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Comparison of BP26, Omp25 and Omp31 and a Multi-Epitope Based Fusion Protein in Serological Detection of Canine Brucellosis

Meixue Yao, Mengda Liu, Xia Chen, Jianjun Li, Yan Li, Runyu Wei, Yong Liu, Long Kang, Xiaoxiao Duan, Weixing Shao, Xiangxiang Sun, Xiaoxu Fan, Shufang Sun, Lili Tian, Dehui Yin, Mingjun Sun,

<h4>Background: </h4> Brucellosis is one of the most important zoonotic diseases in the world. Canine brucellosis caused mainly by B. canis is seriously neglected and there is lack of accurate diagnostic tools. Methods In this study, using 34 brucellosis positive dog sera and 62 negative control sera, the Brucella ... Read more >>

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The Novel Role of Arsenic (+3 oxidation state) Methyltransferase in Arsenic Genotoxicity

Mingjun Sun, Yuefeng He, Huirong Cheng, Yongchang Zhang, Qian Chen, Weihua Wen,

<h4>Background: </h4> Arsenic (+3 oxidation state) methyltransferase ( AS3MT ) is the key enzyme in methylation metabolism of arsenic. It is closely related to DNA methylation, but little is known about the novel molecular mechanisms. <h4>Methods: </h4>: 79 workers and 41 individuals in the control group were recruited. Arsenic, relative ... Read more >>

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Efficacy and safety of lubiprostone for the treatment of functional constipation in Chinese adult patients: a multicenter, randomized, double-blind, placebo-controlled trial.

Yinglian Xiao, Ning Dai, Shuixiang He, De'an Tian, Side Liu, Zibin Tian, Xiaoyan Wang, Yanqing Li, Xiaohua Hou, Xiucai Fang, Zhili Wen, Weizheng Zeng, Hong Xu, Mingjun Sun, Yulan Liu, Yongdong Wu, Xizhong Shen, Xiaowei Liu, Deliang Liu, Minhu Chen,

<h4>Background and aims</h4>Functional constipation is a functional gastrointestinal disorders prevalent around the world. Lubiprostone is the first locally acting type-2 chloride channel activator in the treatment of constipation. The current study aimed to determine the efficacy and safety of lubiprostone in Chinese functional constipation adult patients .<h4>Methods</h4>This was a multicenter, ... Read more >>

J Dig Dis (Journal of digestive diseases)
[2021, :]

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Expression, regulation, and function of exosome-derived miRNAs in cancer progression and therapy.

Bowen Li, Yu Cao, Mingjun Sun, Hui Feng,

Exosomes are a novel class of intercellular signal modulators that contain a wide range of molecules and deliver information between cells and tissues. MicroRNAs (miRNAs), a type of regulatory non-coding RNA, are often incorporated into exosomes as signaling molecules. In this review, we discuss the expression of exosomal miRNAs from ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(10):e21916]

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Establishment and Validation of a Genetic Label Associated With M2 Macrophage Infiltration to Predict Survival in Patients With Colon Cancer and to Assist in Immunotherapy.

Boyang Xu, Ziqi Peng, Guanyu Yan, Ningning Wang, Moye Chen, Xue Yao, Mingjun Sun, Yue An,

<h4>Background</h4>Colon cancer is a malignant tumor with high morbidity and mortality. Researchers have tried to interpret it from different perspectives and divided it into different subtypes to facilitate individualized treatment. With the rise in the use of immunotherapy, its value in the field of tumor has begun to emerge. From ... Read more >>

Front Genet (Frontiers in genetics)
[2021, 12:726387]

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A Multi-Epitope Fusion Protein-Based p-ELISA Method for Diagnosing Bovine and Goat Brucellosis.

Dehui Yin, Qiongqiong Bai, Xiling Wu, Han Li, Jihong Shao, Mingjun Sun, Jinpeng Zhang,

In recent years, the incidence of brucellosis has increased annually, causing tremendous economic losses to animal husbandry in a lot of countries. Therefore, developing rapid, sensitive, and specific diagnostic techniques is critical to control the spread of brucellosis. In this study, bioinformatics technology was used to predict the B cell ... Read more >>

Front Vet Sci (Frontiers in veterinary science)
[2021, 8:708008]

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Paper-based ELISA diagnosis technology for human brucellosis based on a multiepitope fusion protein.

Dehui Yin, Qiongqiong Bai, Xiling Wu, Han Li, Jihong Shao, Mingjun Sun, Hai Jiang, Jingpeng Zhang,

<h4>Background</h4>Brucellosis, as a serious zoonotic infectious disease, has been recognized as a re-emerging disease in the developing countries worldwide. In china, the incidence of brucellosis is increasing each year, seriously threatening the health of humans as well as animal populations. Despite a quite number of diagnostic methods currently being used ... Read more >>

PLoS Negl Trop Dis (PLoS neglected tropical diseases)
[2021, 15(8):e0009695]

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A novel prognostic model based on epithelial-mesenchymal transition-related genes predicts patient survival in gastric cancer.

Wanting Song, Yi Bai, Jialin Zhu, Fanxin Zeng, Chunmeng Yang, Beibei Hu, Mingjun Sun, Chenyan Li, Shiqiao Peng, Moye Chen, Xuren Sun,

<h4>Background</h4>Gastric cancer (GC) represents a major malignancy and is the third deathliest cancer globally. Several lines of evidence indicate that the epithelial-mesenchymal transition (EMT) has a critical function in the development of gastric cancer. Although plentiful molecular biomarkers have been identified, a precise risk model is still necessary to help ... Read more >>

World J Surg Oncol (World journal of surgical oncology)
[2021, 19(1):216]

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Establishment and Validation of a Genetic Label Associated With M2 Macrophage Infiltration to Predict Survival in Colon Cancer Patients and Assist Immunotherapy

Boyang Xu, Ziqi Peng, Guanyu Yan, Ningning Wang, Moye Chen, Xue Yao, Mingjun Sun, Yue An,

<h4>Background: </h4> Colon cancer is a kind of malignant tumor with high morbidity and mortality. Researchers have tried to interpret it from different perspectives and divide it into different subtypes in order to achieve individualized treatment. With the rise of immunotherapy, its value in the field of tumor has initially ... Read more >>

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Comparative analysis of the main outer membrane proteins of Brucella in the diagnosis of brucellosis.

Qiongqiong Bai, Han Li, Xiling Wu, Jihong Shao, Mingjun Sun, Dehui Yin,

Brucellosis has placed a heavy economic burden on numerous countries and has consumed considerable medical resources worldwide. To improve the specificity and sensitivity of serological methods for diagnosing brucellosis, it is important to develop new diagnostic antigens. Brucella outer membrane proteins(omps) possess good immunogenicity, but there is a scarcity of ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2021, 560:126-131]

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Sputum cell-free DNA: Valued surrogate sample for the detection of EGFR exon 20 p.T790M mutation in patients with advanced lung adenocarcinoma and acquired resistance to EGFR-TKIs.

Zheng Wang, Xiaoguang Li, Lin Zhang, Yan Xu, Mengzhao Wang, Li Liang, Peng Jiao, Yuanming Li, Shurong He, Jun Du, Lei He, Min Tang, Mingjun Sun, Li Yang, Jing Di, Guanshan Zhu, Lin Li, Dongge Liu,

<h4>Background</h4>Sputum cell-free DNA (cfDNA) is a valuable surrogate sample for assessing EGFR-sensitizing mutations in patients with advanced lung adenocarcinoma. Detecting EGFR exon 20 p.T790 M (p.T790 M) is much more challenging due to its limited availability in tumor tissues. Exploring sputum cfDNA as an alternative for liquid-based sample type in detecting p.T790 M ... Read more >>

Cancer Med (Cancer medicine)
[2021, 10(10):3323-3331]

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Potential Impact of ALKBH5 and YTHDF1 on Tumor Immunity in Colon Adenocarcinoma.

Guanyu Yan, Yue An, Boyang Xu, Ningning Wang, Xuren Sun, Mingjun Sun,

<h4>Background</h4>ALKBH5 and YTHDF1 are regarded as the eraser and reader, respectively, in N6-methyladenosine (m6A) modification. Recently, immune contexture has been drawing increasing attention in terms of the progression and treatment of cancers. This study aimed to determine the relationship between ALKBH5/YTHDF1 and immunological characteristics of colon adenocarcinoma (COAD).<h4>Methods</h4>Expression of ALKBH5 ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:670490]

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A multiepitope fusion protein-based p-ELISA method for diagnosing bovine and goat brucellosis

Dehui Yin, Qiongqiong Bai, Xiling Wu, Han Li, Jihong Shao, Mingjun Sun, Jingpeng Zhang,

In recent years, the incidence of brucellosis has increased annually, which has caused tremendous economic losses in agriculture and husbandry in various countries. Therefore, developing rapid, sensitive and specific diagnostic techniques for brucellosis has become critical brucellosis research. Bioinformatics technology was used to predict the B cell epitopes of the ... Read more >>

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Paper-based ELISA Diagnosis Technology for Human Brucellosis Based on a Multiepitope Fusion Protein

Dehui Yin, Qiongqiong Bai, Xiling Wu, Han Li, Jihong Shao, Mingjun Sun, Hai Jiang, Jingpeng Zhang,

<h4>Background: </h4> At present, as a serious zoonotic infectious disease, the incidence of brucellosis is increasing each year worldwide, exhibiting signs of resurgence. Brucellosis seriously threatens the health of humans, and it is necessary to strengthen the methods utilized for its rapid and accurate diagnosis. <h4>Methods: </h4>: Bioinformatic technology was ... Read more >>

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Long non-coding RNA DICER1-AS1-low expression in arsenic-treated A549 cells inhibits cell proliferation by regulating the cell cycle pathway.

Chenglan Jiang, Mingjun Sun, Shuting Li, Jingwen Tan, Mengjie Wang, Yuefeng He,

Arsenic, an environmental pollution with diverse toxicities, incurs public health problems. Arsenic trioxide could inhibit cell proliferation in vitro experiments, but the underlying mechanisms are not fully known. LncRNAs are also involved in the arsenic-induced toxicological responses. In our study, we found that the expression of lncRNA DICER1-AS1 was significantly ... Read more >>

Environ Toxicol Pharmacol (Environmental toxicology and pharmacology)
[2021, 84:103617]

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A Four-Immune Gene Prognostic Risk Model for Colorectal Adenocarcinoma Based on the TCGA and Immport Data Sets

Boyang Xu, Ziqi Peng, Yue An, Xue Yao, Mingjun Sun,

<h4>Background: </h4> As one of the hot spots in oncology field, immune research provides new ideas for the diagnosis and treatment of tumors. Different histological types of colorectal cancer are different. Adenocarcinoma, as the type with the highest proportion, has a high research value. This study aims to build an ... Read more >>

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A Four-Immune Gene Prognostic Risk Model for Colorectal Adenocarcinoma Based on the TCGA and ImmPort Data Sets

Boyang Xu, Ziqi Peng, Yue An, Xue Yao, Mingjun Sun,

<h4>Background: </h4> As one of the hot spots in oncology field, immune research provides new ideas for the diagnosis and treatment of tumors. Different histological types of colorectal cancer are different. Adenocarcinoma, as the type with the highest proportion, has a high research value. This study aims to build an ... Read more >>

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Inorganic arsenic-mediated upregulation of AS3MT promotes proliferation of nonsmall cell lung cancer cells by regulating cell cycle genes.

Mingjun Sun, Jingwen Tan, Mengjie Wang, Weihua Wen, Yuefeng He,

Long-term arsenic exposure can promote cancer through epigenetic mechanisms, and arsenite methyltransferase (AS3MT) plays an important role in this process. However, the expression patterns and mechanisms of AS3MT in arsenic carcinogenesis remain unclear. In this study, we found that the AS3MT was overexpressed in arsenic exposed population, non-small cell lung ... Read more >>

Environ Toxicol (Environmental toxicology)
[2021, 36(2):204-212]

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LncRNA-PCAT1 controls the growth, metastasis and drug resistance of human colon cancer cells.

Haiying Sun, Xuren Sun, Huijing Zhang, An Yue, Mingjun Sun,

<h4>Purpose</h4>The long non-coding (lnc) RNAs have been shown to exhibit profound regulatory roles in maintaining the growth and proliferation of human cancer cells. Taking this fact into consideration, the current research work was scheduled to explore the regulatory control of lncRNA-PCAT1 in maintaining the growth and progression of human colon ... Read more >>

J BUON (Journal of B.U.ON. : official journal of the Balkan Union of Oncology)
[2020, 25(5):2180-2185]

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H. pylori slyD, a novel virulence factor, is associated with Wnt pathway protein expression during gastric disease progression.

Aining Chu, Xiuwen Yu, Qianqian Guo, Qiuping Li, Mingjun Sun, Yuan Yuan, Yuehua Gong,

We have previously reported that the virulence factor HpslyD is related to the occurrence of gastric diseases. However, its mechanism of pathogenesis is still unclear. It is commonly believed that the Wnt/β-catenin pathway is indispensable for the development of gastric cancer, but it is unclear whether HpslyD and Wnt/β-catenin interact ... Read more >>

Microb Pathog (Microbial pathogenesis)
[2020, 148:104428]

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Arsenic exposure increased expression of HOTAIR and LincRNA-p21 in vivo and vitro.

Jingwen Tan, Mingjun Sun, Quan Luo, Huiwen Sun, Mengjie Wang, Chenglan Jiang, Shuting Li, Yuefeng He,

Arsenic is an environmental contaminant, its multiple effects on human tend to increase the rate of disease, cancer and other health problems. Some of long non-coding RNAs (lncRNAs) can be induced in major cellular processes such as necrosis, proliferation, and mutation. While the toxicity of arsenic is well established, the ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2021, 28(1):587-596]

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Rational Design of Oxygen Deficiency-Controlled Tungsten Oxide Electrochromic Films with an Exceptional Memory Effect.

Yingdi Shi, Mingjun Sun, Yong Zhang, Jiewu Cui, Xia Shu, Yan Wang, Yongqiang Qin, Jiaqin Liu, Hark Hoe Tan, Yucheng Wu,

Owing to their nonemissive characteristics, electrochromic materials promise distinct advantages in developing next-generation eye-friendly information displays. Yet, it remains a challenge to manipulate the structure of the materials to achieve a strong memory effect with high optical contrast, which is of importance for displaying images with essentially zero energy consumption. ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, 12(29):32658-32665]

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Efficacy of transanal drainage tube and self-expanding metallic stent in acute left malignant colorectal obstruction.

Yue An, Ningning Wang, Zhidong Yang, Yue Li, Boyang Xu, Guangying Guo, Mingjun Sun,

<h4>Background</h4>The self-expanding metal stent (SEMS) or transanal drainage tube (TDT) methods can be used as a palliative treatment before tumor resection surgery. Studies systematically comparing the efficacy and characteristics between SEMS with TDT are limited, especially in a large-scale Chinese population. This retrospective study aimed to compare the outcomes of ... Read more >>

Ann Palliat Med (Annals of palliative medicine)
[2020, 9(4):1614-1621]

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First identification of a Brucella abortus biovar 4 strain from yak in Tibet, China.

Mingjun Sun, Mengda Liu, Xiyue Zhang, Ge Zhang, Liangquan Zhu, Jiabo Ding, Zhicheng Zhang, Shixiong Sun, Shufang Sun, Weixing Shao, Peipei Zhang, Jiandong Zhang, Xiangxiang Sun, Xuezheng Fan, Rong Wei,

Brucellosis is one of the major zoonotic diseases in the world. In China, understanding on its causative agent Brucella is still limited. Recently, we isolated a Brucella strain XZ19-1 from yak in Lhasa, Tibet. Phenotypical characterization proved that it belongs to B. abortus biovar 4, a biotype that has never ... Read more >>

Vet Microbiol (Veterinary microbiology)
[2020, 247:108751]

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Association between body mass index and survival outcomes for cancer patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis.

Yue An, Zhonghua Wu, Ningning Wang, Zhidong Yang, Yue Li, Boyang Xu, Mingjun Sun,

<h4>Background</h4>Immune checkpoint inhibitors (ICIs) have been increasingly applied in the treatment of several kinds of malignancies. Some clinical demographic characteristics were reported to be associated with the ICIs efficacy. The purpose of our current meta-analysis was to clearly evaluated the relationship between BMI and ICIs efficacy for cancer patients receiving ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):235]

Cited: 6 times

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