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Intermediate-risk Prostate Cancer-A Sheep in Wolf's Clothing?

Isabel Heidegger, Freddie C Hamdy, Roderick C N van den Bergh, Axel Heidenreich, Michiel Sedelaar, Morgan Roupret, ,

This case-based discussion describes a 65-year-old man newly diagnosed with International Society of Urological Pathology (ISUP) grade 2 prostate cancer (PCa). According to the European Association of Urology classification system, the patient harbors an intermediate-risk cancer. In step-by step discussion, we elaborate guideline-based treatment modalities for intermediate-risk PCa focused on ... Read more >>

Eur Urol Oncol (European urology oncology)
[2021, :]

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Metabolic syndrome, levels of androgens, and changes of erectile dysfunction and quality of life impairment 1 year after radical prostatectomy.

Yann Neuzillet, Mathieu Rouanne, Jean-François Dreyfus, Jean-Pierre Raynaud, Marc Schneider, Morgan Roupret, Sarah Drouin, Marc Galiano, Xavier Cathelinau, Thierry Lebret, Henry Botto,

Robust data evaluating the association of preoperative parameters of the patients with quality of life after radical prostatectomy are lacking. We investigated whether clinical and biological preoperative characteristics of the patients were associated with impaired patient-reported quality of life (QoL) and sexual outcomes 1 year after radical prostatectomy. We evaluated ... Read more >>

Asian J Androl (Asian journal of andrology)
[2021, 23(4):370-375]

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Prognostic value of the preoperative albumin-globulin ratio in patients with upper urinary tract urothelial carcinoma treated with radical nephroureterectomy: results from a large multicenter international collaboration.

Noriyoshi Miura, Keiichiro Mori, Ekaterina Laukhtina, Victor M Schuettfort, Mohammad Abufaraj, Jeremy Y C Teoh, Stefano Luzzago, Franziska Stolzenbach, Marina Deuker, Pierre I Karakiewicz, Alberto Briganti, Dmitry V Enikeev, Morgan Rouprêt, Vitaly Margulis, Piotr Chlosta, Peter Nyirady, Marek Babjuk, Shin Egawa, Takashi Saika, Shahrokh F Shariat,

<h4>Objective</h4>To assess the value of preoperative albumin to globulin ratio for predicting pathologic and oncological outcomes in patients with upper tract urothelial carcinoma treated with radical nephroureterectomy in a large multi-institutional cohort.<h4>Materials and methods</h4>Preoperative albumin to globulin ratio was assessed in a multi-institutional cohort of 2492 patients. Logistic regression analyses ... Read more >>

Jpn J Clin Oncol (Japanese journal of clinical oncology)
[2021, 51(7):1149-1157]

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Artificial intelligence in bladder cancer prognosis: a pathway for personalized medicine.

Ugo Pinar, Benjamin Pradere, Morgan Roupret,

<h4>Purpose of review</h4>This review aims to provide an update of the results of studies published in the last 2 years involving the use of artificial intelligence in bladder cancer (BCa) prognosis.<h4>Recent findings</h4>Recently, many studies evaluated various artificial intelligence models to predict BCa evolution using either deep learning or machine learning. ... Read more >>

Curr Opin Urol (Current opinion in urology)
[2021, 31(4):404-408]

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The place of robotic-assisted laparoscopy for BPO surgical management in 2021.

Elisabeth Grobet-Jeandin, Ugo Pinar, Morgan Rouprêt,

<h4>Purpose of review</h4>Robot-assisted laparoscopic simple prostatectomy (RASP) is being used increasingly for the surgical treatment of benign prostatic obstruction (BPO). Our purpose is to review the main outcomes of RASP for the management of BPO.<h4>Recent findings</h4>A computerised bibliographic search of Medline was performed for articles that included detailed results of ... Read more >>

Curr Opin Urol (Current opinion in urology)
[2021, :]

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The Genitourinary Pathology Society Update on Classification of Variant Histologies, T1 Substaging, Molecular Taxonomy, and Immunotherapy and PD-L1 Testing Implications of Urothelial Cancers.

Eva Compérat, Mahul B Amin, Jonathan I Epstein, Donna E Hansel, Gladell Paner, Hikmat Al-Ahmadie, Larry True, Dilek Bayder, Trinity Bivalacqua, Fadi Brimo, Liang Cheng, John Cheville, Guido Dalbagni, Sara Falzarano, Jennifer Gordetsky, Charles Guo, Sounak Gupta, Ondrej Hes, Gopa Iyer, Seema Kaushal, Lakshmi Kunju, Cristina Magi-Galluzzi, Andres Matoso, Jesse McKenney, George J Netto, Adeboye O Osunkoya, Chin Chen Pan, Kristina Pivovarcikova, Maria R Raspollini, Henning Reis, Jonathan Rosenberg, Morgan Roupret, Rajal B Shah, Shahrokh F Shariat, Kiril Trpkov, Veronika Weyerer, Ming Zhou, Victor Reuter,

The Genitourinary Pathology Society (GUPS) undertook a critical review of the recent advances in bladder cancer focusing on important topics of high interest for the practicing surgical pathologist and urologist. This review represents the second of 2 manuscripts ensuing from this effort. Herein, we address the effective reporting of bladder ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(4):196-208]

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The Genitourinary Pathology Society Update on Classification and Grading of Flat and Papillary Urothelial Neoplasia With New Reporting Recommendations and Approach to Lesions With Mixed and Early Patterns of Neoplasia.

Mahul B Amin, Eva Comperat, Jonathan I Epstein, Lawrence D True, Donna Hansel, Gladell P Paner, Hikmat Al-Ahmadie, Dilek Baydar, Trinity Bivalacqua, Fadi Brimo, Liang Cheng, John Cheville, Guido Dalbagni, Sara Falzarano, Jennifer Gordetsky, Charles C Guo, Sounak Gupta, Ondra Hes, Gopa Iyer, Seema Kaushal, Lakshmi Kunju, Cristina Magi-Galluzzi, Andres Matoso, George Netto, Adeboye O Osunkoya, Chin Chen Pan, Kristina Pivovarcikova, Maria R Raspollini, Henning Reis, Jonathan Rosenberg, Morgan Roupret, Rajal B Shah, Shahrokh Shariat, Kiril Trpkov, Veronika Weyerer, Ming Zhou, Jesse McKenney, Victor E Reuter,

The Genitourinary Pathology Society (GUPS) undertook a critical review of the recent advances in bladder neoplasia with a focus on issues relevant to the practicing surgical pathologist for the understanding and effective reporting of bladder cancer, emphasizing particularly on the newly accumulated evidence post-2016 World Health Organization (WHO) classification. The ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(4):179-195]

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Impact of the preoperative modified glasgow prognostic score on disease outcome after radical cystectomy for urothelial carcinoma of the bladder.

Victor M Schuettfort, Kilian Gust, David D'Andrea, Fahad Quhal, Hadi Mostafaei, Ekaterina Laukhtina, Keiichiro Mori, Michael Rink, Mohammad Abufaraj, Pierre I Karakiewicz, Stefano Luzzago, Morgan Rouprêt, Dmitry Enikeev, Kristin Zimmermann, Marina Deuker, Marco Moschini, Reza Sari Motlagh, Nico C Grossmann, Satoshi Katayama, Benjamin Pradere, Shahrokh F Shariat,

<h4>Background</h4>To investigate the predictive and prognostic value of the preoperative modified Glasgow Prognostic Score (mGPS) in patients with urothelial carcinoma of the bladder (UCB) treated with radical cystectomy (RC).<h4>Methods</h4>We conducted a retrospective analysis of an established multicenter database consisting of 4,335 patients who were treated with RC +/- adjuvant chemotherapy ... Read more >>

Minerva Urol Nephrol (Minerva urology and nephrology)
[2021, :]

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Urologists, You'll Never Walk Alone! How Novel Immunotherapy and Modern Imaging May Change the Management of Non-muscle-invasive Bladder Cancer.

Gianluca Giannarini, Neeraj Agarwal, Andrea B Apolo, Alberto Briganti, Petros Grivas, Shilpa Gupta, Ashish M Kamat, Francesco Montorsi, Morgan Rouprêt, Andrea Necchi,

Novel immune checkpoint inhibitors hold promise for non-muscle-invasive bladder cancer. Cooperation between urologists and other multidisciplinary bladder cancer specialists can surmount the challenges involved in using these agents in bladder-sparing approaches. This strategy could deliver a new era of comprehensive evaluation and multimodal treatment for this patient population. ... Read more >>

Eur Urol Oncol (European urology oncology)
[2021, :]

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Recommendations for planning and delivery of radical radiotherapy for localized urothelial carcinoma of the bladder.

Jonathan Khalifa, Stéphane Supiot, Géraldine Pignot, Christophe Hennequin, Pierre Blanchard, David Pasquier, Nicolas Magné, Renaud de Crevoisier, Pierre Graff-Cailleaud, Olivier Riou, Morgane Cabaillé, David Azria, Igor Latorzeff, Gilles Créhange, Olivier Chapet, Morgan Rouprêt, Sarah Belhomme, Arnaud Mejean, Stéphane Culine, Paul Sargos,

<h4>Purpose</h4>Curative radio-chemotherapy is recognized as a standard treatment option for muscle-invasive bladder cancer (MIBC). Nevertheless, the technical aspects for MIBC radiotherapy are heterogeneous with a lack of practical recommendations.<h4>Methods and materials</h4>In 2018, a workshop identified the need for two cooperative groups to develop consistent, evidence-based guidelines for irradiation technique in ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2021, 161:95-114]

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Impact of Hospital volume on postoperative outcomes after radical prostatectomy: A 5-Year nationwide database analysis.

Guillaume Ploussard, Annabelle Grabia, Jean-Baptiste Beauval, Romain Mathieu, Laurent Brureau, François Rozet, Morgan Rouprêt, Charles-Edouard Lequeu, ,

<h4>Background</h4>Hospital volume is considered to be a quality measure for outcomes after major oncological surgery. However, countrywide data are lacking for radical prostatectomy (RP).<h4>Objective</h4>To assess the impact of hospital volume on postoperative outcomes after RP performed using an open (ORP) versus a minimally invasive surgery (MIS, including pure and robot-assisted ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Standardizing immunohistochemistry methodology for evaluation of PD-1 and PDL-1 expression in upper tract urothelial carcinoma.

Luca Campedel, Thomas Seisen, Justine Varinot, Géraldine Cancel-Tassin, Alain Ruffion, Emilien Seizilles De Mazancourt, Myriam Decaussin-Petrucci, Grégoire Robert, Nam-Son Vuong, Magali Philipp, Eva Compérat, Morgan Rouprêt, Olivier Cussenot,

<h4>Introduction</h4>Controversy regarding the prognostic and/or predictive role of PD-1 and PD-L1 expression for upper tract urothelial carcinoma (UTUC) could partly be explained by inconsistencies in the immunohistochemistry (IHC) methodology. Objective is to standardize the methodology for routine evaluation of PD-1 and PD-L1 expression in UTUC patients.<h4>Materials and methods</h4>Twenty-two cases treated ... Read more >>

Can J Urol (The Canadian journal of urology)
[2021, 28(3):10719-10724]

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Pretreatment Risk Stratification for Endoscopic Kidney-sparing Surgery in Upper Tract Urothelial Carcinoma: An International Collaborative Study.

Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Gautier Marcq, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Wassim Kassouf, Riccardo Autorino, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat,

<h4>Background</h4>Several groups have proposed features to identify low-risk patients who may benefit from endoscopic kidney-sparing surgery in upper tract urothelial carcinoma (UTUC).<h4>Objective</h4>To evaluate standard risk stratification features, develop an optimal model to identify ≥pT2/N+ stage at radical nephroureterectomy (RNU), and compare it with the existing unvalidated models.<h4>Design, setting, and participants</h4>This ... Read more >>

Eur Urol (European urology)
[2021, :]

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Low-intensity extracorporeal shock wave therapy for Peyronie's disease: a single-center experience.

Maher Abdessater, William Akakpo, Anthony Kanbar, Jérome Parra, Thomas Seisen, Emmanuel Chartier-Kastler, Sarah J Drouin, Morgan Roupret,

The aim of this article is to assess the outcomes of a low-intensity extracorporeal shock wave therapy (LiESWT) protocol for the treatment of Peyronie's disease (PD). Patients treated for PD were prospectively recorded, and data were retrospectively reviewed. Age, characteristics of fibrous plaques, concomitant treatments, International Index of Erectile Function ... Read more >>

Asian J Androl (Asian journal of andrology)
[2021, :]

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Accuracy and Clinical Utility of a Tumor Grade- and Stage-based Predictive Model in Localized Upper Tract Urothelial Carcinoma.

Satoshi Katayama, Keiichiro Mori, Victor M Schuettfort, Benjamin Pradere, Hadi Mostafaei, Fahad Quhal, Pawel Rajwa, Reza Sari Motlagh, Ekaterina Laukhtina, Marco Moschini, Nico C Grossmann, Motoo Araki, Jeremy Yuen-Chun Teoh, Morgan Rouprêt, Vitaly Margulis, Dmitry Enikeev, Pierre I Karakiewicz, Mohammad Abufaraj, Eva Compérat, Yasutomo Nasu, Shahrokh F Shariat,

<h4>Background</h4>Among various clinicopathologic factors used to identify low-risk upper tract urothelial carcinoma (UTUC), tumor grade and stage are of utmost importance. The clinical value added by inclusion of other risk factors remains unproven.<h4>Objective</h4>To assess the performance of a tumor grade- and stage-based (GS) model to identify patients with UTUC for ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Flexible fibre optic vs digital ureteroscopy and enhanced vs unenhanced imaging for diagnosis and treatment of upper tract urothelial carcinoma (UTUC): results from the Clinical Research Office of the Endourology Society (CROES)-UTUC registry.

Francesco Soria, M Pilar Laguna, Morgan Roupret, Patricio Garcia-Marchinena, Mariano Sebastián Gonzalez, Tomonori Habuchi, Erkan Erkan, Anthony Ng, Paolo Gontero, Jean de la Rosette,

<h4>Objectives</h4>To compare the oncological outcomes of patients with upper tract urothelial carcinoma (UTUC) undergoing kidney-sparing surgery (KSS) with fibre-optic (FO) vs digital (D) ureteroscopy (URS). To evaluate the oncological impact of image-enhancement technologies such as narrow-band imaging (NBI) and Image1-S in patients with UTUC.<h4>Patients and methods</h4>The Clinical Research Office of ... Read more >>

BJU Int (BJU international)
[2021, :]

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Adjuvant Systemic Therapy for High-risk Muscle-invasive Bladder Cancer After Radical Cystectomy: Current Options and Future Opportunities.

M Carmen Mir, Riccardo Campi, Yohann Loriot, Javier Puente, Gianluca Giannarini, Andrea Necchi, Morgan Rouprêt, ,

We describe the case of a 71-yr-old woman with locally advanced muscle-invasive bladder cancer and stage III chronic kidney disease due to an obstructed nonfunctional left kidney. She was started on neoadjuvant immunotherapy, but had to stop treatment because of acute worsening of renal function. Radical cystectomy was then performed ... Read more >>

Eur Urol Oncol (European urology oncology)
[2021, :]

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["Treatment of bladder cancer with immune checkpoints inhibitors"].

Élisabeth Grobet-Jeandin, Ugo Pinar, Yohann Loriot, Morgan Roupret,

"Treatment of bladder cancer with immune checkpoints inhibitors .Checkpoint inhibitors could lead to a significant improvement in the management of bladder cancer. For metastatic bladder cancer, checkpoint inhibitors showed an improved overall survival and are currently recommended in second intention. Moreover, they could be used in replacement of standard chemotherapy ... Read more >>

Rev Prat (La Revue du praticien)
[2021, 71(4):391-395]

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SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.

,

<h4>Background</h4>Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling.<h4>Methods</h4>The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an ... Read more >>

Br J Surg (The British journal of surgery)
[2021, :]

Cited: 11 times

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Novel Classification for Upper Tract Urothelial Carcinoma to Better Risk-stratify Patients Eligible for Kidney-sparing Strategies: An International Collaborative Study.

Gautier Marcq, Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Riccardo Autorino, Patricia John, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat, Wassim Kassouf,

<h4>Background</h4>The European Association of Urology risk stratification dichotomizes patients with upper tract urothelial carcinoma (UTUC) into two risk categories.<h4>Objective</h4>To evaluate the predictive value of a new classification to better risk stratify patients eligible for kidney-sparing surgery (KSS).<h4>Design, setting, and participants</h4>This was a retrospective study including 1214 patients from 21 centers ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Relationship of preoperative androgen levels and metabolic syndrome with quality of life and erectile function in patients who are to undergo radical prostatectomy.

Yann Neuzillet, Jean-François Dreyfus, Jean-Pierre Raynaud, Mathieu Rouanne, Marc Schneider, Morgan Roupret, Sarah Drouin, Marc Galiano, Xavier Cathelineau, Thierry Lebret, Henry Botto,

This study aims to investigate whether clinical and biological preoperative characteristics of patients who were to undergo radical prostatectomy were associated with impairment in patient-reported quality of life (QoL) and erectile dysfunction immediately before intervention. We evaluated patient-reported outcomes among 1019 patients (out of 1343) of the AndroCan study, willing ... Read more >>

Asian J Androl (Asian journal of andrology)
[2021, :]

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A panel of systemic inflammatory response biomarkers for outcome prediction in patients treated with radical cystectomy for urothelial carcinoma.

Victor M Schuettfort, David D'Andrea, Fahad Quhal, Hadi Mostafaei, Ekaterina Laukhtina, Keiichiro Mori, Frederik König, Michael Rink, Mohammad Abufaraj, Pierre I Karakiewicz, Stefano Luzzago, Morgan Rouprêt, Dmitry Enikeev, Kristin Zimmermann, Marina Deuker, Marco Moschini, Reza Sari Motlagh, Nico C Grossmann, Satoshi Katayama, Benjamin Pradere, Shahrokh F Shariat,

<h4>Objectives</h4>To determine the predictive and prognostic value of a panel of systemic inflammatory response (SIR) biomarkers relative to established clinicopathological variables in order to improve patient selection and facilitate more efficient delivery of peri-operative systemic therapy.<h4>Materials and methods</h4>The preoperative serum levels of a panel of SIR biomarkers, including albumin-globulin ratio, ... Read more >>

BJU Int (BJU international)
[2021, :]

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[Robots set up in the operating theater].

Jacques Belghiti, Ugo Pinar, Morgan Roupret, Jérémie Belghiti, Catherine Uzan, Geoffroy Canlorbe, Léa Betser, Jules Iquille, Arnaud Roussel, Yves Castier, Pierre Mordant, Alain Valverde,

"Robots set up in the operating theater. The patient's benefit after a minimally invasive approach stimulated the robotic approach of abdominal and thoracic surgical procedures. Although much more expensive, the robots improve the vision of the operating field, the precision of the gestures with a faster training course for the ... Read more >>

Rev Prat (La Revue du praticien)
[2021, 71(3):335-340]

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Correction to: COVID-19 outbreak situation and its psychological impact among surgeons in training in France.

Maher Abdessater, Morgan Rouprêt, Vincent Misrai, Ugo Pinar, Xavier Matillon, Bastien Gondran-Tellier, Lucas Freton, Maxime Vallée, Inès Dominique, Margaux Felber, Zine-Eddine Khene, Edouard Fortier, François Lannes, Clément Michiels, Tristan Grevez, Nicolas Szabla, Florian Bardet, Kevin Kaulanjan, Emilien Seizilles de Mazancourt, Guillaume Ploussard, Benjamin Pradere,

World J Urol (World journal of urology)
[2021, 39(3):973]

Cited: 1 time

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Timing of surgery following SARS-CoV-2 infection: an international prospective cohort study.

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Peri-operative SARS-CoV-2 infection increases postoperative mortality. The aim of this study was to determine the optimal duration of planned delay before surgery in patients who have had SARS-CoV-2 infection. This international, multicentre, prospective cohort study included patients undergoing elective or emergency surgery during October 2020. Surgical patients with pre-operative SARS-CoV-2 ... Read more >>

Anaesthesia (Anaesthesia)
[2021, 76(6):748-758]

Cited: 19 times

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