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Author Minglei Zhao

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Interaction Landscape of K29-Linked Ubiquitin Signaling Revealed by a Linkage-Specific Synthetic Antigen-Binding Fragment

Yuanyuan Yu, Qingyun Zheng, Satchal Erramilli, Man Pan, Seongjin Park, Yuan Xie, Jingxian Li, Jingyi Fei, Anthony Kossiakoff, Lei Liu, Minglei Zhao,

Summary Protein ubiquitination shows remarkable topological and functional diversity through the polymerization of ubiquitin via different linkages. Deciphering the cellular ubiquitin code is of central importance to understand the physiology of the cell. Among the eight possible linkages, K29-linked polyubiquitin is a relatively abundant type of polyubiquitin in both human ... Read more >>

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Selective regulation of human TRAAK channels by biologically active phospholipids.

Samantha Schrecke, Yun Zhu, Jacob W McCabe, Mariah Bartz, Charles Packianathan, Minglei Zhao, Ming Zhou, David Russell, Arthur Laganowsky,

TRAAK is an ion channel from the two-pore domain potassium (K2P) channel family with roles in maintaining the resting membrane potential and fast action potential conduction. Regulated by a wide range of physical and chemical stimuli, the affinity and selectivity of K2P4.1 toward lipids remains poorly understood. Here we show ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, :]

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Corneal Recovery Following Rabbit Peripheral Blood Mononuclear Cell-Amniotic Membrane Transplantation with Antivascular Endothelial Growth Factor in Limbal Stem Cell Deficiency Rabbits.

Minglei Zhao, Hening Zhang, Dongqin Zhen, Mian Huang, Weihua Li, Zhiquan Li, Ying Liu, Yaojue Xie, Baozhu Zeng, Zhichong Wang, Bing Huang,

Background: Limbal stem cell deficiency (LSCD) is a refractory ocular surface disorder characterized by progressive corneal epithelial degeneration, conjunctivalization, and neovascularization, potentially leading to blindness. There are currently no effective therapeutic options for patients experiencing routine symptomatic treatment failure. Transplantation of amniotic membrane (AM) with adherent stem cells (but not ... Read more >>

Tissue Eng Part C Methods (Tissue engineering. Part C, Methods)
[2020, 26(10):541-552]

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Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition

Wenguang Liang, Juwina wijaya, Hui Wei, Alex Noble, Swansea Mo, David Lee, Jordan Mancl, John Lin King, Man Pan, chang Liu, Carla Koehler, Minglei Zhao, Clinton Potter, Bridget Carragher, Sheng Li, Wei-Jen Tang,

Abstract Presequence protease (PreP), a 117 kDa mitochondrial M16C metalloprotease vital for mitochondrial proteostasis, degrades presequence peptides cleaved off from nuclear-encoded proteins and other aggregation-prone peptides, such as amyloid β (Aβ). PreP structures have only been determined in a closed conformation; thus, the mechanisms of substrate binding and selectivity remain ... Read more >>

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Linking key steps of microRNA biogenesis by TREX-2 and the nuclear pore complex in Arabidopsis.

Bailong Zhang, Chenjiang You, Yong Zhang, Liping Zeng, Jun Hu, Minglei Zhao, Xuemei Chen,

Unlike in metazoans, the stepwise biogenesis of microRNAs (miRNAs) in plants occurs within the nucleus. Whether or how the major steps in miRNA biogenesis are coordinated is largely unknown. Here we show that the plant TREX-2 complex promotes multiple steps in miRNA biogenesis, including transcription, processing and nuclear export. THP1 ... Read more >>

Nat Plants (Nature plants)
[2020, 6(8):957-969]

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KNOX protein KNAT1 regulates fruitlet abscission in litchi by repressing ethylene biosynthetic genes.

Minglei Zhao, Caiqin Li, Xingshuai Ma, Rui Xia, Jianye Chen, Xuncheng Liu, Peiyuan Ying, Manjun Peng, Jun Wang, Chun-Lin Shi, Jianguo Li,

Abscission is triggered by multiple environmental and developmental cues, including endogenous plant hormones. KNOTTED-LIKE HOMEOBOX (KNOX) transcription factors (TFs) play an important role in controlling abscission in plants. However, the underlying molecular mechanism of KNOX TFs in abscission is largely unknown. Here, we identified LcKNAT1, a KNOTTED-LIKE FROM ARABIDOPSIS THALIANA1 ... Read more >>

J. Exp. Bot. (Journal of experimental botany)
[2020, 71(14):4069-4082]

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LcEIL2/3 are involved in fruitlet abscission via activating genes related to ethylene biosynthesis and cell wall remodeling in litchi.

Xingshuai Ma, Ye Yuan, Qian Wu, Jun Wang, Jianguo Li, Minglei Zhao,

Fruit crops are subject to precocious fruit abscission, during which the phytohormone ethylene (ET) acts as a major positive regulator. However, the molecular basis of ET-induced fruit abscission remains poorly understood. Here, we show that two ETHYLENE INSENSITIVE 3-like (EIL) homologs in litchi, LcEIL2 and LcEIL3, play a role in ... Read more >>

Plant J (The Plant journal : for cell and molecular biology)
[2020, 103(4):1338-1350]

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Fundus Photography, Fundus Fluorescein Angiography, and Optical Coherence Tomography of Healthy Cynomolgus Monkey, New Zealand Rabbit, Sprague Dawley Rat, and BALB/c Mouse Retina

Bikun Xian, Minglei Zhao, Yuting Peng, Wencong Wang, Zhiquan Li, Henig Zhang, Weihua Li, Bing Huang,

Abstract Background A variety of experimental animal models are used in basic ophthalmological research to elucidate physiological mechanisms of vision and disease pathogenesis. The choice of animal model is based on the measurability of specific parameters or structures, the applicability of clinical measurement technologies, and the similarity to human ... Read more >>

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Prohibitin 2 deficiency impairs cardiac fatty acid oxidation and causes heart failure.

Dechao Wu, Chongshu Jian, Qi Peng, Tingting Hou, Keling Wu, Bizhi Shang, Minglei Zhao, Yanru Wang, Wen Zheng, Qi Ma, Chuan-Yun Li, Heping Cheng, Xianhua Wang, Ling Zhao,

Fatty acids are the most major substrate source for adult cardiac energy generation. Prohibitin 2 (PHB2), a highly conserved protein located in mitochondrial inner membrane, plays key roles in cellular energy metabolic homeostasis. However, its functions in regulating cardiac fatty acid metabolism have remained largely unknown. Our study demonstrates that ... Read more >>

Cell Death Dis (Cell death & disease)
[2020, 11(3):181]

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Effects of radial extracorporeal shockwave therapy on spasticity of upper-limb agonist/antagonist muscles in patients affected by stroke: a randomized, single-blind clinical trial.

Gaiyan Li, Wenchao Yuan, Gongliang Liu, Lei Qiao, Ying Zhang, Yan Wang, Wei Wang, Minglei Zhao, Yanmin Wang, Jie Wang,

BACKGROUND:the effects of radial extracorporeal shock wave therapy (rESWT) were assessed on agonist/antagonist muscles in stroke patients with elbow spasticity, the duration of effects and influence on function. METHODS:patients were randomly assigned into groups: control (A, n = 25), rESWT on agonist muscles (B, n = 27) and rESWT on antagonist muscles (C, n = 30) ... Read more >>

Age Ageing (Age and ageing)
[2020, 49(2):246-252]

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Structure of the teneurin-latrophilin complex: Alternative splicing controls synapse specificity by a novel mechanism

Jingxian Li, Yuan Xie, Shaleeka Cornelius, Xian Jiang, Szymon Kordon, Richard Sando, Man Pan, Katherine Leon, Thomas Südhof, Minglei Zhao, Demet Araç,

SUMMARY The trans-synaptic interaction of the cell-adhesion molecules teneurins (Tenm’s) with latrophilins (Lphn’s) promotes excitatory synapse formation when Lphn’s simultaneously interact with FLRTs. Insertion of a short alternatively-spliced region within Tenm’s abolishes the Tenm-Lphn interaction and switches Tenm function to specify inhibitory synapses. How Tenm’s bind to Lphn’s in a ... Read more >>

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Molecular Events Involved in Fruitlet Abscission in Litchi.

Minglei Zhao, Jianguo Li,

Abscission in plants is an active and highly coordinated physiological process in which organs abscise from the plant body at the abscission zone (AZ) in responding to either developmental or environmental cues. Litchi (Litchi chinensis Sonn.) is an important economic fruit crop widely grown in Southeast Asia particularly in South ... Read more >>

Plants (Basel) (Plants (Basel, Switzerland))
[2020, 9(2):]

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Identification and Characterization of HAESA-Like Genes Involved in the Fruitlet Abscission in Litchi.

Fei Wang, Zhihui Zheng, Ye Yuan, Jianguo Li, Minglei Zhao,

Regulation of abscission is an important agricultural concern since precocious abscission can reduce crop yield. INFLORESCENCE DEFICIENT IN ABSCISSION (IDA) peptide and its receptors the HAESA (HAE) and HAESA-like2 (HSL2) kinases have been revealed to be core components controlling floral organ abscission in the model plant Arabidopsis. However, it is ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(23):]

Cited: 1 time

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Involvement of HD-ZIP I transcription factors LcHB2 and LcHB3 in fruitlet abscission by promoting transcription of genes related to the biosynthesis of ethylene and ABA in litchi.

Caiqin Li, Xingshuai Ma, Xuming Huang, Huicong Wang, Hong Wu, Minglei Zhao, Jianguo Li,

Tree Physiol. (Tree physiology)
[2019, 39(12):2071]

Cited: 1 time

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Structural basis for adhesion G protein-coupled receptor Gpr126 function

Katherine Leon, Rebecca Cunningham, Joshua Riback, Ezra Feldman, Jingxian Li, Tobin Sosnick, Minglei Zhao, Kelly Monk, Demet Araç,

Abstract Many drugs target the extracellular regions (ECRs) of cell-surface receptors. The large and alternatively-spliced ECRs of adhesion G protein-coupled receptors (aGPCRs) have key functions in diverse biological processes including neurodevelopment, embryogenesis, and tumorigenesis. However, their structures and mechanisms of action remain unclear, hampering drug development. The aGPCR Gpr126/Adgrg6 regulates ... Read more >>

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The HD-Zip transcription factor LcHB2 regulates litchi fruit abscission through the activation of two cellulase genes.

Caiqin Li, Minglei Zhao, Xingshuai Ma, Zhenxi Wen, Peiyuan Ying, Manjun Peng, Xiping Ning, Rui Xia, Hong Wu, Jianguo Li,

Cellulases play important roles in the shedding of plant organs; however, little is yet known about the functions of cellulase genes during the process of organ abscission. Abnormal fruitlet abscission is a serious problem in the production of litchi (Litchi chinensis), an economically important fruit widely grown in South Asia. ... Read more >>

J. Exp. Bot. (Journal of experimental botany)
[2019, 70(19):5189-5203]

Cited: 2 times

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Involvement of HD-ZIP I transcription factors LcHB2 and LcHB3 in fruitlet abscission by promoting transcription of genes related to the biosynthesis of ethylene and ABA in litchi.

Caiqin Li, Xingshuai Ma, Xuming Huang, Huicong Wang, Hong Wu, Minglei Zhao, Jianguo Li,

Abnormal fruitlet abscission is a limiting factor in the production of litchi, an economically important fruit in Southern Asia. Both ethylene and abscisic acid (ABA) induce organ abscission in plants. Although ACS/ACO and NCED genes are known to encode key enzymes required for ethylene and ABA biosynthesis, respectively, the transcriptional ... Read more >>

Tree Physiol. (Tree physiology)
[2019, 39(9):1600-1613]

Cited: 1 time

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Remarkable Improvement in Photocatalytic Performance for Tannery Wastewater Processing via SnS2 Modified with N-Doped Carbon Quantum Dots: Synthesis, Characterization, and 4-Nitrophenol-Aided Cr(VI) Photoreduction.

Shuo Wang, Liping Li, Zhenghui Zhu, Minglei Zhao, Liming Zhang, Nannan Zhang, Qiannan Wu, Xiyang Wang, Guangshe Li,

Photocatalytic pathways are proved crucial for the sustainable production of chemicals and fuels required for a pollution-free planet. Electron-hole recombination is a critical problem that has, so far, limited the efficiency of the most promising photocatalytic materials. Here, the efficacy of the 0D N doped carbon quantum dots (N-CQDs) is ... Read more >>

Small (Small (Weinheim an der Bergstrasse, Germany))
[2019, 15(29):e1804515]

Cited: 1 time

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In vivo detecting mouse persistent hyperplastic primary vitreous by Spectralis Optical Coherence Tomography.

Qing Lian, Minglei Zhao, Tianzhong Li, Keling Wu, Deliang Zhu, Bizhi Shang, Tingfang Mei, Weihua Li, Ying Lin, Fuxiang Mao, Yizhi Liu, Chujun Liu, Lin Lu, Ling Zhao,

To identify imaging characteristics of mouse persistent hyperplastic primary vitreous (PHPV) by Spectralis Optical Coherence Tomography (OCT), as well as to assess and compare the sensitivity and precision of OCT with color photography (CP) and Fundus Fluorescein Angiography (FFA) imaging in detecting mouse PHPV. Notch4-/- C57BL/6J mice (224 eyes) aged ... Read more >>

Exp Eye Res (Experimental eye research)
[2019, 181:271-276]

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Stem cell heterogeneity drives the parasitic life cycle of Schistosoma mansoni.

Bo Wang, Jayhun Lee, Pengyang Li, Amir Saberi, Huiying Yang, Chang Liu, Minglei Zhao, Phillip A Newmark,

Schistosomes are parasitic flatworms infecting hundreds of millions of people. These parasites alternate between asexual reproduction in molluscan hosts and sexual reproduction in mammalian hosts; short-lived, water-borne stages infect each host. Thriving in such disparate environments requires remarkable developmental plasticity, manifested by five body plans deployed throughout the parasite's life ... Read more >>

Elife (eLife)
[2018, 7:]

Cited: 7 times

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Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation.

Feng Luo, Xinrui Gui, Heng Zhou, Jinge Gu, Yichen Li, Xiangyu Liu, Minglei Zhao, Dan Li, Xueming Li, Cong Liu,

Thermostable cross-β structures are characteristic of pathological amyloid fibrils, but these structures cannot explain the reversible nature of fibrils formed by RNA-binding proteins such as fused in sarcoma (FUS), involved in RNA granule assembly. Here, we find that two tandem (S/G)Y(S/G) motifs of the human FUS low-complexity domain (FUS LC) ... Read more >>

Nat Struct Mol Biol (Nature structural & molecular biology)
[2018, 25(4):341-346]

Cited: 25 times

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Lead extraction and glass-ceramics synthesis from waste cathode ray tube funnel glass through cooperative smelting process with coal fly ash.

Jianfang Lv, Hongying Yang, Zhenan Jin, Minglei Zhao,

In this study, a novel process was developed for extracting lead from the hazardous waste cathode ray tube (CRT) funnel glass and simultaneously producing glass-ceramics. CRT funnel glass was mixed with coal fly ash and subjected to carbon thermal reduction with the addition of CaO. The homogeneous glass melt and ... Read more >>

Waste Manag (Waste management (New York, N.Y.))
[2018, 76:687-696]

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Comparison of Two Rabbit Models with Deficiency of Corneal Epithelium and Limbal Stem Cells Established by Different Methods.

Hening Zhang, Shaochun Lin, Min Zhang, Qijiong Li, Weihua Li, Wencong Wang, Minglei Zhao, Yaojue Xie, Zhiquan Li, Mian Huang, Zhichong Wang, Xiulan Zhang, Bing Huang,

Limbal stem cell defect model is an important animal model that provides a basis for the study of ocular surface diseases. The rabbit cornea is of moderate size and is widely used in such studies as an experimental animal model. At present, the main modeling methods are alkali burns, and ... Read more >>

Tissue Eng Part C Methods (Tissue engineering. Part C, Methods)
[2017, 23(11):710-717]

Cited: 1 time

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The primed SNARE-complexin-synaptotagmin complex for neuronal exocytosis.

Qiangjun Zhou, Peng Zhou, Austin L Wang, Dick Wu, Minglei Zhao, Thomas C Südhof, Axel T Brunger,

Synaptotagmin, complexin, and neuronal SNARE (soluble N-ethylmaleimide sensitive factor attachment protein receptor) proteins mediate evoked synchronous neurotransmitter release, but the molecular mechanisms mediating the cooperation between these molecules remain unclear. Here we determine crystal structures of the primed pre-fusion SNARE-complexin-synaptotagmin-1 complex. These structures reveal an unexpected tripartite interface between synaptotagmin-1 ... Read more >>

Nature (Nature)
[2017, 548(7668):420-425]

Cited: 45 times

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Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18.

Ying Lai, Ucheor B Choi, Jeremy Leitz, Hong Jun Rhee, Choongku Lee, Bekir Altas, Minglei Zhao, Richard A Pfuetzner, Austin L Wang, Nils Brose, JeongSeop Rhee, Axel T Brunger,

Munc13 catalyzes the transit of syntaxin from a closed complex with Munc18 into the ternary SNARE complex. Here we report a new function of Munc13, independent of Munc18: it promotes the proper syntaxin/synaptobrevin subconfiguration during assembly of the ternary SNARE complex. In cooperation with Munc18, Munc13 additionally ensures the proper syntaxin/SNAP-25 ... Read more >>

Neuron (Neuron)
[2017, 95(3):591-607.e10]

Cited: 49 times

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