. The neuroprotection of <b>BPNs</b><b>1</b>-<b>5</b> has been measured against oligomycin A/rotenone and in an oxygen-glucose deprivation in vitro ischemia model in human neuroblastoma SH-SY5Y cells. Our results indicate ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2021, 26(4):]

Cited: 1 time

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In Vitro and In Silico ADME-Tox Profiling and Safety Significance of Multifunctional Monoamine Oxidase Inhibitors Targeting Neurodegenerative Diseases.

Anna Więckowska, Natalia Szałaj, Izabella Góral, Adam Bucki, Gniewomir Latacz, Katarzyna Kiec-Kononowicz, Òscar M Bautista-Aguilera, Alejandro Romero, Eva Ramos, Javier Egea, Victor Farré Alíns, Águeda González-Rodríguez, Francisco López-Muñoz, Mourad Chioua, José Marco-Contelles,

Herein we report <i>in vitro</i> metabolic stability in human liver microsomes (HLMs), interactions with cytochrome P450 isoenzymes (CYP3A4, CYP2D6, and CYP2C9), and cytotoxicity analyses on HEK-293, HepG2, Huh7, and WTIIB cell lines of our most recent multitarget directed ligands PF9601N, ASS234, and contilisant. Based on these results, we conclude that ... Read more >>

ACS Chem Neurosci (ACS chemical neuroscience)
[2020, 11(22):3793-3801]

Cited: 1 time

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Homo-Tris-Nitrones Derived from α-Phenyl-N-tert-butylnitrone: Synthesis, Neuroprotection and Antioxidant Properties.

Daniel Diez-Iriepa, Beatriz Chamorro, Marta Talaván, Mourad Chioua, Isabel Iriepa, Dimitra Hadjipavlou-Litina, Francisco López-Muñoz, José Marco-Contelles, María Jesús Oset-Gasque,

Herein we report the synthesis, antioxidant and neuroprotective power of homo-tris-nitrones (<b>HTN</b>) <b>1-3</b>, designed on the hypothesis that the incorporation of a third nitrone motif into our previously identified homo-bis-nitrone <b>6</b> (<b>HBN6</b>) would result in an improved and stronger neuroprotection. The neuroprotection of <b>HTNs</b><b>1-3</b>, measured against oligomycin A/rotenone, showed that ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(21):]

Cited: 3 times

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Synthesis, antioxidant properties and neuroprotection of α-phenyl-tert-butylnitrone derived HomoBisNitrones in in vitro and in vivo ischemia models.

Beatriz Chamorro, Daniel Diez-Iriepa, Belén Merás-Sáiz, Mourad Chioua, David García-Vieira, Isabel Iriepa, Dimitra Hadjipavlou-Litina, Francisco López-Muñoz, Ricardo Martínez-Murillo, Daniel Gonzàlez-Nieto, Israel Fernández, José Marco-Contelles, María Jesús Oset-Gasque,

We herein report the synthesis, antioxidant power and neuroprotective properties of nine homo-bis-nitrones HBNs 1-9 as alpha-phenyl-N-tert-butylnitrone (PBN) analogues for stroke therapy. In vitro neuroprotection studies of HBNs 1-9 against Oligomycin A/Rotenone and in an oxygen-glucose-deprivation model of ischemia in human neuroblastoma cell cultures, indicate that (1Z,1'Z)-1,1'-(1,3-phenylene)bis(N-benzylmethanimine oxide) (HBN6) is ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):14150]

Cited: 2 times

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Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer's Disease Therapy.

Óscar M Bautista-Aguilera, Lhassane Ismaili, Mourad Chioua, Rudolf Andrys, Monika Schmidt, Petr Bzonek, María Ángeles Martínez-Grau, Christopher D Beadle, Tatiana Vetman, Francisco López-Muñoz, Isabel Iriepa, Bernard Refouvelet, Kamil Musilek, José Marco-Contelles,

In this communication, we report the synthesis and cholinesterase (ChE)/monoamine oxidase (MAO) inhibition of 19 quinolinones (<b>QN1</b>-<b>19</b>) and 13 dihydroquinolinones (<b>DQN1</b>-<b>13</b>) designed as potential multitarget small molecules (MSM) for Alzheimer's disease therapy. Contrary to our expectations, none of them showed significant <i>human recombinant</i> MAO inhibition, but compounds <b>QN8</b>, <b>QN9</b>, and ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(11):]

Cited: 0 times

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Characterization of a CholesteroNitrone (ISQ-201), a Novel Drug Candidate for the Treatment of Ischemic Stroke.

Emma Martínez-Alonso, Alejandro Escobar-Peso, Maria I Ayuso, Rafael Gonzalo-Gobernado, Mourad Chioua, Juan J Montoya, Joan Montaner, Israel Fernández, José Marco-Contelles, Alberto Alcázar,

Nitrones have a well-recognized capacity as spin-traps and are considered powerful free radical scavengers, which are two important issues in hypoxia-induced oxidative stress and cell death in brain ischemia. Consequently, nitrones have been proposed as therapeutic agents in acute ischemic stroke (AIS). In this paper, we update the biological and ... Read more >>

Antioxidants (Basel) (Antioxidants (Basel, Switzerland))
[2020, 9(4):]

Cited: 1 time

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Chromenones as Multineurotargeting Inhibitors of Human Enzymes.

Carina Lemke, Joscha Christmann, Jiafei Yin, José M Alonso, Estefanía Serrano, Mourad Chioua, Lhassane Ismaili, María Angeles Martínez-Grau, Christopher D Beadle, Tatiana Vetman, Florian M Dato, Ulrike Bartz, Paul W Elsinghorst, Markus Pietsch, Christa E Müller, Isabel Iriepa, Timo Wille, José Marco-Contelles, Michael Gütschow,

The complex nature of multifactorial diseases, such as Morbus Alzheimer, has produced a strong need to design multitarget-directed ligands to address the involved complementary pathways. We performed a purposive structural modification of a tetratarget small-molecule, that is contilisant, and generated a combinatorial library of 28 substituted chromen-4-ones. The compounds comprise ... Read more >>

ACS Omega (ACS omega)
[2019, 4(26):22161-22168]

Cited: 2 times

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QuinoxalineTacrine QT78, a Cholinesterase Inhibitor as a Potential Ligand for Alzheimer's Disease Therapy.

Eva Ramos, Alejandra Palomino-Antolín, Manuela Bartolini, Isabel Iriepa, Ignacio Moraleda, Daniel Diez-Iriepa, Abdelouahid Samadi, Carol V Cortina, Mourad Chioua, Javier Egea, Alejandro Romero, José Marco-Contelles,

We report the synthesis and relevant pharmacological properties of the quinoxalinetacrine (QT) hybrid <b>QT78</b> in a project targeted to identify new non-hepatotoxic tacrine derivatives for Alzheimer's disease therapy. We have found that <b>QT78</b> is less toxic than tacrine at high concentrations (from 100 μM to 1 mM), less potent than ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2019, 24(8):]

Cited: 3 times

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Novel Quinolylnitrones Combining Neuroprotective and Antioxidant Properties.

Mourad Chioua, Manuel Salgado-Ramos, Daniel Diez-Iriepa, Alejandro Escobar-Peso, Isabel Iriepa, Dimitra Hadjipavlou-Litina, Emma Martínez-Alonso, Alberto Alcázar, José Marco-Contelles,

We describe here the preparation, neuroprotective analysis, and antioxidant capacity of 11 novel quinolylnitrones (QN). The neuroprotective analysis of QN1-11 in an oxygen-glucose deprivation model, in primary neuronal cultures, has been determined, allowing us to identify QN6 as a very potent neuroprotective agent, showing significant high value at 0.5 and ... Read more >>

ACS Chem Neurosci (ACS chemical neuroscience)
[2019, 10(6):2703-2706]

Cited: 6 times

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New Quinolylnitrones for Stroke Therapy: Antioxidant and Neuroprotective ( Z)- N- tert-Butyl-1-(2-chloro-6-methoxyquinolin-3-yl)methanimine Oxide as a New Lead-Compound for Ischemic Stroke Treatment.

Mourad Chioua, Emma Martínez-Alonso, Rafael Gonzalo-Gobernado, Maria I Ayuso, Alejandro Escobar-Peso, Lourdes Infantes, Dimitra Hadjipavlou-Litina, Juan J Montoya, Joan Montaner, Alberto Alcázar, José Marco-Contelles,

We describe herein the synthesis and neuroprotective capacity of an array of 31 compounds comprising quinolyloximes, quinolylhydrazones, quinolylimines, QNs, and related heterocyclic azolylnitrones. Neuronal cultures subjected to oxygen-glucose deprivation (OGD), as experimental model for ischemic conditions, were treated with our molecules at the onset of recovery period after OGD and ... Read more >>

J Med Chem (Journal of medicinal chemistry)
[2019, 62(4):2184-2201]

Cited: 9 times

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Synthesis, neuroprotective and antioxidant capacity of PBN-related indanonitrones.

Alicia Jiménez-Almarza, Daniel Diez-Iriepa, Mourad Chioua, Beatriz Chamorro, Isabel Iriepa, Ricardo Martínez-Murillo, Dimitra Hadjipavlou-Litina, María Jesús Oset-Gasque, José Marco-Contelles,

In this work six PBN-related indanonitrones 1-6 have been designed, synthesized, and their neuroprotection capacity tested in vitro, under OGD conditions, in SH-SY5Y human neuroblastoma cell cultures. As a result, we have identified indanonitrones 1, 3 and 4 (EC<sub>50</sub> = 6.64 ± 0.28 μM) as the most neuroprotective agents, and in particular, among them, indanonitrone ... Read more >>

Bioorg Chem (Bioorganic chemistry)
[2019, 86:445-451]

Cited: 4 times

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Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease.

Mourad Chioua, Eleonora Buzzi, Ignacio Moraleda, Isabel Iriepa, Maciej Maj, Artur Wnorowski, Catia Giovannini, Anna Tramarin, Federica Portali, Lhassane Ismaili, Pilar López-Alvarado, Maria Laura Bolognesi, Krzysztof Jóźwiak, J Carlos Menéndez, José Marco-Contelles, Manuela Bartolini,

Notwithstanding the combination of cholinesterase (ChE) inhibition and calcium channel blockade within a multitarget therapeutic approach is envisaged as potentially beneficial to confront Alzheimer's disease (AD), this strategy has been scarcely investigated. To explore this promising line, a series of 5-amino-4-aryl-3,4,6,7,8,9-hexahydropyrimido [4,5-b]quinoline-2(1H)-thiones (tacripyrimidines) (4a-l) were designed by juxtaposition of tacrine, ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2018, 155:839-846]

Cited: 9 times

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Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3 R Antagonism for Neurodegenerative Diseases.

Óscar M Bautista-Aguilera, Stefanie Hagenow, Alejandra Palomino-Antolin, Víctor Farré-Alins, Lhassane Ismaili, Pierre-Louis Joffrin, María L Jimeno, Ondřej Soukup, Jana Janočková, Lena Kalinowsky, Ewgenij Proschak, Isabel Iriepa, Ignacio Moraleda, Johannes S Schwed, Alejandro Romero Martínez, Francisco López-Muñoz, Mourad Chioua, Javier Egea, Rona R Ramsay, José Marco-Contelles, Holger Stark,

The therapy of complex neurodegenerative diseases requires the development of multitarget-directed drugs (MTDs). Novel indole derivatives with inhibitory activity towards acetyl/butyrylcholinesterases and monoamine oxidases A/B as well as the histamine H<sub>3</sub> receptor (H3R) were obtained by optimization of the neuroprotectant ASS234 by incorporating generally accepted H3R pharmacophore motifs. These small-molecule ... Read more >>

Angew Chem Int Ed Engl (Angewandte Chemie (International ed. in English))
[2017, 56(41):12765-12769]

Cited: 17 times

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Quinolinyl Nitrone RP19 Induces Neuroprotection after Transient Brain Ischemia.

Maria I Ayuso, Emma Martínez-Alonso, Mourad Chioua, Alejandro Escobar-Peso, Rafael Gonzalo-Gobernado, Joan Montaner, José Marco-Contelles, Alberto Alcázar,

There is a need to develop additional effective therapies for ischemic stroke. Nitrones, which were first developed as reactive oxygen species (ROS)-trapping compounds, have been proposed as neuroprotective agents for ischemic stroke, a ROS-related disorder. The previous reported ROS-trapping compound, quinolyl nitrone RP19, is here being assayed to induce neuroprotection ... Read more >>

ACS Chem Neurosci (ACS chemical neuroscience)
[2017, 8(10):2202-2213]

Cited: 6 times

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Synthesis and biological assessment of racemic benzochromenopyrimidinetriones as promising agents for Alzheimer's disease therapy.

Youssef Dgachi, Helène Martin, Alexandre Bonet, Mourad Chioua, Isabel Iriepa, Ignacio Moraleda, Fakher Chabchoub, José Marco-Contelles, Lhassane Ismaili,

<h4>Aim</h4>Due to the complex nature of Alzheimer's disease, there is a renewed search for multitarget directed drugs.<h4>Results</h4>This paper describes the synthesis and in vitro biological evaluation of six racemic 13-aryl-2,3,4,13-tetrahydro-1H,12H-benzo[6,7]chromeno[2,3-d]pyrido[1,2-a]pyrimidine-7,12,14-triones (1a-6a), and six racemic 15-aryl-8,9,10,11,12,15-hexahydro-14H-benzo[6',7']chromeno[2',3:4,5] pyr-imido [1,2-a]azepine-5,14,16-triones (1b-6b), showing antioxidant and cholinesterase inhibitory capacity. Among these compounds, 13-phenyl-2,3,4,13-tetrahydro-1H,12H-benzo[6,7]chromeno[2,3-d]pyrido[1,2-a]pyrimidine-7,12,14-trione (1a) is ... Read more >>

Future Med Chem (Future medicinal chemistry)
[2017, 9(8):715-721]

Cited: 1 time

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New (benz)imidazolopyridino tacrines as nonhepatotoxic, cholinesterase inhibitors for Alzheimer disease.

Houssem Boulebd, Lhassane Ismaili, Helene Martin, Alexandre Bonet, Mourad Chioua, José Marco Contelles, Ali Belfaitah,

<h4>Aim</h4>Due to the multifactorial nature of Alzheimer's disease, there is an urgent search for new more efficient, multitarget-directed drugs.<h4>Results</h4>This paper describes the synthesis, antioxidant and in vitro biological evaluation of ten (benz)imidazopyridino tacrines (7-16), showing less toxicity than tacrine at high doses, and potent cholinesterase inhibitory capacity, in the low ... Read more >>

Future Med Chem (Future medicinal chemistry)
[2017, 9(8):723-729]

Cited: 5 times

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5-Methyl-N-(8-(5,6,7,8-tetrahydroacridin-9-ylamino)octyl)-5H-indolo[2,3-b]quinolin-11-amine: a highly potent human cholinesterase inhibitor.

Li Wang, Ignacio Moraleda, Isabel Iriepa, Alejandro Romero, Francisco López-Muñoz, Mourad Chioua, Tsutomu Inokuchi, Manuela Bartolini, José Marco-Contelles,

The synthesis, cholinesterase inhibition, molecular modelling and ADME properties of novel tacrine-neocryptolepine heterodimers are described. Compound <b>3</b> [5-methyl-<i>N</i>-(8-(5,6,7,8-tetrahydroacridin-9-ylamino)octyl)-5<i>H</i>-indolo[2,3-<i>b</i>]quinolin-11-amine], showing a moderate inhibition of the Aβ<sub>1-42</sub> self-aggregation (26.5% at a 1 : 5 ratio with Aβ<sub>1-42</sub>), and a calculated log BB value (0.27) indicating excellent potential BBB penetration, is a highly potent human cholinesterase ... Read more >>

Medchemcomm (MedChemComm)
[2017, 8(6):1307-1317]

Cited: 2 times

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Imidazopyranotacrines as Non-Hepatotoxic, Selective Acetylcholinesterase Inhibitors, and Antioxidant Agents for Alzheimer's Disease Therapy.

Houssem Boulebd, Lhassane Ismaili, Manuela Bartolini, Abdelmalek Bouraiou, Vincenza Andrisano, Helene Martin, Alexandre Bonet, Ignacio Moraleda, Isabel Iriepa, Mourad Chioua, Ali Belfaitah, José Marco-Contelles,

Herein we describe the synthesis and in vitro biological evaluation of thirteen new, racemic, diversely functionalized imidazo pyranotacrines as non-hepatotoxic, multipotent tacrine analogues. Among these compounds, 1-(5-amino-2-methyl-4-(1-methyl-1H-imidazol-2-yl)-6,7,8,9-tetrahydro-4H-pyrano[2,3-b]quinolin-3-yl)ethan-1-one (4) is non-hepatotoxic (cell viability assay on HepG2 cells), a selective but moderately potent EeAChE inhibitor (IC50 = 38.7 ± 1.7 μM), and ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2016, 21(4):400]

Cited: 2 times

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N-Benzylpiperidine Derivatives as α7 Nicotinic Receptor Antagonists.

Manuel Criado, José Mulet, Francisco Sala, Salvador Sala, Inés Colmena, Luis Gandía, Oscar M Bautista-Aguilera, Abdelouahid Samadi, Mourad Chioua, José Marco-Contelles,

A series of multitarget directed propargylamines, as well as other differently susbstituted piperidines have been screened as potential modulators of neuronal nicotinic acetylcholine receptors (nAChRs). Most of them showed antagonist actions on α7 nAChRs. Especially, compounds 13, 26, and 38 displayed submicromolar IC50 values on homomeric α7 nAChRs, whereas they ... Read more >>

ACS Chem Neurosci (ACS chemical neuroscience)
[2016, 7(8):1157-1165]

Cited: 3 times

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Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer's Disease.

Youssef Dgachi, Oscar M Bautista-Aguilera, Mohamed Benchekroun, Hélène Martin, Alexandre Bonet, Damijan Knez, Justyna Godyń, Barbara Malawska, Stanislav Gobec, Mourad Chioua, Jana Janockova, Ondrej Soukup, Fakher Chabchoub, José Marco-Contelles, Lhassane Ismaili,

We report herein the straightforward two-step synthesis and biological assessment of novel racemic benzochromenopyrimidinones as non-hepatotoxic, acetylcholinesterase inhibitors with antioxidative properties. Among them, compound 3Bb displayed a mixed-type inhibition of human acetylcholinesterase (IC50 = 1.28 ± 0.03 μM), good antioxidant activity, and also proved to be non-hepatotoxic on human HepG2 ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2016, 21(5):]

Cited: 3 times

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Potent anticholinesterasic and neuroprotective pyranotacrines as inhibitors of beta-amyloid aggregation, oxidative stress and tau-phosphorylation for Alzheimer's disease.

Nuria García-Font, Hasna Hayour, Ali Belfaitah, Jorge Pedraz, Ignacio Moraleda, Isabel Iriepa, Abdelmalek Bouraiou, Mourad Chioua, José Marco-Contelles, María Jesús Oset-Gasque,

Herein we describe the synthesis and in vitro biological evaluation of thirteen new, racemic, diversely functionalized 2-chloroquinolin-3-yl substituted PyranoTacrines (PTs) as multipotent tacrine analogues for Alzheimer's disease (AD) therapy. Among these compounds, 1-(5-amino-4-(2-chloro-7-methoxyquinolin-3-yl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrano [2,3-b]quinolin-3-yl)éthanone (9) and ethyl 5-amino-4-(2-chloroquinolin-3-yl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrano[2,3-b]quinoline-3-carboxylate (4) were found to be non-neurotoxic agents in human neuroblastoma SHSY5Y cells. Compounds ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2016, 118:178-192]

Cited: 11 times

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Synthesis and Biological Assessment of Racemic Benzochromenopyrimidinimines as Antioxidant, Cholinesterase, and Aβ1-42 Aggregation Inhibitors for Alzheimer's Disease Therapy.

Youssef Dgachi, Lhassane Ismaili, Damijan Knez, Mohamed Benchekroun, Hélène Martin, Natalia Szałaj, Sarah Wehle, Oscar M Bautista-Aguilera, Vincent Luzet, Alexandre Bonnet, Barbara Malawska, Stanislav Gobec, Mourad Chioua, Michael Decker, Fakher Chabchoub, José Marco-Contelles,

Given the complex nature of Alzheimer's disease (AD), compounds that are able to simultaneously address two or more AD-associated targets show greater promise for development into drugs for AD therapy. Herein we report an efficient two-step synthesis and biological evaluation of new racemic benzochromene derivatives as antioxidants, inhibitors of cholinesterase ... Read more >>

ChemMedChem (ChemMedChem)
[2016, 11(12):1318-1327]

Cited: 6 times

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CholesteroNitrones for Stroke.

Maria I Ayuso, Mourad Chioua, Emma Martínez-Alonso, Elena Soriano, Joan Montaner, Jaime Masjuán, Dimitra J Hadjipavlou-Litina, José Marco-Contelles, Alberto Alcázar,

This study describes CholesteroNitrone 2 as an antioxidant and neuroprotective agent against ischemic injury. Neuroprotection was assessed using in vitro and in vivo experimental ischemia models. The compound significantly increased cell viability, induced neuroprotection following ischemic reperfusion, and decreased neurological deficit scores in treated animals, supporting the next preclinical studies ... Read more >>

J Med Chem (Journal of medicinal chemistry)
[2015, 58(16):6704-6709]

Cited: 7 times

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The reaction of 2-amino-4H-pyrans with N-bromosuccinimide.

Abdelouahid Samadi, Daniel Silva, Mourad Chioua, Lourdes Infantes, Elena Soriano, José Marco-Contelles,

The reaction of racemic 2-amino-4H-pyrans, such as 3-amino-1-aryl-1H-benzo[f]chromene-2-carbonitriles, with N-bromosuccinimide (NBS), in CH2Cl2, at room temperature, is a very quick, regio, stereoselective, and high yielding process, affording major racemic (1S, 2S)-2-bromo-3-imino-benzo[f]chromene or racemic (1S, 2S)-2-bromo-3-(bromoimino)-benzo[f]chromene derivatives, when using 1.0 or 2.2 equivalents of NBS, respectively. This reaction, extended to isomeric ... Read more >>

Mol Divers (Molecular diversity)
[2015, 19(1):103-122]

Cited: 0 times

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