Full Text Journal Articles by
Author Mohammad Ali Shariati

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Therapeutic potentials of crocin in medication of neurological disorders.

Salman Ahmed, Muhammad Mohtasheemul Hasan, Mojtaba Heydari, Abdur Rauf, Saud Bawazeer, Tareq Abu-Izneid, Maksim Rebezov, Mohammad Ali Shariati, Maria Daglia, Kannan Rr Rengasamy,

Neurological sicknesses are serious, multifactorial, debilitating disorders that may cause neurodegeneration. Neuroprotection is the protection of the structure and capacity of neurons from affronts emerging from cell injuries instigated by an assortment of specialists or neurodegenerative diseases. Various neurodegenerative diseases, including Alzheimer's, Parkinson's, and epilepsy, afflict many people worldwide, with ... Read more >>

Food Chem Toxicol (Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association)
[2020, 145:111739]

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Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders.

Muhammad Imran, Fereshteh Ghorat, Iahtisham Ul-Haq, Habib Ur-Rehman, Farhan Aslam, Mojtaba Heydari, Mohammad Ali Shariati, Eleonora Okuskhanova, Zhanibek Yessimbekov, Muthu Thiruvengadam, Mohammad Hashem Hashempur, Maksim Rebezov,

Lycopene, belonging to the carotenoids, is a tetraterpene compound abundantly found in tomato and tomato-based products. It is fundamentally recognized as a potent antioxidant and a non-pro-vitamin A carotenoid. Lycopene has been found to be efficient in ameliorating cancer insurgences, diabetes mellitus, cardiac complications, oxidative stress-mediated malfunctions, inflammatory events, skin ... Read more >>

Antioxidants (Basel) (Antioxidants (Basel, Switzerland))
[2020, 9(8):]

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Sesquiterpenes and their derivatives-natural anticancer compounds: An update.

Tareq Abu-Izneid, Abdur Rauf, Mohammad Ali Shariati, Anees Ahmed Khalil, Muhammad Imran, Maksim Rebezov, Md Sahab Uddin, Mohamad Fawzi Mahomoodally, Kannan R R Rengasamy,

Sesquiterpenes belong to the largest group of plant secondary metabolites, which consist of three isoprene building units. These compounds are widely distributed in various angiosperms, a few gymnosperms and bryophytes. Sesquiterpenes and their allied derivatives are bio-synthesized in various plant parts including leaves, fruits and roots. These plant-based metabolites are ... Read more >>

Pharmacol Res (Pharmacological research)
[2020, 161:105165]

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Anti-inflammatory and In Silico Docking Studies of Heterophragma adenophyllum Seem Stem Constituents.

Tareq Abu-Izneid, Zafar Ali Shah, Abdur Rauf, Abdul Wadood, Saud Bawazeer, Naveed Muhammad, Mohamed A El-Esawi, Fahad A Alhumaydhi, Abdullah S M Aljohani, Eman El-Sharkawy, Mohammad S Mubarak, Kuralay Isayeva, Mohammad Ali Shariati,

Heterophragma adenophyllum is a traditional medicinal plant that has been used as anti-inflammatory and to relief muscular tension. In the current research, four isolated constitutes namely lapacho (1), peshawaraquinone (2), indanone derivatives (3), α-lapachone (4) of H. adenophyllum were tested for anti-inflammatory effect using the carrageenan- and histamine-induced paw edema ... Read more >>

Inflammation (Inflammation)
[2020, :]

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Secondary metabolite contents and antimicrobial activity of leaf extracts reveal genetic variability of Vernonia amygdalina and Vernonia calvoana morphotypes.

Nguimkeng Gaintse Eric Dumas, Ngandjui Tchangoue Yvan Anderson, Ntsomboh-Ntsefong Godswill, Muthu Thiruvengadam, Gheldiu Ana-Maria, Paltinean Ramona, Gianina Cristina Crisan, Vlase Laurian, Mohammad Ali Shariati, Zhaiyk Tokhtarov, Youmbi Emmanuel,

Vernonia species (Asteraceae) are indigenous medicinal and food leaf vegetables commonly consumed in some African countries like Cameroon where they constitute a staple dish called "ndolé." Previous studies have demonstrated the nutritional importance of Vernonia, but there is little knowledge of their agronomic value and genetic potentials. Wide genetic variability ... Read more >>

Biotechnol Appl Biochem (Biotechnology and applied biochemistry)
[2020, :]

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An overview on red algae bioactive compounds and their pharmaceutical applications.

Ejaz Aziz, Riffat Batool, Muhammad Usman Khan, Abdur Rauf, Wasim Akhtar, Mojtaba Heydari, Shazia Rehman, Tasmeena Shahzad, Ayesha Malik, Seyed Hamdollah Mosavat, Sergey Plygun, Mohammad Ali Shariati,

Objectives To review red algae bioactive compounds and their pharmaceutical applications. Content Seaweed sources are becoming attractive to be used in health and therapeutics. Among these red algae is the largest group containing bioactive compounds utilized in cosmetic, pharmaceutical, food industry, manure and various supplements in food formula. Various significant ... Read more >>

J Complement Integr Med (Journal of complementary & integrative medicine)
[2020, :]

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Density functional theory, molecular docking and in vivo muscle relaxant, sedative, and analgesic studies of indanone derivatives isolated from Heterophragma adenophyllum.

Abdullah S M Aljohani, Tareq Abu-Izneid, Zafar Ali Shah, Umer Rashid, Khurshid Ayub, Abdur Rauf, Naveed Muhammad, Fahad A Alhumaydhi, Maria Asghar, Mohammad S Mubarak, Mohammad Ali Shariati, Haiyuan Zhang,

Heterophragma adenophyllum (HA) is an important medicinal plant which is used in traditional medicine for the treatment of muscular tension and pain. Herein, we report the isolation of methyl,1,2-dihydroxy-2-(3-methylbut-2-en-1-yl)-3-oxo-2,3-dihydro-1H-indene-1-carboxylate (1), from the roots of H. adenophyllum. The isolated compound 1 was evaluated for in vivo muscle relaxant, sedative, and analgesic potential ... Read more >>

J. Biomol. Struct. Dyn. (Journal of biomolecular structure & dynamics)
[2020, :1-12]

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In vitro α-glycosidase and urease enzyme inhibition profile of some selected medicinal plants of Pakistan.

Abdur Rauf, Saud Bawazeer, Muhammad Naseer, Fahad A Alhumaydhi, Abdullah S M Aljohani, Aamir Habib, Raheem Khan, Urooj Jehan, Muhammad Nasimullah Qureshi, Majid Khan, Umar Farooq, Amirzhan Kassenov, Mohammad Ali Shariati,

The current study aims at exploring enzyme inhibition of four species of medicinal herbs, namely Senna bicapsularis, Thevetia peruviana, Nerium oleander and Vinca major. Plant selection was done on the basis of their therapeutic uses by local practitioners. The crude methanolic extracts of these plants were tested for their α-glycosidase ... Read more >>

Nat. Prod. Res. (Natural product research)
[2020, :1-6]

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Escherichia coli as a carrier of tetracyclines and penicillins resistance in wild pheasant (Phasianus colchicus).

Lukáš Hleba, Miroslava Hlebová, Anton Kováčik, Peter Šmehýl, Nikola Hricáková, Jana Petrová, Mohammad Ali Shariati, Juraj Čuboň,

Wild animals like pheasant seem to be a good source of information about human activities. Therefore, the wild pheasants and relative stable appendix microcenosis were selected for antibiotic resistance testing. Penicillin resistance by MALDI-TOF Mass Spectrometry and tetracyclines resistance by genetic methods using specific primers were tested. Differences between tetracycline ... Read more >>

J Environ Sci Health A Tox Hazard Subst Environ Eng (Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering)
[2020, 55(10):1201-1209]

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Hepcidin, an overview of biochemical and clinical properties.

Abdur Rauf, Mohammad Ali Shariati, Anees Ahmed Khalil, Saud Bawazeer, Mojtaba Heydari, Sergey Plygun, Alexy Laishevtcev, Muhammad Bilal Hussain, Fahad A Alhumaydhi, Abdullah S M Aljohani,

Hepcidin is a peptide hormone which helps in regulating iron homeostasis in the human body. Iron obtained from daily diet is passed through the intestinal enterocyte apical membrane via divalent metal transporter 1 (DMT1), which is either stored as ferritin or moved into the plasma by hepcidin-ferroportin (Fpn) as an ... Read more >>

Steroids (Steroids)
[2020, 160:108661]

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Pomegranate as a source of bioactive constituents: a review on their characterization, properties and applications.

Maryam Pirzadeh, Nicola Caporaso, Abdur Rauf, Mohammad Ali Shariati, Zhanibek Yessimbekov, Muhammad Usman Khan, Muhammad Imran, Mohammad S Mubarak,

Increasing awareness about the use of compounds obtained from natural sources exerting health-beneficial properties, including antimicrobial and antioxidant effects, led to increased number of research papers focusing on the study of functional properties of target compounds to be used as functional foods or in preventive medicine. Pomegranate has shown positive ... Read more >>

Crit Rev Food Sci Nutr (Critical reviews in food science and nutrition)
[2020, :1-18]

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Vision Loss in Optic Disc Drusen Correlates With Increased Macular Vessel Diameter and Flux and Reduced Peripapillary Vascular Density.

Yan Yan, Xiao Zhou, Zhongdi Chu, Laurel Stell, Mohammad Ali Shariati, Ruikang K Wang, Yaping Joyce Liao,

PURPOSE:To determine the key optical coherence tomography (OCT) and OCT angiography (OCTA) parameters that correlate with visual field loss in optic disc drusen (ODD). DESIGN:Retrospective cross-sectional study. METHODS:Single academic center. Seventeen patients with ODD (29 eyes) and 35 age-matched controls (53 eyes). Static perimetry, OCT, and OCTA imaging of optic ... Read more >>

Am J Ophthalmol (American journal of ophthalmology)
[2020, 218:214-224]

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Progress and prospects in the management of bacterial infections and developments in Phytotherapeutic modalities.

Muhammad Akram, Muhammad Riaz, Naveed Munir, Akhtar Rasul, Muhammad Daniyal, Muhammad Daniyal, Syed Muhammad Ali Shah, Mohammad Ali Shariati, Ghazala Shaheen, Naheed Akhtar, Farzana Parveen, Naheed Akhter, Aymen Owais Ghauri, Abdul Wadood Chishti, Muhammad Usman Sarwar, Fahad Said Khan,

The advent of antibiotics revolutionized medical care resulting in significantly reduced mortality and morbidity caused by infectious diseases. However, excessive use of antibiotics has led to the development of antibiotic resistance and indeed, the incidence of multidrug-resistant pathogens is considered as a major disadvantage in medication strategy, which has led ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2020, 47(7):1107-1119]

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Pharmacological applications of phlorotannins: A comprehensive review.

Ahsan Javed, Muhammad Bilal Hussain, Ali Tahir, Marwa Waheed, Ahsan Anwar, Mohammad Ali Shariati, Sergey Plygun, Alexey Laishevtcev, Mehdi Pasalar,

BACKGROUND:Seaweeds including marine brown algae are traditional food sources in Asia. Phlorotannins, as the product of polyketide pathway, are mainly found in brown algae. Different properties have been attributed to this group of marine products ranging from anti-allergic to anticancer activity. Mechanism of action is not obvious for all these ... Read more >>

Curr Drug Discov Technol (Current drug discovery technologies)
[2020, :]

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A Microbiological, Toxicological, and Biochemical Study of the Effects of Fucoxanthin, a Marine Carotenoid, on Mycobacterium tuberculosis and the Enzymes Implicated in Its Cell Wall: A Link Between Mycobacterial Infection and Autoimmune Diseases.

Miroslava Šudomová, Mohammad Ali Shariati, Javier Echeverría, Ioana Berindan-Neagoe, Seyed Mohammad Nabavi, Sherif T S Hassan,

This study explored the antitubercular properties of fucoxanthin, a marine carotenoid, against clinical isolates of Mycobacterium tuberculosis (Mtb). Two vital enzymes involved in Mtb cell wall biosynthesis, UDP-galactopyranose mutase (UGM) and arylamine-N-acetyltransferase (TBNAT), were selected as drug targets to reveal the mechanism underlying the antitubercular effect of fucoxanthin. The obtained ... Read more >>

Mar Drugs (Marine drugs)
[2019, 17(11):]

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Chemical constituents, experimental and clinical pharmacology of Rosa damascena: a literature review.

Muhammad Akram, Muhammad Riaz, Naveed Munir, Naheed Akhter, Sadia Zafar, Farhat Jabeen, Mohammad Ali Shariati, Naheed Akhtar, Zarfishan Riaz, Syed Hassan Altaf, Muhammad Daniyal, Muhammad Daniyal, Rabia Zahid, Fahad Said Khan,

CONTEXT:Rosa damascena Mill. is prescribed for the management of chest and abdominal pain, constipation, digestive disorders, menstrual bleeding and liver ailments. OBJECTIVE:The current review compiles up to date and complete information of whole plant of R. damascena with particular emphasis on its numerous scientifically proved pharmacological effects, traditional and folk medicinal ... Read more >>

J. Pharm. Pharmacol. (The Journal of pharmacy and pharmacology)
[2020, 72(2):161-174]

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Moringa Oleifera in Malnutrition: A Comprehensive Review.

Bilal Sajid Mushtaq, Muhammad Bilal Hussain, Rabia Omer, Hafiz Ahmad Toor, Marwa Waheed, Mohammad Ali Shariati, Plygun Sergey, Mojtaba Heydari,

Nutritional deficiency is a major concern in developing countries resulting in serious health consequences like mental and physical growth retardation. Moringa oleifera(Moringa), a nutritious plantgrowing in tropical regions of developing countries, is a candidate for overcoming nutritional deficiency. Moringa leaves are rich in protein including Sulphur containing amino acids.It contains ... Read more >>

Curr Drug Discov Technol (Current drug discovery technologies)
[2019, :]

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Awareness and current knowledge of epilepsy.

Asmat Ullah Khan, Muhammad Akram, Muhammad Daniyal, Naheed Akhter, Muhammad Riaz, Naheed Akhtar, Mohammad Ali Shariati, Fozia Anjum, Samreen Gul Khan, Abida Parveen, Saeed Ahmad,

Epilepsy is a severe neural disorder that affects approximately fifty million individuals globally. Despite the fact that for most of the people with epilepsy, convulsions are better controlled by current accessible antiepileptic medicines, yet there are more than 30% of individuals affected with medically intractable epilepsy and around 30-40% of ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2020, 35(1):45-63]

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Xanthophyll: Health benefits and therapeutic insights.

Ejaz Aziz, Riffat Batool, Wasim Akhtar, Shazia Rehman, Tasmeena Shahzad, Ayesha Malik, Mohammad Ali Shariati, Alexey Laishevtcev, Sergey Plygun, Mojtaba Heydari, Abdur Rauf, Shaheer Ahmed Arif,

Xanthophylls constitute a major part of carotenoids in nature. They are an oxidized version of carotenoid. Xanthophyll has widely drawn scientists' attentions in terms of its functionality, bioavailability and diversity. An assortment of xanthophyll varieties includes lutein, zeaxanthin, β-cryptoxanthin, capsanthin, astaxanthin, and fucoxanthin. Chemically, lutein and zeaxanthin are dipolar carotenoids ... Read more >>

Life Sci. (Life sciences)
[2020, 240:117104]

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Role of medicinal plants in HIV/AIDS therapy.

Umme Laila, Muhammad Akram, Mohammad Ali Shariati, Asif Mehmmod Hashmi, Naheed Akhtar, Imtiaz Mahmood Tahir, Aymen Owais Ghauri, Naveed Munir, Muhammad Riaz, Naheed Akhter, Ghazala Shaheen, Qamar Ullah, Rabia Zahid, Saeed Ahmad,

Human immunodeficiency virus (HIV) causes the potentially life-threatening and chronic disease called acquired immune deficiency syndrome (AIDS). The main target of this viral disease is to suppress the immune system and make the body unresponsive to external stimuli. According to global health observatory data since epidemic, more than 78 million ... Read more >>

Clin. Exp. Pharmacol. Physiol. (Clinical and experimental pharmacology & physiology)
[2019, 46(12):1063-1073]

Cited: 1 time

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Chrysin: Pharmacological and therapeutic properties.

Saima Naz, Muhammad Imran, Abdur Rauf, Ilkay Erdogan Orhan, Mohammad Ali Shariati, Iahtisham-Ul-Haq, IqraYasmin, Muhammad Shahbaz, Tahira Batool Qaisrani, Zafar Ali Shah, Sergey Plygun, Mojtaba Heydari,

Chrysin is a promising phytochemical that is categorized under the class of flavonoids based on its chemical structure. Naturally, it is widely present in propolis, honey, passion fruit, and even in mushrooms and other plant sources, whereas its synthetic counterparts are also being employed for pharmacological purposes. It has widely ... Read more >>

Life Sci. (Life sciences)
[2019, 235:116797]

Cited: 4 times

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Increased ER Stress After Experimental Ischemic Optic Neuropathy and Improved RGC and Oligodendrocyte Survival After Treatment With Chemical Chaperon.

Varun Kumar, Louise Alessandra Mesentier-Louro, Angela Jinsook Oh, Kathleen Heng, Mohammad Ali Shariati, Haoliang Huang, Yang Hu, Yaping Joyce Liao,

Purpose:Increased endoplasmic reticulum (ER) stress is one of the earliest subcellular changes in neuro-ophthalmic diseases. In this study, we investigated the expression of key molecules in the ER stress pathways following nonarteritic anterior ischemic optic neuropathy (AION), the most common acute optic neuropathy in adults over 50, and assessed the ... Read more >>

Invest. Ophthalmol. Vis. Sci. (Investigative ophthalmology & visual science)
[2019, 60(6):1953-1966]

Cited: 1 time

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Corrigendum to "Luteolin, a flavonoid, as an anticancer agent: A review" [Biomed. Pharmacother. 112 (2019) 108612].

Muhammad Imran, Abdur Rauf, Tareq Abu-Izneid, Muhammad Nadeem, Mohammad Ali Shariati, Imtiaz Ali Khan, Ali Imran, Ilkay Erdogan Orhan, Muhammad Rizwan, Muhammad Atif, Tanweer Aslam Gondal, Mohammad S Mubarak,

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2019, 116:109084]

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Phytochemical and pharmacological attributes of piperine: A bioactive ingredient of black pepper.

Sergey Shityakov, Ehsan Bigdelian, Aqeel A Hussein, Muhammad Bilal Hussain, Yogesh Chandra Tripathi, Muhammad Usman Khan, Mohammad Ali Shariati,

Plants are vital for the wellbeing of humankind in a variety of ways. Some plant extracts contain antimicrobial properties that can treat different pathogens. Most of the world's population relies on medicinal plants and natural products for their primary health care needs. Therefore, there is a growing interest in natural ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2019, 176:149-161]

Cited: 2 times

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Honey and cancer: A mechanistic review.

Marwa Waheed, Muhammad Bilal Hussain, Ahsan Javed, Zarina Mushtaq, Sadia Hassan, Mohammad Ali Shariati, Muhammad Usman Khan, Majid Majeed, Manisha Nigam, Abhay Prakash Mishra, Mojtaba Heydari,

BACKGROUND:Globally, cancer ranks among the most common causes of death. Multiple experimental and clinical studies have investigated anticancer effects of honey with promising results. This study focused on potential background mechanisms of this effect. METHODS:The current literature was reviewed for potential anticancer pathways which are suggested for honey and its ... Read more >>

Clin Nutr (Clinical nutrition (Edinburgh, Scotland))
[2019, 38(6):2499-2503]

Cited: 2 times

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