Full Text Journal Articles by
Author Mohammad M Abd Alhaseeb

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Rational design of biodegradable sulphonamide candidates treating septicaemia by synergistic dual inhibition of COX-2/PGE2 axis and DHPS enzyme.

Nada H El-Dershaby, Soad A El-Hawash, Shaymaa E Kassab, Hoda G Dabees, Ahmed E Abdel Moneim, Ibrahim A Abdel Wahab, Mohammad M Abd-Alhaseeb, Mostafa M M El-Miligy,

A new series of co-drugs was designed based on hybridising the dihydropteroate synthase (DHPS) inhibitor sulphonamide scaffold with the COX-2 inhibitor salicylamide pharmacophore through biodegradable linkage to achieve compounds with synergistic dual inhibition of COX-2/PGE2 axis and DHPS enzyme to enhance antibacterial activity for treatment of septicaemia. Compounds <b>5 b, 5j, ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2022, 37(1):1737-1751]

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Comparative metabolomics reveal intraspecies variability in bioactive compounds of different cultivars of pomegranate fruit (Punica granatum L.) and their waste by-products.

Nihal M El Newehy, Mohammad M Abd-Alhaseeb, Gamal A Omran, Fathallah M Harraz, Eman Shawky,

The different parts of pomegranate fruit are considered a powerful mixture of bioactive compounds yet the peels and pulps of the fruits are usually discarded and considered as industrial waste. In this work, ultra-performance liquid chromatography coupled with triple quadrupole mass spectrometry (UPLC-QqQ-MS) was utilized for metabolomics analysis of different ... Read more >>

J Sci Food Agric (Journal of the science of food and agriculture)
[2022, :]

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