Full Text Journal Articles by
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Current Status of Endoplasmic Reticulum Stress in Type II Diabetes.

Sagir Mustapha, Mustapha Mohammed, Ahmad Khusairi Azemi, Abubakar Ibrahim Jatau, Aishatu Shehu, Lukman Mustapha, Ibrahim Muazzamu Aliyu, Rabi'u Nuhu Danraka, Abdulbasit Amin, Auwal Adam Bala, Wan Amir Nizam Wan Ahmad, Aida Hanum Ghulam Rasool, Mohd Rais Mustafa, Siti Safiah Mokhtar,

The endoplasmic reticulum (ER) plays a multifunctional role in lipid biosynthesis, calcium storage, protein folding, and processing. Thus, maintaining ER homeostasis is essential for cellular functions. Several pathophysiological conditions and pharmacological agents are known to disrupt ER homeostasis, thereby, causing ER stress. The cells react to ER stress by initiating ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2021, 26(14):]

Cited: 1 time

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Current Status of Endoplasmic Reticulum Stress in Type II Diabetes

Sagir Mustapha, Mustapha Mohammed, Ahmad Khusairi Azemi, Abubakar Ibrahim Jatau, Aishatu Shehu, Lukman Mustapha, Ibrahim Muazzamu Aliyu, Rabi’u Nuhu Danraka, Abdulbasit Amin, Auwal Adam Bala, Wan Amir Nizam Wan Ahmad, Aida Hanum Ghulam Rasool, Mohd Rais Mustafa, Siti Safiah Mokhtar,

The endoplasmic reticulum (ER) plays a multifunctional role in lipid biosynthesis, calcium storage, protein folding, and processing. Thus, maintaining ER homeostasis is essential for cellular functions. Several pathophysiological conditions and pharmacological agents are known to disrupt ER homeostasis, thereby, causing ER stress. The cells react to ER stress by initiating ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2021, 26(14):]

Cited: 0 times

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Current Status of Endoplasmic Reticulum Stress in Type II Diabetes

Sagir Mustapha, Mustapha Mohammed, Ahmad Khusairi Azemi, Abubakar Ibrahim Jatau, Aishatu Shehu, Lukman Mustapha, Muazzamu Aliyu, Rabi’u Nuhu Danraka, Abdulbasit Amin, Auwal Adam Bala, Wan Amir Nizam Wan Ahmad, Aida Hanum Ghulam Rasool, Mohd Rais Mustafa, Siti Safiah Mokhtar,

The endoplasmic reticulum (ER) plays a multifunctional role in lipid biosynthesis, calcium storage, protein folding, and processing. Thus, maintaining ER homeostasis in insulin-secreting beta-cells is essential. Several pathophysiological conditions and pharmacological agents disrupt the ER homeostasis, thereby causing ER stress. The cells react to ER stress by initiating an adaptive ... Read more >>

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Vernodalin induces apoptosis through the activation of ROS/JNK pathway in human colon cancer cells.

Nooshin Mohebali, Ashok Kumar Pandurangan, Mohd Rais Mustafa, Suresh Kumar Anandasadagopan, Tamilselvi Alagumuthu,

Colorectal cancer is one of the most leading death-causing cancers in the world. Vernodalin, a cytotoxic sesquiterpene, has been reported to possess anticancer properties against human breast cancer cells. We aimed to examine the anticancer mechanism of vernodalin on human colon cancer cells. Vernodalin was used on human colon cancer ... Read more >>

J Biochem Mol Toxicol (Journal of biochemical and molecular toxicology)
[2020, 34(12):e22587]

Cited: 1 time

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Banana inflorescence: Its bio-prospects as an ingredient for functional foods

Beng Fye Lau, Kin Weng Kong, Kok Hoong Leong, Jian Sun, Xuemei He, Zhenxing Wang, Mohd Rais Mustafa, Tau Chuan Ling, Amin Ismail,

There is a renewed interest in the utilisation of agricultural by-products, particularly those from crop plants, as a source of functional ingredients. The banana (Musa spp.) is a popular food crop worldwide but its inflorescence is often undervalued, similar to other agricultural by-products. As the banana inflorescence is traditionally consumed ... Read more >>

(Trends in food science & technology.)
[2020, 97:14-28]

Cited: 0 times

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Therapeutic Implications of Nitrite in Hypertension.

Wei Chih Ling, Mohd Rais Mustafa, Dharmani Devi Murugan,

Nitrite, an anion produced from the oxidative breakdown of nitric oxide (NO), has traditionally been viewed as an inert molecule. However, this dogma has been challenged with the findings that nitrite can be readily reduced to NO under pathological conditions, hence representing a physiologically relevant storage reservoir of NO either ... Read more >>

J Cardiovasc Pharmacol (Journal of cardiovascular pharmacology)
[2020, 75(2):123-134]

Cited: 3 times

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Flavonoids as Natural Anti-Inflammatory Agents Targeting Nuclear Factor-Kappa B (NFκB) Signaling in Cardiovascular Diseases: A Mini Review.

Ker Woon Choy, Dharmani Murugan, Xin-Fang Leong, Razif Abas, Aspalilah Alias, Mohd Rais Mustafa,

Cardiovascular diseases (CVDs) such as angina, hypertension, myocardial ischemia, and heart failure are the leading causes of morbidity and mortality worldwide. One of the major transcription factors widely associated with CVDs is nuclear factor-kappa B (NFκB). NFκB activation initiates the canonical and non-conical pathways that promotes activation of transcription factors ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2019, 10:1295]

Cited: 29 times

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Senescent HUVECs-secreted exosomes trigger endothelial barrier dysfunction in young endothelial cells.

Pooi-Fong Wong, Kind-Leng Tong, Juliana Jamal, Eng-Soon Khor, Siew-Li Lai, Mohd Rais Mustafa,

Accumulation of senescent endothelial cells can cause endothelium dysfunction which eventually leads to age-related vascular disorders. The senescent-associated secretory phenotype (SASP) cells secrete a plethora of soluble factors that negatively influence the surrounding tissue microenvironment. The present study sought to investigate the effects of exosomes, which are nano-sized extracellular vesicles ... Read more >>

EXCLI J (EXCLI journal)
[2019, 18:764-776]

Cited: 7 times

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Effect of high-salt diet on mean arterial pressure, renal epithelial sodium channels and aquaporin subunits expression levels in Spontaneously Hypertensive Rats

Chitra Devi Ramachandran, Khadijeh Gholami, Sau-Kuen Lam, Mohd Rais Mustafa, See-Ziau Hoe,

An increase in blood pressure (BP) by a high-salt (HS) diet may involve the changes in the expression of epithelium sodium channels (ENaCs) and aquaporins (AQPs) in the kidney which affect the sodium- and water-handling mechanisms. In the present study, spontaneously hypertensive rats (SHRs) and Wistar Kyoto (WKY) rats were ... Read more >>

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Edible Bird's Nest Protects Against Hyperglycemia-Induced Oxidative Stress and Endothelial Dysfunction.

Dharmani Devi Murugan, Zuhaida Md Zain, Ker Woon Choy, Nor Hisam Zamakshshari, Mel June Choong, Yang Mooi Lim, Mohd Rais Mustafa,

Increased oxidative stress by hyperglycemia is a major cause of vascular complications in diabetes. Bird's nest, which is made from the saliva of swiftlets has both medicinal and nutritional values dated back to ancient China. However, its role in improving endothelial dysfunction due to diabetes is yet to be elucidated. ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2019, 10:1624]

Cited: 4 times

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The role of miRNAs 34a, 146a, 320a and 542 in the synergistic anticancer effects of methyl 2-(5-fluoro-2-hydroxyphenyl)-1H- benzo[d]imidazole-5-carboxylate (MBIC) with doxorubicin in breast cancer cells.

Mohadeseh Hasanpourghadi, Nazia Abdul Majid, Mohd Rais Mustafa,

Combination Index (CI) analysis suggested that MBIC and doxorubicin synergistically inhibited up to 97% of cell proliferation in ER<sup>+</sup>/PR<sup>+</sup>MCF-7 and triple negative MDA-MB-231 breast cancer cell lines. Moreover, treatment of the breast cancer cells with the combined drugs resulted in lower IC<sub>50</sub> values in contrast to the individual drug treatment. ... Read more >>

PeerJ (PeerJ)
[2018, 6:e5577]

Cited: 1 time

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Circulating MicroRNAs in Young Patients with Acute Coronary Syndrome.

Kind-Leng Tong, Ahmad Syadi Mahmood Zuhdi, Wan Azman Wan Ahmad, Paul M Vanhoutte, Joao Pedro de Magalhaes, Mohd Rais Mustafa, Pooi-Fong Wong,

Circulating microRNAs (miRNAs) hold great potential as novel diagnostic markers for acute coronary syndrome (ACS). This study sought to identify plasma miRNAs that are differentially expressed in young ACS patients (mean age of 38.5 ± 4.3 years) and evaluate their diagnostic potentials. Small RNA sequencing (sRNA-seq) was used to profile ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2018, 19(5):]

Cited: 7 times

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Natural products targeting ER stress pathway for the treatment of cardiovascular diseases.

Ker Woon Choy, Dharmani Murugan, Mohd Rais Mustafa,

Endoplasmic reticulum (ER) is the main organelle for the synthesis, folding, and processing of secretory and transmembrane proteins. Pathological stimuli including hypoxia, ischaemia, inflammation and oxidative stress interrupt the homeostatic function of ER, leading to accumulation of unfolded proteins, a condition referred to as ER stress. ER stress triggers a ... Read more >>

Pharmacol Res (Pharmacological research)
[2018, 132:119-129]

Cited: 21 times

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Activation of autophagy by stress-activated signals as a cellular self-defense mechanism against the cytotoxic effects of MBIC in human breast cancer cells in vitro.

Mohadeseh Hasanpourghadi, Nazia Abdul Majid, Mohd Rais Mustafa,

We recently reported that methyl 2-(-5-fluoro-2-hydroxyphenyl)-1H-benzo[d]imidazole-5-carboxylate (MBIC) is a microtubule targeting agent (MTA) with multiple mechanisms of action including apoptosis in two human breast cancer cell-lines MCF-7 and MDA-MB-231. In the present study, investigation of early molecular events following MBIC treatment demonstrated the induction of autophagy. This early (<24 h) response ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2018, 152:174-186]

Cited: 5 times

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Panduratin A induces protective autophagy in melanoma via the AMPK and mTOR pathway.

Siew-Li Lai, Mohd Rais Mustafa, Pooi-Fong Wong,

<h4>Background</h4>Targeting autophagy is emerging as a promising strategy in cancer therapeutics in recent years. Autophagy can be modulated to drive cancer cell deaths that are notoriously resistant to apoptotic-inducing drugs. In addition, autophagy has been implicated as a prosurvival mechanism in mediating cancer chemoresistance. Our previous study has demonstrated that ... Read more >>

Phytomedicine (Phytomedicine : international journal of phytotherapy and phytopharmacology)
[2018, 42:144-151]

Cited: 9 times

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3',4'-dihydroxyflavonol ameliorates endoplasmic reticulum stress-induced apoptosis and endothelial dysfunction in mice.

Yeh Siang Lau, Mohd Rais Mustafa, Ker Woon Choy, Stanley M H Chan, Simon Potocnik, Terence P Herbert, Owen L Woodman,

Endoplasmic reticulum (ER) stress has been implicated in the development of hypertension 3 through the induction of endothelial impairment. As 3',4'-dihydroxyflavonol (DiOHF) 4 reduces vascular injury caused by ischaemia/reperfusion or diabetes, and flavonols have been demonstrated to attenuate ER stress, we investigated whether DiOHF can protect mice from ER stress-induced ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):1818]

Cited: 5 times

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Paeonol Attenuates LPS-Induced Endothelial Dysfunction and Apoptosis by Inhibiting BMP4 and TLR4 Signaling Simultaneously but Independently.

Ker Woon Choy, Yeh Siang Lau, Dharmani Murugan, Paul M Vanhoutte, Mohd Rais Mustafa,

Inflammatory injury of the endothelium leads to apoptosis and endothelial dysfunction. The current study explored the effect and mechanisms of paeonol in inflammation-induced apoptosis and endothelial dysfunction induced by lipopolysaccharides (LPSs). The effects of paeonol on LPS-induced inflammatory injury were assessed by Western blotting, flow cytometry and reactive oxygen species ... Read more >>

J Pharmacol Exp Ther (The Journal of pharmacology and experimental therapeutics)
[2018, 364(3):420-432]

Cited: 9 times

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Modulation of oncogenic transcription factors by bioactive natural products in breast cancer.

Mohadeseh Hasanpourghadi, Ashok Kumar Pandurangan, Mohd Rais Mustafa,

Carcinogenesis, a multi-step phenomenon, characterized by alterations at genetic level and affecting the main intracellular pathways controlling cell growth and development. There are growing number of evidences linking oncogenes to the induction of malignancies, especially breast cancer. Modulations of oncogenes lead to gain-of-function signals in the cells and contribute to ... Read more >>

Pharmacol Res (Pharmacological research)
[2018, 128:376-388]

Cited: 10 times

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Deregulation of hsa-miR-20b expression in TNF-α-induced premature senescence of human pulmonary microvascular endothelial cells.

Pooi-Fong Wong, Juliana Jamal, Kind-Leng Tong, Eng-Soon Khor, Chia-Earn Yeap, Hui-Lan Jong, Sui-Ting Lee, Mohd Rais Mustafa, Sazaly Abubakar,

miRNAs are important regulators of cellular senescence yet the extent of their involvement remains to be investigated. We sought to identify miRNAs that are involved in cytokine-induced premature senescence (CIPS) in endothelial cells. CIPS was established in young human pulmonary microvascular endothelial cells (HMVEC-Ls) following treatment with a sublethal dose ... Read more >>

Microvasc Res (Microvascular research)
[2017, 114:26-33]

Cited: 11 times

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Chronic treatment with paeonol improves endothelial function in mice through inhibition of endoplasmic reticulum stress-mediated oxidative stress.

Ker Woon Choy, Yeh Siang Lau, Dharmani Murugan, Mohd Rais Mustafa,

Endoplasmic reticulum (ER) stress leads to endothelial dysfunction which is commonly associated in the pathogenesis of several cardiovascular diseases. We explored the vascular protective effects of chronic treatment with paeonol (2'-hydroxy-4'-methoxyacetophenone), the major compound from the root bark of Paeonia suffruticosa on ER stress-induced endothelial dysfunction in mice. Male C57BL/6J ... Read more >>

PLoS One (PloS one)
[2017, 12(5):e0178365]

Cited: 13 times

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Chronic administration of sodium nitrite prevents hypertension and protects arterial endothelial function by reducing oxidative stress in angiotensin II-infused mice.

Wei Chih Ling, Mohd Rais Mustafa, Paul M Vanhoutte, Dharmani Devi Murugan,

<h4>Aim</h4>Endothelial dysfunction accompanied by an increase in oxidative stress is a key event leading to hypertension. As dietary nitrite has been reported to exert antihypertensive effect, the present study investigated whether chronic oral administration of sodium nitrite improves vascular function in conduit and resistance arteries of hypertensive animals with elevated ... Read more >>

Vascul Pharmacol (Vascular pharmacology)
[2018, 102:11-20]

Cited: 7 times

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Mechanisms of the anti-tumor activity of Methyl 2-(-5-fluoro-2-hydroxyphenyl)-1 H-benzo[d]imidazole-5-carboxylate against breast cancer in vitro and in vivo.

Mohadeseh Hasanpourghadi, Ashok Kumar Pandurangan, Chandrabose Karthikeyan, Piyush Trivedi, Mohd Rais Mustafa,

Microtubule Targeting Agents (MTAs) induce cell death through mitotic arrest, preferentially affecting rapidly dividing cancer cells over slowly proliferating normal cells. Previously, we showed that Methyl 2-(-5-fluoro-2-hydroxyphenyl)-1H-benzo[d]imidazole-5-carboxylate (MBIC) acts as a potential MTA. In this study, we demonstrated that MBIC exhibits greater toxicity towards non-aggressive breast cancer cell-line, MCF-7 (IC50 ... Read more >>

Oncotarget (Oncotarget)
[2017, 8(17):28840-28853]

Cited: 5 times

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Treatment with salvianolic acid B restores endothelial function in angiotensin II-induced hypertensive mice.

Wei Chih Ling, Jian Liu, Chi Wai Lau, Dharmani Devi Murugan, Mohd Rais Mustafa, Yu Huang,

Salvianolic acid B (Sal B) is one of the most abundant phenolic acids derived from the root of Danshen with potent anti-oxidative properties. The present study examined the vasoprotective effect of Sal B in hypertensive mice induced by angiotensin II (Ang II). Sal B (25mg/kg/day) was administered via oral gavage ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2017, 136:76-85]

Cited: 10 times

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Quercetin and pioglitazone synergistically reverse endothelial dysfunction in isolated aorta from fructose-streptozotocin (F-STZ)-induced diabetic rats.

Thubasni Kunasegaran, Mohd Rais Mustafa, Francis I Achike, Dharmani Devi Murugan,

Pioglitazone is an anti-diabetic drug with potential to cause adverse effects following prolonged use. This study, therefore, investigated the effects of combination treatment of a subliminal concentration of pioglitazone and quercetin, a potent antioxidant, on vascular reactivity of aorta isolated from fructose-streptozotocin (F-STZ)-induced diabetic rats. Relaxation to acetylcholine and sodium ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[2017, 799:160-170]

Cited: 5 times

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A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma.

Xiaoyun Dai, Lingzhi Wang, Amudha Deivasigamni, Chung Yeng Looi, Chandrabose Karthikeyan, Piyush Trivedi, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Frank Arfuso, Arunasalam Dharmarajan, Boon Cher Goh, Kam Man Hui, Alan Prem Kumar, Mohd Rais Mustafa, Gautam Sethi,

A prior screening programme carried out using MTT assay by our group identified a series of novel benzimidazole derivatives, among which Methyl 2-(5-fluoro-2-hydroxyphenyl)-1H- benzo[d]imidazole-5-carboxylate (MBIC) showed highest anticancer efficacy compared to that of chemotherapeutic agent, cisplatin. In the present study, we found that MBIC inhibited cell viability in different hepatocellular ... Read more >>

Oncotarget (Oncotarget)
[2017, 8(8):12831-12842]

Cited: 26 times

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