Full Text Journal Articles by
Author Mohammad M Abd Alhaseeb

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Baicalin; a promising chemopreventive agent, enhances the antitumor effect of 5-FU against breast cancer and inhibits tumor growth and angiogenesis in Ehrlich solid tumor.

Nisreen H Shehatta, Tarek M Okda, Gamal A Omran, Mohammad M Abd-Alhaseeb,

Despite considerable advances in cancer treatment, chemotherapy remains a cornerstone in breast cancer therapy. Therefore, reducing chemoresistance and adverse effects of chemotherapy is a priority. In this regard, Baicalin (BA) is the dominant natural flavonoid extracted from the roots of Scutellaria baicalensis showed fascinating antitumor activity in many types of ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2021, 146:112599]

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Rosmarinic acid suppresses inflammation, angiogenesis, and improves paclitaxel induced apoptosis in a breast cancer model via NF3 κB-p53-caspase-3 pathways modulation.

Marwa A Mahmoud, Tark M Okda, Gamal A Omran, Mohammad M Abd-Alhaseeb,

Rosmarinic acid is a natural polyphenolic compound that is found in different plant species and used for different medicinal purposes. This study aimed to investigate the chemo-preventive effect of rosmarinic acid and evaluate its antitumor efficacy alone or in combination with Paclitaxel in breast cancer mice model. Ehrlich induced mice ... Read more >>

J Appl Biomed (Journal of applied biomedicine)
[2021, 19(4):202-209]

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Transforming iodoquinol into broad spectrum anti-tumor leads: Repurposing to modulate redox homeostasis.

Ibrahim Chaaban, Haidy Hafez, Ibrahim AlZaim, Cynthia Tannous, Hanan Ragab, Aly Hazzaa, Salma Ketat, Asser Ghoneim, Mohamed Katary, Mohammad M Abd-Alhaseeb, Fouad A Zouein, Amgad Albohy, Ahmed Noby Amer, Ahmed F El-Yazbi, Ahmed S F Belal,

We managed to repurpose the old drug iodoquinol to a series of novel anticancer 7-iodo-quinoline-5,8-diones. Twelve compounds were identified as inhibitors of moderate to high potency on an inhouse MCF-7 cell line, of which 2 compounds (5 and 6) were capable of reducing NAD level in MCF-7 cells in concentrations ... Read more >>

Bioorg Chem (Bioorganic chemistry)
[2021, 113:105035]

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Chemopreventive and anticancer activities of indomethacin and vitamin D combination on colorectal cancer induced by 1,2-dimethylhydrazine in rats.

Tarek M Okda, Sary K Abd-Elghaffar, Mohamed A Katary, Mohammad M Abd-Alhaseeb,

Several studies have revealed that the combination of indomethacin, a nonsteroidal anti-inflammatory drug (NSAID), and vitamin D reduces the risk of common types of cancers. Nonetheless, research on the deal concentrations used to test the impact of vitamin D on colon cancer is deficient. Along these lines, the aim of ... Read more >>

Biomed Rep (Biomedical reports)
[2021, 14(2):27]

Cited: 1 time

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Synthesis and biological screening of some novel 6-substituted 2-alkylpyridazin-3(2H)-ones as anti-inflammatory and analgesic agents.

Yasser M Loksha, Mohammad M Abd-Alhaseeb,

Some novel derivatives of 2-alkyl 6-substituted pyridazin-3(2H)-ones were synthesized by condensation of 3,6-dichloropyridazine with the sodium salt of benzyl cyanide, followed by hydrolysis and coupling with alkyl halides. The synthesized compounds were screened as cyclooxygenase (COX)-1/COX-2 inhibitors and as analgesic and anti-inflammatory agents. Among the synthesized compounds, 6-benzyl-2-methylpyridazin-3(2H)-one (4a), 6-benzoyl-2-propylpyridazin-3(2H)-one ... Read more >>

Arch Pharm (Weinheim) (Archiv der Pharmazie)
[2020, 353(3):e1900295]

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Hesperidin, piperine and bee venom synergistically potentiate the anticancer effect of tamoxifen against breast cancer cells.

Abeer A A Khamis, Ehab M M Ali, Mohamed A Abd El-Moneim, Mohammad M Abd-Alhaseeb, Mohammed Abu El-Magd, Elsayed I Salim,

Despite advances in cancer treatment, breast cancer remains one of the main life threatening diseases in women. Most anti-breast cancer drugs cause severe health complications and multidrug resistance. Although, some natural products, such as hesperidin (Hes), piperine (Pip) and bee venom (BV), showed anti-breast cancer effect when used separately, their ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2018, 105:1335-1343]

Cited: 15 times

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Fingerprint profile and efficacy-associated markers of Nigella sativa oil for geographical origin determination using targeted and untargeted HPTLC-multivariate analysis.

Eman Shawky, Nihal M El Newehy, Amira M Beltagy, Mohammad M Abd-Alhaseeb, Gamal A Omran, Fathallah M Harraz,

Efficacy directed-fingerprint analysis of high-performance thin layer chromatography is proposed to set up fingerprint activity relationship modeling for precise discrimination of chemical and effective consistency of Nigella sativa oils from different geographical origins. A whole of 27 samples of N. sativa oils from three geographical area (Egypt, Ethiopia and Syria) ... Read more >>

J Chromatogr B Analyt Technol Biomed Life Sci (Journal of chromatography. B, Analytical technologies in the biomedical and life sciences)
[2018, 1087-1088:108-117]

Cited: 1 time

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Olmesartan potentiates the anti-angiogenic effect of sorafenib in mice bearing Ehrlich's ascites carcinoma: role of angiotensin (1-7).

Mohammad M Abd-Alhaseeb, Sawsan A Zaitone, Soad H Abou-El-Ela, Yasser M Moustafa,

Local renin-angiotensin systems exist in various malignant tumor tissues; this suggests that the main effector peptide, angiotensin II, could act as a key factor in tumor growth. The underlying mechanisms for the anti-angiogenic effect of angiotensin II type 1 receptor blockers need to be further evaluated. The present study was ... Read more >>

PLoS One (PloS one)
[2014, 9(1):e85891]

Cited: 15 times

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