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Author Momokazu Gotoh

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Daily urine loss immediately after urethral catheter removal may be an effective predictor of long-term urinary incontinence following robot-assisted laparoscopic radical prostatectomy.

Yoshihisa Matsukawa, Yasushi Yoshino, Takashi Fujita, Yasuhito Funahashi, Tsuyoshi Majima, Shohei Ishida, Masashi Kato, Momokazu Gotoh,

PURPOSE:Some patients who undergo robot-assisted laparoscopic radical prostatectomy (RARP) continue to experience long-term urinary incontinence (UI). This study aimed to evaluate easily obtainable factors that can predict long-term UI following RARP. MATERIALS AND METHODS:A total of 315 patients who underwent RARP for localized prostatic cancer were analyzed. We separated the ... Read more >>

Int J Clin Pract (International journal of clinical practice)
[2020, :e13736]

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TAS-303 effects on urethral sphincter function in women with stress urinary incontinence: phase I study.

Makoto Yono, Shin Irie, Momokazu Gotoh,

INTRODUCTION AND HYPOTHESIS:TAS-303, which selectively inhibits noradrenaline reuptake, was developed for treating stress urinary incontinence (SUI). The proximal urethra mainly comprises smooth muscle fibers in which α1 adrenergic receptors are abundant. This study was conducted to evaluate the effect of TAS-303 on urethral function and its safety profile in female ... Read more >>

Int Urogynecol J (International urogynecology journal)
[2020, :]

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UroVysion® predicts intravesical recurrence after radical nephroureterectomy for urothelial carcinoma of the upper urinary tract: a prospective study.

Hidehiro Iwata, Naoto Sassa, Masashi Kato, Yota Murase, Shuko Seko, Hideji Kawanishi, Ryohei Hattori, Momokazu Gotoh, Toyonori Tsuzuki,

BACKGROUND:Intravesical recurrence (IVR) after radical nephroureterectomy (RNU) for urothelial carcinoma of the upper urinary tract (UCUUT) is common. One of the mechanisms driving this is the implantation of cancer cells from the UCUUT at the RNUs. Therefore, their detection after RNU can assist in predicting IVR. This study aimed to ... Read more >>

Int. J. Clin. Oncol. (International journal of clinical oncology)
[2020, :]

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Presence of constipation predicts the therapeutic efficacy of pembrolizumab in metastatic urothelial cancer patients.

Satoshi Inoue, Naoto Sassa, Takashi Kato, Yushi Yamauchi, Tsuyoki Hirabayashi, Yuri Yuguchi, Motohiro Maeda, Yuya Soeda, Ryohei Hattori, Momokazu Gotoh,

OBJECTIVES:To study bowel function in urothelial cancer patients treated with pembrolizumab and to assess its association with treatment efficacy. METHODS:This retrospective study was analyzed for patients with metastatic urothelial cancer who received immune checkpoint inhibitor treatment between December 2017 and June 2019 at Nagoya University and affiliated hospitals in Japan. ... Read more >>

Int J Urol (International journal of urology : official journal of the Japanese Urological Association)
[2020, :]

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The clinical benefit of sequential therapy with androgen receptor axis-targeted agents alone in patients with castration-resistant prostate cancer: A propensity score-matched comparison study.

Yushi Naito, Masashi Kato, Hideji Kawanishi, Yuri Yuguchi, Takuma Yuba, Tomohiro Ishikawa, Kyosuke Hattori, Akiyuki Yamamoto, Tomoyasu Sano, Yoshihisa Matsukawa, Toru Kimura, Toshinori Nishikimi, Ryohei Hattori, Toyonori Tsuzuki, Momokazu Gotoh,

BACKGROUND:The optimal sequential therapy for castration-resistant prostate cancer (CRPC) remains unknown. In recent years, some doubts have emerged regarding the clinical benefit of sequential therapy with androgen receptor axis-targeted agents (ART) such as abiraterone (ABI) or enzalutamide (ENZ) for patients with CRPC. We compared the effect of ART-to-ART (AA) sequential ... Read more >>

Prostate (The Prostate)
[2020, :]

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A case of primary adenocarcinoma of the seminal vesicle treated by total laparoscopic pelvic exenteration.

Kosuke Tochigi, Yoshihisa Matsukawa, Shohei Ishida, Yasuhito Funahashi, Takashi Fujita, Masashi Kato, Momokazu Gotoh,

An adenocarcinoma of the seminal vesicle is a rare malignancy with a poor prognosis. Its symptoms are non-specific, rendering diagnosis difficult. We present the case of a 74-year-old male with haematospermia. Magnetic resonance imaging revealed a bulky tumour of the seminal vesicle infiltrating the prostate gland, bladder and rectum. A ... Read more >>

Aktuelle Urol (Aktuelle Urologie)
[2020, :]

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Techniques of transvaginal mesh prolapse surgery in Japan, and the comparison of complication rates by surgeons' specialty and experience.

Kumiko Kato, Momokazu Gotoh, Satoru Takahashi, Hiroshi Kusanishi, Masami Takeyama, Masayasu Koyama,

OBJECTIVES:To investigate techniques of transvaginal mesh prolapse surgery in Japan, and compare complication rates by surgeons' specialty and experience with transvaginal mesh prolapse surgery. METHODS:We carried out an anonymous questionnaire survey for surgeons attending a national transvaginal mesh prolapse surgery meeting in 2010. The surgeons were asked to state their ... Read more >>

Int. J. Urol. (International journal of urology : official journal of the Japanese Urological Association)
[2020, :]

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Newly emerged immunogenic neoantigens in established tumors enable hosts to regain immunosurveillance in a T cell-dependent manner.

Tomoaki Muramatsu, Takuro Noguchi, Daisuke Sugiyama, Yoshie Kanada, Kaori Fujimaki, Sachiko Ito, Momokazu Gotoh, Hiroyoshi Nishikawa,

Tumor neoantigens derived from genetic alterations are potential T cell targets for antitumor immunity. However, tumors develop immune escape mechanisms including loss of preexisting neoantigens and/or impairment of T cell responses during tumor development and progression. Here, we addressed whether newly emerged immunogenic neoantigens in established tumors enabled hosts to ... Read more >>

Int. Immunol. (International immunology)
[2020, :]

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Characteristics of primary and repeated recurrent retroperitoneal liposarcoma: outcomes after aggressive surgeries at a single institution.

Kenta Ishii, Yukihiro Yokoyama, Yoshihiro Nishida, Hiroshi Koike, Suguru Yamada, Yasuhiro Kodera, Naoto Sassa, Momokazu Gotoh, Masato Nagino,

OBJECTIVE:This study sought to investigate the characteristics of primary and repeated recurrent retroperitoneal liposarcoma. METHODS:Patients treated with primary or recurrent retroperitoneal liposarcoma between 2005 and 2018 were retrospectively reviewed. Survival time analysis of recurrence-free survival and overall survival was conducted using Kaplan-Meier analysis and log-rank test. RESULTS:Fifty-two patients with primary ... Read more >>

Jpn. J. Clin. Oncol. (Japanese journal of clinical oncology)
[2020, :]

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Regenerative treatment for male stress urinary incontinence by periurethral injection of adipose-derived regenerative cells: Outcome of the ADRESU study.

Momokazu Gotoh, Shinobu Shimizu, Tokunori Yamamoto, Osamu Ishizuka, Tomonori Yamanishi, Atsushi Mizokami, Kazutaka Narimoto, Kazuhiro Toriyama, Yuzuru Kamei, Shinobu Nakayama, Yachiyo Kuwatsuka, Masaaki Mizuno, Akihiro Hirakawa,

OBJECTIVES:To report the outcome of the ADRESU study, a multicenter, single-arm, investigator-initiated clinical trial to confirm the efficacy and safety of regenerative treatment for male patients with stress urinary incontinence. METHODS:The participants were male patients with mild-to-moderate stress urinary incontinence persisting for >1 year after prostatectomy. Autologous adipose-derived regenerative cells were ... Read more >>

Int J Urol (International journal of urology : official journal of the Japanese Urological Association)
[2020, 27(10):859-865]

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Comparison of cernitin pollen extract vs tadalafil therapy for refractory chronic prostatitis/chronic pelvic pain syndrome: A randomized, prospective study.

Yoshihisa Matsukawa, Yushi Naito, Yasuhito Funahashi, Shohei Ishida, Takashi Fujita, Kosuke Tochigi, Masashi Kato, Momokazu Gotoh,

AIMS:To compare the efficacy of cernitin pollen extract (cernitin) or tadalafil for treating persistent chronic pelvic pain despite α1-blocker monotherapy in men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and lower urinary tract symptoms (LUTS). METHODS:A total of 100 patients with refractory CP/CPPS despite ongoing α1-blocker monotherapy were randomized to ... Read more >>

Neurourol. Urodyn. (Neurourology and urodynamics)
[2020, 39(7):1994-2002]

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Influence of human adipose stem cells on prostate cancer cell growth.

Tokunori Yamamoto, Momokazu Gotoh, Naoshi Koide, Yasuhito Funahashi, Shinobu Shimizu, Yoshifumi Takei,

In a novel regenerative cell-based treatment developed by us for the patients with stress urinary incontinence, autologous adipose-derived stem cells (ASCs) are injected into the periurethral region and the external urethral sphincter. Since the candidates for this treatment included prostate cancer patients after radical prostatectomy, we investigated the effects of ... Read more >>

Nagoya J Med Sci (Nagoya journal of medical science)
[2020, 82(2):217-224]

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Useful parameters to predict the presence of detrusor overactivity in male patients with lower urinary tract symptoms.

Yoshihisa Matsukawa, Tsuyoshi Majima, Shohei Ishida, Yasuhito Funahashi, Masashi Kato, Momokazu Gotoh,

AIMS:This study aimed to identify the easily obtainable parameters that predict the presence of detrusor overactivity (DO) in male patients with lower urinary tract symptoms (LUTS), because urodynamic studies cannot be performed in all cases. METHODS:A total of 605 treatment-naïve men with non-neurogenic LUTS who underwent subjective and objective evaluations ... Read more >>

Neurourol. Urodyn. (Neurourology and urodynamics)
[2020, 39(5):1394-1400]

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Real world data of liver injury induced by immune checkpoint inhibitors in Japanese patients with advanced malignancies.

Kazuyuki Mizuno, Takanori Ito, Masatoshi Ishigami, Yoji Ishizu, Teiji Kuzuya, Takashi Honda, Hiroki Kawashima, Yosuke Inukai, Hidenori Toyoda, Kenji Yokota, Tetsunari Hase, Osamu Maeda, Hitoshi Kiyoi, Masato Nagino, Hideharu Hibi, Yasuhiro Kodera, Yasushi Fujimoto, Michihiko Sone, Momokazu Gotoh, Yuichi Ando, Masashi Akiyama, Yoshinori Hasegawa, Mitsuhiro Fujishiro,

BACKGROUND:Liver injury induced by immune checkpoint inhibitors (ICIs) is an immune-related adverse event (irAE) whose incidence has increased with the broader use of ICIs in clinical practice. However, the incidental risk factors of immune-related liver injury are unknown. We investigated the clinical characteristics of immune-related liver injury. METHODS:A total of ... Read more >>

J. Gastroenterol. (Journal of gastroenterology)
[2020, 55(6):653-661]

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Efficacy of vibegron, a novel β3-adrenoreceptor agonist, on severe urgency urinary incontinence related to overactive bladder: post hoc analysis of a randomized, placebo-controlled, double-blind, comparative phase 3 study.

Masaki Yoshida, Masayuki Takeda, Momokazu Gotoh, Osamu Yokoyama, Hidehiro Kakizaki, Satoru Takahashi, Naoya Masumori, Shinji Nagai, Kazuyoshi Minemura,

OBJECTIVE:To evaluate the efficacy of a novel and selective β3-adrenoreceptor agonist vibegron on urgency urinary incontinence (UUI) in patients with overactive bladder (OAB). PATIENTS AND METHODS:A post hoc analysis was performed in patients with UUI (>0 episodes/day) who were assigned to receive vibegron or placebo in a vibegron phase 3 ... Read more >>

BJU Int (BJU international)
[2020, 125(5):709-717]

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Anti-thyroid antibodies and thyroid echo pattern at baseline as risk factors for thyroid dysfunction induced by anti-programmed cell death-1 antibodies: a prospective study.

Norio Okada, Shintaro Iwama, Takayuki Okuji, Tomoko Kobayashi, Yoshinori Yasuda, Eri Wada, Takeshi Onoue, Motomitsu Goto, Mariko Sugiyama, Taku Tsunekawa, Hiroshi Takagi, Daisuke Hagiwara, Yoshihiro Ito, Hidetaka Suga, Ryoichi Banno, Tetsunari Hase, Masahiro Morise, Mitsuro Kanda, Kenji Yokota, Naozumi Hashimoto, Masahiko Ando, Yasushi Fujimoto, Masato Nagino, Yasuhiro Kodera, Mitsuhiro Fujishiro, Hideharu Hibi, Michihiko Sone, Hitoshi Kiyoi, Momokazu Gotoh, Yuichi Ando, Masashi Akiyama, Yoshinori Hasegawa, Hiroshi Arima,

BACKGROUND:Anti-programmed cell death-1 (PD-1) antibodies can cause thyroid dysfunction. However, no predictive biomarkers enabling stratification of thyroid dysfunction risk have been identified. METHODS:A total of 209 patients treated with an anti-PD-1 antibody were evaluated for anti-thyroid antibodies at baseline and prospectively for thyroid function every 6 weeks for 24 weeks ... Read more >>

Br. J. Cancer (British journal of cancer)
[2020, 122(6):771-777]

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Clinical characteristics and surgical outcomes of retroperitoneal tumors: a comprehensive data collection from multiple departments.

Naoto Sassa, Yukihiro Yokoyama, Yoshihiro Nishida, Suguru Yamada, Hiroo Uchida, Hiroaki Kajiyama, Masato Nagino, Yasuhiro Kodera, Momokazu Gotoh,

BACKGROUND:There are only a limited number of comprehensive reports for retroperitoneal tumors (RPTs). The aim of this study was to perform an interdepartmental data collection for RPTs and to comprehensively clarify the clinical characteristics of this rare disease. METHODS:All patients who were diagnosed with RPT from January 2005 to July ... Read more >>

Int. J. Clin. Oncol. (International journal of clinical oncology)
[2020, 25(5):929-936]

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Propensity score-matched comparison of docetaxel and androgen receptor axis-targeted agents in patients with castration-resistant intraductal carcinoma of the prostate.

Akiyuki Yamamoto, Masashi Kato, Kyosuke Hattori, Yushi Naito, Kosuke Tochigi, Tomoyasu Sano, Hideji Kawanishi, Tomohiro Ishikawa, Takuma Yuba, Ryohei Hattori, Momokazu Gotoh, Toyonori Tsuzuki,

OBJECTIVE:To evaluate the efficacy of docetaxel and androgen receptor axis-targeted (ARAT) agents in patients with castration-resistant prostate cancer (CRPC) with intraductal carcinoma of the prostate (IDC-P) using a propensity score-matched analysis. PATIENTS AND METHODS:We retrospectively identified 309 patients with CRPC from February 2007 to February 2016 at Nagoya University and ... Read more >>

BJU Int (BJU international)
[2020, 125(5):702-708]

Cited: 1 time

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Response of intraductal carcinoma of the prostate to androgen deprivation therapy predicts prostate cancer prognosis in radical prostatectomy patients.

Masashi Kato, Akihiro Hirakawa, Yumiko Kobayashi, Akiyuki Yamamoto, Ryo Ishida, Osamu Kamihira, Tomoyasu Sano, Tsuyoshi Majima, Shohei Ishida, Yasuhito Funahashi, Naoto Sassa, Takashi Fujita, Yoshihisa Matsukawa, Ryohei Hattori, Momokazu Gotoh, Toyonori Tsuzuki,

BACKGROUND:Intraductal carcinoma of the prostate (IDC-P) has a poor prognosis and is thought to be completely resistant to current therapies, including androgen deprivation therapy (ADT). However, to date, there are no data showing direct evidence of such resistance. METHODS:We retrospectively evaluated 145 patients with high-risk prostate cancer who underwent radical ... Read more >>

Prostate (The Prostate)
[2020, 80(3):284-290]

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A case of advanced prostate cancer controlled for the long term by flutamide after bicalutamide failure.

Tomoaki Muramatsu, Yasuhito Funahashi, Akiyuki Yamamoto, Naoto Sassa, Yoshihisa Matsukawa, Momokazu Gotoh,

Currently, the early introduction of new antiandrogens is popular for castration-resistant prostate cancer (CRPC). However, adverse events can be severe and their costs are high. Here, we present a patient with CRPC in whom flutamide controlled disease progression for 10 years. This case report shows that conventional alternative antiandrogens are ... Read more >>

Nagoya J Med Sci (Nagoya journal of medical science)
[2019, 81(4):707-710]

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The effect of mirabegron on bladder blood flow in a rat model of bladder outlet obstruction.

Tsuyoshi Majima, Yoshihisa Matsukawa, Yasuhito Funahashi, Masashi Kato, Tokunori Yamamoto, Momokazu Gotoh,

PURPOSE:To evaluate the effects of mirabegron on bladder blood flow in a rat model of bladder outlet obstruction (BOO). METHODS:Adult female Sprague-Dawley rats were divided into three groups based on whether they underwent a sham operation (sham group) or an operation to establish partial BOO (BOO and BOO + mirabegron groups). The ... Read more >>

World J Urol (World journal of urology)
[2020, 38(8):2021-2027]

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What Are Factors Contributing to Improvement of Overactive Bladder Symptoms after Alpha-1 Blocker Treatment in Patients with Both Storage and Voiding Symptoms?

Yoshihisa Matsukawa, Tsuyoshi Majima, Shun Takai, Yasuhito Funahashi, Masashi Kato, Momokazu Gotoh,

INTRODUCTION:To determine the pre-treatment factors related to the improvement of overactive bladder (OAB) symptom after alpha-1 blocker monotherapy in patients with benign prostatic hyperplasia complicated by OAB (BPH/OAB). METHODS:Post-hoc analysis of a prospective study in patients with BPH/OAB, randomized to receive silodosin 8 mg (n = 157) or naftopidil 75 ... Read more >>

Urol. Int. (Urologia internationalis)
[2019, 103(4):439-443]

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Clinical characteristics and useful signs to differentiate detrusor underactivity from bladder outlet obstruction in men with non-neurogenic lower urinary tract symptoms.

Yoshihisa Matsukawa, Masaki Yoshida, Osamu Yamaguchi, Shun Takai, Tsuyoshi Majima, Yasuhito Funahashi, Makoto Yono, Noritoshi Sekido, Momokazu Gotoh,

OBJECTIVE:To investigate the clinical characteristics and useful signs to differentiate detrusor underactivity from bladder outlet obstruction in men with non-neurogenic lower urinary tract symptoms. METHODS:A total of 638 treatment-naive men with non-neurogenic lower urinary tract symptoms who underwent subjective and objective evaluations were reviewed retrospectively. We divided the patients into ... Read more >>

Int. J. Urol. (International journal of urology : official journal of the Japanese Urological Association)
[2020, 27(1):47-52]

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Factors contributing to the efficacy of two add-on therapies of fesoterodine or mirabegron to silodosin monotherapy for persistent overactive bladder in men with lower urinary tract symptoms.

Yoshihisa Matsukawa, Momokazu Gotoh,

Int. J. Urol. (International journal of urology : official journal of the Japanese Urological Association)
[2020, 27(1):85-86]

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A case of bulky pseudohyperplastic prostatic adenocarcinoma.

Tomoya Narita, Atsuya Kondo, Motohiro Maeda, Yasuhito Funahashi, Kuniaki Tanaka, Momokazu Gotoh,

A 67-year-old male with a pelvic mass 13 × 7 cm in dimension was diagnosed with a pseudohyperplastic prostatic adenocarcinoma via mass biopsy. Androgen-deprivation therapy was remarkably effective, resulting in rapid tumor shrinkage. ... Read more >>

Aktuelle Urol (Aktuelle Urologie)
[2019, :]

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