Full Text Journal Articles by
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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1063-e1143]

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Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):1974-1982]

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Temporal Trends in ICU Survival for Coronavirus Disease 2019: A Bumpy Road.

Hallie C Prescott, Mitchell M Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):1986-1988]

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Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Intensive Care Med (Intensive care medicine)
[2021, :]

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Fluid Therapy and Acute Respiratory Distress Syndrome.

Jisoo Lee, Keith Corl, Mitchell M Levy,

The optimal fluid management for acute respiratory distress syndrome (ARDS) remains unknown. Liberal fluid management may improve cardiac function and end-organ perfusion, but may lead to increased pulmonary edema and inhibit gas exchange. Trials suggest that conservative fluid management leads to better clinical outcomes, although prospective randomized, controlled trials have ... Read more >>

Crit Care Clin (Critical care clinics)
[2021, 37(4):867-875]

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50 Years of Sepsis Investigation/Enlightenment Among Adults-The Long and Winding Road.

R Phillip Dellinger, Mitchell M Levy, Christa A Schorr, Sean R Townsend,

Crit Care Med (Critical care medicine)
[2021, 49(10):1606-1625]

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BMI and pneumonia outcomes in critically ill covid-19 patients: An international multicenter study.

Mikael Chetboun, Violeta Raverdy, Julien Labreuche, Arthur Simonnet, Florent Wallet, Cyrielle Caussy, Massimo Antonelli, Antonio Artigas, Gemma Goma, Ferhat Meziani, Julie Helms, Eleftherios Mylonakis, Mitchell M Levy, Markos Kalligeros, Nicola Latronico, Simone Piva, Charles Cerf, Mathilde Neuville, Kada Klouche, Romaric Larcher, Fabienne Tamion, Emilie Occhiali, Morgane Snacken, Jean-Charles Preiser, Loay Kontar, Antoine Riviere, Stein Silva, Benjamine Sarton, Raphael Krouchi, Victoria Dubar, Leonidas Palaiodimos, Dimitrios Karamanis, Juliette Perche, Erwan L'Her, Luca Busetto, Dror Dicker, Shaul Lev, Alain Duhamel, Mercè Jourdain, François Pattou,

<h4>Objective</h4>Previous studies have unveiled a relationship between the severity of coronavirus disease 2019 (COVID-19) pneumonia and obesity. The aims of this multicenter retrospective cohort study were to disentangle the association of BMI and associated metabolic risk factors (diabetes, hypertension, hyperlipidemia, and current smoking status) in critically ill patients with COVID-19.<h4>Methods</h4>Patients ... Read more >>

Obesity (Silver Spring) (Obesity (Silver Spring, Md.))
[2021, 29(9):1477-1486]

Cited: 1 time

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Effects of Compliance With the Early Management Bundle (SEP-1) on Mortality Changes Among Medicare Beneficiaries With Sepsis: A Propensity Score Matched Cohort Study.

Sean R Townsend, Gary S Phillips, Reena Duseja, Lemeneh Tefera, Derek Cruikshank, Robert Dickerson, H Bryant Nguyen, Christa A Schorr, Mitchell M Levy, R Phillip Dellinger, William A Conway, Warren S Browner, Emanuel P Rivers,

<h4>Background</h4>US hospitals have reported compliance with the SEP-1 quality measure to Medicare since 2015. Finding an association between compliance and outcomes is essential to gauge measure effectiveness.<h4>Research question</h4>What is the association between compliance with SEP-1 and 30-day mortality among Medicare beneficiaries?<h4>Study design and methods</h4>Studying patient-level data reported to Medicare by ... Read more >>

Chest (Chest)
[2021, :]

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Rationale and protocol for the efficacy, safety and tolerability of nangibotide in patients with septic shock (ASTONISH) phase IIb randomised controlled trial.

Bruno Francois, Simon Lambden, Sebastien Gibot, Marc Derive, Aurelie Olivier, Valerie Cuvier, Stephan Witte, Jean-Marie Grouin, Jean Jacques Garaud, Margarita Salcedo-Magguilli, Mitchell Levy, Pierre-François Laterre,

<h4>Introduction</h4>Septic shock is the subgroup of patients with sepsis, which presents as vasopressor dependence, an elevated blood lactate concentration and is associated with a mortality of at least 30%. Expression of the triggering receptor expressed on myeloid cells 1 (TREM-1) pathway, measured using a serum biomarker of pathway activation (soluble ... Read more >>

BMJ Open (BMJ open)
[2021, 11(7):e042921]

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The Surviving Sepsis Campaign: research priorities for the administration, epidemiology, scoring and identification of sepsis.

Mark E Nunnally, Ricard Ferrer, Greg S Martin, Ignacio Martin-Loeches, Flavia R Machado, Daniel De Backer, Craig M Coopersmith, Clifford S Deutschman, ,

<h4>Objective</h4>To identify priorities for administrative, epidemiologic and diagnostic research in sepsis.<h4>Design</h4>As a follow-up to a previous consensus statement about sepsis research, members of the Surviving Sepsis Campaign Research Committee, representing the European Society of Intensive Care Medicine and the Society of Critical Care Medicine addressed six questions regarding care delivery, ... Read more >>

Intensive Care Med Exp (Intensive care medicine experimental)
[2021, 9(1):34]

Cited: 1 time

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Developing Treatment Guidelines During a Pandemic Health Crisis: Lessons Learned From COVID-19.

Safia Kuriakose, Kanal Singh, Alice K Pau, Eric Daar, Rajesh Gandhi, Pablo Tebas, Laura Evans, Roy M Gulick, H Clifford Lane, Henry Masur, , Judith A Aberg, Adaora A Adimora, Jason Baker, Lisa Baumann Kreuziger, Roger Bedimo, Pamela S Belperio, Stephen V Cantrill, Craig M Coopersmith, Susan L Davis, Amy L Dzierba, John J Gallagher, David V Glidden, Birgit Grund, Erica J Hardy, Carl Hinkson, Brenna L Hughes, Steven Johnson, Marla J Keller, Arthur Y Kim, Jeffrey L Lennox, Mitchell M Levy, Jonathan Z Li, Greg S Martin, Susanna Naggie, Andrew T Pavia, Nitin Seam, Steven Q Simpson, Susan Swindells, Phyllis Tien, Alpana A Waghmare, Kevin C Wilson, Jinoos Yazdany, Philip Zachariah, Danielle M Campbell, Carly Harrison, Timothy Burgess, Joseph Francis, Virginia Sheikh, Timothy M Uyeki, Robert Walker, John T Brooks, Laura Bosque Ortiz, Richard T Davey, Laurie K Doepel, Robert W Eisinger, Alison Han, Elizabeth S Higgs, Martha C Nason, Page Crew, Andrea M Lerner, Claire Lund, Christopher Worthington,

The development of the National Institutes of Health (NIH) COVID-19 Treatment Guidelines began in March 2020 in response to a request from the White House Coronavirus Task Force. Within 4 days of the request, the NIH COVID-19 Treatment Guidelines Panel was established and the first meeting took place (virtually-as did ... Read more >>

Ann Intern Med (Annals of internal medicine)
[2021, 174(8):1151-1158]

Cited: 1 time

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Using Readmission Rates as a Quality Indicator in Sepsis-Addressing the Problem or Adding to It?

Mitchell M Levy,

JAMA Netw Open (JAMA network open)
[2021, 4(6):e2112873]

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Differences in Family Involvement in the Bedside Care of Patients in the ICU Based on Self-Identified Race.

Eduardo R Nunez, Gianluca Villa, Rory McFadden, Amy Palmisciano, Iacopo Lanini, Sean O'Mahony, J Randall Curtis, Mitchell M Levy, Timothy Amass,

<h4>Objectives</h4>Being a caregiver for a patient in the ICU can place emotional burden on families and engaging families in caregiving can reduce psychological distress. Our goal was to observe support methods used by families in the ICU and identify differences between race/ethnicity.<h4>Design</h4>A secondary analysis of a multicenter before-and-after clinical trial.<h4>Setting</h4>Three ... Read more >>

Crit Care Explor (Critical care explorations)
[2021, 3(3):e0365]

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Surviving Sepsis Campaign Guidelines on the Management of Adults With Coronavirus Disease 2019 (COVID-19) in the ICU: First Update.

Waleed Alhazzani, Laura Evans, Fayez Alshamsi, Morten Hylander Møller, Marlies Ostermann, Hallie C Prescott, Yaseen M Arabi, Mark Loeb, Michelle Ng Gong, Eddy Fan, Simon Oczkowski, Mitchell M Levy, Lennie Derde, Amy Dzierba, Bin Du, Flavia Machado, Hannah Wunsch, Mark Crowther, Maurizio Cecconi, Younsuck Koh, Lisa Burry, Daniel S Chertow, Wojciech Szczeklik, Emilie Belley-Cote, Massimiliano Greco, Malgorzata Bala, Ryan Zarychanski, Jozef Kesecioglu, Allison McGeer, Leonard Mermel, Manoj J Mammen, Sheila Nainan Myatra, Amy Arrington, Ruth Kleinpell, Giuseppe Citerio, Kimberley Lewis, Elizabeth Bridges, Ziad A Memish, Naomi Hammond, Frederick G Hayden, Muhammed Alshahrani, Zainab Al Duhailib, Greg S Martin, Lewis J Kaplan, Craig M Coopersmith, Massimo Antonelli, Andrew Rhodes,

<h4>Background</h4>The coronavirus disease 2019 pandemic continues to affect millions worldwide. Given the rapidly growing evidence base, we implemented a living guideline model to provide guidance on the management of patients with severe or critical coronavirus disease 2019 in the ICU.<h4>Methods</h4>The Surviving Sepsis Campaign Coronavirus Disease 2019 panel has expanded to ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(3):e219-e234]

Cited: 37 times

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Deep RNA Sequencing of Intensive Care Unit Patients with COVID-19

Sean Monaghan, Alger Fredericks, Maximilian Jentzsch, William Cioffi, Maya Cohen, William Fairbrother, Shivam Gandhi, Elizabeth Harrington, Gerard Nau, Jonathan Reichner, Corey Ventetuolo, Mitchell Levy, Alfred Ayala,

<h4>Purpose</h4> COVID-19 has impacted millions of patients across the world. Molecular testing occurring now identifies the presence of the virus at the sampling site: nasopharynx, nares, or oral cavity. RNA sequencing has the potential to establish both the presence of the virus and define the host’s response in COVID-19. <h4>Methods</h4> ... Read more >>

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Survival From Severe Coronavirus Disease 2019: Is It Changing?

Hallie C Prescott, Mitchell M Levy,

Crit Care Med (Critical care medicine)
[2021, 49(2):351-353]

Cited: 2 times

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Deep RNA Sequencing of Intensive Care Unit Patients with COVID-19

Sean Monaghan, Alger Fredericks, Maximilian Jentzsch, William Cioffi, Maya Cohen, William Fairbrother, Shivam Gandhi, Elizabeth Harrington, Gerard Nau, Jonathan Reichner, Corey Ventetuolo, Mitchell Levy, Alfred Ayala,

Background: COVID-19 has impacted millions of patients across the world. Molecular testing occurring now identifies the presence of the virus at the sampling site: nasopharynx, nares, or oral cavity. RNA sequencing has the potential to establish both the presence of the virus and define the host’s response in ... Read more >>

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The authors reply.

Keith A Corl, Mitchell M Levy, Aisling R Caffrey, Kerry L LaPlante,

Crit Care Med (Critical care medicine)
[2020, 48(12):e1371-e1372]

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Correlation Between Restraint Use and Engaging Family Members in the Care of ICU Patients.

Sarah J Hochendoner, Gianluca Villa, Emily Sokol, Mitchell M Levy, Jason M Aliotta, Sarah J Timothy H Amass,

Crit Care Explor (Critical care explorations)
[2020, 2(11):e0255]

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Development of a Deep Learning Network to Classify Inferior Vena Cava Collapse to Predict Fluid Responsiveness.

Michael Blaivas, Laura Blaivas, Gary Philips, Roland Merchant, Mitchell Levy, Adeel Abbasi, Carsten Eickhoff, Nathan Shapiro, Keith Corl,

<h4>Objectives</h4>To create a deep learning algorithm capable of video classification, using a long short-term memory (LSTM) network, to analyze collapsibility of the inferior vena cava (IVC) to predict fluid responsiveness in critically ill patients.<h4>Methods</h4>We used a data set of IVC ultrasound (US) videos to train the LSTM network. The data ... Read more >>

J Ultrasound Med (Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine)
[2021, 40(8):1495-1504]

Cited: 1 time

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Increasing Quality, Not Costs.

Mitchell M Levy,

Crit Care Med (Critical care medicine)
[2020, 48(10):1528-1529]

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Association of Body Mass Index and Other Metabolic Risk Factors with Pneumonia Outcomes in Critically Ill Patients with Coronavirus Disease-19: An International Multicenter Retrospective Cohort Study

Mikael Chetboun, Violeta Raverdy, Julien Labreuche, Arthur Simonnet, Florent Wallet, Cyrielle Caussy, Massimo Antonelli, Antonio Artigas, Gemma Goma, Ferhat Meziani, Julie Helms, Eleftherios Mylonakis, Mitchell Levy, Markos Kalligeros, Nicola Latronico, Simone Piva, Charles Cerf, Mathilde Neuville, Kada Klouche, Romaric Larchar, Fabienne Tamion, Emilie Occhiali, Morgane Snacken, Jean-Charles Preiser, Loay Kontar, Antoine Riviere, Stein Silva, Benjamine Sarton, Raphael Krouchi, Victoria Dubar, Leonidas Palaiodimos, Dimitrios Karamanis, Juliette Perche, Erwan L'Her, Luca Busetto, Dror Dicker, Shaul Lev, Alain Duhamel, Mercèdes Jourdain, Francois Pattou,

Previous studies unveiled a relation between COVID-19 severity and obesity. The aims of this multicenter retrospective cohort study were to disentangle the association of body mass index (BMI) and associated metabolic risk factors, with pneumonia outcomes in critically ill patients with COVID-19, and explore the impact of age and sex ... Read more >>

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Convalescent Plasma for the Treatment of COVID-19: Perspectives of the National Institutes of Health COVID-19 Treatment Guidelines Panel.

Alice K Pau, Judith Aberg, Jason Baker, Pamela S Belperio, Craig Coopersmith, Page Crew, Birgit Grund, Roy M Gulick, Carly Harrison, Arthur Kim, H Clifford Lane, Henry Masur, Virginia Sheikh, Kanal Singh, Jinoos Yazdany, Pablo Tebas, ,

Ann Intern Med (Annals of internal medicine)
[2021, 174(1):93-95]

Cited: 14 times

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The authors reply.

Timothy Amass, Mitchell M Levy,

Crit Care Med (Critical care medicine)
[2020, 48(9):e841-e842]

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Change in Carotid Blood Flow and Carotid Corrected Flow Time Assessed by Novice Sonologists Fails to Determine Fluid Responsiveness in Spontaneously Breathing Intensive Care Unit Patients.

Adeel Abbasi, Nader Azab, Mohammed Nayeemuddin, Alexandra Schick, Thomas Lopardo, Gary S Phillips, Roland C Merchant, Mitchell M Levy, Michael Blaivas, Keith A Corl,

Measurement of carotid blood flow (CBF) and corrected carotid flow time (ccFT) has been proposed as a non-invasive means of determining fluid responsiveness. We evaluated the ability of CBF and ccFT as assessed by novice sonologists to determine fluid responsiveness in intensive care unit patients. Three novice physician sonologists performed ... Read more >>

Ultrasound Med Biol (Ultrasound in medicine & biology)
[2020, 46(10):2659-2666]

Cited: 0 times

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