Full Text Journal Articles by
Author Mirjam Zeisel

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Targeting clinical epigenetic reprogramming for chemoprevention of metabolic and viral hepatocellular carcinoma.

Frank Jühling, Nourdine Hamdane, Emilie Crouchet, Shen Li, Houssein El Saghire, Atish Mukherji, Naoto Fujiwara, Marine A Oudot, Christine Thumann, Antonio Saviano, Armando Andres Roca Suarez, Kaku Goto, Ricard Masia, Mozhdeh Sojoodi, Gunisha Arora, Hiroshi Aikata, Atsushi Ono, Parissa Tabrizian, Myron Schwartz, Stephen J Polyak, Irwin Davidson, Christian Schmidl, Christoph Bock, Catherine Schuster, Kazuaki Chayama, Patrick Pessaux, Kenneth K Tanabe, Yujin Hoshida, Mirjam B Zeisel, François Ht Duong, Bryan C Fuchs, Thomas F Baumert,

OBJECTIVE:Hepatocellular carcinoma (HCC) is the fastest-growing cause of cancer-related mortality with chronic viral hepatitis and non-alcoholic steatohepatitis (NASH) as major aetiologies. Treatment options for HCC are unsatisfactory and chemopreventive approaches are absent. Chronic hepatitis C (CHC) results in epigenetic alterations driving HCC risk and persisting following cure. Here, we aimed ... Read more >>

Gut (Gut)
[2020, :]

Cited: 1 time

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Hepatitis B protein HBx binds the DLEU2 lncRNA to sustain cccDNA and host cancer-related gene transcription.

Debora Salerno, Letizia Chiodo, Vincenzo Alfano, Oceane Floriot, Grazia Cottone, Alexia Paturel, Matteo Pallocca, Marie-Laure Plissonnier, Safaa Jeddari, Laura Belloni, Mirjam Zeisel, Massimo Levrero, Francesca Guerrieri,

OBJECTIVE:The HBV HBx regulatory protein is required for transcription from the covalently closed circular DNA (cccDNA) minichromosome and affects the epigenetic control of both viral and host cellular chromatin. DESIGN:We explored, in relevant cellular models of HBV replication, the functional consequences of HBx interaction with DLEU2, a long non-coding RNA ... Read more >>

Gut (Gut)
[2020, :]

Cited: 0 times

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Interferon-Induced Transmembrane Proteins Mediate Viral Evasion in Acute and Chronic Hepatitis C Virus Infection.

Florian Wrensch, Gaëtan Ligat, Laura Heydmann, Catherine Schuster, Mirjam B Zeisel, Patrick Pessaux, François Habersetzer, Barnabas J King, Alexander W Tarr, Jonathan K Ball, Michael Winkler, Stefan Pöhlmann, Zhen-Yong Keck, Steven K H Foung, Thomas F Baumert,

Although adaptive immune responses against hepatitis C virus (HCV) infection have been studied in great detail, the role of innate immunity in protection against HCV infection and immune evasion is only partially understood. Interferon-induced transmembrane proteins (IFITMs) are innate effector proteins restricting host cell entry of many enveloped viruses, including ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2019, 70(5):1506-1520]

Cited: 4 times

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Functional microRNA screen uncovers O-linked N-acetylglucosamine transferase as a host factor modulating hepatitis C virus morphogenesis and infectivity.

Katharina Herzog, Simonetta Bandiera, Sophie Pernot, Catherine Fauvelle, Frank Jühling, Amélie Weiss, Anne Bull, Sarah C Durand, Béatrice Chane-Woon-Ming, Sébastien Pfeffer, Marion Mercey, Hervé Lerat, Jean-Christophe Meunier, Wolfgang Raffelsberger, Laurent Brino, Thomas F Baumert, Mirjam B Zeisel,

OBJECTIVE:Infection of human hepatocytes by the hepatitis C virus (HCV) is a multistep process involving both viral and host factors. microRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression. Given that miRNAs were indicated to regulate between 30% and 75% of all human genes, we aimed to investigate ... Read more >>

Gut (Gut)
[2020, 69(2):380-392]

Cited: 2 times

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Combined Analysis of Metabolomes, Proteomes, and Transcriptomes of Hepatitis C Virus-Infected Cells and Liver to Identify Pathways Associated With Disease Development.

Joachim Lupberger, Tom Croonenborghs, Armando Andres Roca Suarez, Nicolaas Van Renne, Frank Jühling, Marine A Oudot, Alessia Virzì, Simonetta Bandiera, Carole Jamey, Gergö Meszaros, Daniel Brumaru, Atish Mukherji, Sarah C Durand, Laura Heydmann, Eloi R Verrier, Hussein El Saghire, Nourdine Hamdane, Ralf Bartenschlager, Shaunt Fereshetian, Evelyn Ramberger, Rileen Sinha, Mohsen Nabian, Celine Everaert, Marko Jovanovic, Philipp Mertins, Steven A Carr, Kazuaki Chayama, Nassim Dali-Youcef, Romeo Ricci, Nabeel M Bardeesy, Naoto Fujiwara, Olivier Gevaert, Mirjam B Zeisel, Yujin Hoshida, Nathalie Pochet, Thomas F Baumert,

BACKGROUND & AIMS:The mechanisms of hepatitis C virus (HCV) infection, liver disease progression, and hepatocarcinogenesis are only partially understood. We performed genomic, proteomic, and metabolomic analyses of HCV-infected cells and chimeric mice to learn more about these processes. METHODS:Huh7.5.1dif (hepatocyte-like cells) were infected with culture-derived HCV and used in RNA ... Read more >>

Gastroenterology (Gastroenterology)
[2019, 157(2):537-551.e9]

Cited: 6 times

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HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response.

Nourdine Hamdane, Frank Jühling, Emilie Crouchet, Houssein El Saghire, Christine Thumann, Marine A Oudot, Simonetta Bandiera, Antonio Saviano, Clara Ponsolles, Armando Andres Roca Suarez, Shen Li, Naoto Fujiwara, Atsushi Ono, Irwin Davidson, Nabeel Bardeesy, Christian Schmidl, Christoph Bock, Catherine Schuster, Joachim Lupberger, François Habersetzer, Michel Doffoël, Tullio Piardi, Daniele Sommacale, Michio Imamura, Takuro Uchida, Hideki Ohdan, Hiroshi Aikata, Kazuaki Chayama, Tujana Boldanova, Patrick Pessaux, Bryan C Fuchs, Yujin Hoshida, Mirjam B Zeisel, François H T Duong, Thomas F Baumert,

BACKGROUND & AIMS:Chronic hepatitis C virus (HCV) infection is an important risk factor for hepatocellular carcinoma (HCC). Despite effective antiviral therapies, the risk for HCC is decreased but not eliminated after a sustained virologic response (SVR) to direct-acting antiviral (DAA) agents, and the risk is higher in patients with advanced ... Read more >>

Gastroenterology (Gastroenterology)
[2019, 156(8):2313-2329.e7]

Cited: 15 times

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In vivo combination of human anti-envelope glycoprotein E2 and -Claudin-1 monoclonal antibodies for prevention of hepatitis C virus infection.

Laurent Mailly, Florian Wrensch, Laura Heydmann, Catherine Fauvelle, Nicolas Brignon, Mirjam B Zeisel, Patrick Pessaux, Zhen-Yong Keck, Catherine Schuster, Thomas R Fuerst, Steven K H Foung, Thomas F Baumert,

Despite the development of direct-acting antivirals (DAAs), hepatitis C virus (HCV) infection remains a major cause for liver disease and cancer worldwide. Entry inhibitors block virus host cell entry and, therefore, prevent establishment of chronic infection and liver disease. Due to their unique mechanism of action, entry inhibitors provide an ... Read more >>

Antiviral Res. (Antiviral research)
[2019, 162:136-141]

Cited: 0 times

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Tight junction proteins in gastrointestinal and liver disease.

Mirjam B Zeisel, Punita Dhawan, Thomas F Baumert,

Over the past two decades a growing body of evidence has demonstrated an important role of tight junction (TJ) proteins in the physiology and disease biology of GI and liver disease. On one side, TJ proteins exert their functional role as integral proteins of TJs in forming barriers in the ... Read more >>

Gut (Gut)
[2019, 68(3):547-561]

Cited: 11 times

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[Risk of hepatocellular carcinoma after hepatitis C virus cure with direct-acting antivirals: the next challenges].

Nourdine Hamdane, Thomas F Baumert, Mirjam B Zeisel,

Med Sci (Paris) (Medecine sciences : M/S)
[2018, 34(5):391-394]

Cited: 0 times

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Plasmodium P36 determines host cell receptor usage during sporozoite invasion.

Giulia Manzoni, Carine Marinach, Selma Topçu, Sylvie Briquet, Morgane Grand, Matthieu Tolle, Marion Gransagne, Julien Lescar, Chiara Andolina, Jean-François Franetich, Mirjam B Zeisel, Thierry Huby, Eric Rubinstein, Georges Snounou, Dominique Mazier, François Nosten, Thomas F Baumert, Olivier Silvie,

Plasmodium sporozoites, the mosquito-transmitted forms of the malaria parasite, first infect the liver for an initial round of replication before the emergence of pathogenic blood stages. Sporozoites represent attractive targets for antimalarial preventive strategies, yet the mechanisms of parasite entry into hepatocytes remain poorly understood. Here we show that the ... Read more >>

Elife (eLife)
[2017, 6:]

Cited: 15 times

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Humanisation of a claudin-1-specific monoclonal antibody for clinical prevention and cure of HCV infection without escape.

Che C Colpitts, Rajiv G Tawar, Laurent Mailly, Christine Thumann, Laura Heydmann, Sarah C Durand, Fei Xiao, Eric Robinet, Patrick Pessaux, Mirjam B Zeisel, Thomas F Baumert,

HCV infection is a leading cause of chronic liver disease and a major indication for liver transplantation. Although direct-acting antivirals (DAAs) have much improved the treatment of chronic HCV infection, alternative strategies are needed for patients with treatment failure. As an essential HCV entry factor, the tight junction protein claudin-1 ... Read more >>

Gut (Gut)
[2018, 67(4):736-745]

Cited: 12 times

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Chronic hepatitis C virus infection and pathogenesis of hepatocellular carcinoma.

Simonetta Bandiera, C Billie Bian, Yujin Hoshida, Thomas F Baumert, Mirjam B Zeisel,

Hepatitis C virus (HCV) infection is one of the major causes of advanced liver disease and hepatocellular carcinoma (HCC) worldwide. While the knowledge about the molecular virology of HCV infection has markedly advanced, the molecular mechanisms of disease progression leading to fibrosis, cirrhosis and HCC are still unclear. Accumulating experimental ... Read more >>

Curr Opin Virol (Current opinion in virology)
[2016, 20:99-105]

Cited: 23 times

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Broad neutralization of hepatitis C virus-resistant variants by Civacir hepatitis C immunoglobulin.

Rajiv G Tawar, Laura Heydmann, Charlotte Bach, Jörg Schüttrumpf, Shailesh Chavan, Barnabas J King, C Patrick McClure, Jonathan K Ball, Patrick Pessaux, François Habersetzer, Ralf Bartenschlager, Mirjam B Zeisel, Thomas F Baumert,

Hepatitis C virus (HCV)-induced end-stage liver disease is the major indication for liver transplantation (LT). However, reinfection of the liver graft is still common, especially in patients with detectable viral load at the time of LT. Limited data are available on direct-acting antivirals in the transplant setting for prevention of ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2016, 64(5):1495-1506]

Cited: 2 times

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Clinical development of hepatitis C virus host-targeting agents.

Mirjam B Zeisel, Thomas F Baumert,

Lancet (Lancet (London, England))
[2017, 389(10070):674-675]

Cited: 3 times

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miR-135a-5p-mediated downregulation of protein tyrosine phosphatase receptor delta is a candidate driver of HCV-associated hepatocarcinogenesis.

Nicolaas Van Renne, Armando Andres Roca Suarez, Francois H T Duong, Claire Gondeau, Diego Calabrese, Nelly Fontaine, Amina Ababsa, Simonetta Bandiera, Tom Croonenborghs, Nathalie Pochet, Vito De Blasi, Patrick Pessaux, Tullio Piardi, Daniele Sommacale, Atsushi Ono, Kazuaki Chayama, Masashi Fujita, Hidewaki Nakagawa, Yujin Hoshida, Mirjam B Zeisel, Markus H Heim, Thomas F Baumert, Joachim Lupberger,

BACKGROUND AND AIMS:HCV infection is a leading risk factor of hepatocellular carcinoma (HCC). However, even after viral clearance, HCC risk remains elevated. HCV perturbs host cell signalling to maintain infection, and derailed signalling circuitry is a key driver of carcinogenesis. Since protein phosphatases are regulators of signalling events, we aimed ... Read more >>

Gut (Gut)
[2018, 67(5):953-962]

Cited: 11 times

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Translation and protein expression of lncRNAs: Impact for liver disease and hepatocellular carcinoma.

Mirjam B Zeisel, Thomas F Baumert,

Hepatology (Hepatology (Baltimore, Md.))
[2016, 64(2):671-674]

Cited: 5 times

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Addressing the next challenges: A summary of the 22nd international symposium on hepatitis C virus and related viruses.

Thomas F Baumert, Catherine Schuster, François-Loïc Cosset, Jean Dubuisson, Maike Hofmann, Norbert Tautz, Mirjam B Zeisel, Robert Thimme,

Following the discovery of the hepatitis C virus (HCV) more than 25 years ago the field has succeeded to develop methods that have changed the safety of blood products, understand the molecular virology, epidemiology and clinical disease of HCV, and identify specific targets for the development of direct-acting antivirals for ... Read more >>

J. Hepatol. (Journal of hepatology)
[2016, 64(4):968-973]

Cited: 4 times

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Acute hepatitis C virus infection induces anti-host cell receptor antibodies with virus-neutralizing properties.

Rajiv G Tawar, Che C Colpitts, Jörg Timm, Tanja Fehm, Michael Roggendorf, Helga Meisel, Nicolas Meyer, François Habersetzer, François-Loïc Cosset, Thomas Berg, Mirjam B Zeisel, Thomas F Baumert,

Hepatitis C virus (HCV) causes persistent infection in the majority of infected individuals. The mechanisms of persistence and clearance are only partially understood. Antibodies (Abs) against host cell entry receptors have been shown to inhibit HCV infection in cell culture and animal models. In this study, we aimed to investigate ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2015, 62(3):726-736]

Cited: 2 times

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[Locked outside: cure of chronic hepatitis C using an entry inhibitor].

Laurent Mailly, Mirjam B Zeisel, Thomas F Baumert,

Med Sci (Paris) (Medecine sciences : M/S)
[2015, 31(12):1075-1077]

Cited: 1 time

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When one receptor closes, another opens: claudins and the hepatitis C virus E1 glycoprotein.

Che C Colpitts, Mirjam B Zeisel, Thomas F Baumert,

Hepatology (Hepatology (Baltimore, Md.))
[2015, 62(4):991-993]

Cited: 2 times

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Claudins and pathogenesis of viral infection.

Rajiv G Tawar, Che C Colpitts, Joachim Lupberger, Hussein El-Saghire, Mirjam B Zeisel, Thomas F Baumert,

Since their discovery, tremendous progress has been made in our understanding of the roles of claudins in tight junction physiology. In addition, interactions between claudins and other cellular proteins have highlighted their novel roles in cell physiology. Moreover, the importance of claudins is becoming apparent in the pathophysiology of several ... Read more >>

Semin. Cell Dev. Biol. (Seminars in cell & developmental biology)
[2015, 42:39-46]

Cited: 4 times

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Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody.

Laurent Mailly, Fei Xiao, Joachim Lupberger, Garrick K Wilson, Philippe Aubert, François H T Duong, Diego Calabrese, Céline Leboeuf, Isabel Fofana, Christine Thumann, Simonetta Bandiera, Marc Lütgehetmann, Tassilo Volz, Christopher Davis, Helen J Harris, Christopher J Mee, Erika Girardi, Béatrice Chane-Woon-Ming, Maria Ericsson, Nicola Fletcher, Ralf Bartenschlager, Patrick Pessaux, Koen Vercauteren, Philip Meuleman, Pascal Villa, Lars Kaderali, Sébastien Pfeffer, Markus H Heim, Michel Neunlist, Mirjam B Zeisel, Maura Dandri, Jane A McKeating, Eric Robinet, Thomas F Baumert,

Hepatitis C virus (HCV) infection is a leading cause of liver cirrhosis and cancer. Cell entry of HCV and other pathogens is mediated by tight junction (TJ) proteins, but successful therapeutic targeting of TJ proteins has not been reported yet. Using a human liver-chimeric mouse model, we show that a ... Read more >>

Nat. Biotechnol. (Nature biotechnology)
[2015, 33(5):549-554]

Cited: 65 times

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miR-122--a key factor and therapeutic target in liver disease.

Simonetta Bandiera, Sébastien Pfeffer, Thomas F Baumert, Mirjam B Zeisel,

Being the largest internal organ of the human body with the unique ability of self-regeneration, the liver is involved in a wide variety of vital functions that require highly orchestrated and controlled biochemical processes. Increasing evidence suggests that microRNAs (miRNAs) are essential for the regulation of liver development, regeneration and ... Read more >>

J. Hepatol. (Journal of hepatology)
[2015, 62(2):448-457]

Cited: 176 times

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Synergy of entry inhibitors with direct-acting antivirals uncovers novel combinations for prevention and treatment of hepatitis C.

Fei Xiao, Isabel Fofana, Christine Thumann, Laurent Mailly, Roxane Alles, Eric Robinet, Nicolas Meyer, Mickaël Schaeffer, François Habersetzer, Michel Doffoël, Pieter Leyssen, Johan Neyts, Mirjam B Zeisel, Thomas F Baumert,

Although direct-acting antiviral agents (DAAs) have markedly improved the outcome of treatment in chronic HCV infection, there continues to be an unmet medical need for improved therapies in difficult-to-treat patients as well as liver graft infection. Viral entry is a promising target for antiviral therapy.Aiming to explore the role of ... Read more >>

Gut (Gut)
[2015, 64(3):483-494]

Cited: 47 times

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IFN-λ receptor 1 expression is induced in chronic hepatitis C and correlates with the IFN-λ3 genotype and with nonresponsiveness to IFN-α therapies.

Francois H T Duong, Gaia Trincucci, Tujana Boldanova, Diego Calabrese, Benedetta Campana, Ilona Krol, Sarah C Durand, Laura Heydmann, Mirjam B Zeisel, Thomas F Baumert, Markus H Heim,

The molecular mechanisms that link IFN-λ3 genotypes to differential induction of interferon (IFN)-stimulated genes (ISGs) in the liver of patients with chronic hepatitis C (CHC) are not known. We measured the expression of IFN-λ and of the specific IFN-λ receptor chain (IFN-λR1) in 122 liver biopsies of patients with CHC ... Read more >>

J. Exp. Med. (The Journal of experimental medicine)
[2014, 211(5):857-868]

Cited: 34 times

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