Full Text Journal Articles by
Author Moran Yang

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The prognostic significance of tumor-infiltrating lymphocytes in cervical cancer.

Mengdi He, Yiying Wang, Guodong Zhang, Kankan Cao, Moran Yang, Haiou Liu,

<h4>Objective</h4>To predict the prognosis of cervical cancer, we constructed a novel model with 5 specific cell types and identified a potential biomarker.<h4>Methods</h4>We employed CIBERSORT and xCell method to evaluate the abundances of 23 cells types in tumor microenvironment. Five specific cell types were filtrated to determine different immunotypes by applying ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(3):e32]

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The immune landscape during the tumorigenesis of cervical cancer.

Yiying Wang, Mengdi He, Guodong Zhang, Kankan Cao, Moran Yang, Hongwei Zhang, Haiou Liu,

<h4>Objective</h4>Deciphering the determinants of the intralesional immune reaction in cervical carcinogenesis may be conducive to improving the understanding of the disease and then improve outcomes.<h4>Methods</h4>Public gene-expression data and full clinical annotation were searched in Gene Expression Omnibus in the joint analysis of the array-based four eligible cohorts. The infiltrating estimation ... Read more >>

Cancer Med (Cancer medicine)
[2021, 10(7):2380-2395]

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Tumour-associated neutrophils orchestrate intratumoural IL-8-driven immune evasion through Jagged2 activation in ovarian cancer.

Moran Yang, Guodong Zhang, Yiying Wang, Mengdi He, Qing Xu, Jiaqi Lu, Haiou Liu, Congjian Xu,

<h4>Background</h4>Tumour associated neutrophils (TANs) play a controversial role in regulating immune surveillance and immune evasion in various malignancies. Here, we investigated the relevance of TANs with the prognosis and immune microenvironment of epithelial ovarian cancer (EOC).<h4>Methods</h4>We characterised TANs using flow cytometric analysis and immunofluorescence analysis. The prognostic merit of TANs ... Read more >>

Br J Cancer (British journal of cancer)
[2020, 123(9):1404-1416]

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Elevated GALNT10 expression identifies immunosuppressive microenvironment and dismal prognosis of patients with high grade serous ovarian cancer.

Guodong Zhang, Jiaqi Lu, Moran Yang, Yiying Wang, Haiou Liu, Congjian Xu,

High grade ovarian serous cancer (HGSC) is a malignant disease with high mortality. Glycosylation plays important roles in tumor invasion and immune evasion, but its effect on the immune microenvironment of HGSC remains unclear. This study examined the association of glycosyltransferase expression with HGSC prognosis and explored the underlying mechanism ... Read more >>

Cancer Immunol Immunother (Cancer immunology, immunotherapy : CII)
[2020, 69(2):175-187]

Cited: 2 times

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