Full Text Journal Articles by
Author Mohammad Reza Ghovanloo

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Cannabidiol and Sodium Channel Pharmacology: General Overview, Mechanism, and Clinical Implications.

Mohammad-Reza Ghovanloo, Peter C Ruben,

Voltage-gated sodium (Nav) channels initiate action potentials in excitable tissues. Altering these channels' function can lead to many pathophysiological conditions. Nav channels are composed of several functional and structural domains that could be targeted pharmacologically as potential therapeutic means against various neurological conditions. Mutations in Nav channels have been suggested ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :10738584211017009]

Cited: 0 times

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Cannabidiol inhibits the skeletal muscle Nav1.4 by blocking its pore and by altering membrane elasticity.

Mohammad-Reza Ghovanloo, Koushik Choudhury, Tagore S Bandaru, Mohamed A Fouda, Kaveh Rayani, Radda Rusinova, Tejas Phaterpekar, Karen Nelkenbrecher, Abeline R Watkins, Damon Poburko, Jenifer Thewalt, Olaf S Andersen, Lucie Delemotte, Samuel J Goodchild, Peter C Ruben,

Cannabidiol (CBD) is the primary nonpsychotropic phytocannabinoid found in Cannabis sativa, which has been proposed to be therapeutic against many conditions, including muscle spasms. Among its putative targets are voltage-gated sodium channels (Navs), which have been implicated in many conditions. We investigated the effects of CBD on Nav1.4, the skeletal ... Read more >>

J Gen Physiol (The Journal of general physiology)
[2021, 153(5):]

Cited: 0 times

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Biophysical Characterization of a Novel SCN5A Mutation Associated With an Atypical Phenotype of Atrial and Ventricular Arrhythmias and Sudden Death.

Mohammad-Reza Ghovanloo, Joseph Atallah, Carolina A Escudero, Peter C Ruben,

<h4>Background</h4>Sudden cardiac death (SCD) is an unexpected death that occurs within an hour of the onset of symptoms. Hereditary primary electrical disorders account for up to 1/3 of all SCD cases in younger individuals and include conditions such as catecholaminergic polymorphic ventricular tachycardia (CPVT). These disorders are caused by mutations ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:610436]

Cited: 1 time

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Cannabidiol interactions with voltage-gated sodium channels.

Lily Goodyer Sait, Altin Sula, Mohammad-Reza Ghovanloo, David Hollingworth, Peter C Ruben, B A Wallace,

Voltage-gated sodium channels are targets for a range of pharmaceutical drugs developed for the treatment of neurological diseases. Cannabidiol (CBD), the non-psychoactive compound isolated from cannabis plants, was recently approved for treatment of two types of epilepsy associated with sodium channel mutations. This study used high-resolution X-ray crystallography to demonstrate ... Read more >>

Elife (eLife)
[2020, 9:]

Cited: 2 times

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Biophysical Characterization of A Novel SCN5A Mutation Associated with an Atypical Phenotype of Atrial and Ventricular Arrhythmias and Sudden Death

Mohammad-Reza Ghovanloo, Joseph Atallah, Carolina Escudero, Peter Ruben,

<h4>Background</h4> Sudden cardiac death (SCD) is an unexpected death that occurs within an hour of the onset of symptoms. Hereditary primary electrical disorders account for up to 1/3 of all SCD cases in younger individuals and include conditions such as catecholaminergic polymorphic ventricular tachycardia (CPVT). These disorders are caused by ... Read more >>

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Mechanism and effects of the skeletal muscle Nav1.4 inhibition by cannabidiol

Mohammad-Reza Ghovanloo, Koushik Choudhury, Tagore Bandaru, Mohamed Fouda, Kaveh Rayani, Radda Rusinova, Tejas Phaterpekar, Karen Nelkenbrecher, Abeline Watkins, Damon Poburko, Jenifer Thewalt, Olaf Andersen, Lucie Delemotte, Samuel Goodchild, Peter Ruben,

<h4>ABSTRACT</h4> Cannabis sativa contains active constituents called phytocannabinoids. Some phytocannabinoids are psychotropic and others are not. The primary non-psychotropic phytocannabinoid is cannabidiol (CBD), which is proposed to be therapeutic against many conditions, including muscle spasms. Mechanisms have been proposed for the action of CBD on different systems, involving multiple targets, ... Read more >>

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Cannabidiol protects against high glucose-induced oxidative stress and cytotoxicity in cardiac voltage-gated sodium channels.

Mohamed A Fouda, Mohammad-Reza Ghovanloo, Peter C Ruben,

<h4>Background and purpose</h4>Cardiovascular complications are the major cause of mortality in diabetic patients. However, the molecular mechanisms underlying diabetes-associated arrhythmias are unclear. We hypothesized that high glucose could adversely affect Na<sub>v</sub> 1.5, the major cardiac sodium channel isoform of the heart, at least partially via oxidative stress. We further hypothesized ... Read more >>

Br J Pharmacol (British journal of pharmacology)
[2020, 177(13):2932-2946]

Cited: 7 times

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Say Cheese: Structure of the Cardiac Electrical Engine Is Captured.

Mohammad-Reza Ghovanloo, Peter C Ruben,

Voltage-gated sodium channel (Nav)1.5 is the predominantly expressed sodium channel in the myocardium. Mutations in the gene encoding Nav1.5 are associated with several types of cardiac arrhythmias. In their recent study, Jiang et al. provide a detailed structure of the rat Nav1.5, with major implications regarding its physiology, pharmacology, and ... Read more >>

Trends Biochem Sci (Trends in biochemical sciences)
[2020, 45(5):369-371]

Cited: 2 times

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Inhibitory effects of cannabidiol on voltage-dependent sodium currents.

Mohammad-Reza Ghovanloo, Noah Gregory Shuart, Janette Mezeyova, Richard A Dean, Peter C Ruben, Samuel J Goodchild,

<i>Cannabis sativa</i> contains many related compounds known as phytocannabinoids. The main psychoactive and nonpsychoactive compounds are Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD), respectively. Much of the evidence for clinical efficacy of CBD-mediated antiepileptic effects has been from case reports or smaller surveys. The mechanisms for CBD's anticonvulsant effects are unclear and ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2018, 293(43):16546-16558]

Cited: 29 times

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pH Modulation of Voltage-Gated Sodium Channels.

Colin H Peters, Mohammad-Reza Ghovanloo, Cynthia Gershome, Peter C Ruben,

Changes in blood and tissue pH accompany physiological and pathophysiological conditions including exercise, cardiac ischemia, ischemic stroke, and cocaine ingestion. These conditions are known to trigger the symptoms of electrical diseases in patients carrying sodium channel mutations. Protons cause a diverse set of changes to sodium channel gating, which generally ... Read more >>

Handb Exp Pharmacol (Handbook of experimental pharmacology)
[2018, 246:147-160]

Cited: 3 times

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A Mixed Periodic Paralysis & Myotonia Mutant, P1158S, Imparts pH-Sensitivity in Skeletal Muscle Voltage-gated Sodium Channels.

Mohammad-Reza Ghovanloo, Mena Abdelsayed, Colin H Peters, Peter C Ruben,

Skeletal muscle channelopathies, many of which are inherited as autosomal dominant mutations, include myotonia and periodic paralysis. Myotonia is defined by a delayed relaxation after muscular contraction, whereas periodic paralysis is defined by episodic attacks of weakness. One sub-type of periodic paralysis, known as hypokalemic periodic paralysis (hypoPP), is associated ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):6304]

Cited: 4 times

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Effects of acidosis on neuronal voltage-gated sodium channels: Nav1.1 and Nav1.3.

Mohammad-Reza Ghovanloo, Colin H Peters, Peter C Ruben,

Voltage-gated sodium channels are key contributors to membrane excitability. These channels are expressed in a tissue-specific manner. Mutations and modulation of these channels underlie various physiological and pathophysiological manifestations. The effects of changes in extracellular pH on channel gating have been studied on several sodium channel subtypes. Among these, Nav1.5 ... Read more >>

Channels (Austin) (Channels (Austin, Tex.))
[2018, 12(1):367-377]

Cited: 3 times

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A Mixed Periodic Paralysis & Myotonia Mutant, P1158S, Imparts pH Sensitivity in Skeletal Muscle Voltage-gated Sodium Channels

Mohammad-Reza Ghovanloo, Mena Abdelsayed, Colin Peters, Peter Ruben,

<h4>ABSTRACT</h4> Skeletal muscle channelopathies, many of which are inherited as autosomal dominant mutations, include both myotonia and periodic paralysis. Myotonia is defined by a delayed relaxation after muscular contraction, whereas periodic paralysis is defined by episodic attacks of weakness. One sub-type of periodic paralysis, known as hypokalemic periodic paralysis (hypoPP), ... Read more >>

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Effects of Amiodarone and N-desethylamiodarone on Cardiac Voltage-Gated Sodium Channels.

Mohammad-Reza Ghovanloo, Mena Abdelsayed, Peter C Ruben,

Amiodarone (AMD) is a potent antiarrhythmic drug with high efficacy for treating atrial fibrillation and tachycardia. The pharmacologic profile of AMD is complex. AMD possesses biophysical characteristics of all of class I, II, III, and IV agents. Despite its adverse side effects, AMD remains the most commonly prescribed antiarrhythmic drug. ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2016, 7:39]

Cited: 10 times

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