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Author Mitsuru Naito

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Systemic single administration of anti-inflammatory microRNA 146a-5p loaded in polymeric nanomedicines with active targetability attenuates neointimal hyperplasia by controlling inflammation in injured arteries in a rat model.

Masaya Sano, Daisuke Akagi, Mitsuru Naito, Katsuyuki Hoshina, Kanjiro Miyata, Kazunori Kataoka, Soichiro Ishihara,

Neointimal hyperplasia (NIH) after revascularization is a key unsolved clinical problem. Various studies have shown that attenuation of the acute inflammatory response on the vascular wall can prevent NIH. MicroRNA146a-5p (miR146a-5p) has been reported to show anti-inflammatory effects by inhibiting the NF-κB pathway, a well-known key player of inflammation of ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2022, 36(9):e22486]

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Analysis of the sustained release ability of bevacizumab-loaded tetra-PEG gel.

Tomoya Murakami, Sujin Hoshi, Fumiki Okamoto, Takamasa Sakai, Takuya Katashima, Mitsuru Naito, Tetsuro Oshika,

Multiple intravitreal injections, which are painful and costly, are often required in the treatment of retinal disorders. Therefore, a novel drug delivery system using hydrogels is currently being evaluated as an alternative. This study aimed to evaluate the ability of tetra-armed polyethylene glycol (tetra-PEG) gel for sustained release in vitro. ... Read more >>

Exp Eye Res (Experimental eye research)
[2022, 223:109206]

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