Full Text Journal Articles by
Author Mohamed Ameen

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Posterolateral Fusion Versus Posterior Lumbar Interbody Fusion: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Elsayed Said, Mohamed E Abdel-Wanis, Mohamed Ameen, Ali A Sayed, Khaled H Mosallam, Ahmed M Ahmed, Hamdy Tammam,

<h4>Study design</h4>Systematic review and meta-analysis.<h4>Objectives</h4>Arthrodesis has been a valid treatment option for spinal diseases, including spondylolisthesis and lumbar spinal stenosis. Posterolateral and posterior lumbar interbody fusion are amongst the most used fusion techniques. Previous reports comparing both methods have been contradictory. Thus, we conducted a systematic review and meta-analysis of ... Read more >>

Global Spine J (Global spine journal)
[2021, :21925682211016426]

Cited: 0 times

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Investigating the Need for Calibration to Track Eye Movements: A Feasibility Study

Mohamed Abul Hassan Ameen, Chad Aldridge, Yan Zhuang, Xuwang Yin, Timothy McMurry, Gustavo Rohde, Andrew Southerland,

Automated eye tracking technology could enhance diagnosis and treatment for many neurological diseases, including posterior circulation stroke. Much of the current literature focuses on gaze estimation through a form of calibration. Unlike other fields, medicine has a clear need to better track eye symmetry during movement for better detection of ... Read more >>

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Generation of Human iPSCs by Protein Reprogramming and Stimulation of TLR3 Signaling.

Chun Liu, Mohamed Ameen, Sukaina Himmati, Dilip Thomas, Nazish Sayed,

The discovery of induced pluripotent stem cells (iPSCs) allows for establishment of human embryonic stem-like cells from various adult human somatic cells (e.g., fibroblasts), without the need for destruction of human embryos. This provides an unprecedented opportunity where patient-specific iPSCs can be subsequently differentiated to many cell types, e.g., cardiac ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2021, 2239:153-162]

Cited: 1 time

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Transcriptome Analysis of Non-Human Primate Induced Pluripotent Stem Cell-Derived Cardiomyocytes in 2D Monolayer Culture versus 3D Engineered Heart Tissue.

Huaxiao Yang, Ningyi Shao, Alexandra Holmström, Xin Zhao, Tony Chour, Haodong Chen, Ilanit Itzhaki, Haodi Wu, Mohamed Ameen, Nathan J Cunningham, Chengyi Tu, Ming-Tao Zhao, Alice F Tarantal, Oscar J Abilez, Joseph C Wu,

<h4>Aims</h4>Stem cell therapy has shown promise for treating myocardial infarction (MI) via re-muscularization and paracrine signaling in both small and large animals. Non-human primates (NHPs), such as rhesus macaques (Macaca mulatta), are primarily utilized in preclinical trials due to their similarity to humans, both genetically and physiologically. Currently, induced pluripotent ... Read more >>

Cardiovasc Res (Cardiovascular research)
[2020, :]

Cited: 1 time

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Endogenous Retrovirus-Derived lncRNA BANCR Promotes Cardiomyocyte Migration in Humans and Non-human Primates.

Kitchener D Wilson, Mohamed Ameen, Hongchao Guo, Oscar J Abilez, Lei Tian, Maxwell R Mumbach, Sebastian Diecke, Xulei Qin, Yonggang Liu, Huaxiao Yang, Ning Ma, Sadhana Gaddam, Nathan J Cunningham, Mingxia Gu, Evgenios Neofytou, Maricela Prado, Thomas B Hildebrandt, Ioannis Karakikes, Howard Y Chang, Joseph C Wu,

Transposable elements (TEs) comprise nearly half of the human genome and are often transcribed or exhibit cis-regulatory properties with unknown function in specific processes such as heart development. In the case of endogenous retroviruses (ERVs), a TE subclass, experimental interrogation is constrained as many are primate-specific or human-specific. Here, we ... Read more >>

Dev Cell (Developmental cell)
[2020, 54(6):694-709.e9]

Cited: 3 times

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Thermodynamic Characterization of the Interaction between the Antimicrobial Drug Sulfamethazine and Two Selected Cyclodextrins.

Hiba Mohamed Ameen, Sándor Kunsági-Máté, Balázs Bognár, Lajos Szente, Miklós Poór, Beáta Lemli,

Sulfamethazine is a representative member of the sulfonamide antibiotic drugs; it is still used in human and veterinary therapy. The protonation state of this drug affects its aqueous solubility, which can be controlled by its inclusion complexes with native or chemically-modified cyclodextrins. In this work, the temperature-dependent (298-313 K) interaction ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2019, 24(24):]

Cited: 4 times

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Procedural memory consolidation is associated with heart rate variability and sleep spindles.

Frank J van Schalkwijk, Theresa Hauser, Kerstin Hoedlmoser, Mohamed S Ameen, Frank H Wilhelm, Cornelia Sauter, Gerhard Klösch, Doris Moser, Georg Gruber, Peter Anderer, Bernd Saletu, Silvia Parapatics, Josef Zeitlhofer, Manuel Schabus,

Sleep and memory studies often focus on overnight rather than long-term memory changes, traditionally associating overnight memory change (OMC) with sleep architecture and sleep patterns such as spindles. In addition, (para-)sympathetic innervation has been associated with OMC after a daytime nap using heart rate variability (HRV). In this study we ... Read more >>

J Sleep Res (Journal of sleep research)
[2020, 29(3):e12910]

Cited: 2 times

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About the Accuracy and Problems of Consumer Devices in the Assessment of Sleep.

Mohamed S Ameen, Lok Man Cheung, Theresa Hauser, Michael A Hahn, Manuel Schabus,

Commercial sleep devices and mobile-phone applications for scoring sleep are gaining ground. In order to provide reliable information about the quantity and/or quality of sleep, their performance needs to be assessed against the current gold standard, i.e., polysomnography (PSG; measuring brain, eye, and muscle activity). Here, we assessed some commercially ... Read more >>

Sensors (Basel) (Sensors (Basel, Switzerland))
[2019, 19(19):]

Cited: 7 times

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About the Accuracy and Problems of Consumer Devices in the Assessment of Sleep

Mohamed Ameen, Lok Man Cheung, Theresa Hauser, Michael Hahn, Manuel Schabus,

Commercial sleep devices and mobile-phone applications for scoring sleep are gaining ground. In order to provide reliable information about the quantity and/or quality of sleep, their performance needs to be assessed against the current gold-standard, i.e. polysomnography (PSG; measuring brain, eye and muscle activity). We here assessed some commercially available ... Read more >>

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Encapsulation of sulfamethazine by native and randomly methylated β-cyclodextrins: The role of the dipole properties of guests.

Hiba Mohamed Ameen, Sándor Kunsági-Máté, Lajos Szente, Beáta Lemli,

Sulfonamides are preventive and therapeutic agents for certain infections caused by gram-positive and gram-negative microorganisms. In this work the interactions of sulfamethazine, a representative of sulfonamide antibiotics, with two β-cyclodextrin derivatives were investigated at different pH. Results show formation of stable sulfamethazine - β-cyclodextrin complexes and reflect importance of the ... Read more >>

Spectrochim Acta A Mol Biomol Spectrosc (Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy)
[2020, 225:117475]

Cited: 2 times

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Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy.

Jaecheol Lee, Vittavat Termglinchan, Sebastian Diecke, Ilanit Itzhaki, Chi Keung Lam, Priyanka Garg, Edward Lau, Matthew Greenhaw, Timon Seeger, Haodi Wu, Joe Z Zhang, Xingqi Chen, Isaac Perea Gil, Mohamed Ameen, Karim Sallam, June-Wha Rhee, Jared M Churko, Rinkal Chaudhary, Tony Chour, Paul J Wang, Michael P Snyder, Howard Y Chang, Ioannis Karakikes, Joseph C Wu,

Lamin A/C (LMNA) is one of the most frequently mutated genes associated with dilated cardiomyopathy (DCM). DCM related to mutations in LMNA is a common inherited cardiomyopathy that is associated with systolic dysfunction and cardiac arrhythmias. Here we modelled the LMNA-related DCM in vitro using patient-specific induced pluripotent stem cell-derived ... Read more >>

Nature (Nature)
[2019, 572(7769):335-340]

Cited: 34 times

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Personalized medicine in cardio-oncology: the role of induced pluripotent stem cell.

Nazish Sayed, Mohamed Ameen, Joseph C Wu,

Treatment of cancer has evolved in the last decade with the introduction of new therapies. Despite these successes, the lingering cardiotoxic side-effects from chemotherapy remain a major cause of morbidity and mortality in cancer survivors. These effects can develop acutely during treatment, or even years later. Although many risk factors ... Read more >>

Cardiovasc Res (Cardiovascular research)
[2019, 115(5):949-959]

Cited: 16 times

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Global variation in anastomosis and end colostomy formation following left-sided colorectal resection.

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<h4>Background</h4>End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection.<h4>Methods</h4>This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, ... Read more >>

BJS Open (BJS open)
[2019, 3(3):403-414]

Cited: 3 times

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Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy.

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<h4>Background</h4>The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality ... Read more >>

Br J Surg (The British journal of surgery)
[2019, 106(2):e103-e112]

Cited: 13 times

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Functional Biointerfaces Based on Mixed Zwitterionic Self-Assembled Monolayers for Biosensing Applications.

Yu-Sin Wang, Shuehlin Yau, Lai-Kwan Chau, Ameen Mohamed, Chun-Jen Huang,

Surface modification for biosensors has focused attention for improvement of their sensitivity and specificity, particularly for the detection in complex medium. In this work, we have synthesized zwitterionic carboxybetaine-thiols (CB-thiols) and sulfobetaine-thiols (SB-thiols) for modification of gold substrates to form a functional self-assembled monolayer (SAM) for the immunoassay in a ... Read more >>

Langmuir (Langmuir : the ACS journal of surfaces and colloids)
[2019, 35(5):1652-1661]

Cited: 5 times

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Laparoscopy in management of appendicitis in high-, middle-, and low-income countries: a multicenter, prospective, cohort study.

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<h4>Background</h4>Appendicitis is the most common abdominal surgical emergency worldwide. Differences between high- and low-income settings in the availability of laparoscopic appendectomy, alternative management choices, and outcomes are poorly described. The aim was to identify variation in surgical management and outcomes of appendicitis within low-, middle-, and high-Human Development Index (HDI) ... Read more >>

Surg Endosc (Surgical endoscopy)
[2018, 32(8):3450-3466]

Cited: 12 times

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Induced Pluripotent Stem Cell Model of Pulmonary Arterial Hypertension Reveals Novel Gene Expression and Patient Specificity.

Silin Sa, Mingxia Gu, James Chappell, Ning-Yi Shao, Mohamed Ameen, Kathryn A T Elliott, Dan Li, Fabian Grubert, Caiyun G Li, Shalina Taylor, Aiqin Cao, Yu Ma, Ryan Fong, Long Nguyen, Joseph C Wu, Michael P Snyder, Marlene Rabinovitch,

<h4>Rationale</h4>Idiopathic or heritable pulmonary arterial hypertension is characterized by loss and obliteration of lung vasculature. Endothelial cell dysfunction is pivotal to the pathophysiology, but different causal mechanisms may reflect a need for patient-tailored therapies.<h4>Objectives</h4>Endothelial cells differentiated from induced pluripotent stem cells were compared with pulmonary arterial endothelial cells from the ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2017, 195(7):930-941]

Cited: 35 times

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Transcriptomic and epigenomic differences in human induced pluripotent stem cells generated from six reprogramming methods.

Jared M Churko, Jaecheol Lee, Mohamed Ameen, Mingxia Gu, Meenakshi Venkatasubramanian, Sebastian Diecke, Karim Sallam, Hogune Im, Gavin Wang, Joseph D Gold, Nathan Salomonis, Michael P Snyder, Joseph C Wu,

Many reprogramming methods can generate human induced pluripotent stem cells (hiPSCs) that closely resemble human embryonic stem cells (hESCs). This has led to assessments of how similar hiPSCs are to hESCs, by evaluating differences in gene expression, epigenetic marks and differentiation potential. However, all previous studies were performed using hiPSCs ... Read more >>

Nat Biomed Eng (Nature biomedical engineering)
[2017, 1(10):826-837]

Cited: 12 times

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Determinants of morbidity and mortality following emergency abdominal surgery in children in low-income and middle-income countries.

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<h4>Background</h4>Child health is a key priority on the global health agenda, yet the provision of essential and emergency surgery in children is patchy in resource-poor regions. This study was aimed to determine the mortality risk for emergency abdominal paediatric surgery in low-income countries globally.<h4>Methods</h4>Multicentre, international, prospective, cohort study. Self-selected surgical ... Read more >>

BMJ Glob Health (BMJ global health)
[2016, 1(4):e000091]

Cited: 10 times

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A Comprehensive TALEN-Based Knockout Library for Generating Human-Induced Pluripotent Stem Cell-Based Models for Cardiovascular Diseases.

Ioannis Karakikes, Vittavat Termglinchan, Diana A Cepeda, Jaecheol Lee, Sebastian Diecke, Ayal Hendel, Ilanit Itzhaki, Mohamed Ameen, Rajani Shrestha, Haodi Wu, Ning Ma, Ning-Yi Shao, Timon Seeger, Nicole Woo, Kitchener D Wilson, Elena Matsa, Matthew H Porteus, Vittorio Sebastiano, Joseph C Wu,

<h4>Rationale</h4>Targeted genetic engineering using programmable nucleases such as transcription activator-like effector nucleases (TALENs) is a valuable tool for precise, site-specific genetic modification in the human genome.<h4>Objective</h4>The emergence of novel technologies such as human induced pluripotent stem cells (iPSCs) and nuclease-mediated genome editing represent a unique opportunity for studying cardiovascular diseases ... Read more >>

Circ Res (Circulation research)
[2017, 120(10):1561-1571]

Cited: 27 times

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Magnetic Resonance Imaging of Cardiac Strain Pattern Following Transplantation of Human Tissue Engineered Heart Muscles.

Xulei Qin, Johannes Riegler, Malte Tiburcy, Xin Zhao, Tony Chour, Babacar Ndoye, Michael Nguyen, Jackson Adams, Mohamed Ameen, Thomas S Denney, Phillip C Yang, Patricia Nguyen, Wolfram H Zimmermann, Joseph C Wu,

<h4>Background</h4>The use of tissue engineering approaches in combination with exogenously produced cardiomyocytes offers the potential to restore contractile function after myocardial injury. However, current techniques assessing changes in global cardiac performance after such treatments are plagued by relatively low detection ability. Since the treatment is locally performed, this detection could ... Read more >>

Circ Cardiovasc Imaging (Circulation. Cardiovascular imaging)
[2016, 9(11):]

Cited: 7 times

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Patient-Specific iPSC-Derived Endothelial Cells Uncover Pathways that Protect against Pulmonary Hypertension in BMPR2 Mutation Carriers.

Mingxia Gu, Ning-Yi Shao, Silin Sa, Dan Li, Vittavat Termglinchan, Mohamed Ameen, Ioannis Karakikes, Gustavo Sosa, Fabian Grubert, Jaecheol Lee, Aiqin Cao, Shalina Taylor, Yu Ma, Zhixin Zhao, James Chappell, Rizwan Hamid, Eric D Austin, Joseph D Gold, Joseph C Wu, Michael P Snyder, Marlene Rabinovitch,

In familial pulmonary arterial hypertension (FPAH), the autosomal dominant disease-causing BMPR2 mutation is only 20% penetrant, suggesting that genetic variation provides modifiers that alleviate the disease. Here, we used comparison of induced pluripotent stem cell-derived endothelial cells (iPSC-ECs) from three families with unaffected mutation carriers (UMCs), FPAH patients, and gender-matched controls ... Read more >>

Cell Stem Cell (Cell stem cell)
[2017, 20(4):490-504.e5]

Cited: 78 times

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Comparison of Magnetic Resonance Imaging and Serum Biomarkers for Detection of Human Pluripotent Stem Cell-Derived Teratomas.

Johannes Riegler, Antje Ebert, Xulei Qin, Qi Shen, Mouer Wang, Mohamed Ameen, Kazuki Kodo, Sang-Ging Ong, Won Hee Lee, Grace Lee, Evgenios Neofytou, Joseph D Gold, Andrew J Connolly, Joseph C Wu,

The use of cells derived from pluripotent stem cells (PSCs) for regenerative therapies confers a considerable risk for neoplastic growth and teratoma formation. Preclinical and clinical assessment of such therapies will require suitable monitoring strategies to understand and mitigate these risks. Here we generated human-induced pluripotent stem cells (iPSCs), selected ... Read more >>

Stem Cell Reports (Stem cell reports)
[2016, 6(2):176-187]

Cited: 16 times

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Human induced pluripotent stem cell-derived cardiomyocytes: insights into molecular, cellular, and functional phenotypes.

Ioannis Karakikes, Mohamed Ameen, Vittavat Termglinchan, Joseph C Wu,

Disease models are essential for understanding cardiovascular disease pathogenesis and developing new therapeutics. The human induced pluripotent stem cell (iPSC) technology has generated significant enthusiasm for its potential application in basic and translational cardiac research. Patient-specific iPSC-derived cardiomyocytes offer an attractive experimental platform to model cardiovascular diseases, study the earliest ... Read more >>

Circ Res (Circulation research)
[2015, 117(1):80-88]

Cited: 153 times

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Statistical modelling of networked human-automation performance using working memory capacity.

Nisar Ahmed, Ewart de Visser, Tyler Shaw, Amira Mohamed-Ameen, Mark Campbell, Raja Parasuraman,

This study examines the challenging problem of modelling the interaction between individual attentional limitations and decision-making performance in networked human-automation system tasks. Analysis of real experimental data from a task involving networked supervision of multiple unmanned aerial vehicles by human participants shows that both task load and network message quality ... Read more >>

Ergonomics (Ergonomics)
[2014, 57(3):295-318]

Cited: 5 times

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