Full Text Journal Articles by
Author Mohamed Said Maghezzi

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Cerebrospinal Fluid Characterization in Cynomolgus Monkeys, Beagle Dogs, and Göttingen Minipigs.

Cristina Ballesteros, Mylène Pouliot, Rémi Froment, Mohamed Said Maghezzi, Camille St-Jean, Christian Li, Dominique Paquette, Simon Authier,

Intrathecal administration is an important route for drug delivery, and in pharmacology and toxicology studies, cerebrospinal fluid (CSF) collection and analysis is required for evaluating blood-brain barrier penetration and central nervous system exposure. The characteristics of CSF in commonly used nonrodent models are lacking. The purpose of this study is ... Read more >>

Int. J. Toxicol. (International journal of toxicology)
[2020, 39(2):124-130]

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Occurrence of spontaneous arrhythmias in freely moving non-treated healthy telemetered Sprague-Dawley rats.

Paula Juliana Brizuela de Seadi Pereira, Mylene Pouliot, Alison Easter, Claudia Harper, Annick Prefontaine, Lois Miraucourt, Wendy Tan, Mohamed Said Maghezzi, Rob Wallis, Simon Authier,

J Pharmacol Toxicol Methods (Journal of pharmacological and toxicological methods)
[2019, 99:106595]

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Incidence of spontaneous arrhythmias in freely moving healthy untreated Sprague-Dawley rats.

Paula Juliana Seadi Pereira, Michael K Pugsley, Eric Troncy, Wendy Tan, Mylene Pouliot, Claudia Harper, Annick Prefontaine, Alison Easter, Rob Wallis, Lois Miraucourt, Hai Huang, Michael V Accardi, Emmanuel Boulay, Mohamed Said Maghezzi, Simon Authier,

Spontaneous arrhythmia characterization in healthy rats can support interpretation when studying novel therapies. Male (n = 55) and female (n = 40) Sprague-Dawley rats with telemetry transmitters for a derivation II ECG. Arrhythmias were assessed from continuous ECG monitoring over a period of 24-48 h, and data analyzed using an automated detection algorithm with 100% ... Read more >>

J Pharmacol Toxicol Methods (Journal of pharmacological and toxicological methods)
[2019, 99:106589]

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