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Author Mohammed Akhtar

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Carcinomas of the Uterine Cervix: Comprehensive Review With An Update on Pathogenesis, Nomenclature of Precursor and Invasive Lesions, and Differential Diagnostic Considerations.

Maria Arafah, Sameera Rashid, Asma Tulbah, Mohammed Akhtar,

Most cervical carcinomas and their related lesions are attributed to an infection by human papillomavirus (HPV). The infection usually starts in the basal cells at the squamocolumnar junction. It causes cell proliferation and maturation abnormalities along with nuclear abnormalities resulting in low-grade squamous intraepithelial lesions. An overwhelming majority of these ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(3):150-170]

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Florid Interstitial Hemorrhages: A Novel Feature of Amoxicillin-Clavulanate-Induced Acute Tubulointerstitial Nephritis.

Muhammad Asim, Farooq Ahmad, Mohammed Akhtar,

BACKGROUND Acute tubulointerstitial nephritis is most often induced by drug therapy and is characterized by the presence of edema, inflammatory infiltrates, and sometimes granulomas within the interstitium. We report this case to describe florid interstitial hemorrhages as a novel feature of Amoxicillin-Clavulanate-induced acute tubulointerstitial nephritis. CASE REPORT A young man ... Read more >>

Am J Case Rep (The American journal of case reports)
[2021, 22:e928989]

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COVID-19 and changes in activity and treatment of ST elevation MI from a UK cardiac centre.

Yang Chen, Krishnaraj S Rathod, Stephen Hamshere, Fizzah Choudry, Mohammed M Akhtar, Miles Curtis, Rajiv Amersey, Oliver Guttmann, Constantinos O'Mahony, Ajay Jain, Andrew Wragg, Andreas Baumbach, Anthony Mathur, Daniel A Jones,

<h4>Background</h4>The international healthcare response to COVID-19 has been driven by epidemiological data related to case numbers and case fatality rate. Second order effects have been less well studied. This study aimed to characterise the changes in emergency activity of a high-volume cardiac catheterisation centre and to cautiously model any excess ... Read more >>

Int J Cardiol Heart Vasc (International journal of cardiology. Heart & vasculature)
[2021, 33:100736]

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Endometriosis: A Comprehensive Review.

Maria Arafah, Sameera Rashid, Mohammed Akhtar,

Endometriosis is a relatively common condition in which endometrial tissue is established in locations outside the uterus where, like the eutopic endometrium, it responds to hormonal stimuli and develops internal bleeding, inflammation, and fibrosis. These changes are associated with chronic and often debilitating cyclic pain and infertility. The pathogenesis of ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(1):30-43]

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Anti-glomerular Basement Membrane Disease: What Have We Learned?

Mohammed Akhtar, Noheir M Taha, Muhammad Asim,

Since the first clinicopathologic description by Ernest Goodpasture of a patient whom he considered to have died of influenza in 1919, substantial progress has been made in our knowledge of anti-glomerular basement membrane disease. This has led to a significant decrease in the morbidity and mortality associated with this disease. ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(1):59-65]

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The novel desmin variant p.Leu115Ile is associated with a unique form of biventricular Arrhythmogenic Cardiomyopathy.

Alexandros Protonotarios, Andreas Brodehl, Angeliki Asimaki, Joanna Jager, Ellie Quinn, Caroline Stanasiuk, Sandra Ratnavadivel, Marta Futema, Mohammed M Akhtar, Thomas D Gossios, Michael Ashworth, Konstantinos Savvatis, Volker Walhorn, Dario Anselmetti, Perry M Elliott, Petros Syrris, Hendrik Milting, Luis R Lopes,

<h4>Background</h4>Arrhythmogenic Cardiomyopathy (AC) is a heritable myocardial disorder and a major cause of sudden cardiac death. It is typically caused by mutations in desmosomal genes. Desmin gene (DES) variants have been previously reported in AC, but with insufficient evidence to support their pathogenicity.<h4>Methods</h4>We aimed to assess a large AC patient ... Read more >>

Can J Cardiol (The Canadian journal of cardiology)
[2020, :]

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CK20 and CK5/6 Immunohistochemical Staining of Urothelial Neoplasms: A Perspective.

Mohammed Akhtar, Sameera Rashid, Mohamed Ben Gashir, Noheir Mostafa Taha, Issam Al Bozom,

Cytokeratins belong to the family of intermediate filaments. They are expressed in a highly specific manner in epithelial cells where they play a crucial role in the integrity and mechanical stability of the cells. Several types of cytokeratins have been described in normal as well as neoplastic urothelium. In the ... Read more >>

Adv Urol (Advances in urology)
[2020, 2020:4920236]

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Clinical Phenotypes and Prognosis of Dilated Cardiomyopathy Caused by Truncating Variants in the TTN Gene.

Mohammed Majid Akhtar, Massimiliano Lorenzini, Marcos Cicerchia, Juan Pablo Ochoa, Thomas Morris Hey, Maria Sabater Molina, Maria Alejandra Restrepo-Cordoba, Matteo Dal Ferro, Davide Stolfo, Renee Johnson, José M Larrañaga-Moreira, Ainhoa Robles-Mezcua, Jose F Rodriguez-Palomares, Guillem Casas, Maria Luisa Peña-Peña, Luis Rocha Lopes, Maria Gallego-Delgado, Maria Franaszczyk, Gemma Laucey, Diego Rangel-Sousa, Mayte Basurte, Julian Palomino-Doza, Eduardo Villacorta, Zofia Bilinska, Javier Limeres Freire, José M Garcia Pinilla, Roberto Barriales-Villa, Diane Fatkin, Gianfranco Sinagra, Pablo Garcia-Pavia, Juan R Gimeno, Jens Mogensen, Lorenzo Monserrat, Perry M Elliott,

<h4>Background</h4>Truncating variants in the <i>TTN</i> gene (TTNtv) are the commonest cause of heritable dilated cardiomyopathy. This study aimed to study the phenotypes and outcomes of TTNtv carriers.<h4>Methods</h4>Five hundred thirty-seven individuals (61% men; 317 probands) with TTNtv were recruited in 14 centers (372 [69%] with baseline left ventricular systolic dysfunction [LVSD]). ... Read more >>

Circ Heart Fail (Circulation. Heart failure)
[2020, 13(10):e006832]

Cited: 2 times

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Rituximab-Induced Remission in Epstein-Barr Virus-Associated Glomerulonephritis.

Mohamad S Alabdaljabar, Turki O Al-Hussain, Mohammed Akhtar, Walter Conca, Maged H Hussein,

Kidney Int Rep (Kidney international reports)
[2020, 5(11):2109-2113]

Cited: 0 times

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An unusual cause of heart failure in a young female: a case of massive left atrial mxyoma.

Ahmed Mohamed Abdel Shafi, Mohammed A Akhtar, Alexander Smith, Martin Yates, Aung Y Oo,

Benign cardiac tumors are rare; they can present with nonspecific symptoms and represent a diagnostic challenge to the clinician. We describe an interesting case of a 26-year-old female who presented with a 6-month history of cough, breathlessness, palpitations, dizziness, and fever. Despite repeated clinical reviews in the community, diagnosis of ... Read more >>

J Card Surg (Journal of cardiac surgery)
[2020, 35(11):3227-3230]

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Penetrance of Hypertrophic Cardiomyopathy in Sarcomere Protein Mutation Carriers.

Massimiliano Lorenzini, Gabrielle Norrish, Ella Field, Juan Pablo Ochoa, Marcos Cicerchia, Mohammed M Akhtar, Petros Syrris, Luis R Lopes, Juan Pablo Kaski, Perry M Elliott,

<h4>Background</h4>Predictive genetic screening of relatives of patients with hypertrophic cardiomyopathy (HCM) caused by sarcomere protein (SP) gene mutations is current standard of care, but there are few data on long-term outcomes in mutation carriers without HCM.<h4>Objectives</h4>The aim of this study was to determine the incidence of new HCM diagnosis in ... Read more >>

J Am Coll Cardiol (Journal of the American College of Cardiology)
[2020, 76(5):550-559]

Cited: 1 time

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High Thrombus Burden in Patients With COVID-19 Presenting With ST-Segment Elevation Myocardial Infarction.

Fizzah A Choudry, Stephen M Hamshere, Krishnaraj S Rathod, Mohammed M Akhtar, R Andrew Archbold, Oliver P Guttmann, Simon Woldman, Ajay K Jain, Charles J Knight, Andreas Baumbach, Anthony Mathur, Daniel A Jones,

<h4>Background</h4>Coronavirus disease-2019 (COVID-19) is thought to predispose patients to thrombotic disease. To date there are few reports of ST-segment elevation myocardial infarction (STEMI) caused by type 1 myocardial infarction in patients with COVID-19.<h4>Objectives</h4>The aim of this study was to describe the demographic, angiographic, and procedural characteristics alongside clinical outcomes of ... Read more >>

J Am Coll Cardiol (Journal of the American College of Cardiology)
[2020, 76(10):1168-1176]

Cited: 27 times

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An expert consensus document on the management of cardiovascular manifestations of Fabry disease.

Aleš Linhart, Dominique P Germain, Iacopo Olivotto, Mohammed M Akhtar, Aris Anastasakis, Derralynn Hughes, Mehdi Namdar, Maurizio Pieroni, Albert Hagège, Franco Cecchi, Juan R Gimeno, Giuseppe Limongelli, Perry Elliott,

Fabry disease (FD) is an X-linked lysosomal storage disorder caused by pathogenic variants in the α-galactosidase A (GLA) gene that leads to reduced or undetectable α-galactosidase A enzyme activity and progressive accumulation of globotriaosylceramide and its deacylated form globotriaosylsphingosine in cells throughout the body. FD can be multisystemic with neurological, ... Read more >>

Eur J Heart Fail (European journal of heart failure)
[2020, 22(7):1076-1096]

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Primary mediastinal choriocarcinoma presenting as cutaneous metastasis with resistance to chemotherapy: case report and literature review.

Khaled A Murshed, Aladdin Kanbour, Mohammed Akhtar, Samir Al Hyassat,

Cutaneous metastases of choriocarcinoma are rare. They may indicate poor prognosis and resistance to chemotherapy. In this report, we present a case of a 25-year-old man who presented with central pleuritic chest pain and right upper arm mass for about a week. The patient also had significant weight loss during ... Read more >>

J Cutan Pathol (Journal of cutaneous pathology)
[2021, 48(1):81-85]

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Mutations in TRIM63 cause an autosomal-recessive form of hypertrophic cardiomyopathy.

Joel Salazar-Mendiguchía, Juan Pablo Ochoa, Julian Palomino-Doza, Fernando Domínguez, Carles Díez-López, Mohammed Akhtar, Soraya Ramiro-León, María M Clemente, Antonia Pérez-Cejas, María Robledo, Iria Gómez-Díaz, María Luisa Peña-Peña, Vicente Climent, Francisco Salmerón-Martínez, Celestino Hernández, Pablo E García-Granja, M Victoria Mogollón, Ivonne Cárdenas-Reyes, Marcos Cicerchia, Diego García-Giustiniani, Arsonval Lamounier, Belén Gil-Fournier, Felícitas Díaz-Flores, Rafael Salguero, Luis Santomé, Petros Syrris, Montse Olivé, Pablo García-Pavía, Martín Ortiz-Genga, Perry M Elliott, Lorenzo Monserrat, ,

OBJECTIVE:Up to 50% of patients with hypertrophic cardiomyopathy (HCM) show no disease-causing variants in genetic studies. TRIM63 has been suggested as a candidate gene for the development of cardiomyopathies, although evidence for a causative role in HCM is limited. We sought to investigate the relationship between rare variants in TRIM63 ... Read more >>

Heart (Heart (British Cardiac Society))
[2020, 106(17):1342-1348]

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Epididymal leiomyoadenomatoid tumor: A case report with literature review.

Bara Wazwaz, Khaled Murshed, Eiman Musa, Noheir Taha, Mohammed Akhtar,

Primary epididymal tumors are rare. Adenomatoid tumors comprise 30% of paratesticular tumors. They are benign neoplasms originating from mesothelial cells. On the other hand, leiomyomas, originating from smooth muscle cells, are less common in paratesticular region. Leiomyoadenomatoid tumor is a benign tumor which combines the morphologic features of adenomatoid tumor ... Read more >>

Urol Case Rep (Urology case reports)
[2020, 32:101226]

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Dilated cardiomyopathy and arrhythmogenic left ventricular cardiomyopathy: a comprehensive genotype-imaging phenotype study.

João B Augusto, Rocio Eiros, Eleni Nakou, Sara Moura-Ferreira, Thomas A Treibel, Gabriella Captur, Mohammed M Akhtar, Alexandros Protonotarios, Thomas D Gossios, Konstantinos Savvatis, Petros Syrris, Saidi Mohiddin, James C Moon, Perry M Elliott, Luis R Lopes,

<h4>Aims</h4>Myocardial scar detected by cardiovascular magnetic resonance has been associated with sudden cardiac death in dilated cardiomyopathy (DCM). Certain genetic causes of DCM may cause a malignant arrhythmogenic phenotype. The concepts of arrhythmogenic left ventricular (LV) cardiomyopathy (ALVC) and arrhythmogenic DCM are currently ill-defined. We hypothesized that a distinctive imaging ... Read more >>

Eur Heart J Cardiovasc Imaging (European heart journal cardiovascular Imaging)
[2020, 21(3):326-336]

Cited: 12 times

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Diabetic Kidney Disease: Past and Present.

Mohammed Akhtar, Noheir M Taha, Awais Nauman, Imaad B Mujeeb, Ajayeb Dakhilalla M H Al-Nabet,

Diabetes mellitus (DM) afflicting humans has been recognized as a disease for >3000 years. However, very little was known about its etiology and pathogenesis until about a century ago when increasing knowledge about anatomy and physiology of the human body gradually led to our understanding that the hormone insulin produced ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2020, 27(2):87-97]

Cited: 2 times

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Classification of Endometrial Carcinoma: New Perspectives Beyond Morphology.

Mohammed Akhtar, Samir Al Hyassat, Orwa Elaiwy, Sameera Rashid, Ajayeb D M H Al-Nabet,

Endometrial carcinoma has been traditionally divided into type 1 or endometrioid type that is usually moderate to well differentiated and type 2 that is usually poorly differentiated with high histologic grade and aggressive clinical behavior. However, interobserver diagnostic agreement is suboptimal, particularly among the high-grade histotypes. Furthermore, recent data indicate ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2019, 26(6):421-427]

Cited: 1 time

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Filamin C variants are associated with a distinctive clinical and immunohistochemical arrhythmogenic cardiomyopathy phenotype.

Charlotte L Hall, Mohammed M Akhtar, Maria Sabater-Molina, Marta Futema, Angeliki Asimaki, Alexandros Protonotarios, Chrysoula Dalageorgou, Alan M Pittman, Mari Paz Suarez, Beatriz Aguilera, Pilar Molina, Esther Zorio, Juan Pedro Hernández, Francisco Pastor, Juan R Gimeno, Petros Syrris, William J McKenna,

<h4>Background</h4>Pathogenic variants in the filamin C (FLNC) gene are associated with inherited cardiomyopathies including dilated cardiomyopathy with an arrhythmogenic phenotype. We evaluated FLNC variants in arrhythmogenic cardiomyopathy (ACM) and investigated the disease mechanism at a molecular level.<h4>Methods</h4>120 gene-elusive ACM patients who fulfilled diagnostic criteria for arrhythmogenic right ventricular cardiomyopathy (ARVC) ... Read more >>

Int J Cardiol (International journal of cardiology)
[2020, 307:101-108]

Cited: 14 times

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Prevalence of TTR variants detected by whole-exome sequencing in hypertrophic cardiomyopathy.

Luis R Lopes, Marta Futema, Mohammed M Akhtar, Massimiliano Lorenzini, Alan Pittman, Petros Syrris, Perry M Elliott,

<b>Background:</b> A proportion of patients with hypertrophic cardiomyopathy (HCM) have a diagnosis of cardiac amyloidosis. Hereditary transthyretin amyloid cardiomyopathy (ATTRv-CM) is caused by mutations in the <i>TTR</i> gene. Our aim was to study the prevalence of potentially amyloidogenic <i>TTR</i> variants in a whole-exome sequencing (WES) study of a large HCM ... Read more >>

Amyloid (Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis)
[2019, 26(4):243-247]

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Urothelial Carcinoma In Situ (CIS): New Insights.

Mohammed Akhtar, Issam A Al-Bozom, Mohamed Ben Gashir, Noheir M Taha, Sameera Rashid, Ajayeb D M H Al-Nabet,

Urothelial carcinoma in situ (CIS) is a high-grade noninvasive malignancy with a high tendency of progression. Although it is typically grouped with other nonmuscle invasive bladder cancers, its higher grade and aggressiveness make it a unique clinical entity. Urothelial CIS is histologically characterized by replacement of the urothelium by cells ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2019, 26(5):313-319]

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Hidden in Heart Failure.

Douglas Ewan Cannie, Mohammed Majid Akhtar, Perry Elliott,

Current diagnostic strategies fail to illuminate the presence of rare disease in the heart failure population. One-third of heart failure patients are categorised as suffering an idiopathic dilated cardiomyopathy, while others are labelled only as heart failure with preserved ejection fraction. Those affected frequently suffer from delays in diagnosis, which ... Read more >>

Eur Cardiol (European cardiology)
[2019, 14(2):89-96]

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Helical and kinase domain mutations of PIK3CA, and their association with hormone receptor expression in breast cancer.

Chittibabu Vatte, Ali Mohammed Al Amri, Cyril Cyrus, Shahanas Chathoth, Ahmed Alsayyah, Arafat Ahmad, Mohammed Shakil Akhtar, Nada Fehaid Alrashidi, Nithya Jayaseeli, Hamed Al Wadani, Alhussain Al Zahrani, Amein Kadhem Al Ali,

Breast cancer is one of the major causes of female morbidity and mortality, accounting for ~25% of the total cancer cases in women. Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic α subunit (<i>PIK3CA</i>) mutations serve a major role in downstream signaling of receptor tyrosine kinases. The present study aimed to elucidate the frequency of ... Read more >>

Oncol Lett (Oncology letters)
[2019, 18(3):2427-2433]

Cited: 2 times

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Intrinsic Molecular Subclassification of Urothelial Carcinoma of the Bladder: Are We Finally there?

Mohammed Akhtar, Issam A Al-Bozom, Mohamed Ben Gashir, Noheir M Taha,

Bladder cancer is a highly prevalent disease throughout the world usually encountered in older patients, and associated with substantial morbidity, mortality, and cost. The treatment of bladder cancer has remained unchanged for the last several decades. However, in recent years the availability of comprehensive genomic data from The Cancer Genome ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2019, 26(4):251-256]

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