Full Text Journal Articles by
Author Monica C Panelli

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JTM advances in uncharted territories: diseases and disorders of unknown etiology.

Monica C Panelli,

We are delighted to announce a new section in the Journal of Translational Medicine, 'Illnesses of Unknown Etiology'. This section aims to provide a translational medicine forum for the publication of research on illnesses, multisystem diseases and syndromes of unknown etiology. Examples of these include Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and ... Read more >>

J Transl Med (Journal of translational medicine)
[2017, 15(1):192]

Cited: 1 time

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A multi-factorial genetic model for prognostic assessment of high risk melanoma patients receiving adjuvant interferon.

Ena Wang, Yingdong Zhao, Alessandro Monaco, Lorenzo Uccellini, John M Kirkwood, Maria Spyropoulou-Vlachou, Monica C Panelli, Francesco M Marincola, Helen Gogas,

<h4>Purpose</h4>IFNa was the first cytokine to demonstrate anti-tumor activity in advanced melanoma. Despite the ability of high-dose IFNa reducing relapse and mortality by up to 33%, large majority of patients experience side effects and toxicity which outweigh the benefits. The current study attempts to identify genetic markers likely to be ... Read more >>

PLoS One (PloS one)
[2012, 7(7):e40805]

Cited: 8 times

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Concomitant detection of IFNα signature and activated monocyte/dendritic cell precursors in the peripheral blood of IFNα-treated subjects at early times after repeated local cytokine treatments.

Eleonora Aricò, Luciano Castiello, Francesca Urbani, Paola Rizza, Monica C Panelli, Ena Wang, Francesco M Marincola, Filippo Belardelli,

<h4>Background</h4>Interferons alpha (IFNα) are the cytokines most widely used in clinical medicine for the treatment of cancer and viral infections. Among the immunomodulatory activities possibly involved in their therapeutic efficacy, the importance of IFNα effects on dendritic cells (DC) differentiation and activation has been considered. Despite several studies exploiting microarray ... Read more >>

J Transl Med (Journal of translational medicine)
[2011, 9:67]

Cited: 14 times

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Microrna profiling analysis of differences between the melanoma of young adults and older adults.

Drazen M Jukic, Uma N M Rao, Lori Kelly, Jihad S Skaf, Laura M Drogowski, John M Kirkwood, Monica C Panelli,

<h4>Background</h4>This study represents the first attempt to perform a profiling analysis of the intergenerational differences in the microRNAs (miRNAs) of primary cutaneous melanocytic neoplasms in young adult and older age groups. The data emphasize the importance of these master regulators in the transcriptional machinery of melanocytic neoplasms and suggest that ... Read more >>

J Transl Med (Journal of translational medicine)
[2010, 8:27]

Cited: 71 times

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Serum vascular endothelial growth factor and fibronectin predict clinical response to high-dose interleukin-2 therapy.

Marianna Sabatino, Seunghee Kim-Schulze, Monica C Panelli, David Stroncek, Ena Wang, Bret Taback, Dae Won Kim, Gail Deraffele, Zoltan Pos, Francesco M Marincola, Howard L Kaufman,

<h4>Purpose</h4>High-dose interleukin-2 (IL-2) induces durable therapeutic responses in a small subset of patients with metastatic melanoma and renal cell carcinoma, but simple pretreatment predictors of response have not been identified.<h4>Patients and methods</h4>To identify predictive biomarkers of clinical response, sera from patients treated with high-dose IL-2 were collected for analysis using ... Read more >>

J Clin Oncol (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2009, 27(16):2645-2652]

Cited: 108 times

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Next generation of immunotherapy for melanoma.

John M Kirkwood, Ahmad A Tarhini, Monica C Panelli, Stergios J Moschos, Hassane M Zarour, Lisa H Butterfield, Helen J Gogas,

<h4>Purpose</h4>Immunotherapy has a long history with striking but limited success in patients with melanoma. To date, interleukin-2 and interferon-alfa2b are the only approved immunotherapeutic agents for melanoma in the United States.<h4>Design</h4>Tumor evasion of host immune responses, and strategies for overcoming tumor-induced immunosuppression are reviewed. Several novel immunotherapies currently in worldwide ... Read more >>

J Clin Oncol (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2008, 26(20):3445-3455]

Cited: 112 times

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GM-CSF/IL-3/IL-5 receptor common beta chain (CD131) expression as a biomarker of antigen-stimulated CD8+ T cells.

Silvia Selleri, Sara Deola, Zoltan Pos, Ping Jin, Andrea Worschech, Stefanie L Slezak, Cristiano Rumio, Monica C Panelli, Dragan Maric, David F Stroncek, Ena Wang, Francesco M Marincola,

<h4>Background</h4>Upon Ag-activation cytotoxic T cells (CTLs) produce IFN-gamma GM-CSF and TNF-alpha, which deliver simultaneously pro-apoptotic and pro-inflammatory signals to the surrounding microenvironment. Whether this secretion affects in an autocrine loop the CTLs themselves is unknown.<h4>Methods</h4>Here, we compared the transcriptional profile of Ag-activated, Flu-specific CTL stimulated with the FLU M1:58-66 peptide ... Read more >>

J Transl Med (Journal of translational medicine)
[2008, 6:17]

Cited: 6 times

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Helper B cells promote cytotoxic T cell survival and proliferation independently of antigen presentation through CD27/CD70 interactions.

Sara Deola, Monica C Panelli, Dragan Maric, Silvia Selleri, Natalia I Dmitrieva, Ching Y Voss, Harvey Klein, David Stroncek, Ena Wang, Francesco M Marincola,

CD8-expressing cytotoxic T cell (CTL) interactions with APCs and helper T cells determine their function and ability to survive. In this study, we describe a novel interaction independent of Ag presentation between activated CTLs and bystander CD19-expressing B lymphocytes. Ag-stimulated CTLs serially engage autologous B lymphocytes through CD27/CD70 contact that ... Read more >>

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2008, 180(3):1362-1372]

Cited: 37 times

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Adjuvant therapy with high-dose interferon alpha 2b in patients with high-risk stage IIB/III melanoma.

John M Kirkwood, Ahmad A Tarhini, Stergios J Moschos, Monica C Panelli,

Nat Clin Pract Oncol (Nature clinical practice. Oncology)
[2008, 5(1):2-3]

Cited: 19 times

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Comprehensive epitope mapping of the Epstein-Barr virus latent membrane protein-2 in normal, non tumor-bearing individuals.

Maurizio Provenzano, Silvia Selleri, Ping Jin, Ena Wang, Rosemary Werden, Stephanie Slezak, Sharon D Adams, Monica C Panelli, Susan F Leitman, David F Stroncek, Francesco M Marincola,

Latent membrane protein (LMP)-2 is one of the Epstein-Barr virus (EBV)-encoded proteins consistently expressed by nasopharyngeal carcinoma (NPC). EBV-transformed lymphoblastoid cell lines (LCL) have been used in patients with NPC to induce LMP-2-recognizing T cell lines which have been in turn utilized for protein-wide mapping of T cell epitopes. However, ... Read more >>

Cancer Immunol Immunother (Cancer immunology, immunotherapy : CII)
[2007, 56(7):1047-1063]

Cited: 6 times

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Comparison of proteomic profiles of serum, plasma, and modified media supplements used for cell culture and expansion.

Saleh Ayache, Monica C Panelli, Karen M Byrne, Stefanie Slezak, Susan F Leitman, Francesco M Marincola, David F Stroncek,

<h4>Background</h4>The culture and expansion of human cells for clinical use requires the presence of human serum or plasma in culture media. Although these supplements have been extensively characterized in their chemical composition, only recently it has been possible to provide by high throughput protein analysis, a comprehensive profile of the ... Read more >>

J Transl Med (Journal of translational medicine)
[2006, 4:40]

Cited: 35 times

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Common cancer biomarkers.

Christopher F Basil, Yingdong Zhao, Katia Zavaglia, Ping Jin, Monica C Panelli, Sonia Voiculescu, Susanna Mandruzzato, Hueling M Lee, Barbara Seliger, Ralph S Freedman, Phil R Taylor, Nan Hu, Paola Zanovello, Francesco M Marincola, Ena Wang,

There is an increasing interest in complementing conventional histopathologic evaluation with molecular tools that could increase the sensitivity and specificity of cancer staging for diagnostic and prognostic purposes. This study strove to identify cancer-specific markers for the molecular detection of a broad range of cancer types. We used 373 archival ... Read more >>

Cancer Res (Cancer research)
[2006, 66(6):2953-2961]

Cited: 55 times

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Gene expression profiling of cutaneous wound healing.

Kavita Deonarine, Monica C Panelli, Mitchell E Stashower, Ping Jin, Kina Smith, Herbert B Slade, Christopher Norwood, Ena Wang, Francesco M Marincola, David F Stroncek,

<h4>Background</h4>Although the sequence of events leading to wound repair has been described at the cellular and, to a limited extent, at the protein level this process has yet to be fully elucidated. Genome wide transcriptional analysis tools promise to further define the global picture of this complex progression of events.<h4>Study ... Read more >>

J Transl Med (Journal of translational medicine)
[2007, 5:11]

Cited: 104 times

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MHC-peptide specificity and T-cell epitope mapping: where immunotherapy starts.

Maurizio Provenzano, Monica C Panelli, Simone Mocellin, Laura Bracci, Giovanni Sais, David F Stroncek, Giulio C Spagnoli, Francesco M Marincola,

The evaluation and characterization of epitope-specific human leukocyte antigen (HLA)-restricted memory T-cell reactivity is an important step for the development of preventive vaccines and peptide-based immunotherapies for viral and tumor diseases. The past decade has witnessed the use of HLA-restricted peptides as tools to activate strong immune responses of naïve ... Read more >>

Trends Mol Med (Trends in molecular medicine)
[2006, 12(10):465-472]

Cited: 15 times

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Sequential gene profiling of basal cell carcinomas treated with imiquimod in a placebo-controlled study defines the requirements for tissue rejection.

Monica C Panelli, Mitchell E Stashower, Herbert B Slade, Kina Smith, Christopher Norwood, Andrea Abati, Patricia Fetsch, Armando Filie, Shelley-Ann Walters, Calvin Astry, Eleonora Aricó, Yingdong Zhao, Silvia Selleri, Ena Wang, Francesco M Marincola,

<h4>Background</h4>Imiquimod is a Toll-like receptor-7 agonist capable of inducing complete clearance of basal cell carcinoma (BCC) and other cutaneous malignancies. We hypothesized that the characterization of the early transcriptional events induced by imiquimod may provide insights about immunological events preceding acute tissue and/or tumor rejection.<h4>Results</h4>We report a paired analysis of ... Read more >>

Genome Biol (Genome biology)
[2007, 8(1):R8]

Cited: 55 times

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Molecular signatures induced by interleukin-2 on peripheral blood mononuclear cells and T cell subsets.

Ping Jin, Ena Wang, Maurizio Provenzano, Sara Deola, Silvia Selleri, Jiaqiang Ren, Sonia Voiculescu, David Stroncek, Monica C Panelli, Francesco M Marincola,

Experimentally, interleukin-2 (IL-2) exerts complex immunological functions promoting the proliferation, survival and activation of T cells on one hand and inducing immune regulatory mechanisms on the other. This complexity results from a cross talk among immune cells which sways the effects of IL-2 according to the experimental or clinical condition ... Read more >>

J Transl Med (Journal of translational medicine)
[2006, 4:26]

Cited: 25 times

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Inflammatory protein profile during systemic high dose interleukin-2 administration.

Leonardo Rossi, Brian M Martin, Glen L Hortin, Richard L White, Mareva Foster, Ramy Moharram, David Stroncek, Ena Wang, Francesco M Marincola, Monica C Panelli,

Systemic interleukin-2 (IL-2) administration induces an assortment of downstream effects whose biological and therapeutic significance remains unexplored mostly because of the methodological inability to globally address their complexity. Protein array analysis of sera from patients with renal cell carcinoma obtained prior and during high-dose IL-2 therapy had previously revealed extensive ... Read more >>

Proteomics (Proteomics)
[2006, 6(2):709-720]

Cited: 27 times

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The pathway to biomarker discovery: carbonic anhydrase IX and the prediction of immune responsiveness.

Monica C Panelli, Ena Wang, Francesco M Marincola,

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2005, 11(10):3601-3603]

Cited: 8 times

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Detection of human MCP-4/CCL13 isoforms by SELDI immunoaffinity capture.

Leonardo Rossi, Ramy Moharram, Brian M Martin, Richard L White, Monica C Panelli,

Monocyte Chemoattractant Proteins 4 (MCP-4/CCL13) is a member of a distinct, structurally-related subclass of CC chemokines mainly involved in recruitment of eosinphils to inflammatory sites. Recent evidence demonstrates that serum level of this protein strongly increases following high dose IL-2 immunotherapy. The physiological form of human MCP-4/CCL13 has yet to ... Read more >>

J Transl Med (Journal of translational medicine)
[2006, 4:5]

Cited: 5 times

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Understanding the response to immunotherapy in humans.

Ena Wang, Monica C Panelli, Francesco M Marincola,

Whether the efforts of the last decade aimed at the development of vaccines against tumor-specific antigens encountered success or failure is a matter of expectations. On the bright side, we could optimistically observe that anti-cancer-vaccines stand as an outstanding example of the successful implementation of modern biotechnology tools for the ... Read more >>

Springer Semin Immunopathol (Springer seminars in immunopathology)
[2005, 27(1):105-117]

Cited: 8 times

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Polarized monocyte response to cytokine stimulation.

Dirk Nagorsen, Sara Deola, Kina Smith, Ena Wang, Vladia Monsurro, Paola Zanovello, Francesco M Marincola, Monica C Panelli,

<h4>Background</h4>Mononuclear phagocytes (MPs) stand at the crossroads between the induction of acute inflammation to recruit and activate immune effector cells and the downmodulation of the inflammatory process to contain collateral damage. This decision is extensively modulated by the cytokine microenvironment, which includes a broad array of cytokines whose direct effect ... Read more >>

Genome Biol (Genome biology)
[2005, 6(2):R15]

Cited: 20 times

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Ontogeny and oncogenesis balance the transcriptional profile of renal cell cancer.

Ena Wang, Rudolf Lichtenfels, Jurgen Bükur, Yvonne Ngalame, Monica C Panelli, Barbara Seliger, Francesco M Marincola,

Global transcript analysis is increasingly used to describe cancer taxonomies beyond the microscopic reach of the eye. Diagnostic and prognostic portraits are formulated by ranking cancers according to transcriptional proximity. However, the role that distinct biological factors play in defining these portraits remains undefined. It is likely that the transcriptional ... Read more >>

Cancer Res (Cancer research)
[2004, 64(20):7279-7287]

Cited: 16 times

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Melanoma-restricted genes.

Ena Wang, Monica C Panelli, Katia Zavaglia, Susanna Mandruzzato, Nan Hu, Phil R Taylor, Barbara Seliger, Paola Zanovello, Ralph S Freedman, Francesco M Marincola,

Human metastatic cutaneous melanoma has gained a well deserved reputation for its immune responsiveness. The reason(s) remain(s) unknown. We attempted previously to characterize several variables that may affect the relationship between tumor and host immune cells but, taken one at the time, none yielded a convincing explanation. With explorative purposes, ... Read more >>

J Transl Med (Journal of translational medicine)
[2004, 2(1):34]

Cited: 28 times

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Proteomic signature of myeloproliferation and neutrophilia: analysis of serum and plasma from healthy subjects given granulocyte colony-stimulating factor.

David Stroncek, Stefanie Slezak, Hanh Khuu, Christopher Basil, John Tisdale, Susan F Leitman, Francesco M Marincola, Monica C Panelli,

<h4>Objective</h4>Proteomic analysis could improve our understanding of the mechanisms and consequences of myeloproliferation. Healthy subjects treated with granulocyte colony-stimulating factor (G-CSF) were used as a model of myeloproliferation.<h4>Methods</h4>Levels of 80 soluble factors were measured by enzyme-linked immunosorbent assay before and after 5 days of G-CSF. Both serum and plasma levels ... Read more >>

Exp Hematol (Experimental hematology)
[2005, 33(10):1109-1117]

Cited: 10 times

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A global approach to tumor immunology.

Ena Wang, Monica C Panelli, Vladia Monsurró, Francesco M Marincola,

Biological and clinical advances in the understanding of tumor immunology suggest that immune responsiveness of human tumors is a complex biological phenomenon that could be best studied by a real-time comparison of tumor/host interactions in the tumor microenvironment through a high-throughput discovery-driven approach. This conclusion is derived from our recognition ... Read more >>

Cell Mol Immunol (Cellular & molecular immunology)
[2004, 1(4):256-265]

Cited: 15 times

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