Full Text Journal Articles by
Author Mogens S Lund

Advertisement

Find full text journal articles






Genetic parameters of semen quality traits and genetic correlations with service sire nonreturn rate in Nordic Holstein bulls.

Grum Gebreyesus, Mogens S Lund, Kasia Kupisiewicz, Guosheng Su,

Despite the importance of the quality of semen used in artificial insemination to the reproductive success of dairy herds, few studies have estimated the extent of genetic variability in semen quality traits. Even fewer studies have quantified the correlation between semen quality traits and male fertility. In this study, records ... Read more >>

J Dairy Sci (Journal of dairy science)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Genomic prediction using a reference population of multiple pure breeds and admixed individuals.

Emre Karaman, Guosheng Su, Iola Croue, Mogens S Lund,

<h4>Background</h4>In dairy cattle populations in which crossbreeding has been used, animals show some level of diversity in their origins. In rotational crossbreeding, for instance, crossbred dams are mated with purebred sires from different pure breeds, and the genetic composition of crossbred animals is an admixture of the breeds included in ... Read more >>

Genet Sel Evol (Genetics, selection, evolution : GSE)
[2021, 53(1):46]

Cited: 0 times

View full text PDF listing >>



Advertisement

Genomic selection in American mink (Neovison vison) using a single-step genomic best linear unbiased prediction model for size and quality traits graded on live mink.

Trine M Villumsen, Guosheng Su, Bernt Guldbrandtsen, Torben Asp, Mogens S Lund,

Genomic selection relies on single-nucleotide polymorphisms (SNPs), which are often collected using medium-density SNP arrays. In mink, no such array is available; instead, genotyping by sequencing (GBS) can be used to generate marker information. Here, we evaluated the effect of genomic selection for mink using GBS. We compared the estimated ... Read more >>

J Anim Sci (Journal of animal science)
[2021, 99(1):]

Cited: 0 times

View full text PDF listing >>



Novel approach to incorporate information about recessive lethal genes increases the accuracy of genomic prediction for mortality traits.

Grum Gebreyesus, Goutam Sahana, A Christian Sørensen, Mogens S Lund, Guosheng Su,

The genetic underpinnings of calf mortality can be partly polygenic and partly due to deleterious effects of recessive lethal alleles. Prediction of the genetic merits of selection candidates should thus take into account both genetic components contributing to calf mortality. However, simultaneously modeling polygenic risk and recessive lethal allele effects ... Read more >>

Heredity (Edinb) (Heredity)
[2020, 125(3):155-166]

Cited: 0 times

View full text PDF listing >>



Correction: Multi-trait single-step genomic prediction accounting for heterogeneous (co)variances over the genome.

Emre Karaman, Mogens S Lund, Guosheng Su,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Heredity (Edinb) (Heredity)
[2020, 124(4):618]

Cited: 1 time

View full text PDF listing >>



Novel haplotypes responsible for prenatal death in Nordic Red and Danish Jersey cattle.

Xiaoping Wu, Md Mesbah-Uddin, Bernt Guldbrandtsen, Mogens S Lund, Goutam Sahana,

Haplotypes that are common in a population but not observed as homotypes in living animals may harbor lethal alleles that compromise embryo survival. In this study, we searched for homozygous-deficient haplotypes in the genomes of 19,309 Nordic Red Dairy (RDC) and 4,291 Danish Jersey (JER) cattle genotyped using the Illumina ... Read more >>

J Dairy Sci (Journal of dairy science)
[2020, 103(5):4570-4578]

Cited: 2 times

View full text PDF listing >>



Multi-trait single-step genomic prediction accounting for heterogeneous (co)variances over the genome.

Emre Karaman, Mogens S Lund, Guosheng Su,

Widely used genomic prediction models may not properly account for heterogeneous (co)variance structure across the genome. Models such as BayesA and BayesB assume locus-specific variance, which are highly influenced by the prior for (co)variance of single nucleotide polymorphism (SNP) effect, regardless of the size of data. Models such as BayesC ... Read more >>

Heredity (Edinb) (Heredity)
[2020, 124(2):274-287]

Cited: 4 times

View full text PDF listing >>



Haplotypes responsible for early embryonic lethality detected in Nordic Holsteins.

Xiaoping Wu, Md Mesbah-Uddin, Bernt Guldbrandtsen, Mogens S Lund, Goutam Sahana,

Widespread use of a limited number of elite sires in dairy cattle breeding increases the risk of some deleterious allelic variants spreading in the population. Genomic data are being used to detect relatively common (frequency >1%) haplotypes that never occur in the homozygous state in live animals. Such haplotypes likely ... Read more >>

J Dairy Sci (Journal of dairy science)
[2019, 102(12):11116-11123]

Cited: 0 times

View full text PDF listing >>



Quantifying the contribution of sequence variants with regulatory and evolutionary significance to 34 bovine complex traits.

Ruidong Xiang, Irene van den Berg, Iona M MacLeod, Benjamin J Hayes, Claire P Prowse-Wilkins, Min Wang, Sunduimijid Bolormaa, Zhiqian Liu, Simone J Rochfort, Coralie M Reich, Brett A Mason, Christy J Vander Jagt, Hans D Daetwyler, Mogens S Lund, Amanda J Chamberlain, Michael E Goddard,

Many genome variants shaping mammalian phenotype are hypothesized to regulate gene transcription and/or to be under selection. However, most of the evidence to support this hypothesis comes from human studies. Systematic evidence for regulatory and evolutionary signals contributing to complex traits in a different mammalian model is needed. Sequence variants ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2019, 116(39):19398-19408]

Cited: 22 times

View full text PDF listing >>



Reliability of genomic prediction for milk fatty acid composition by using a multi-population reference and incorporating GWAS results.

Grum Gebreyesus, Henk Bovenhuis, Mogens S Lund, Nina A Poulsen, Dongxiao Sun, Bart Buitenhuis,

<h4>Background</h4>Large-scale phenotyping for detailed milk fatty acid (FA) composition is difficult due to expensive and time-consuming analytical techniques. Reliability of genomic prediction is often low for traits that are expensive/difficult to measure and for breeds with a small reference population size. An effective method to increase reference population size could ... Read more >>

Genet Sel Evol (Genetics, selection, evolution : GSE)
[2019, 51(1):16]

Cited: 2 times

View full text PDF listing >>



Use of a Bayesian model including QTL markers increases prediction reliability when test animals are distant from the reference population.

Peipei Ma, Mogens S Lund, Gert P Aamand, Guosheng Su,

Relatedness between reference and test animals has an important effect on the reliability of genomic prediction for test animals. Because genomic prediction has been widely applied in practical cattle breeding and bulls have been selected according to genomic breeding value without progeny testing, the sires or grandsires of candidates might ... Read more >>

J Dairy Sci (Journal of dairy science)
[2019, 102(8):7237-7247]

Cited: 2 times

View full text PDF listing >>



Selection for temperament has no negative consequences on important production traits in farmed mink1.

Janne P Thirstrup, Trine M Villumsen, Jens Malmkvist, Mogens S Lund,

Danish and European legislation recommend mink breeding programs that include selection for "confidence," defined as exploratory activity in a standardized behavioral test. Although this recommendation may improve mink welfare, farmers may consider this criterion risky due to possible negative consequences on other traits. The overall objectives of this study were ... Read more >>

J Anim Sci (Journal of animal science)
[2019, 97(5):1987-1995]

Cited: 2 times

View full text PDF listing >>



Introgression of Chinese haplotypes contributed to the improvement of Danish Duroc pigs.

Minhui Chen, Guosheng Su, Jinluan Fu, Aiguo Wang, Jian-Feng Liu, Mogens S Lund, Bernt Guldbrandtsen,

The distribution of Asian ancestry in the genome of Danish Duroc pigs was investigated using whole-genome sequencing data from European wild boars, Danish Duroc, Chinese Meishan and Bamaxiang pigs. Asian haplotypes deriving from Meishan and Bamaxiang occur widely across the genome. Signatures of selection on Asian haplotypes are common in ... Read more >>

Evol Appl (Evolutionary applications)
[2019, 12(2):292-300]

Cited: 2 times

View full text PDF listing >>



A Meta-Analysis Including Pre-selected Sequence Variants Associated With Seven Traits in Three French Dairy Cattle Populations.

Andrew G Marete, Bernt Guldbrandtsen, Mogens S Lund, Sébastien Fritz, Goutam Sahana, Didier Boichard,

A within-breed genome-wide association study (GWAS) is useful when identifying the QTL that segregates in a breed. However, an across-breed meta-analysis can be used to increase the power of identification and precise localization of QTL that segregate in multiple breeds. Precise localization will allow including QTL information from other breeds ... Read more >>

Front Genet (Frontiers in genetics)
[2018, 9:522]

Cited: 6 times

View full text PDF listing >>



Genomic Prediction Using Multi-trait Weighted GBLUP Accounting for Heterogeneous Variances and Covariances Across the Genome.

Emre Karaman, Mogens S Lund, Mahlet T Anche, Luc Janss, Guosheng Su,

Implicit assumption of common (co)variance for all loci in multi-trait Genomic Best Linear Unbiased Prediction (GBLUP) results in a genomic relationship matrix (<b>G</b>) that is common to all traits. When this assumption is violated, Bayesian whole genome regression methods may be superior to GBLUP by accounting for unequal (co)variance for ... Read more >>

G3 (Bethesda) (G3 (Bethesda, Md.))
[2018, 8(11):3549-3558]

Cited: 10 times

View full text PDF listing >>



Meta-analysis of genome-wide association studies for cattle stature identifies common genes that regulate body size in mammals.

Aniek C Bouwman, Hans D Daetwyler, Amanda J Chamberlain, Carla Hurtado Ponce, Mehdi Sargolzaei, Flavio S Schenkel, Goutam Sahana, Armelle Govignon-Gion, Simon Boitard, Marlies Dolezal, Hubert Pausch, Rasmus F Brøndum, Phil J Bowman, Bo Thomsen, Bernt Guldbrandtsen, Mogens S Lund, Bertrand Servin, Dorian J Garrick, James Reecy, Johanna Vilkki, Alessandro Bagnato, Min Wang, Jesse L Hoff, Robert D Schnabel, Jeremy F Taylor, Anna A E Vinkhuyzen, Frank Panitz, Christian Bendixen, Lars-Erik Holm, Birgit Gredler, Chris Hozé, Mekki Boussaha, Marie-Pierre Sanchez, Dominique Rocha, Aurelien Capitan, Thierry Tribout, Anne Barbat, Pascal Croiseau, Cord Drögemüller, Vidhya Jagannathan, Christy Vander Jagt, John J Crowley, Anna Bieber, Deirdre C Purfield, Donagh P Berry, Reiner Emmerling, Kay-Uwe Götz, Mirjam Frischknecht, Ingolf Russ, Johann Sölkner, Curtis P Van Tassell, Ruedi Fries, Paul Stothard, Roel F Veerkamp, Didier Boichard, Mike E Goddard, Ben J Hayes,

Stature is affected by many polymorphisms of small effect in humans <sup>1</sup> . In contrast, variation in dogs, even within breeds, has been suggested to be largely due to variants in a small number of genes<sup>2,3</sup>. Here we use data from cattle to compare the genetic architecture of stature to ... Read more >>

Nat Genet (Nature genetics)
[2018, 50(3):362-367]

Cited: 74 times

View full text PDF listing >>



Modeling heterogeneous (co)variances from adjacent-SNP groups improves genomic prediction for milk protein composition traits.

Grum Gebreyesus, Mogens S Lund, Bart Buitenhuis, Henk Bovenhuis, Nina A Poulsen, Luc G Janss,

<h4>Background</h4>Accurate genomic prediction requires a large reference population, which is problematic for traits that are expensive to measure. Traits related to milk protein composition are not routinely recorded due to costly procedures and are considered to be controlled by a few quantitative trait loci of large effect. The amount of ... Read more >>

Genet Sel Evol (Genetics, selection, evolution : GSE)
[2017, 49(1):89]

Cited: 6 times

View full text PDF listing >>



Sequence variants selected from a multi-breed GWAS can improve the reliability of genomic predictions in dairy cattle.

Irene van den Berg, Didier Boichard, Mogens S Lund,

<h4>Background</h4>Sequence data can potentially increase the reliability of genomic predictions, because such data include causative mutations instead of relying on linkage disequilibrium (LD) between causative mutations and prediction variants. However, the location of the causative mutations is not known, and the presence of many variants that are in low LD ... Read more >>

Genet Sel Evol (Genetics, selection, evolution : GSE)
[2016, 48(1):83]

Cited: 19 times

View full text PDF listing >>



Using Sequence Variants in Linkage Disequilibrium with Causative Mutations to Improve Across-Breed Prediction in Dairy Cattle: A Simulation Study.

Irene van den Berg, Didier Boichard, Bernt Guldbrandtsen, Mogens S Lund,

Sequence data are expected to increase the reliability of genomic prediction by containing causative mutations directly, especially in cases where low linkage disequilibrium between markers and causative mutations limits prediction reliability, such as across-breed prediction in dairy cattle. In practice, the causative mutations are unknown, and prediction with only variants ... Read more >>

G3 (Bethesda) (G3 (Bethesda, Md.))
[2016, 6(8):2553-2561]

Cited: 18 times

View full text PDF listing >>



Association analysis for udder health based on SNP-panel and sequence data in Danish Holsteins.

Xiaoping Wu, Mogens S Lund, Goutam Sahana, Bernt Guldbrandtsen, Dongxiao Sun, Qin Zhang, Guosheng Su,

<h4>Background</h4>The sensitivity of genome-wide association studies for the detection of quantitative trait loci (QTL) depends on the density of markers examined and the statistical models used. This study compares the performance of three marker densities to refine six previously detected QTL regions for mastitis traits: 54 k markers of a medium-density ... Read more >>

Genet Sel Evol (Genetics, selection, evolution : GSE)
[2015, 47:50]

Cited: 15 times

View full text PDF listing >>



Runs of homozygosity and distribution of functional variants in the cattle genome.

Qianqian Zhang, Bernt Guldbrandtsen, Mirte Bosse, Mogens S Lund, Goutam Sahana,

<h4>Background</h4>Recent developments in sequencing technology have facilitated widespread investigations of genomic variants, including continuous stretches of homozygous genomic regions. For cattle, a large proportion of these runs of homozygosity (ROH) are likely the result of inbreeding due to the accumulation of elite alleles from long-term selective breeding programs. In the ... Read more >>

BMC Genomics (BMC genomics)
[2015, 16:542]

Cited: 54 times

View full text PDF listing >>



Genome-wide association study for female fertility in Nordic Red cattle.

Johanna K Höglund, Bart Buitenhuis, Bernt Guldbrandtsen, Mogens S Lund, Goutam Sahana,

<h4>Background</h4>The Nordic Red Cattle (NRC) consists of animls belonging to the Danish Red, Finnish Ayrshire, and Swedish Red breeds. Compared to the Holstein breed, NRC animals are smaller, have a shorter calving interval, lower mastitis incidence and lower rates of stillborn calves, however they produce less milk, fat and protein. ... Read more >>

BMC Genet (BMC genetics)
[2015, 16:110]

Cited: 18 times

View full text PDF listing >>



Genetic evaluation for three-way crossbreeding.

Ole F Christensen, Andres Legarra, Mogens S Lund, Guosheng Su,

<h4>Background</h4>Commercial pig producers generally use a terminal crossbreeding system with three breeds. Many pig breeding organisations have started to use genomic selection for which genetic evaluation is often done by applying single-step methods for which the pedigree-based additive genetic relationship matrix is replaced by a combined relationship matrix based on ... Read more >>

Genet Sel Evol (Genetics, selection, evolution : GSE)
[2015, 47:98]

Cited: 14 times

View full text PDF listing >>



Genetic dissection of milk yield traits and mastitis resistance quantitative trait loci on chromosome 20 in dairy cattle.

Naveen K Kadri, Bernt Guldbrandtsen, Mogens S Lund, Goutam Sahana,

Intense selection to increase milk yield has had negative consequences for mastitis incidence in dairy cattle. Due to low heritability of mastitis resistance and an unfavorable genetic correlation with milk yield, a reduction in mastitis through traditional breeding has been difficult to achieve. Here, we examined quantitative trait loci (QTL) ... Read more >>

J Dairy Sci (Journal of dairy science)
[2015, 98(12):9015-9025]

Cited: 11 times

View full text PDF listing >>



Selection of haplotype variables from a high-density marker map for genomic prediction.

Beatriz Cd Cuyabano, Guosheng Su, Mogens S Lund,

<h4>Background</h4>Using haplotype blocks as predictors rather than individual single nucleotide polymorphisms (SNPs) may improve genomic predictions, since haplotypes are in stronger linkage disequilibrium with the quantitative trait loci than are individual SNPs. It has also been hypothesized that an appropriate selection of a subset of haplotype blocks can result in ... Read more >>

Genet Sel Evol (Genetics, selection, evolution : GSE)
[2015, 47:61]

Cited: 11 times

View full text PDF listing >>



Advertisement

Disclaimer
1.077 s