Full Text Journal Articles by
Author Mohamed A Fouda

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Distinct effects of calcineurin dependent and independent immunosuppressants on endotoxaemia-induced nephrotoxicity in rats: Role of androgens.

Shrouk S Elzokm, Mohamed A Fouda, Rahab A Abdel Moneim, Mahmoud M El-Mas,

Evidence suggests that immunosuppressant therapies protect against harmful effects of endotoxaemia. In this study, we tested whether calcineurin-dependent (cyclosporine/tacrolimus) and -independent (sirolimus) immunosuppressants variably influence nephrotoxicity induced by endotoxaemia and whether this interaction is modulated by testosterone. We investigated the effects of immunosuppressants on renal histopathological, biochemical and inflammatory profiles ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2021, 48(9):1261-1270]

Cited: 0 times

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Protein Kinases Mediate Anti-Inflammatory Effects of Cannabidiol and Estradiol Against High Glucose in Cardiac Sodium Channels.

Mohamed A Fouda, Peter C Ruben,

<b>Background:</b> Cardiovascular anomalies are predisposing factors for diabetes-induced morbidity and mortality. Recently, we showed that high glucose induces changes in the biophysical properties of the cardiac voltage-gated sodium channel (Nav1.5) that could be strongly correlated to diabetes-induced arrhythmia. However, the mechanisms underlying hyperglycemia-induced inflammation, and how inflammation provokes cardiac arrhythmia, ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2021, 12:668657]

Cited: 1 time

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Nicotine uncovers endotoxic-like cardiovascular manifestations in female rats: Estrogen and nitric oxide dependency.

Mohammed A El-Lakany, Hanan M El-Gowelli, Mohamed A Fouda, Marwa Y Sallam, Mahmoud M El-Mas,

Endotoxic manifestations are diminished in female populations due to immune boosting actions of sex steroids. Considering that tobacco constituents including nicotine inhibit estrogen synthesis, we tested the hypothesis that nicotine exposure unveils cardiovascular anomalies of endotoxemia in female rats. Studies were undertaken in conscious female rats treated with i.v. lipopolysaccharide ... Read more >>

Toxicol Lett (Toxicology letters)
[2020, 335:28-36]

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Cannabidiol protects against high glucose-induced oxidative stress and cytotoxicity in cardiac voltage-gated sodium channels.

Mohamed A Fouda, Mohammad-Reza Ghovanloo, Peter C Ruben,

<h4>Background and purpose</h4>Cardiovascular complications are the major cause of mortality in diabetic patients. However, the molecular mechanisms underlying diabetes-associated arrhythmias are unclear. We hypothesized that high glucose could adversely affect Na<sub>v</sub> 1.5, the major cardiac sodium channel isoform of the heart, at least partially via oxidative stress. We further hypothesized ... Read more >>

Br J Pharmacol (British journal of pharmacology)
[2020, 177(13):2932-2946]

Cited: 9 times

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Estrogen-dependent hypersensitivity to diabetes-evoked cardiac autonomic dysregulation: Role of hypothalamic neuroinflammation.

Mohamed A Fouda, Korin E Leffler, Abdel A Abdel-Rahman,

<h4>Aims</h4>To investigate if autonomic dysregulation is exacerbated in female rats, subjected to diabetes mellitus (DM), via a paradoxical estrogen (E<sub>2</sub>)-evoked provocation of neuroinflammation/injury of the hypothalamic paraventricular nucleus (PVN).<h4>Main methods</h4>We measured cardiac autonomic function and conducted subsequent PVN neurochemical studies, in DM rats, and their respective controls, divided as follows: ... Read more >>

Life Sci (Life sciences)
[2020, 250:117598]

Cited: 1 time

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Ovariectomy provokes inflammatory and cardiovascular effects of endotoxemia in rats: Dissimilar benefits of hormonal supplements.

Mohammed A El-Lakany, Mohamed A Fouda, Hanan M El-Gowelli, Mahmoud M El-Mas,

The female gender is protected against immunological complications of endotoxemia. Here we investigated whether gonadal hormone depletion by ovariectomy (OVX) uncovers inflammatory and cardiovascular effects of endotoxemia and whether these effects are reversed by hormone replacement therapies. Changes in inflammatory cytokines, blood pressure (BP), left ventricular (LV) function, and cardiac ... Read more >>

Toxicol Appl Pharmacol (Toxicology and applied pharmacology)
[2020, 393:114928]

Cited: 1 time

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Amelioration of perivascular adipose inflammation reverses vascular dysfunction in a model of nonobese prediabetic metabolic challenge: potential role of antidiabetic drugs.

Mohammed A W Elkhatib, Ali Mroueh, Rim W Rafeh, Fatima Sleiman, Hosny Fouad, Evan I Saad, Mohamed A Fouda, Ola Elgaddar, Khodr Issa, Ali H Eid, Assaad A Eid, Khaled S Abd-Elrahman, Ahmed F El-Yazbi,

The onset of vascular impairment precedes that of diagnostic hyperglycemia in diabetic patients suggesting a vascular insult early in the course of metabolic dysfunction without a well-defined mechanism. Mounting evidence implicates adipose inflammation in the pathogenesis of insulin resistance and diabetes. It is not certain whether amelioration of adipose inflammation ... Read more >>

Transl Res (Translational research : the journal of laboratory and clinical medicine)
[2019, 214:121-143]

Cited: 4 times

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Brainstem cholinergic pathways diminish cardiovascular and neuroinflammatory actions of endotoxemia in rats: Role of NFκB/α7/α4β2AChRs signaling.

Marwa Y Sallam, Sahar M El-Gowilly, Mohamed A Fouda, Mohammed M Abd-Alhaseeb, Mahmoud M El-Mas,

Nicotine improves endotoxic manifestations of hypotension and cardiac autonomic dysfunction in rats. Here, we test the hypothesis that brainstem antiinflammatory pathways of α7/α4β2 nicotinic acetylcholine receptors (nAChRs) modulate endotoxic cardiovascular derangements. Pharmacologic and molecular studies were performed to determine the influence of nicotine or selective α7/α4β2-nAChR ligands on cardiovascular derangements ... Read more >>

Neuropharmacology (Neuropharmacology)
[2019, 157:107683]

Cited: 1 time

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Restoration of Rostral Ventrolateral Medulla Cystathionine-γ Lyase Activity Underlies Moxonidine-Evoked Neuroprotection and Sympathoinhibition in Diabetic Rats.

Mohamed A Fouda, Shaimaa S El-Sayed, Abdel A Abdel-Rahman,

We recently demonstrated a fundamental role for cystathionine-<i>γ</i> lyase (CSE)-derived hydrogen sulfide (H<sub>2</sub>S) in the cardioprotective effect of the centrally acting drug moxonidine in diabetic rats. Whether a downregulated CSE/H<sub>2</sub>S system in the rostral ventrolateral medulla (RVLM) underlies neuronal oxidative stress and sympathoexcitation in diabetes has not been investigated. Along ... Read more >>

J Pharmacol Exp Ther (The Journal of pharmacology and experimental therapeutics)
[2018, 364(2):170-178]

Cited: 2 times

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Gonadal hormone receptors underlie the resistance of female rats to inflammatory and cardiovascular complications of endotoxemia.

Mohammed A El-Lakany, Mohamed A Fouda, Hanan M El-Gowelli, Sahar M El-Gowilly, Mahmoud M El-Mas,

The male gender is more vulnerable to immunological complications of sepsis. Here, we tested the hypotheses that female rats are protected against endotoxemia-evoked hypotension and cardiac autonomic dysfunction, and that gonadal hormone receptors account for such protection. Changes in blood pressure, heart rate, and cardiac sympathovagal balance caused by i.v. ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[2018, 823:41-48]

Cited: 5 times

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Virulence and extended-spectrum β-lactamase encoding genes in Escherichia coli recovered from chicken meat intended for hospitalized human consumption.

Gamal A Younis, Rasha M Elkenany, Mohamed A Fouda, Noura F Mostafa,

Aim:This study describes the prevalence of Escherichia coli in frozen chicken meat intended for human consumption with emphasis on their virulence determinants through detection of the virulence genes and recognition of the extended-spectrum β-lactamase (ESBL) encoding genes (blaOXA and blaTEM genes). Materials and Methods:A total of 120 frozen chicken meat ... Read more >>

Vet World (Veterinary world)
[2017, 10(10):1281-1285]

Cited: 2 times

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Hemin blunts the depressant effect of chronic nicotine on reflex tachycardia via activation of central NOS/PI3K pathway in female rats.

Mohamed A Fouda, Hanan M El-Gowelli, Sahar M El-Gowilly, Mahmoud M El-Mas,

BACKGROUND:Chronic nicotine administration impairs reflex chronotropic responses that follow arterial baroreceptor unloading in female rats with repleted, but not depleted (ovariectomized, OVX), estrogen (E2). This study investigated whether products of nitric oxide synthase (NOS) and/or heme oxygenase (HO) and related soluble guanylate cyclase (sGC)/phosphatidylinositol 3-kinase (PI3K)/mitogen-activated protein kinases (MAPKs) signaling ... Read more >>

Pharmacol Rep (Pharmacological reports : PR)
[2018, 70(3):455-462]

Cited: 0 times

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Endothelin Confers Protection against High Glucose-Induced Neurotoxicity via Alleviation of Oxidative Stress.

Mohamed A Fouda, Abdel A Abdel-Rahman,

Recent findings linked the inhibition in the neuromodulator peptide endothelin-1 (ET-1) level to the high glucose-evoked neurotoxicity. However, definitive neuroprotective role for ET-1 and the major neuronal ET (ET-3) against high glucose-evoked toxicity and the implicated neurochemical responses triggered by their ET-A and ET-B receptors remain unknown. Here, we tested ... Read more >>

J Pharmacol Exp Ther (The Journal of pharmacology and experimental therapeutics)
[2017, 361(1):130-139]

Cited: 7 times

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The estrogen-dependent baroreflex dysfunction caused by nicotine in female rats is mediated via NOS/HO inhibition: Role of sGC/PI3K/MAPKERK.

Mohamed A Fouda, Hanan M El-Gowelli, Sahar M El-Gowilly, Mahmoud M El-Mas,

We have previously reported that estrogen (E2) exacerbates the depressant effect of chronic nicotine on arterial baroreceptor activity in female rats. Here, we tested the hypothesis that this nicotine effect is modulated by nitric oxide synthase (NOS) and/or heme oxygenase (HO) and their downstream soluble guanylate cyclase (sGC)/phosphatidylinositol 3-kinase (PI3K)/mitogen-activated ... Read more >>

Toxicol Appl Pharmacol (Toxicology and applied pharmacology)
[2015, 289(3):466-473]

Cited: 0 times

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Impairment of nitric oxide synthase but not heme oxygenase accounts for baroreflex dysfunction caused by chronic nicotine in female rats.

Mohamed A Fouda, Hanan M El-Gowelli, Sahar M El-Gowilly, Laila Rashed, Mahmoud M El-Mas,

We recently reported that chronic nicotine impairs reflex chronotropic activity in female rats. Here, we sought evidence to implicate nitric oxide synthase (NOS) and/or heme oxygenase (HO) in the nicotine-baroreflex interaction. Baroreflex curves relating changes in heart rate to increases (phenylephrine) or decreases (sodium nitroprusside) in blood pressure were generated ... Read more >>

PLoS One (PloS one)
[2014, 9(5):e98681]

Cited: 1 time

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Estrogen provokes the depressant effect of chronic nicotine on vagally mediated reflex chronotropism in female rats.

Mahmoud M El-Mas, Hanan M El-Gowelli, Sahar M El-Gowilly, Mohamed A Fouda, Mai M Helmy,

We recently reported that acute nicotine impairs reflex tachycardic activity in estrogen-depleted, but not estrogen-repleted, female rats, suggesting a restraining influence for estrogen against the nicotine effect. In this study, we tested whether the baroreflex-protective effect of estrogen can be replicated when nicotine was administered chronically. We also report on ... Read more >>

J Pharmacol Exp Ther (The Journal of pharmacology and experimental therapeutics)
[2012, 342(2):568-575]

Cited: 9 times

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Central estrogenic pathways protect against the depressant action of acute nicotine on reflex tachycardia in female rats.

Mahmoud M El-Mas, Mohamed A Fouda, Sahar M El-Gowilly, Evan I Saad,

We have previously shown that acute exposure of male rats to nicotine preferentially attenuates baroreceptor-mediated control of reflex tachycardia in contrast to no effect on reflex bradycardia. Here, we investigated whether female rats are as sensitive as their male counterparts to the baroreflex depressant effect of nicotine and whether this ... Read more >>

Toxicol Appl Pharmacol (Toxicology and applied pharmacology)
[2012, 258(3):410-417]

Cited: 5 times

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Hyperechogenic renal parenchyma in potential live related kidney donors: Does it justify exclusion?

Mohamed A Fouda, Ahmed A Shokeir, Ehab W Wafa, Ayman F Refaie, Tarek El Diasty, Mona Abdelrahim, Mohamed A Sobh, Mohamed A Ghoneim,

<h4>Objectives</h4>To assess the predictive importance of ultrasonic grade 1 hyperechogenicity in potential live related kidney donors in the absence of urinary abnormalities and with perfect renal function.<h4>Subjects and methods</h4>The study included 34 potential living related kidney donors with this abnormality; their mean (SD, range) age was 32.7 (8.45, 23-48) years. ... Read more >>

Arab J Urol (Arab journal of urology)
[2011, 9(4):235-239]

Cited: 0 times

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Role of adenosine A2A receptor signaling in the nicotine-evoked attenuation of reflex cardiac sympathetic control.

Mahmoud M El-Mas, Sahar M El-Gowilly, Mohamed A Fouda, Evan I Saad,

Baroreflex dysfunction contributes to increased cardiovascular risk in cigarette smokers. Given the importance of adenosinergic pathways in baroreflex control, the hypothesis was tested that defective central adenosinergic modulation of cardiac autonomic activity mediates the nicotine-baroreflex interaction. Baroreflex curves relating changes in heart rate (HR) to increases or decreases in blood ... Read more >>

Toxicol Appl Pharmacol (Toxicology and applied pharmacology)
[2011, 254(3):229-237]

Cited: 9 times

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Effect of donor and recipient variables on the long-term live-donor renal allograft survival in children.

Ehab W Wafa, Ahmed A Shokeir, Ahmed Akl, Nabil Hassan, Mohamed A Fouda, Kalid El Dahshan, Mohamed A Ghoneim,

<h4>Objective</h4>We aimed to analyse donor and recipient predictors of graft survival in children who received live-donor renal grafts.<h4>Patients and methods</h4>The study comprised 273 children who received live-donor renal transplants at our center between March 1976 and October 2010. The follow-up ranged from 6 months to 25 years. Donor variables included donor age, ... Read more >>

Arab J Urol (Arab journal of urology)
[2011, 9(2):85-91]

Cited: 2 times

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End-stage renal disease among living-kidney donors: single-center experience.

Ehab W Wafa, Ayman F Refaie, Tarek M Abbas, Mohamed A Fouda, Hussein A Sheashaa, Amani Mostafa, Mohamed I Abo El Ghar, Mohamed A Ghoneim,

<h4>Objectives</h4>Renal transplant from living donors is widely accepted as a highly effective treatment for end-stage renal disease. Donors undergo a major operation with considerable perioperative risks of morbidity and mortality. Living with a single kidney also confers long-term risks. This study sought the incidence and causes of end-stage renal disease ... Read more >>

Exp Clin Transplant (Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation)
[2011, 9(1):14-19]

Cited: 11 times

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Comparative analysis of azathioprine versus cyclosporine-based therapy in primary haplo-identical live-donor kidney transplantation: a 20-year experience.

Osama A Gheith, Mohamed A Bakr, Mohamed A Fouda, Ahmed A Shokeir, Mohamed Sobh, Mohamed Ghoneim,

Chronic allograft nephropathy (CAN) remains a major cause of graft failure over the long term, second only to patient mortality. The main adverse effects of cyclosporine A (CsA) include nephrotoxicity, hypertension, symptomatic hyperuricemia, hirsutism, and gum hyperplasia. Available studies among live related donor renal transplants lack adequate information regarding the ... Read more >>

Saudi J Kidney Dis Transpl (Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia)
[2008, 19(4):564-570]

Cited: 2 times

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Steroid and azathioprine versus steroid, cyclosporine, and azathioprine therapies in primary haplo-identical living donor kidney transplantation: twenty-year experience.

Osama A Gheith, Mohamed A Bakr, Mohamed A Fouda, Ahmed A Shokeir, Ahmed Bayoumy, Mohamed Sobh, Mohamed Ghoneim,

<h4>Introduction</h4>Achievements in short-term graft survival since the introduction of cyclosporine has not been matched by improvement in long-term graft function, and chronic allograft nephropathy remains the second commonest cause of graft attrition over time. We aimed to evaluate the long-term results of conventional immunosuppression by steroid and azathioprine in comparison ... Read more >>

Iran J Kidney Dis (Iranian journal of kidney diseases)
[2008, 2(1):34-39]

Cited: 4 times

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Prospective randomized study of azathioprine vs cyclosporine based therapy in primary haplo-identical living-donor kidney transplantation: 20-year experience.

Osama A Gheith, Mohamed A Bakr, Mohamed A Fouda, Ahmed A Shokeir, Mohamed Sobh, Mohamed Ghoneim,

<h4>Background</h4>The achievements in short-term graft survival since the introduction of cyclosporine (CsA) have not been matched by improvements in long-term graft function. Chronic allograft nephropathy (CAN) remains the second most common cause of graft attrition over time, after patient mortality. We aimed to evaluate the long-term results of azathioprine vs ... Read more >>

Clin Exp Nephrol (Clinical and experimental nephrology)
[2007, 11(2):151-155]

Cited: 8 times

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Coronary artery bypass grafting on beating heart. Does it provide superior myocardial preservation than conventional technique?

Anjum Jalal, Aftab Yunus, Ahmed Mn Abualazm, Bakir M Bakir, Nazeh E El-Fakarany, Khaled A Abdul-Salam, Mohamed A Fouda,

OBJECTIVE: To compare myocardial injury caused by 3 commonly used methods for coronary artery bypass grafting (CABG). METHODS: A prospective randomized study conducted at King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia. The study started in February 2003 and concluded in April 2004 after including 45 patients (15 patients ... Read more >>

Saudi Med J (Saudi medical journal)
[2007, 28(6):848-854]

Cited: 2 times

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