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COVID 19-related Burnout among Healthcare Workers in India and ECG based Predictive Machine Learning Model: Insights from the BRUCEE- Li Study

Mohit D. Gupta, Manish Kumar Jha, Ankit Bansal, Rakesh Yadav, Sivasubramanian Ramakrishanan, Girish MP, Prattay G. Sarkar, Arman Qamar, Suresh Kumar, Satish Kumar, M.Ch Ajeet Jain, Rajni Saijpaul, Vandana Gupta, Deepankar Kansal, Sandeep Garg, Sameer Arora, P.S. Biswas, Jamal Yusuf, Rajeev K. Malhotra, Vishal Batra, Sanjeev Kathuria, Vimal Mehta, D.M. Safal, Manu Kumar Shetty, Saibal Mukhopadhyay, Sanjay Tyagi, Anubha Gupta, for the BRUCEE Li Investigators,

<h4>Objectives</h4> COVID-19 pandemic has led to unprecedented increase in rates of stress and burn out among healthcare workers (HCWs). Heart rate variability (HRV) has been shown to be reflective of stress and burnout. The present study evaluated the prevalence of burnout and attempted to develop a HRV based predictive machine ... Read more >>

Indian Heart J (Indian heart journal)
[2021, :]

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Left ventricular global longitudinal strain in COVID-19 recovered patients.

Sudhanshu Mahajan, Shekhar Kunal, Bhushan Shah, Shobhit Garg, Girish M Palleda, Ankit Bansal, Vishal Batra, Jamal Yusuf, Saibal Mukhopadhyay, Suresh Kumar, Sanjay Tyagi, Anubha Gupta, Mohit D Gupta,

<h4>Objectives</h4>Myocardial injury during active coronavirus disease-2019 (COVID-19) infection is well described; however, its persistence during recovery is unclear. We assessed left ventricle (LV) global longitudinal strain (GLS) using speckle tracking echocardiography (STE) in COVID-19 recovered patients and its correlation with various parameters.<h4>Methods</h4>A total of 134 subjects within 30-45 days post ... Read more >>

Echocardiography (Echocardiography (Mount Kisco, N.Y.))
[2021, :]

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Hypertensive Patients Exhibit Enhanced Thrombospondin-1 Levels at High-Altitude.

Kavita Sharma, Neha Chanana, Ghulam Mohammad, Tashi Thinlas, Mohit Gupta, Mansoor Ali Syed, Rajat Subhra Das, Qadar Pasha, Aastha Mishra,

Thrombospondin-1 (THBS1) levels elevate under hypoxia and have relevance in several cardiovascular disorders. The association of THBS1 with endothelial dysfunction implies its important role in hypertension. To establish the hypothesis, we screened patients with hypertension and their respective controls from the two different environmental regions. Cohort 1 was composed of ... Read more >>

Life (Basel) (Life (Basel, Switzerland))
[2021, 11(9):]

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The study of novel inflammatory markers in takayasu arteritis and its correlation with disease activity.

Antony P Pathadan, Sanjay Tyagi, Mohit D Gupta, Girish M P, Sudhanshu Mahajan, Shekhar Kunal, Bhawna Mahajan, Ankit Bansal,

<h4>Objectives</h4>Currently, erythrocyte sedimentation rate (ESR) and highly sensitive serum C-reactive protein (hsCRP) levels are used to monitor disease activity and guide therapy in Takayasu Arteritis (TA). However, non-specificity of these markers suggests the need for novel biomarkers. In this pilot study, we explore the role of novel biomarkers for evaluating ... Read more >>

Indian Heart J (Indian heart journal)
[2021, 73(5):640-643]

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Review of chemotherapy-associated paronychia.

Mohit K Gupta, Shari R Lipner,

Chemotherapy-associated paronychia (CAP) is an inflammation of the nail folds in response to various chemotherapeutic medications. Altered proliferation of keratinocytes or nail matrix stem cells is thought to be a major causative factor. Prophylactic tetracyclines, topical povidone-iodine, and general irritation avoidance measures are among some of the recommended interventions for ... Read more >>

Int J Dermatol (International journal of dermatology)
[2021, :]

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Changing pattern of admissions for acute myocardial infarction in India during the COVID-19 pandemic.

Geevar Zachariah, Sivasubramanian Ramakrishnan, Mrinal Kanti Das, Abdullakutty Jabir, Pathiyil Balagopalan Jayagopal, Krishnannair Venugopal, Kalaivani Mani, Amal Kumar Khan, Amit Malviya, Anshul Gupta, Ashok Goyal, B P Singh, Bishav Mohan, Bishwa Bhushan Bharti, Biswajit Majumder, Bivin Wilson, Chakkalakkal Prabhakaran Karunadas, Chandra Bhan Meena, Cholenahally Nanjappa Manjunath, Mathew Cibu, Debabrata Roy, Dinesh Choudhary, Dipak Ranjan Das, Dipak Sarma, Meennahalli Palleda Girish, Gurpreet Singh Wander, Harsh Wardhan, Janakiraman Ezhilan, Karthik Tummala, Virender Kumar Katyal, Kewal Goswami, Kodangala Subramanyam, Krishna Kishore Goyal, Kenchappa Kumar, Lekha Adik Pathak, Manish Bansal, Manoranjan Mandal, Mohit Dayal Gupta, Narendra Nath Khanna, Natesh Bangalore Hanumanthappa, Neil Bardoloi, Nitin Modi, Nitish Naik, Pradeep K Hasija, Prafulla Kerkar, Pranab Jyoti Bhattacharyya, Pushkraj Gadkari, Rabindra Nath Chakraborthy, Rahul Raosaheb Patil, Rakesh Gupta, Rakesh Yadav, Rambhatla Suryanarayana Murty, Ranjit Kumar Nath, Rathinavel Sivakumar, Rishi Sethi, Rituparna Baruah, Sanjay Tyagi, Santanu Guha, Santhosh Krishnappa, Satish Kumar, Satya Narayan Routray, Satyendra Tewari, Saumitra Ray, Seemala Saikrishna Reddy, Sharad Chandra, Shashi Bhushan Gupta, Shashi Shekhar Chatterjee, K K H Siddiqui, Maduramuthu Sivabalan, Sreekanth Yerram, Sudeep Kumar, Swaminathan Nagarajan, Tom Devasia, Uday Jadhav, Varun Shankar Narain, Vijay Kumar Garg, Vitull K Gupta, Dorairaj Prabhakaran, Pradip Kumar Deb, Padinhare Purayil Mohanan, ,

<h4>Aim</h4>Studies on the changes in the presentation and management of acute myocardial infarction (AMI) during the COVID-19 pandemic from low- and middle-income countries are limited. We sought to determine the changes in the number of admissions, management practices, and outcomes of AMI during the pandemic period in India.<h4>Methods & results</h4>In ... Read more >>

Indian Heart J (Indian heart journal)
[2021, 73(4):413-423]

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Point-of-care ultrasonography for the hospitalist.

Guramrinder Singh Thind, Steven Fox, Mohit Gupta, Praveen Chahar, Robert Jones, Siddharth Dugar,

Point-of-care ultrasonography (POCUS) has emerged as a vital tool in medicine. Initially used for procedural guidance, POCUS is now used for diagnostics and monitoring of the lung, heart, abdomen, and deep vein thrombosis. This wide applicability makes it an essential tool for hospitalists in daily clinical practice. This article provides ... Read more >>

Cleve Clin J Med (Cleveland Clinic journal of medicine)
[2021, 88(6):345-359]

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Susceptibility of CTLA-4 -1661A/G polymorphism towards severity of rheumatic heart disease.

Ankit Bansal, Sana Tasnim, Mohit D Gupta, Girish Mp, Vishal Batra, Samantha Kohli, Sanjay Tyagi, M A Qadar Pasha,

<h4>Aim</h4>Genetic contribution in acute rheumatic fever (ARF)/rheumatic heart disease (RHD) has been suggested but not according to severity of the valve involvement. This study attempts to identify the relevance of CTLA-4 polymorphism with severity of the disease.<h4>Methods</h4>In a case-control design, 291 healthy controls and 83 patients were genotyped for association ... Read more >>

Indian Heart J (Indian heart journal)
[2021, 73(4):511-515]

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Pretreatment Risk Stratification for Endoscopic Kidney-sparing Surgery in Upper Tract Urothelial Carcinoma: An International Collaborative Study.

Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Gautier Marcq, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Wassim Kassouf, Riccardo Autorino, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat,

<h4>Background</h4>Several groups have proposed features to identify low-risk patients who may benefit from endoscopic kidney-sparing surgery in upper tract urothelial carcinoma (UTUC).<h4>Objective</h4>To evaluate standard risk stratification features, develop an optimal model to identify ≥pT2/N+ stage at radical nephroureterectomy (RNU), and compare it with the existing unvalidated models.<h4>Design, setting, and participants</h4>This ... Read more >>

Eur Urol (European urology)
[2021, 80(4):507-515]

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Subclinical left ventricular dysfunction in COVID-19 recovered patients using speckle tracking echocardiography

Sudhanshu Mahajan, Shekhar Kunal, Bhushan Shah, Shobhit Garg, Girish MP, Ankit Bansal, Vishal Batra, Jamal Yusuf, Saibal Mukhopadhyay, Suresh Kumar, Sanjay Tyagi, Anubha Gupta, Mohit Gupta,

<h4>Objectives: </h4> Myocardial injury during active coronavirus disease-2019 (COVID-19) infection is well described however, its persistence during recovery is unclear. We assessed left ventricle (LV) global longitudinal strain (GLS) using speckle tracking echocardiography (STE) in COVID-19 recovered patients and studied its correlation with various parameters. <h4>Methods:</h4> A total of 134 ... Read more >>

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PREVALENCE AND PREDICTORS OF COVID 19 RELATED BURNOUT AMONG HEALTHCARE WORKERS; FINDINGS FROM BRUCEE LI STUDY

Mohit Dayal Gupta, Manish Jha, M.P. Girish, Ankit Bansal, Prattay G. Sarkar, Jamal Yusuf, Suresh Kumar, Satish Kumar, Ajeet Jain, Sanjeev Kathuria, Rajni Saijpaul, Rakesh Yadav, Ramakrishnan S, Rajeev Malhotra, Vishal Batra, Saibal Mukhopadhyay, Anubha Gupta, Manu Shetty, Anurag Mishra, Vikas Malhotra, Sandeep Garg,

J Am Coll Cardiol (Journal of the American College of Cardiology)
[2021, 77(18):3110-3110]

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Novel Classification for Upper Tract Urothelial Carcinoma to Better Risk-stratify Patients Eligible for Kidney-sparing Strategies: An International Collaborative Study.

Gautier Marcq, Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Riccardo Autorino, Patricia John, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat, Wassim Kassouf,

<h4>Background</h4>The European Association of Urology risk stratification dichotomizes patients with upper tract urothelial carcinoma (UTUC) into two risk categories.<h4>Objective</h4>To evaluate the predictive value of a new classification to better risk stratify patients eligible for kidney-sparing surgery (KSS).<h4>Design, setting, and participants</h4>This was a retrospective study including 1214 patients from 21 centers ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Testicular ultrasound underestimates the size of small testicular masses: a radiologic-pathologic correlation study.

Zeyad R Schwen, James L Liu, Andrew T Gabrielson, Hiten D Patel, Mohit Gupta, Steven P Rowe, Amin S Herati, Phillip M Pierorazio,

<h4>Purpose</h4>Increasing use and resolution of testicular ultrasound imaging has resulted in a greater diagnosis of non-palpable small testicular masses and subsequent over-treatment with orchiectomy. Our aim was to determine the diagnostic accuracy of testicular ultrasound to accurately determine the pathologic size of small testicular masses (SMTMs) and to evaluate the ... Read more >>

World J Urol (World journal of urology)
[2021, 39(9):3399-3405]

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Crystal structure of tert-butyl 4-[4-(4-fluoro-phen-yl)-2-methyl-but-3-yn-2-yl]piperazine-1-carboxyl-ate.

Ashwini Gumireddy, Kevin DeBoyace, Alexander Rupprecht, Mohit Gupta, Saloni Patel, Patrick T Flaherty, Peter L D Wildfong,

The title sterically congested piperazine derivative, C<sub>20</sub>H<sub>27</sub>FN<sub>2</sub>O<sub>2</sub>, was prepared using a modified Bruylants approach. A search of the Cambridge Structural Database identified 51 compounds possessing an <i>N-tert-</i>butyl piperazine substructure. Of these only 14 were asymmetrically substituted on the piperazine ring and none with a synthetically useful second nitro-gen. Given the ... Read more >>

Acta Crystallogr E Crystallogr Commun (Acta crystallographica. Section E, Crystallographic communications)
[2021, 77(Pt 4):360-365]

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Review of Nail Lichen Planus: Epidemiology, Pathogenesis, Diagnosis, and Treatment.

Mohit Kumar Gupta, Shari R Lipner,

Nail lichen planus is an inflammatory disorder of the nails with potential for significant cosmetic disfigurement and functional impairment. Nail manifestations may be isolated or appear concurrently with other forms of lichen planus. Longitudinal ridging is the most common clinical finding, but progressive disease may result in irreversible scarring (dorsal ... Read more >>

Dermatol Clin (Dermatologic clinics)
[2021, 39(2):221-230]

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Changing Pattern of Admissions for Acute Myocardial Infarction in India During the COVID-19 Pandemic

Geevar Zachariah, Ramakrishnan Sivasubramanian, Mrinal Kanti Das, Abdullakutty Jabir, Jayagopal Pathiyil Balagopalan, Venugopal Krishnan Nair, Kalaivani Mani, Amal Kumar Khan, Amit Malviya, Anshul Gupta, Ashok Goyal, Bateshwar Prasad Singh, Bishav Mohan, Bishwa Bhushan Bharti, Biswajit Majumder, Bivin Wilson, Chakkalakkal Prabhakaran Karunadas, Chandra Bhan Meena, Cholenahally Nanjappa Manjunath, Cibu Mathew, Debabrata Roy, Dinesh Choudhary, Dipak Ranjan Das, Diapk Sarma, Girish Meennahalli Palleda, Gurpreet Singh Wander, Harsh Wardhan, Janakiraman Ezhilan, Karthik Tummala, Katyal Virender Kumar, Kewal Goswami, Kodangala Subramanyam, Krishna Kishore Goyal, Kumar Kenchappa, Lekha Adik Pathak, Manish Bansal, Manoranjan Mandal, Mohit Dayal Gupta, Narendranath Khanna, Natesh Bangalore Hanumanthappa, Neil Bardoloi, Nitin Modi, Nitish Naik, Pradeep Hasija, Prafulla Kerker, Pranab Jyoti Bhattacharyya, Pushkraj Gadkari, Rabindra Nath Chakraborthy, Rahul Raosaheb Patil, Rakesh Gupta, Rakesh Yadav, Rambhatla Suryanarayana Murty, Ranjit Kumar Nath, Rathinavel Sivakumar, Rishi Sethi, Rituparna Baruah, Sanjay Tyagi, Santanu Guha, Santhosh Krishnappa, Satish Kumar, Satyanarayan Routray, Satyendra Tiwari, Saumitra Ray, Seemala Saikrishna Reddy, Sharad Chandra, Shashi Bhushan Gupta, Shashi Shekhar Chatterjee, Siddiqui KKH, Sivabalan Maduramuthu, Sreekanth Yerram, Sudeep Kumar, Swaminathan Nagarajan, Tom Devasia, Uday Jadhav, Varun Shankar Narain, Vijay Kumar Garg, Vitull Gupta, Dorairaj Prabhakaran, Pradip Kumar Deb, Padinhare Purayil Mohanan,

Background: Admissions for acute myocardial infarction (MI) have declined significantly during the COVID-19 pandemic. The changes in the presentation, management, and outcomes of MI during the pandemic period are not well recognized, and data from low- and middle-income countries are limited.<br><br>Methods: In this two-timepoint cross-sectional study involving 187 hospitals across ... Read more >>

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Chromosomes Conformation Capture Coupled with Next-Generation Sequencing (Hi-C) in Plasmodium falciparum.

Mohit Kumar Gupta, Todd Lenz, Karine G Le Roch,

Over the last decades, novel methods have been developed to study the role of chromosome positioning within the nucleus may play in gene regulation. Established proximity ligation-based chromosome conformation capture (3C) techniques such as Hi-C have revealed the existence of chromosome territories, functional nuclear landmarks, and topologically associating domains (TAPs) ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2021, 2369:15-25]

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Pistachio nut shell as a nail substitute to improve function in patients with nail lichen planus.

Mohit Kumar Gupta, Shari R Lipner,

Int J Womens Dermatol (International journal of women's dermatology)
[2021, 7(3):353-354]

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Trends, Management, and Outcomes of Acute Myocardial Infarction Hospitalizations With In-Hospital-Onset Versus Out-of-Hospital Onset: The ARIC Study.

Melissa C Caughey, Sameer Arora, Arman Qamar, Zainali Chunawala, Mohit D Gupta, Puneet Gupta, Muthiah Vaduganathan, Ambarish Pandey, Xuming Dai, Sidney C Smith, Kunihiro Matsushita,

Background Acute myocardial infarction (AMI) with in-hospital onset (AMI-IHO) has poor prognosis but is clinically underappreciated. Whether its occurrence has changed over time is uncertain. Methods and Results Since 1987, the ARIC (Atherosclerosis Risk in Communities) study has conducted adjudicated surveillance of AMI hospitalizations in 4 US communities. Our analysis ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2021, 10(2):e018414]

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A Comprehensive Review on Fused Heterocyclic as DNA Intercalators: Promising Anticancer Agents.

Vikas Sharma, Mohit Gupta, Pradeep Kumar, Atul Sharma,

Since the discovery of DNA intercalating agents (by Lerman, 1961), a growing number of organic, inorganic, and metallic compounds have been developed to treat life-threatening microbial infections and cancers. Fused-heterocycles are amongst the most important group of compounds that have the ability to interact with DNA. DNA intercalators possess a ... Read more >>

Curr Pharm Des (Current pharmaceutical design)
[2021, 27(1):15-42]

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Atypical optic neuritis: An overview.

Prathama Sarkar, Amit Mehtani, H C Gandhi, Vinita Dubey, Parag Maroti Tembhurde, Mohit Kumar Gupta,

Optic neuritis (ON) refers to conditions that involve inflammation of the optic nerve. Various autoantibodies have been found, which are associated with central nervous system inflammatory disorders and have provided much information about the immune targets and mechanisms that impact the prognosis, treatment, and recurrence of atypical ON. Therefore, neurologists ... Read more >>

Indian J Ophthalmol (Indian journal of ophthalmology)
[2021, 69(1):27-35]

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Design and rationale of an intelligent algorithm to detect BuRnoUt in HeaLthcare workers in COVID era using ECG and artificiaL intelligence: The BRUCEE-LI study.

Mohit D Gupta, Ankit Bansal, Prattay G Sarkar, M P Girish, Manish Jha, Jamal Yusuf, Suresh Kumar, Satish Kumar, Ajeet Jain, Sanjeev Kathuria, Rajni Saijpaul, Anurag Mishra, Vikas Malhotra, Rakesh Yadav, S Ramakrishanan, Rajeev K Malhotra, Vishal Batra, Manu Kumar Shetty, Nandini Sharma, Saibal Mukhopadhyay, Sandeep Garg, Anubha Gupta,

<h4>Background</h4>There is no large contemporary data from India to see the prevalence of burnout in HCWs in covid era. Burnout and mental stress is associated with electrocardiographic changes detectable by artificial intelligence (AI).<h4>Objective</h4>The present study aims to estimate the prevalence of burnout in HCWs in COVID-19 era using Mini Z-scale ... Read more >>

Indian Heart J (Indian heart journal)
[2021, 73(1):109-113]

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Association between anti-acid therapies and advanced fibrosis in type 2 diabetics with biopsy-proven non-alcoholic fatty liver disease.

Amandeep Singh, Rajat Garg, Nan Lan, Mohamed Tausif Siddiqui, Mohit Gupta, Naim Alkhouri,

<h4>Backgrounds and aims</h4>Data on associations of antacid therapies with advanced fibrosis (AF) in patients with non-alcoholic fatty liver disease (NAFLD) are limited. We aimed to assess the association of histamine-2 receptor antagonists (H<sub>2</sub>RAs) and proton pump inhibitors (PPIs) with AF in NAFLD patients with underlying type 2 diabetes (T2D).<h4>Methods</h4>We retrospectively ... Read more >>

Indian J Gastroenterol (Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology)
[2020, 39(6):591-598]

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Telomere length in young patients with acute myocardial infarction without conventional risk factors: A pilot study from a South Asian population.

Mohit D Gupta, Manjula Miglani, Ankit Bansal, Vardhmaan Jain, Sameer Arora, Sameer Kumar, Salim S Virani, Ankur Kalra, Rakesh Yadav, Q Pasha, Jamal Yusuf, Saibal Mukhopadhyay, Sanjay Tyagi, M P Girish,

<h4>Background</h4>There is need to identify novel markers that lead to an early occurrence of myocardial infarction (MI) in young South Asian population. This population has different risk profile as compared with others. Telomere length is known to be a marker of aging, and shorter telomeres have been reported in cardiovascular ... Read more >>

Indian Heart J (Indian heart journal)
[2020, 72(6):619-622]

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Accuracy of Noninvasive Fibrosis Scores to Detect Advanced Fibrosis in Patients With Type-2 Diabetes With Biopsy-proven Nonalcoholic Fatty Liver Disease.

Amandeep Singh, Falgun Gosai, Mohamed T Siddiqui, Mohit Gupta, Rocio Lopez, Eric Lawitz, Fred Poordad, William Carey, Arthur McCullough, Naim Alkhouri,

<h4>Background</h4>Recent guidelines have recommended screening for nonalcoholic fatty liver disease (NAFLD) and case finding of advanced disease with fibrosis in patients with type-2 diabetes (T2D). The aim of this study is to assess the accuracy of commonly used noninvasive scores to predict the presence of advanced fibrosis (AF) in a ... Read more >>

J Clin Gastroenterol (Journal of clinical gastroenterology)
[2020, 54(10):891-897]

Cited: 5 times

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