Full Text Journal Articles by
Author Morris A Blajchman

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Effects of red-cell storage duration on patients undergoing cardiac surgery.

Marie E Steiner, Paul M Ness, Susan F Assmann, Darrell J Triulzi, Steven R Sloan, Meghan Delaney, Suzanne Granger, Elliott Bennett-Guerrero, Morris A Blajchman, Vincent Scavo, Jeffrey L Carson, Jerrold H Levy, Glenn Whitman, Pamela D'Andrea, Shelley Pulkrabek, Thomas L Ortel, Larissa Bornikova, Thomas Raife, Kathleen E Puca, Richard M Kaufman, Gregory A Nuttall, Pampee P Young, Samuel Youssef, Richard Engelman, Philip E Greilich, Ronald Miles, Cassandra D Josephson, Arthur Bracey, Rhonda Cooke, Jeffrey McCullough, Robert Hunsaker, Lynne Uhl, Janice G McFarland, Yara Park, Melissa M Cushing, Charles T Klodell, Ravindra Karanam, Pamela R Roberts, Cornelius Dyke, Eldad A Hod, Christopher P Stowell,

<h4>Background</h4>Some observational studies have reported that transfusion of red-cell units that have been stored for more than 2 to 3 weeks is associated with serious, even fatal, adverse events. Patients undergoing cardiac surgery may be especially vulnerable to the adverse effects of transfusion.<h4>Methods</h4>We conducted a randomized trial at multiple sites ... Read more >>

N Engl J Med (The New England journal of medicine)
[2015, 372(15):1419-1429]

Cited: 209 times

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Age of transfused blood in critically ill adults.

Jacques Lacroix, Paul C Hébert, Dean A Fergusson, Alan Tinmouth, Deborah J Cook, John C Marshall, Lucy Clayton, Lauralyn McIntyre, Jeannie Callum, Alexis F Turgeon, Morris A Blajchman, Timothy S Walsh, Simon J Stanworth, Helen Campbell, Gilles Capellier, Pierre Tiberghien, Laurent Bardiaux, Leo van de Watering, Nardo J van der Meer, Elham Sabri, Dong Vo, , ,

<h4>Background</h4>Fresh red cells may improve outcomes in critically ill patients by enhancing oxygen delivery while minimizing the risks of toxic effects from cellular changes and the accumulation of bioactive materials in blood components during prolonged storage.<h4>Methods</h4>In this multicenter, randomized, blinded trial, we assigned critically ill adults to receive either red ... Read more >>

N Engl J Med (The New England journal of medicine)
[2015, 372(15):1410-1418]

Cited: 250 times

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Effect of fresh red blood cell transfusions on clinical outcomes in premature, very low-birth-weight infants: the ARIPI randomized trial.

Dean A Fergusson, Paul Hébert, Debora L Hogan, Louise LeBel, Nicole Rouvinez-Bouali, John A Smyth, Koravangattu Sankaran, Alan Tinmouth, Morris A Blajchman, Lajos Kovacs, Christian Lachance, Shoo Lee, C Robin Walker, Brian Hutton, Robin Ducharme, Katelyn Balchin, Tim Ramsay, Jason C Ford, Ashok Kakadekar, Kuppuchipalayam Ramesh, Stan Shapiro,

<h4>Context</h4>Even though red blood cells (RBCs) are lifesaving in neonatal intensive care, transfusing older RBCs may result in higher rates of organ dysfunction, nosocomial infection, and length of hospital stay.<h4>Objective</h4>To determine if RBCs stored for 7 days or less compared with usual standards decreased rates of major nosocomial infection and ... Read more >>

JAMA (JAMA)
[2012, 308(14):1443-1451]

Cited: 186 times

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Addressing the risk of bacterial contamination of platelets within the United States: a history to help illuminate the future.

Mark E Brecher, Morris A Blajchman, Roslyn Yomtovian, Paul Ness, James P AuBuchon,

Transfusion (Transfusion)
[2013, 53(1):221-231]

Cited: 26 times

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Clinical review: Canadian National Advisory Committee on Blood and Blood Products--Massive transfusion consensus conference 2011: report of the panel.

Walter H Dzik, Morris A Blajchman, Dean Fergusson, Morad Hameed, Blair Henry, Andrew W Kirkpatrick, Teresa Korogyi, Sarvesh Logsetty, Robert C Skeate, Simon Stanworth, Charles MacAdams, Brian Muirhead,

In June 2011 the Canadian National Advisory Committee on Blood and Blood Products sponsored an international consensus conference on transfusion and trauma. A panel of 10 experts and two external advisors reviewed the current medical literature and information presented at the conference by invited international speakers and attendees. The Consensus ... Read more >>

Crit Care (Critical care (London, England))
[2011, 15(6):242]

Cited: 63 times

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The role of comparative effectiveness research in transfusion medicine clinical trials: proceedings of a National Heart, Lung, and Blood Institute workshop.

Morris A Blajchman, Jeffrey L Carson, John W Eikelboom, Nancy M Heddle, Jacques Lacroix, Michael S Lauer, Richard Platt, Barbara Tilley, Darrell Triulzi, Andrew J Vickers, Salim Yusuf, Simone Glynn, Traci Heath Mondoro, Elizabeth Wagner,

Comparative effectiveness research (CER) is the study of existing treatments or ways to deliver health care to determine what intervention works best under specific circumstances. CER evaluates evidence from existing studies or generates new evidence, in different populations and under specific conditions in which the treatments are actually used. CER ... Read more >>

Transfusion (Transfusion)
[2012, 52(6):1363-1378]

Cited: 7 times

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The Age of Blood Evaluation (ABLE) randomized controlled trial: study design.

Jacques Lacroix, Paul Hébert, Dean Fergusson, Alan Tinmouth, Morris A Blajchman, Jeannie Callum, Deborah Cook, John C Marshall, Lauralyn McIntyre, Alexis F Turgeon, ,

Red blood cells (RBCs) are transfused to treat anemia and to maintain oxygen delivery to vital organs during critical illness. Laboratory and observational studies have raised the possibility that prolonged RBC storage may adversely affect clinical outcomes. Compared with RBCs stored less than 1 week, there are no clinical data ... Read more >>

Transfus Med Rev (Transfusion medicine reviews)
[2011, 25(3):197-205]

Cited: 99 times

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Clinical trial opportunities in hemostasis and thrombosis: NHBLI State-of-the-Science symposium.

Douglas B Cines, Morris A Blajchman, Katherine A High, James B Bussel, ,

Clinical trials in hemostasis and thrombosis (HT) are needed to guide medical practice and future research. Providing public support for trials that could have the greatest impact on clinical care has been a major challenge. The National Heart, Lung and Blood Institute (NHLBI) convened a State-of-the-Science meeting in Bethesda on ... Read more >>

Am J Hematol (American journal of hematology)
[2012, 87(2):235-238]

Cited: 1 time

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Proceedings of a consensus conference: Risk-Based Decision Making for Blood Safety.

Judie Leach Bennett, Morris A Blajchman, Gilles Delage, Margaret Fearon, Dana Devine,

Blood safety decision making has become increasingly complex, and a framework for risk-based decision making is, thus, needed. The purpose of this consensus conference was to bring together international experts in an effort to develop the foundations for such a framework. These proceedings are described with a view to making ... Read more >>

Transfus Med Rev (Transfusion medicine reviews)
[2011, 25(4):267-292]

Cited: 12 times

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A multidisciplinary "think tank": the top 10 clinical trial opportunities in transfusion medicine from the National Heart, Lung, and Blood Institute-sponsored 2009 state-of-the-science symposium.

Cassandra D Josephson, Simone A Glynn, Steve H Kleinman, Morris A Blajchman, ,

<h4>Background</h4>In September 2009, the National Heart, Lung, and Blood Institute convened the State-of-the-Science Symposium in Transfusion Medicine to identify Phase II and/or III clinical trials that would provide important information to advance transfusion medicine.<h4>Study design and methods</h4>Seven multidisciplinary subcommittees developed proposals in the following areas: 1) platelet (PLT) product use, ... Read more >>

Transfusion (Transfusion)
[2011, 51(4):828-841]

Cited: 25 times

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Clinical trial opportunities in Transfusion Medicine: proceedings of a National Heart, Lung, and Blood Institute State-of-the-Science Symposium.

Morris A Blajchman, Simone A Glynn, Cassandra D Josephson, Steve H Kleinman, ,

The use of blood products to support patients undergoing the large variety of medical and surgical interventions requiring such support has continued to escalate very significantly over time. Relevantly, significant practice variation in the use of blood products exists among practitioners and institutions, largely because of the lack of robust ... Read more >>

Transfus Med Rev (Transfusion medicine reviews)
[2010, 24(4):259-285]

Cited: 15 times

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Warm autoimmune hemolytic anemia: recent progress in understanding the immunobiology and the treatment.

Melca M O Barros, Morris A Blajchman, José O Bordin,

Autoimmune hemolytic anemia (AIHA) is defined as a condition associated with the increased destruction of red blood cells (RBCs) associated with the presence of IgG anti-RBC autoantibodies. The etiology underlying the pathogenesis of such autoantibodies is still uncertain. In the present article, we will discuss the postulated mechanisms that produce ... Read more >>

Transfus Med Rev (Transfusion medicine reviews)
[2010, 24(3):195-210]

Cited: 40 times

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Extending the horizon for cell-based immunotherapy by understanding the mechanisms of action of photopheresis.

Ching Y Voss, Terry J Fry, Max J Coppes, Morris A Blajchman,

Most of the current cell-based immunotherapy protocols concentrate on immune stimulatory effects against certain pathogenic insults, such as cancer. In this article, a potential cell-based immunotherapeutic strategy to induce immune tolerance by infusion of apoptotic leukocytes is presented in conjunction with a review of newly understood mechanisms of action of ... Read more >>

Transfus Med Rev (Transfusion medicine reviews)
[2010, 24(1):22-32]

Cited: 14 times

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Research opportunities for pathogen reduction/inactivation of blood components: summary of an NHLBI workshop.

Harvey G Klein, Simone A Glynn, Paul M Ness, Morris A Blajchman, ,

In July 2008, a workshop sponsored by the Division of Blood Diseases and Resources of the National Heart, Lung, and Blood Institute (NHLBI) was convened to identify potential research opportunities that could advance our understanding of both the biologic and the clinical impact of the various available pathogen reduction/inactivation (PR/PI) ... Read more >>

Transfusion (Transfusion)
[2009, 49(6):1262-1268]

Cited: 18 times

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Severe hemolytic anemia post-renal transplantation produced by donor anti-D passenger lymphocytes: case report and literature review.

Craig D Ainsworth, Mark A Crowther, Darin Treleaven, Denise Evanovitch, Kathryn E Webert, Morris A Blajchman,

The passenger lymphocyte syndrome (PLS), often associated with immune-mediated hemolytic anemia after solid organ and hematopoietic stem cell transplantation, is the result of concomitant transplantation of donor lymphocytes along with the donor allograft. Antibodies directed against recipient red blood cells (RBCs) are frequently found in ABO-mismatched solid organ transplants; however, ... Read more >>

Transfus Med Rev (Transfusion medicine reviews)
[2009, 23(2):155-159]

Cited: 16 times

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Transfusion-related mortality: the ongoing risks of allogeneic blood transfusion and the available strategies for their prevention.

Eleftherios C Vamvakas, Morris A Blajchman,

As the risks of allogeneic blood transfusion (ABT)-transmitted viruses were reduced to exceedingly low levels in the US, transfusion-related acute lung injury (TRALI), hemolytic transfusion reactions (HTRs), and transfusion-associated sepsis (TAS) emerged as the leading causes of ABT-related deaths. Since 2004, preventive measures for TRALI and TAS have been implemented, ... Read more >>

Blood (Blood)
[2009, 113(15):3406-3417]

Cited: 277 times

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Neurodevelopmental outcome of extremely low birth weight infants randomly assigned to restrictive or liberal hemoglobin thresholds for blood transfusion.

Robin K Whyte, Haresh Kirpalani, Elizabeth V Asztalos, Chad Andersen, Morris Blajchman, Nancy Heddle, Meena LaCorte, Charlene M T Robertson, Maxine C Clarke, Michael J Vincer, Lex W Doyle, Robin S Roberts, ,

<h4>Background and objective</h4>Extremely low birth weight infants frequently receive red cell transfusions. We sought to determine whether a restrictive versus liberal hemoglobin transfusion threshold results in differences in death or adverse neurodevelopmental outcomes of extremely low birth weight infants.<h4>Patients and methods</h4>Extremely low birth weight infants previously enrolled in the Preterm ... Read more >>

Pediatrics (Pediatrics)
[2009, 123(1):207-213]

Cited: 74 times

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The age of red blood cells in premature infants (ARIPI) randomized controlled trial: study design.

Dean Fergusson, Brian Hutton, Debora L Hogan, Louise LeBel, Morris A Blajchman, Jason C Ford, Paul Hebert, Ashok Kakadekar, Lajos Kovacs, Shoo Lee, Koravangattu Sankaran, Stan Shapiro, John A Smyth, Kuppuchipalayam Ramesh, Nicole Rouvinez Bouali, Alan Tinmouth, Robin Walker,

Despite recent trends in decreasing transfusion thresholds and the development of technologies designed to avoid allogeneic exposure, allogeneic red blood cell (RBC) transfusions remain an important supportive and life-saving measure for neonatal intensive care patients experiencing illness and anemia. Reluctantly, a number of laboratory and observational studies have indicated that ... Read more >>

Transfus Med Rev (Transfusion medicine reviews)
[2009, 23(1):55-61]

Cited: 44 times

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CD200-dependent and nonCD200-dependent pathways of NK cell suppression by human IVIG.

David A Clark, Karrie Wong, Daljeet Banwatt, Ziqhi Chen, Jian Liu, Lydia Lee, Reginald M Gorczynski, Morris A Blajchman,

<h4>Problem</h4>Intravenous immunoglobulin (IVIG) has been used to suppress autoimmune and inflammatory disorders by a variety of mechanisms. Recently, the CD200 tolerance-promoting signal has been found to play a role in IVIG suppression of blood natural killer (NK) cells. Further, different types of IVIG have been reported to differ in this ... Read more >>

J Assist Reprod Genet (Journal of assisted reproduction and genetics)
[2008, 25(2-3):67-72]

Cited: 16 times

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New strategies for the optimal use of platelet transfusions.

Morris A Blajchman, Sherrill J Slichter, Nancy M Heddle, Michael F Murphy,

Patients with severe thrombocytopenia are presumed to be at increased risk for bleeding, and consequently it has been standard practice for the past four decades to give allogeneic platelet transfusions to severely thrombocytopenic patients as supportive care. Platelet transfusions may be given either prophylactically to reduce the risk of bleeding, ... Read more >>

Hematology Am Soc Hematol Educ Program (Hematology. American Society of Hematology. Education Program)
[2008, :198-204]

Cited: 27 times

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A comparison of aprotinin and lysine analogues in high-risk cardiac surgery.

Dean A Fergusson, Paul C Hébert, C David Mazer, Stephen Fremes, Charles MacAdams, John M Murkin, Kevin Teoh, Peter C Duke, Ramiro Arellano, Morris A Blajchman, Jean S Bussières, Dany Côté, Jacek Karski, Raymond Martineau, James A Robblee, Marc Rodger, George Wells, Jennifer Clinch, Roanda Pretorius, ,

<h4>Background</h4>Antifibrinolytic agents are commonly used during cardiac surgery to minimize bleeding and to reduce exposure to blood products. We sought to determine whether aprotinin was superior to either tranexamic acid or aminocaproic acid in decreasing massive postoperative bleeding and other clinically important consequences.<h4>Methods</h4>In this multicenter, blinded trial, we randomly assigned ... Read more >>

N Engl J Med (The New England journal of medicine)
[2008, 358(22):2319-2331]

Cited: 474 times

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Why implement universal leukoreduction?

Wafaa Y Bassuni, Morris A Blajchman, May A Al-Moshary,

The improvement of transfusion medicine technology is an ongoing process primarily directed at increasing the safety of allogeneic blood component transfusions for recipients. Over the years, relatively little attention had been paid to the leukocytes present in the various blood components. The availability of leukocyte removal (leukoreduction) techniques for blood ... Read more >>

Hematol Oncol Stem Cell Ther (Hematology/oncology and stem cell therapy)
[2008, 1(2):106-123]

Cited: 19 times

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A multicenter pilot-randomized controlled trial of the feasibility of an augmented red blood cell transfusion strategy for patients treated with induction chemotherapy for acute leukemia or stem cell transplantation.

Kathryn E Webert, Richard J Cook, Stephen Couban, Julie Carruthers, Ker-Ai Lee, Morris A Blajchman, Jeffrey H Lipton, Joseph M Brandwein, Nancy M Heddle,

<h4>Background</h4>Anemia may be an important factor contributing to an increased risk of bleeding, particularly in patients with thrombocytopenia.<h4>Study design and methods</h4>A multicenter, single-blinded pilot randomized controlled trial (RCT) was performed to evaluate the feasibility of conducting a larger RCT to determine the effect of the hemoglobin (Hb) concentration on bleeding ... Read more >>

Transfusion (Transfusion)
[2008, 48(1):81-91]

Cited: 34 times

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Platelet transfusions: an historical perspective.

Morris A Blajchman,

Hematology Am Soc Hematol Educ Program (Hematology. American Society of Hematology. Education Program)
[2008, :197]

Cited: 3 times

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Transfusion-related immunomodulation due to peripheral blood dendritic cells expressing the CD200 tolerance signaling molecule and alloantigen.

David A Clark, Reginald M Gorczynski, Morris A Blajchman,

<h4>Background</h4>The transfusion of allogeneic blood products containing white cells (WBCs) has been reported to reduce resistance to infection, stimulate the growth of some types of tumors in animal models, and prevent abortion of allogeneic embryos in the CBAxDBA/2 murine model.<h4>Study design and methods</h4>In this study, the issue explored was whether ... Read more >>

Transfusion (Transfusion)
[2008, 48(5):814-821]

Cited: 18 times

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